53results about How to "Improve quality of life after surgery" patented technology

The invention discloses a proton therapy system based on a compact superconducting cyclotron. The proton therapy system includes a superconducting cyclotron system, an energy selection system and a beam transportation system, a fixed treatment room subsystem and a rotary frame treatment subsystem; the fixed energy proton beam led out by the superconducting cyclotron in the superconducting cyclotron system can be a continuously adjusting proton beam of 70-200MeV via the energy selection system, so that the longitudinal adjustment of the range during the proton therapy of tumors can be met; thebeam is transmitted to the fixed treatment room subsystem and the rotary frame treatment subsystem via the beam transportation system; the superconducting cyclotron system, the energy selection system, the beam transportation system and a treatment head are subjected to cooperative control to realize the transverse expansion of the proton beam, so that the intensity modulation treatment of the tumor can be completed. According to the invention, the innovation is good, the practicability is high, the beam intensity of the superconducting cyclotron is adjustable, and the intensity modulation treatment can be realized; and the system has an extremely important promotion effect on the accuracy, effectiveness and high efficiency of tumor treatment of a patient.

The invention provides a molecular imaging probe which is a polypeptide molecule, including a specific targeted section on one end, a responding assembly-retention section in the middle, and a color developing section on a side chain; wherein the responding assembly-retention section includes a responding sequence as the SEQ ID No.1 and an assembling sequence as the SEQ ID No.2. The molecular imaging probe can recognize a tumor cell through the specific targeted section and achieves assembly retention in a tumor microenvironment through a "responding assembly-retention effect", thereby achieving high-amount and long-acting imaging in a tumor tissue; through near-infrared light excitation, the molecular imaging probe can achieve imaging navigation during a stable and long-acting operation on a tumor focus part, thus achieving visible localization of the tumor. The accuracy of resection of tumors by a doctor is improved, operation success rate is greatly increased and post-operation recurrence rate is reduced; the molecular imaging probe can improve the post-operation life quality of patients.

The invention discloses a knee joint balance detection system in total knee replacement and a balance discrimination method thereof. The system is characterized in that a left pressure sensor set anda right pressure sensor set are attached to the left and right regions of a gasket, in the operation process, the gasket is placed in a gap between the thigh bone prosthesis and the tibia bracket, data of the left and right sensor sets can be obtained during 0-degree knee bending, 90-degree knee bending, internal rotation and ectropion, due to data analysis, whether the knee joints are located inthe balanced state or not is judged, and if the knee joints are in the non-balanced state, by properly repairing bones or adjusting the position of a prosthesis, the knee joints are in the balanced state finally. By keeping the position unchanged, surgical suturing is performed. By improving the accuracy of surgical knee joint balance, the important role in prolonging the service life of the postoperation prosthesis of a patient, reducing postoperative complications, and improving the postoperation living quality of the patient is achieved.

The invention relates to polypropylene / polylactic acid interwoven composite pelvic floor mesh and a preparation method thereof. The mesh is in a meshwork structure. Preparation of the mesh includes: weaving medical-grade polypropylene monofilaments and medical-grade polylactic acid monofilaments to obtain a mesh in the meshwork structure; flushing the mesh, naturally air-drying at normal temperature, and carrying out thermal setting, cooling, cutting and sterilizing to obtain the mesh. The mesh has the advantages such as low sense of foreign matters, high porosity, structural stability and good biocompatibility.

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for improving postoperative prognosis of breast cancer and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition consists of the following raw materials in parts by weight of 15-30 parts of radix astragali, 15-30 parts of radix codonopsis, 15-30 parts of rhizoma curcumae, 15-30 parts of herba salviae chinensis, 6-12 parts of radix bupleuri and 9-15 parts of radix paeoniae alba. Aiming at syndrome differentiation and treatment of the breast cancer, all the raw materials and the weight part ratio thereof are preferably selected; the traditional Chinese medicines in a formula conform to the compatibility requirement of monarch, minister, assistant and guide, specifically, the radix codonopsis and the radix astragali are used as monarch medicines for invigorating the spleen and replenishing qi, the rhizoma curcumae and the herba salviae chinensis are used as ministerial medicines for reducing phlegm and removing stasis, the radix paeoniae alba is used as the adjuvant medicine for nourishing yin and soothing the liver, and the radix bupleuri enters the liver channel as the guide medicine; all the medicines are combined for achieving the effects of tonifying qi, strengthening the body resistance, reducing phlegm, removing stasis, soothing the liver and promoting the circulation of qi; and the whole formula combines tonification and purgation and gives consideration to both symptoms and root causes. Experimental results show that the prognosis (including OS, DFS indexes and the like) of a patient treated with the traditional Chinese medicine formula is obviously superior to that of a patient not using the traditional Chinese medicine formula, and the application prospect is wide.

