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Supercritical CO2 fluid extraction method for directly extracting dehydroepiandrosterone from sweet potato

A dehydroepiandrosterone and sweet potato technology, applied in the production of steroids, bulk chemicals, organic chemistry, etc., can solve the problems of raw material shortage, diosgenin raw material cost increase, etc., and achieve low raw material cost, easy popularization and The effect of promotion and high extraction rate

Inactive Publication Date: 2016-10-05
WUXI MEDER BIOTECH CO LTD
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

In recent years, the price of turmeric has continued to rise (the market price in some areas has reached more than 10 yuan / catties), which has caused a significant increase in the cost of diosgenin raw materials and a shortage of raw materials.

Method used

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  • Supercritical CO2 fluid extraction method for directly extracting dehydroepiandrosterone from sweet potato
  • Supercritical CO2 fluid extraction method for directly extracting dehydroepiandrosterone from sweet potato
  • Supercritical CO2 fluid extraction method for directly extracting dehydroepiandrosterone from sweet potato

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Embodiment Construction

[0012] The present invention adopts supercritical CO 2 The fluid extraction method directly extracts dehydroepiandrosterone from sweet potato, and the specific steps are as follows (see attached image 3 ):

[0013] 1. Raw material pretreatment and fermentation: Clean the fresh sweet potatoes, crush them into pulp with a pulverizer, and then add water (the ratio of sweet potatoes to water is about 1:2), and use the bacteria in the air at 40°C The sweet potato puree was fermented for 24 hours to obtain a fermented product.

[0014] 2. Enzymatic hydrolysis: add cellulase and amylase compound enzyme preparation to the fermentation product (the ratio of cellulase and amylase is 1:1), the ratio of compound enzyme addition to sweet potato is 1:1000; at 50-60 ℃ Enzymatic hydrolysis at the same temperature for 12 hours to fully hydrolyze the material.

[0015] 3. Drying and ball milling: Dry the hydrolyzate, then put it in a ball mill, and roll the ball to grind it into powder.

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Abstract

The invention discloses a method for directly extracting dehydroepiandrosterone from sweet potato. According to the invention, sweet potatoes are cleaned and are ground into a raw pulp; a fermentation treatment is carried out; cellulase and amylase are added, such that hydrolysis is fully carried out; an obtained hydrolysis product is dried; the dried product is ball-milled into powder; supercritical CO2 fluid extraction is carried out; and the content of an extraction product is analyzed with a high performance liquid chromatography method. According to current industry, a dehydroepiandrosterone production method comprises the following steps: diosgenin is extracted from turmeric; and diosgenin is converted into dehydroepiandrosterone with a chemical synthesis method. The structure and chemical properties of the synthesized dehydroepiandrosterone are hard to be kept consistent with those of natural dehydroepiandrosterone. The extraction raw material adopted by the invention is sweet potato which has rich source and low price. The method overcomes defects of traditional processing methods, and has the advantages of simple process, high extraction efficiency, high product purity and no environmental pollution. The extraction product is fully natural dehydroepiandrosterone. The method provided by the invention is an ideal green processing and resource optimal utilization novel technology.

Description

technical field [0001] The invention relates to a method for extracting dehydroepiandrosterone from sweet potatoes, in particular to a supercritical CO 2 A method for the direct extraction of dehydroepiandrosterone from sweet potatoes. Background technique [0002] Dehydroepiandrosterone (dehydroepiandrosterone, also known as dehydroepiandrosterone, chemical name is 3-beta-hydroxyandrost-5-en-17-one, its molecular formula is C 19 H 28 O 2 , see appendix for structure figure 1 ) is the precursor substance for the synthesis of various sex hormones by the human body, and is mainly synthesized and secreted by the adrenal tissue in the human body. Medical research has proved that for middle-aged and elderly people, reasonable supplementation of DHEA can effectively prevent the occurrence of diseases such as aging, obesity, hyperlipidemia, diabetes, and prostatitis. [0003] At present, the method of chemical synthesis is used to obtain DHEA in my country's industry (see appe...

Claims

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Application Information

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IPC IPC(8): C07J13/00
CPCY02P20/54
Inventor 黄文成
Owner WUXI MEDER BIOTECH CO LTD
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