The invention discloses an anti-theft lock core with a multi-gear marble structure and an application thereof on an anti-theft frame lock. The lock core structure comprises an upper clamping plate 1, a lower clamping plate 2, an upper marble 3, a lower marble 4, an upper clamping plate pipe 5, a lower clamping plate pipe 6, a short shaft pin 7, a long shaft pin 8, a positioning piece 9, a cushion block 10, an upper marble pressure spring 11, an upper clamping plate jacket 12, a pushing disk pressure spring 13 and a pushing disk 14. A is a sealed marble which is a go side in a normal state. Because the invention changes the traditional lock core structure and the traditional drilling process, the coaxiality accuracy of an upper marble hole and a lower marble hole of the lock core is ensured, so that the lock core can be designed into an anti-theft lock core with a 6-gear, 10-gear or 20-gear marble structure. The lock core can be unlocked in a linear pushing mode, and in order to adapt to the requirements of the related prior art, the lock core can be also designed for unlocking in a 360 degree rotating mode. Because the current anti-theft lock can not perform an anti-theft function, the invention can enable the anti-theft lock to really perform functions of guard against theft and security.