The invention discloses a prognostic marker of gliomas circ8: 127890589|127890998 and application, namely circRNA circ8: 127890589|127890998 reagents of detecting brain tissue sources for preparing the prognostic marker of gliomas patients. Researchers find that an expression level of the circRNA circ8: 127890589|127890998 is significantly downregulated in brain tissues of the glioma patients (P less than 0.0001). Patients with higher expression levels of circRNA circ8: 127890589|127890998 in gliomas have a higher postoperative survival rate (P equal to 0.086). Therefore, the prognostic markerof the gliomas circ8: 127890589|127890998 and the application can determine prognosis of the glioma patients by detecting the expression level of circRNA circ8: 127890589|127890998 in the glioma tissues of the glioma patients.

The invention discloses a novel method for determining force line balance in total knee arthroplasty by finite element analysis. The method comprises the following steps of carrying out data acquisition and modelling on a leg at an uninjured side before operation; carrying out finite element stress analysis on a leg model on the uninjured side of a patient, and carrying out data acquisition and modeling on a replaced knee joint in an operation process; making a mirror image of the model on the uninured side correspond to an affected side, carrying out data analysis through a Fourier transform-high-pass filtering image enhancement algorithm, and judging whether a force line of a lower limb of the affected side is in a balanced state; if the force line of the lower limb of the affected sideis in an unbalanced state, prompting a proper bone repair or prosthesis adjustment position to a doctor through the leg model on the uninjured side, and finally, enabling the knee joint to be in the balanced state; and keeping the position unchanged, and carrying out surgical suture. According to the method, the accuracy of knee joint balance in the operation is improved, the service life of the postoperative prosthesis is prolonged, the postoperative complications are reduced, and the method plays an important role in improving the postoperative life quality of the patient.

The invention belongs to the technical field of biology and discloses application of a glioma prognostic marker Circ9:135881633|135883078, in particular to application of a reagent for detecting the expression quantity of cyclic RNA (Ribonucleic Acid) Circ9:135881633|135883078 from a brain tissue in preparing a prognostic preparation of a glioma patient. The study proves that patients with higherexpression quantity of the cyclic RNA Circ9:135881633|135883078 in the glioma have a higher postoperative survival rate. Prognostic judgement of the glioma patients is made by detecting the expressionlevel of the cyclic RNA Circ9:135881633|135883078 in glioma tissues of the glioma patients.

A proton therapy system based on a compact superconducting cyclotron, including: a superconducting cyclotron system, an energy selection system, a beam transport system, a fixed therapy room subsystem and a rotating frame therapy subsystem; a fixed-energy proton beam extracted from a superconducting cyclotron of the superconducting cyclotron system is adjusted into a continuous and adjustable proton beam of 70 MeV to 200 MeV by the energy selection system, thus realizing a longitudinal adjustment for a proton range during treating a tumor, and the continuous and adjustable proton beam is respectively transmitted to the fixed therapy room subsystem and the rotating frame therapy subsystem by the beam transport system. The cooperative control of the superconducting cyclotron system, the energy selection system, the beam transport system and the therapy head realizes the transverse expansion of proton beams, thus realizing intensity modulated radiation therapy for the tumor.

The invention relates to application, a kit and a detection method for a novel molecular marker non-coding RNA LINC00958 for lung cancer prognosis. Through real-time fluorescent quantitative PCR and survival curve analysis, the non-coding RNA LINC00958 from lung cancer tissues is found to be associated with the survival rate of a patient; the more the content is, the more the survival rate is. Themethod provides a powerful technical support for analyzing prognosis lifetime of cancer patients, favorably improves the postoperative life quality and has profound clinical significance; by means ofthe method, a postoperative treatment scheme is formulated and the survival rate is improved.

