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45 results about "Artificial enzyme" patented technology
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An artificial enzyme is a synthetic, organic molecule or ion that recreate some function of an enzyme. The area promises to deliver catalysis at rates and selectivity observed in many enzymes.
Methods and compositions for directed microwave chemistry
InactiveUS7351590B2Immobilised enzymesBioreactor/fermenter combinationsArtificial enzymeChemical measurement
The present invention concerns a novel means by which specific chosen reactions can be accelerated through the use of a new type of artificial enzyme. The invention allows specific reactions to occur at an accelerated rate, even in the presence of other non-chosen molecules, which may be very similar in structure to the chosen reactant. The reactions may be stoichiometric or catalytic.
Owner:MILESTONE SRL
Methods and compositions for directed microwave chemistry
InactiveUS20020197645A1Facilitate decision-makingReduce chanceImmobilised enzymesBioreactor/fermenter combinationsArtificial enzymeChemical measurement
The present invention concerns a novel means by which specific chosen reactions can be accelerated through the use of a new type of artificial enzyme. The invention allows specific reactions to occur at an accelerated rate, even in the presence of other non-chosen molecules, which may be very similar in structure to the chosen reactant. The reactions may be stoichiometric or catalytic.
Owner:MILESTONE SRL
Silk functional fiber preparation method
InactiveCN101187160ASolve usabilityResolve separabilityAnimal fibresChemical LinkageArtificial enzyme
The invention relates to a process for preparing silk functional fabric, which grafts the cyclodextrin onto the silk fiber through the chemical bond to obtain the silk functional fabric product with cyclodextrin solid chirality hydrophobic cavity, wherein the process can be used for preparing fabric with aromatic and medical health care functions and also can be used in the fields of molecule identification, waste water purification, artificial enzyme system forming and pharmaceutical slow releasing.
Owner:ZHEJIANG SCI-TECH UNIV
Gum-containing silk functional fiber preparation method
InactiveCN101187156ASolve usabilityResolve separabilityAnimal fibresChemical LinkageArtificial enzyme
The invention relates to a process for preparing sericin silk functional fiber, which comprises: processing the sericin fixation on the sericin silk, then grafting cyclodextrin onto the silk fiber through chemical bond to obtain the sericin silk functional fiber product with cyclodextrin solid chirality hydrophobic cavity. The process for preparartion can be applied in the preparation of aromatic and medical health care functional fiber and also can be applied in the fields of molecule identification, waste water purification, artificial enzyme system forming and pharmaceutical slow release.
Owner:ZHEJIANG SCI-TECH UNIV
DNA (deoxyribonucleic acid) three-dimensional nano-structure artificial enzyme precursor, and preparation and application thereof
ActiveCN104774857AChemically stableStable structureHydrolasesMaterial analysis by electric/magnetic meansArtificial enzymeCompound (substance)
The invention relates to the technical field of biology, particularly a DNA (deoxyribonucleic acid) three-dimensional nano-structure artificial enzyme precursor, and preparation and application thereof. The invention provides a stable chemical environment by using a DNA tetrahedron as a nuclease framework; and by utilizing the controllability of the DNA tetrahedron nano structure, nucleases are respectively connected to different positions of the DNA tetrahedron framework, thereby forming the DNA tetrahedron nano-structure artificial enzyme precursor with different structures. Compared with the traditional nucleases, the enzyme formed by the DNA tetrahedron nano-structure artificial enzyme precursor with different structures has more stable structure and higher sensitivity, and the catalytic activity is 6-14 times of the traditional nuclease.
Owner:SHANGHAI ADVANCED RES INST CHINESE ACADEMY OF SCI +1
Method for improving peroxidase-like activity of nanozyme and product thereof
ActiveUS20200078766A1Easy to operateLow costCatalyst activation/preparationMetal/metal-oxides/metal-hydroxide catalystsHigh concentrationArtificial enzyme
A method for improving peroxidase-like activity of nanozyme and a product thereof are disclosed, which relate to the field of artificial enzymes in biochemistry. The method adopts a hydrogen peroxide solution with high concentration to treat the VO2(B) powder for obtaining a product with high peroxidase-like activity. Compared with the pure VO2(B) powder, the peroxidase-like activity of the product obtained by the method is increased by 4 to 12 times. The method provided by the present invention adopts raw materials with low cost and mild reaction conditions, is simple in operation and low in cost, which is conducive to batch preparation. The powder product obtained by the method is able to be applied to detect hydrogen peroxide, glucose, etc., and has great application prospects in biosensing, industrial wastewater treatment and sewage treatment.
