Loxoprofen sodium patch

Abstract

The invention discloses a loxoprofen sodium patch. The loxoprofen sodium patch is characterized by comprising paste which coats a supporting layer, wherein the paste is prepared from the following components in percentage by weight: 4%-6% of loxoprofen sodium, 4%-6% of diethanol amine, 1.8%-2.2% of propylene glycol, 2.5%-3.5% of azone, 2.5%-3.5% of menthol, 0.5%-1% of ascorbic acid, 0.1%-0.2% of nicotinamide, 0.1%-0.2% of tocopheryl acetate and the balance of substrate prepared from emulsion type polyacrylate pressure-sensitive adhesive; and the area content of the loxoprofen sodium of the patch is 0.6-1.0 mg / cm<2>.

Description

technical field [0001] The present invention relates to loxoprofen sodium patch. Background technique [0002] Loxoprofen Sodium (CAS: 80382-23-6, Monosodium [0003] 2-{4-[(2-oxocyclopentyl)methyl]phenyl}propanoatedihydrate, 2-[4-(2-oxocyclopentyl-1-ylmethyl)phenyl]propanoate dihydrate) belongs to phenylpropanoid Acid NSAIDs, whose molecular formula is as follows: [0004] [0005] Loxoprofen sodium can be widely used in anti-inflammatory and analgesic clinically for rheumatoid arthritis, low back pain, frozen shoulder, neck, shoulder and wrist syndrome, etc. Its external preparations are mainly patches and cataplasms produced by Daiichi Sankyo. The specifications of the loxoprofen sodium patch are 100mg (calculated as loxoprofen) / 2g paste / 10cm×14cm. Using a rubber matrix as the pressure-sensitive adhesive may easily cause skin allergic reactions to the user during actual use, which affects the compliance of the patch. Chinese literature - the development of loxoprof...

AI Technical Summary

Problems solved by technology

However, traditional skin irritation experiments all use healthy animal models, but in actual use, because loxoprofen sodium itself belongs to non-steroidal anti-inflammatory drugs, in its indications, rheumatoid arthritis, frozen shoulder and other diseases Patients themselves are often in the middle of delayed hypersensitivity reaction, so in the actual application process, symptoms of contact dermatitis such as skin redness, itching, rash, etc. The loxoprofen sodium patch of the skin irritation becomes urgent problem in the prior art

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