The invention belongs to the biotechnology field, and discloses a glioma prognostic marker hsa_circ_0125365 and application. A reagent for detecting circRNA hsa_circ_0125365 of a glioma source is usedfor preparing a prognostic preparation of a glioma patient. Research proves that the glioma patient with relatively high expression of circRNA hsa_circ_0125365 has relatively high postoperative survival rate. A prognosis of the glioma patient is made by detecting the expression level of circRNA hsa_circ_0125365 in glioma tissue of the glioma patient.

The invention discloses a method for determining force line balance through finite element analysis in total knee replacement. The method comprises the steps of before the operation, conducting data collecting and modeling on the legs of the uninjured sides, conducting finite element stress analysis on an uninjured side leg model of a patient, and conducting data collecting and modeling on the knee joint which is subjected to replacement in the operation process; corresponding images of the uninjured side model to the injured side, conducting data analysis through a Gaussian-Laplacian pyramidmethod, and judging whether the force line of the lower limb of the injured side is in a balanced state or not; if not, giving a doctor a prompt about properly conducting bone repairing or adjusting the prosthesis position through the uninjured side leg model, so that finally, the knee joint is in the balanced state. The position is kept unchanged for operation suturing. By means of the method, the accuracy of knee joint balancing in the operation is improved, the service life of the prosthesis of the patient after the operation is prolonged, the postoperative complications are reduced, and the effect of improving the living quality of the patient after the operation is improved.

The invention relates to a prognostic marker for glioma, belonging to the technical field of biology. The marker is lnc RNA TCONS_00020456, and the sequence is shown in SEQ ID NO.1. The sequence of aspecific primer for detecting the expression level of the marker is as follows: F:5'-CTCAGGTGGTGCCATTCTC-3', R:5'-GACCTTGTCCTGCTCTTCATT-3'. The invention uses qRT-PCR detection method to detect the expression level of lnc RNA TCONS_00020456 in the source of glioma tissues of patients; the study confirms that the patients with higher expression quantity in the glioma have a higher postoperative survival rate. Therefore, the lnc RNA TCONS_00020456 can be used for prognostic analysis of the patients with the glioma as the prognostic marker for the glioma.

The invention discloses a method for preventing anastomotic fistula after colorectal surgery. The method comprises the following steps of: step 1, performing preoperative preparation, cutting off a colorectal lesion part, and suturing an anastomotic stoma; step 2, mounting a supporting protective net to protect the anastomotic stoma; step 3, guiding a fixed part at the head end of a catheter from anumbral tract to a ileocecal flap, inflating the fixed part to enable the fixed part to be clamped at the ileocecal flap, enabling the position of the catheter and the position of the ileocecal flap to be relatively fixed through the fixed part, performing double blocking on the intestinal tract, and meanwhile, guiding out intestinal contents through the catheter; and step 4, after the anastomotic stoma of a patient is healed, exhausting the catheter, and withdrawing the catheter and the fixed part from the ileocecal flap through the anus. The method can prevent the anastomotic fistula, is beneficial to wound healing of the patient, only needs to perform surgical suturing on the anastomotic stoma, does not need to perform surgical opening and suturing on other parts, reduces body trauma brought to the patient by surgery, is beneficial to improving the postoperative life quality of the patient, and is suitable for the technical field of medical instruments.

The invention discloses a corticospinal tract fiber tracking method based on FMRI and DTI fusion. The method comprises the following steps: preprocessing fMRI and DTI magnetic resonance image data, extracting a maximum activation area seed point through task-state function activation to determine an important motion area, selecting ROIs (regions of interest), and completing fiber tracking by usinga probability tracking method of a multi-fiber model. According to the method, a motion activation area of fMRI is selected as a seed point for DTI fiber tracking, and CST fiber tracking of patientswith brain tumor is compared with traditional anatomical location definition to evaluate a spatial position relationship between different components of CST and boundary of the brain tumor, thus the method can provide valuable preoperative information for the patients with brain tumor.