Owner:UNIV OF ELECTRONICS SCI & TECH OF CHINA
Biohydrogen production by an artificial enzymatic pathway
The present invention comprises an in vitro enzymatic process that effectively converts renewable polysaccharides into high yields of hydrogen at mild conditions, using only enzymes and water. The process comprises a number of enzymes: (1) phosphorylases, (2) phosphoglucomutases, (3) hydrogenases, and (4) enzymes involved in the pentose-phosphate pathway. Preferred embodiments of the process produce only hydrogen and carbon dioxide as net products, translating into an inexpensive method of generating hydrogen in very large quantities from low-cost feedstocks.
Owner:VIRGINIA TECH INTPROP INC +1
Nucleotide-transition metal complex catalyst
InactiveUS20090148958A1Disadvantage of to deactivationDisadvantage of to denaturationSugar derivativesOrganic-compounds/hydrides/coordination-complexes catalystsArtificial enzymeMonomer
This invention is to provide a catalyst (an artificial enzyme) which can be used as an alternative to a protein enzyme in the field relating to medicine, pharmaceuticals, biochemistry or chemical engineering. Such a catalyst comprises a complex of a transition metal and a monomeric or polymeric nucleotide or an analogue thereof.
Owner:ONECELL
Enzyme and application thereof
ActiveUS20190153403A1High catalytic efficiencyImprove nicotine transformation abilityNervous disorderPeptide/protein ingredientsArtificial enzymeSide chain
Provides an artificial enzyme obtained by improving upon a sequence of a natural nicotine dehydrogenase, wherein the improvement comprises replacing at least one amino acid hindering product release with an amino acid with smaller side chains, thereby improving a catalytic rate.
Owner:SHANGHAI JIAO TONG UNIV
Biosynthesis of preparing nicotinamide mononucleotide and derivatives thereof
PendingUS20210246476A1Increase productionHigh yieldFermentationGlycosyltransferasesArtificial enzymePhosphoric acid
A method of making nicotinamide mononucleotide (NMN), nicotinamide mononucleotide derivatives, or mixtures thereof is disclosed. The method involves the in vitro artificial enzymatic pathways comprised: the generation of alpha-D-ribose-1-phosphate from numerous substrates followed by the synthesis of nicotinamide mononucleotide catalyzed by nicotinamide riboside phosphorylase and nicotinamide riboside kinase or the generation of 5-phospho-alpha-D-ribose-1-diphosphate from nucleotides followed by the synthesis of nicotinamide mononucleotide catalyzed by nicotinamide phosphoribosyltransferase. The multiple enzymes were reconstituted in one pot, wherein in-situ removal of byproducts that can be converted to other non-inhibitory chemicals with supplementary enzymes push the overall biotransformation toward the synthesis of nicotinamide mononucleotide. Furthermore, nicotinamide mononucleotide can be converted to its derivatives—nicotinamide adenine dinucleotide and nicotinamide adenine dinucleotide phosphate.
Owner:ZHANG YI HENG PERCIVAL
Artificial enzyme and method for producing the same
InactiveUS20060188958A1Easily amplifiedEasy to copySugar derivativesHydrolasesArtificial enzymeModified nucleosides
The method for producing an artificial enzyme according to the invention is a method for producing an artificial enzyme and includes the step of selecting an artificial enzyme precursor which includes an oligonucleotide sequence containing modified nucleosides prepared by introducing a substituent into each nucleoside and at least one of the modified nucleoside capable of reacting with a raw substance of a target reaction which the artificial enzyme catalyzes; and the step of producing the artificial enzyme which is capable of catalyzing a target reaction and includes the oligonucleotide sequence in which the modified nucleoside capable of reacting with the raw substance of the artificial enzyme precursor is substituted with a non-reactive modified nucleoside which is non-reactive with the raw substance of the target reaction.
