The invention discloses a cotton picker spindle with hook teeth of an anti-attrition structure, and relates to the technical field of cotton picking machinery. The cotton picker spindle comprises a picking head, a picking spindle rod and a bevel gear, the picking head is connected with one end of the picking spindle rod, the bevel gear is connected with the other end of the picking spindle rod, and three rows of hook teeth are evenly distributed on the periphery of the picking head. In order to avoid the phenomena of hook tooth abrasion and tooth breakage in the cotton picking process, an anti-abrasion structure is arranged on the inner side of each hook tooth of the spindle, and further, the anti-abrasion structures are treated through an ultrasonic nanometer modification technology. Meanwhile, flow guide grooves are formed in tooth grooves of the picking head, so that flow guide of the wetting liquid is facilitated. Therefore, the phenomena of abrasion and tooth breakage of the spindle can be effectively reduced, the maintenance cost of a cotton picker is reduced, and the economic benefit is improved; and heat generated when the spindle works can be reduced in time, and potential safety hazards caused by cotton picking work are reduced.