Short peptide having kidney protection function as well as preparation method and application thereof

A kidney protection and effect technology is applied to short peptides with kidney protection effect and the fields of preparation and application thereof, which can solve the problems of promoting tumor formation, increasing adverse reactions, and promoting thrombosis, and achieves easy operation, high preparation efficiency, biological Highly active effect
CN102180948AInactive Publication Date: 2011-09-14ZHONGSHAN HOSPITAL FUDAN UNIV
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Patent Information

Authority / Receiving Office
CN Β· China
Current Assignee / Owner
ZHONGSHAN HOSPITAL FUDAN UNIV
Publication Date
2011-09-14
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The invention relates to a short peptide having a kidney protection function as well as a preparation method and application thereof. The short peptide having the kidney protection function is characterized in that the amino acid sequence of the short peptide is QEQLERALNSS. The preparation method is characterized by comprising the following steps: successively coupling Ser, Asn, Leu, Ala, Arg, Glu, Leu, Gln, Glu and Gln on serine which is based on resin as a vector; after cracking, and settling with ice ether so as to obtain coarse peptide; and purifying with a high performance liquid chromatography (HPLC) so as to obtain the product. The invention also discloses application of the short peptide having the kidney protection function in the aspects of preparing formulations for treating renal ischemia-reperfusion injury along with acute tubular necrosis, local renal tissue inflammation and renal tubular epithelium cell apoptosis which are caused by the renal ischemia-reperfusion injury. The invention provides a novel clinic medicament for preventing and treating the renal ischemia-reperfusion injury, thereby bringing good news for patients suffering renal transplant.
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Description

technical field

[0001] The present invention relates to a short peptide with renal protective effect and its preparation method and application. Its sequence and structure are derived from the surface peptide segment (Helix B surface peptide, HBSP) of erythropoietin (EPO) B helix. Background technique

[0002] Renal ischemia and hypoxia lead to insufficient energy metabolism and excessive ATP depletion, and a large number of oxygen free radicals are produced during reperfusion, both of which can lead to apoptosis of renal tubular epithelial cells and severely damage renal function. At the same time, in the process of ischemia, a large number of inflammatory cells are recruited into the renal tubulointerstitium and release various inflammatory mediators, which not only cause direct damage to renal tissue, but also cause damage to renal vascular endothelial cells and enhance immunogenicity, and further lead to immune vascular injury. Clinically, the main causes of renal ische...

Claims

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