Owner:FUJITSU LTD
Preparation of tellurium contained transparent acid with activity of high glutathione peroxidase
InactiveCN1644588AImproves antioxidant activityStable physical and chemical propertiesHigh resistanceTe element
Production of transparent acid containing tellurium with high glutathione oxide enzyme activity is artificial enzyme process with GPX activity. It consists of transparent acid activating, tellurium sodium hydride preparing, transparent acid tellurium reacting, tellurium transparent acid oxidizing and after processing. The production is carried out by activating transparent acid with tolylsulfonyl chlorin, preparing transparent acid benzene sulfonyl ester, dialyzing in distilled water, adding tellurium powder and sodium borohydride into anhydrous alcohol, heating and reverse flowing in nitrogen system, adding anaerobic glacial acetic acid, preparing alcohol solution of tellurium sodium hydride preparing, alcohol of tellurium sodium hydride reacting with transparent acid benzene sulfonyl ester solution, obtaining transparent acid containing the, the reacting system expose in air, centrifugal oxidizing, alcohol settling, and washing. It achieves simple process, high output, higher resistance to oxidation and GPX activity.
Owner:JILIN UNIV
Glutathione peroxidase GPX2 mutant containing serine and preparation method of mutant
The invention discloses a glutathione peroxidase GPX2 mutant containing serine and a preparation method of the mutant, and belongs to the field of biotechnology. The novel high-activity glutathione peroxidase GPX2 mutant is obtained by taking human GPX2 as a template through computer simulation and site-specific mutagenesis, and the mutant consists of 203 amino acids; compared with the human GPX2, the mutant is free from cysteine, and is relatively high in GPX activity and better in stability; all cysteine in the human GPX2 is mutated into serine, but the 40th site is still selenocysteine (SeCys), alanine (Ala) on the 117th-site is mutated into serine (Ser), and a formed sequence is as shown in SEQ ID No:2. The method can achieve the direct expression of GPX2 mutant protein having high enzymatic activity in mammalian cell lines or auxotroph prokaryotic expression system and SPP low-temperature expression system thereof by virtue of genetic engineering technology. The method can prepare a novel artificial enzyme having quite high GPX activity without chemical modification. The method disclosed by the invention has a broad application prospect in the aspect of biological pharmacy.
Owner:JILIN UNIV
Artificial photosynthesis system and application thereof
InactiveCN105728048AImprove accessibilityHigh selectivityOrganic compound preparationOrganic-compounds/hydrides/coordination-complexes catalystsSemiconductor materialsArtificial enzyme
The invention discloses an artificial photosynthesis system and an application thereof. The artificial photosynthesis system comprises an artificial enzyme carrier, a light capture agent and an artificial enzyme, wherein the artificial enzyme comprises a coordination compound formed by metal ions and more than two nitrogen-atoms in melamine molecule in the artificial enzyme carrier. The artificial photosynthesis system contains 0.5-6wt% of melamine. The artificial photosynthesis system provided by the invention takes the melamine as the photosensitizer and the artificial enzyme carrier and the coordination compound formed between metal ions and nitrogen-atoms as the artificial enzyme, so that the selectivity of the photocatalytic reduction products to methyl alcohol is increased. The artificial photosynthesis system provided by the invention puts forward taking the semiconductor material ceric oxide coupling metal complex as the artificial enzyme for constructing a theoretical model for the artificial photosynthesis system, so that the applications of the semiconductor material CeO2 and melamine in the photocatalysis field are widened, the photocatalyst preparation process according to the invention is simple and the raw materials are low-cost and easily acquired.
