Loxoprofen sodium patch

A technology of loxoprofen sodium and patch, which is applied in the field of loxoprofen sodium patch to achieve obvious effects, reduce the incidence of side effects, and improve compliance

Inactive Publication Date: 2018-05-29
北京茗泽中和药物研究有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, traditional skin irritation experiments all use healthy animal models, but in actual use, because loxoprofen sodium itself belongs to non-steroidal anti-inflammatory drugs, in its indications, rheumatoid arthritis, frozen shoulder and other diseases Patients themselves are often in the middle of delayed hypersensitivity reaction, so in the actual application process, symptoms of contact dermatitis such as skin redness, itching, rash, etc. The loxoprofen sodium patch of the skin irritation becomes urgent problem in the prior art

Method used

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Examples

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Embodiment 1

[0028] Pharmacological Example 1: New Zealand Rabbit Animal Model Skin Irritation Experiment for Delayed Hypersensitivity

[0029] 1. Experimental animals: select New Zealand white rabbits, weighing 2.0-2.5 kg, male or female, 10 rabbits in each group.

[0030] 2. Modeling, the model group uses potassium dichromate (K 2 Cr 2 o 7 ) for immunization, each rabbit was injected intramuscularly with 1% K 2 Cr 2 o 7 + Freund's complete adjuvant mixture (volume ratio 1:1) 0.5ml. At the same time, 0.1ml of the mixed solution was injected intradermally in 4 places, and after continuous injection for 7 days, the back was treated with K 2 Cr 2 o 7 / 40% dimethyl sulfoxide solution for skin application. In the third week after the first injection, 0.5ml of 0.5% K2Cr2O7 solution was injected intramuscularly to strengthen the hypersensitivity reaction.

[0031] 3. Experimental method

[0032] After the last injection, cut off most of the rabbit hair on both sides of the spine with ...

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Abstract

The invention discloses a loxoprofen sodium patch. The loxoprofen sodium patch is characterized by comprising paste which coats a supporting layer, wherein the paste is prepared from the following components in percentage by weight: 4%-6% of loxoprofen sodium, 4%-6% of diethanol amine, 1.8%-2.2% of propylene glycol, 2.5%-3.5% of azone, 2.5%-3.5% of menthol, 0.5%-1% of ascorbic acid, 0.1%-0.2% of nicotinamide, 0.1%-0.2% of tocopheryl acetate and the balance of substrate prepared from emulsion type polyacrylate pressure-sensitive adhesive; and the area content of the loxoprofen sodium of the patch is 0.6-1.0 mg / cm<2>.

Description

technical field [0001] The present invention relates to loxoprofen sodium patch. Background technique [0002] Loxoprofen Sodium (CAS: 80382-23-6, Monosodium [0003] 2-{4-[(2-oxocyclopentyl)methyl]phenyl}propanoatedihydrate, 2-[4-(2-oxocyclopentyl-1-ylmethyl)phenyl]propanoate dihydrate) belongs to phenylpropanoid Acid NSAIDs, whose molecular formula is as follows: [0004] [0005] Loxoprofen sodium can be widely used in anti-inflammatory and analgesic clinically for rheumatoid arthritis, low back pain, frozen shoulder, neck, shoulder and wrist syndrome, etc. Its external preparations are mainly patches and cataplasms produced by Daiichi Sankyo. The specifications of the loxoprofen sodium patch are 100mg (calculated as loxoprofen) / 2g paste / 10cm×14cm. Using a rubber matrix as the pressure-sensitive adhesive may easily cause skin allergic reactions to the user during actual use, which affects the compliance of the patch. Chinese literature - the development of loxoprof...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/216A61K47/18A61K47/22A61P19/02A61P19/00A61P29/00
CPCA61K9/7061A61K31/216A61K47/18A61K47/22
Inventor 李斐菲姚永波杨红伟
Owner 北京茗泽中和药物研究有限公司
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