Owner:SUZHOU UNIV OF SCI & TECH
Making method for improving quality of whole wheat bread
PendingCN112400950AFacilitate cross-linkingHelp formDough treatmentPre-baking dough treatmentBiotechnologyArtificial enzyme
The invention relates to the technical field of food processing, and particularly relates to a making method for improving the quality of whole wheat bread. The making method comprises the following steps of performing enzymolysis on wheat bran by a natural and artificial complex enzyme method, performing wheat germination treatment through safe and effective sterilization of artificial enzymes, preparing malt flour, and adding the wheat bran after enzymolysis, the malt flour and konjac gum to high gluten flour to make bran-containing whole wheat bread. Through enzymolysis of complex enzymes,crude fibers in the wheat bran are degraded, the roughness of the bread is reduced, non-starch polysaccharide in whole wheat flour is hydrolyzed into water-soluble sugar, and the mouth feel is improved; and through the stickiness of the konjac gum, the whole wheat flour is promoted to form gluten in mixing, and the whole wheat bread is easy to process and shape, so that the limitation of the content of the whole wheat flour is broken through. In the baking process of the konjac gum, a reticular tissue structure having supporting effects is formed, and generated gas is wrapped in the reticularstructure, so that the texture of the bread is soft. Besides, sterilization treatment of the artificial enzymes is used, so that the shelf life of the bread is prolonged.
Owner:云南伦扬科技有限公司
4D intelligent aerogel and preparation method thereof
ActiveCN109293979ALow densityHigh porosityAdditive manufacturing apparatusArtificial enzymeNew energy
The invention relates to a 4D intelligent aerogel and a preparation method thereof. The preparation method is characterized by regulating the shape memory property and regulating the microstructure, the density and the hydrophilicity. The 4D intelligent aerogel is prepared by a one-step crosslinking vacuum freeze-drying process, and the technical problems of complexness and poor controllability ofexisting intelligent aerogel preparation methods are solved. The preparation method has the advantages of simple preparation process, low cost, good controllability, strong universality, and easinessin modification and compounding of a material. The 4D aerogel has the advantages of strong controllability, good structural designability, good density and hydrophilicity controllability and good mechanical properties, can be used in fields of marine development, intelligent drugs, environmental protection, porous electrodes, intelligent adsorption, intelligent artificial enzymes, intelligent sound absorption, new energy development, intelligent protection, building materials, lightweight structural materials, thermal insulation materials, flame retardant materials, shock absorbing materials,reinforced framework materials, energy storage devices and aerospace, ad provides a way for studying multifunctional materials.
Owner:HAINAN UNIVERSITY +1
Applications of heme/chaperonin artificial enzyme in detection of substance content in solution
InactiveCN108132240AReduce pollutionEasy to handleAnalysis by subjecting material to chemical reactionColor/spectral properties measurementsArtificial enzymeChaperonin
The invention provides applications of heme / chaperonin artificial enzyme in detection of substance content in solution, and belongs to the technical field of biological enzyme detection. Compared withnatural heme enzyme, the heme / chaperonin artificial enzyme possesses more active sites and a larger reactor, and can be used for sewage monitoring and biological diagnosis applications with high efficiency. According to the invention, o-phenylenediamine is taken as the substrate of the heme / chaperonin artificial enzyme, and reaction with hydrogen peroxide is adopted so as to realize direct / indirect detection of substance content in solution. The heme / chaperonin artificial enzyme can be used for hydrogen peroxide monitoring in industrial / municipal sewage, and detection of glucose in serum.
Owner:CHINA UNIV OF PETROLEUM (EAST CHINA)
Ruthenium-based metal ion liquid polymer microsphere artificial enzyme as well as preparation method and application thereof
ActiveCN114272862APromote oxidation reactionImprove bindingMaterial analysis by observing effect on chemical indicatorColor/spectral properties measurementsArtificial enzymeMicrosphere
The invention discloses a ruthenium-based metal ion liquid polymer microsphere artificial enzyme as well as a preparation method and application thereof. The preparation method comprises the following steps: (1) mixing a salicylic acid solution, a vinyl imidazole solution and a ruthenium trichloride solution, stirring, extracting, evaporating the obtained oil phase solution to remove a solvent, and drying to obtain ruthenium salicylic acid vinyl imidazole ionic liquid; (2) dispersing the ionic liquid obtained in the step (1) in a solvent, adding divinyl benzene, mixing, adding a free radical initiator, reacting, separating, precipitating, washing with water, and drying to obtain solid powder; and (3) dispersing the solid powder obtained in the step (2) in a solvent to obtain a reactant, adding a reducing agent to react, and drying the solid obtained by filtering to obtain the ruthenium-based metal ion liquid polymer microsphere artificial enzyme. The artificial enzyme prepared by the invention has good dispersibility and high oxidase-like activity, and can be used for detecting prochloraz by a colorimetric method.
Owner:SPECIAL EQUIP SAFETY SUPERVISION INSPECTION INST OF JIANGSU PROVINCE
DNA hybrid catalyst/MOFs composite material and preparation and application thereof
InactiveCN111111782AImprove toleranceImprove high temperature resistanceOrganic compound preparationOrganic-compounds/hydrides/coordination-complexes catalystsPtru catalystArtificial enzyme
The invention discloses a preparation method of a DNA hybrid catalyst (G4DNA) / MOFs composite material. The preparation method comprises the following steps: sequentially mixing a guanine (G)-rich single-stranded DNA buffer solution with a potassium chloride (KCl) buffer solution and a hemin buffer solution to obtain a DNA hybrid catalyst (G4DNA); and mixing a certain amount of G4DNA with an aqueous imidazole-2-formaldehyde solution (having a concentration of 200 mM and containing 2 wt% of a stabilizer polyvinylpyrrolidone (PVP)) at room temperature, adding an aqueous solution (with a concentration of 416 mM) of zinc nitrate, and carrying out stirring to obtain the DNA hybrid catalyst / MOFs composite material, namely G4DNA@ZIF-90. The preparation method has the advantages of simple reactionconditions, few synthesis steps, short time consumption and low production cost. The preparation method of the DNA hybrid catalyst / MOFs composite material is used for applying artificial enzyme to thefield of industrial catalysis, and has potential application value.
Owner:EAST CHINA NORMAL UNIVERSITY
Intelligent aerogel in-situ composite system with shape memory performance and preparation method thereof
InactiveCN112844255AHas shape memory propertiesPorosityCarbon preparation/purificationAerogel preparationEnvironmental energyArtificial enzyme
The invention belongs to the field of preparation of porous intelligent materials, and particularly relates to preparation of an intelligent aerogel in-situ composite system with shape memory performance. In-situ composite regulation and control on the nanoparticles is achieved. The microstructure and the performance of the porous intelligent aerogel are regulated and controlled. The shape memory aerogel in-situ composite material is prepared by using a vacuum freeze-drying-controllable carbonization method, and the technical problems of non-uniform dispersion and poor performance controllability when a nano material is adopted for modifying the surface of a porous intelligent material are solved. The preparation process is good in controllability, in-situ composite modification of the nano material and the porous intelligent material is easy to realize, and the universality is high. The intelligent aerogel in-situ composite system is high in structural designability, good in mechanical property, good in shape memory controllability, low in density and good in hydrophilicity, and has excellent application potential in the fields of intelligent adsorption and detection, environmental energy catalysis, marine resource development and utilization, intelligent gas-sensitive materials, artificial enzymes and the like; and an effective way is provided for developing a porous intelligent composite material.
Owner:HAINAN UNIVERSITY
High-vitality glutathione peroxidase GPX3 (glutathione peroxidase) mutant and preparation method thereof
InactiveCN103881988AEasy to prepareIncrease vitalityOxidoreductasesVector-based foreign material introductionMutated proteinArtificial enzyme
The invention discloses a high-vitality glutathione peroxidase GPX3 (glutathione peroxidase) mutant and a preparation method thereof, belonging to the field of biotechnologies. With a human GPX3 as a template, through computer simulation and fixed point mutation, a novel high-vitality glutathione peroxidase GPX3 mutant is obtained, wherein the high-vitality glutathione peroxidase GPX3 mutant comprises 207 amino acids; and compared with the human GPX3, the high-vitality glutathione peroxidase GPX3 mutant does not contain cysteine and is higher in GPX activity and better in stability; all cysteines in the human GPX3 are mutated into serines or alanines, but the 54th site is always selenocysteine (SeCys). According to the method, the high-enzyme activity GPX3 mutant protein is directly expressed in a mammal cell strain or auxotroph prokaryotic expression system and an SPP (trisodium phosphate) low-temperature expression system thereof by using a genetic engineering technology. According to the preparation method, a novel extremely high GPX activity artificial enzyme can be prepared without chemical modification. The preparation method disclosed by the invention is wide in application prospect on the aspect of bio-pharmaceuticals.
Owner:JILIN UNIV
Enzyme and application thereof
ActiveUS11279916B2Increase catalytic rateImprove catalytic performanceNervous disorderPeptide/protein ingredientsArtificial enzymeNicotine dehydrogenase
Owner:SHANGHAI JIAOTONG UNIV
A method for efficiently producing chondroitin sulfate a by artificial enzymatic method
ActiveCN111621533BUniform structureNo potential pathogenic factorFungiAntibody mimetics/scaffoldsHeterologousArtificial enzyme
The invention discloses a method for efficiently producing chondroitin sulfate A by artificial enzyme method, which belongs to the technical field of bioengineering. This method expresses a bifunctional protein chondroitin 4‑O‑sulfotransferase C4ST and aryl sulfotransferase AST IV through microbial heterologous expression, which is used to catalyze the synthesis of chondroitin sulfate A from chondroitin, combined with site-directed mutagenesis and The optimization of the components of the reaction system accelerates the synthesis efficiency of chondroitin sulfate.
Owner:JIANGNAN UNIV
Leaf-shaped metal organic framework nano artificial enzyme hybrid and preparation method of tandem catalytic fluorescent probe from enzyme hybrid
The invention discloses a leaf-shaped metal organic framework nano artificial enzyme hybrid and a preparation method of a tandem catalytic fluorescent probe from the enzyme hybrid. A novel gold nanocage (AuNC) and urate oxidase (UOx) double-loaded metal organic framework compound (MOF) is prepared in a water phase by adopting a one-pot method, and is used as a leaf-shaped metal organic framework nano artificial enzyme hybrid UOx @MOF (AuNC) for catalyzing uric acid to generate hydrogen peroxide, and the hydrogen peroxide reacts with ferrous ions to generate .OH hydroxyl radicals; the .OH hydroxyl radicals cause fluorescence quenching of rhodamine B. The linear relationship between the fluorescence emission peak intensity of rhodamine B in the mixed system and the concentration of uric acidis fit, and the novel fluorescent probe based on the hybrid and the tandem catalytic reaction thereof is constructed, and is used for high-sensitivity and specific quantitative detection of uric acid.
Owner:QINGDAO UNIV
Preparation of tellurium contained transparent acid with activity of high glutathione peroxidase
InactiveCN100391984CImproves antioxidant activityStable physical and chemical propertiesHigh resistanceTe element
Production of transparent acid containing tellurium with high glutathione oxide enzyme activity is artificial enzyme process with GPX activity. It consists of transparent acid activating, tellurium sodium hydride preparing, transparent acid tellurium reacting, tellurium transparent acid oxidizing and after processing. The production is carried out by activating transparent acid with tolylsulfonyl chlorin, preparing transparent acid benzene sulfonyl ester, dialyzing in distilled water, adding tellurium powder and sodium borohydride into anhydrous alcohol, heating and reverse flowing in nitrogen system, adding anaerobic glacial acetic acid, preparing alcohol solution of tellurium sodium hydride preparing, alcohol of tellurium sodium hydride reacting with transparent acid benzene sulfonyl ester solution, obtaining transparent acid containing the, the reacting system expose in air, centrifugal oxidizing, alcohol settling, and washing. It achieves simple process, high output, higher resistance to oxidation and GPX activity.
Owner:JILIN UNIV
Method for improving peroxidase-like activity of nanozyme and product thereof
ActiveUS11033881B2Improving peroxidase-like activityEasy to operateCatalyst activation/preparationMetal/metal-oxides/metal-hydroxide catalystsHigh concentrationArtificial enzyme
A method for improving peroxidase-like activity of nanozyme and a product thereof are disclosed, which relate to the field of artificial enzymes in biochemistry. The method adopts a hydrogen peroxide solution with high concentration to treat the VO2(B) powder for obtaining a product with high peroxidase-like activity. Compared with the pure VO2(B) powder, the peroxidase-like activity of the product obtained by the method is increased by 4 to 12 times. The method provided by the present invention adopts raw materials with low cost and mild reaction conditions, is simple in operation and low in cost, which is conducive to batch preparation. The powder product obtained by the method is able to be applied to detect hydrogen peroxide, glucose, etc., and has great application prospects in biosensing, industrial wastewater treatment and sewage treatment.
Owner:UNIV OF ELECTRONICS SCI & TECH OF CHINA
Artificial G-quadruplex DNA metalloenzyme and application thereof
ActiveCN113492020ASelectivity can be maintainedGood choiceOrganic compound preparationOrganic-compounds/hydrides/coordination-complexes catalystsArtificial enzymeBiochemistry
The invention discloses an artificial G-quadruplex DNA metalloenzyme and application thereof. The metalloenzyme consists of ferriporphyrin and artificial G-quadruplex DNA. In the presence of K < + >, the artificial G-quadruplex DNA and ferriporphyrin are mixed in a buffer solution, and the artificial G-quadruplex DNA metalloenzyme can be obtained through in-situ synthesis by stirring. When the artificial G-quadruplex metalloenzyme is applied to olefin asymmetric cyclopropanation reaction, the artificial G-quadruplex metalloenzyme shows relatively high catalytic activity and relatively high selectivity. The artificial G-quadruplex DNA metalloenzyme does not contain precious metal components, the reaction cost is remarkably reduced, and the artificial G-quadruplex DNA metalloenzyme is mild in use condition and is a novel artificial enzyme which is environmentally friendly, high in activity, high in selectivity and excellent in stability.
Owner:DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
Highly active glutathione peroxidase gpx2 mutant and preparation method thereof
ActiveCN103756984BIncrease vitalityImprove protectionOxidoreductasesVector-based foreign material introductionGPX2Artificial enzyme
Owner:JILIN UNIV
Electric response intelligent high molecular catalyst and its preparing process
InactiveCN1457925AAddress accessibility issuesEasy to spreadOrganic-compounds/hydrides/coordination-complexes catalystsArtificial enzymeEmulsion polymerization
The intelligent catalyst consists of vinyl imidazole 20-40 wt%, 2-acrylic amino-2-methyl-1-propyl sulfonic acid 20-40 wt%, and N, N-methylene-diacrylamide 11-22 wt% to form crosslinked polymer compound as well as additive reagent 9-18 wt%. Its preparation includes the steps of: free radical emulsion polymerization of vinyl imidazole, 2-acrylic amino-2-methyl-1-propyl sulfonic acid, and N, N-methylene-diacrylamide to form crosslinked electric response intelligent polymer catalyst; and the test of the catalytic activity. The present invention has the advantages of the flexibility and mobility introduced into the catalyst structure to solve the problem of the polymer catalyst in accessibility and to raise the activity; and the capacity of using the catalyst as artificial enzyme model to simulate the flexibility of enzyme.
Owner:TIANJIN UNIVERSITY OF TECHNOLOGY
Biohydrogen production by an artificial enzymatic pathway
The present invention comprises an in vitro enzymatic process that effectively converts renewable polysaccharides into high yields of hydrogen at mild conditions, using only enzymes and water. The process comprises a number of enzymes: (1) phosphorylases, (2) phosphoglucomutases, (3) hydrogenases, and (4) enzymes involved in the pentose-phosphate pathway. Preferred embodiments of the process produce only hydrogen and carbon dioxide as net products, translating into an inexpensive method of generating hydrogen in very large quantities from low-cost feedstocks.
Owner:VIRGINIA TECH INTPROP INC +1
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