The invention relates to application, a kit and a detection method of novel molecular marker non-coding RNA LINC00671 for prognosis of kidney cancer. Real-time fluorescence quantitative PCR (Polymerase Chain Reaction) and survival curve analysis show that the non-coding RNA LINC00671 derived from kidney cancer tissues is related with a survival rate of a patient, the content is higher and the survival rate is higher. The method provides powerful technical support for predicting prognosis survival ratio of kidney cancer patients, the postoperative life quality of the kidney cancer patients is facilitated, the developing of a postoperative treatment scheme is facilitated, the survival rate is increased, and the application, the kit and the detection method of the novel molecular marker non-coding RNA LINC00671 for prognosis of the kidney cancer disclosed by the invention have profound clinical significance.

The invention discloses a glioma prognostic marker circ7:66286511|66286709 and applications, namely a reagent for detecting circRNA circ7:66286511|66286709 coming from brain tissues; and the glioma prognostic marker is used for preparing a prognostic preparation for patients with glioma. Investigators find that the expression quantity of circRNA circ7:66286511|66286709 is obviously down-regulated(P is less than 0.0001) in the brain tissues of patients with glioma, and patients with glioma having higher expression quantity of circRNA circ7:66286511|66286709 have higher postoperative survival rate (P=0.005). The prognostic prediction on the patients with glioma can be made by detecting the expression level of circRNA circ7:66286511|66286709 in glioma tissues of patients with glioma.

The invention belongs to the biotechnology field, and discloses a glioma prognostic marker circ7:42148226|42148468 and application. A reagent for detecting the expression quantity of circRNAcirc7:42148226|42148468 of a glioma source is used for preparing a prognostic preparation of a glioma patient. Research proves that the glioma patient with relatively low expression of circRNAcirc 7:42148226|42148468 has relatively high postoperative survival rate. A prognosis of the glioma patient is made by detecting the expression level of circRNAcirc7:42148226|42148468 in glioma tissue of the glioma patient.

The invention belongs to the biotechnology field, and discloses a glioma prognostic marker circ 7:73686636|73687095 and application. A reagent for detecting the expression quantity of circRNA circ 7:73686636|73687095 of a glioma source is used for preparing a prognostic preparation of a glioma patient. Research proves that the glioma patient with relatively low expression of circRNA circ 7:73686636|73687095 has relatively high postoperative survival rate. A prognosis of the glioma patient is made by detecting the expression level of circRNA circ 7:73686636|73687095 in glioma tissue of the glioma patient.

The invention belongs to the biotechnical field, and discloses a glioma prognostic marker circ15:101235082|101235577 and applications, namely a reagent for detecting circRNA circ15:101235082|101235577coming from brain tissues; and the glioma prognostic marker is used for preparing a prognostic preparation for patients with glioma. Study proves that patients with glioma having higher expression quantity of circRNA circ15:101235082|101235577 have higher postoperative survival rate. The prognostic prediction on the patients with glioma can be made by detecting the expression level of circRNA circ15:101235082|101235577 in glioma tissues of patients with glioma.

The invention aims to provide a biomarker long-chain non-coding RNA LINC02447 and kit for predicting the prognosis of colon cancer to predict the prognostic lifetime of colon cancer patients. The preparation for predicting the prognosis of colon cancer is a real-time fluorescent quantitative PCR detection kit. The kit contains specific primers for detecting the expression of the target gene LINC02447 and specific primers for detecting the expression of the internal reference gene TUBA1A, and also includes real-time fluorescent quantitative SYBR dye and RNA enzyme-free water. By means of fluorescent quantitative PCR and survival curve analysis, the invention finds that the LINC02447 derived from colon cancer tissue is related to the survival rate of patients, and the higher the content is,the higher the survival rate is. The method provides powerful technical support for analysis predicting the prognostic lifetime of colon cancer patients, is conducive to enhancing the postoperative quality of life of colon cancer patients, formulating the postoperative therapeutic scheme and improving the survival rate, thus having far-reaching clinical significance.

The present invention provides a molecular imaging probe, which is a polypeptide molecule, including a specific targeting part at one end, a response assembly retaining part in the middle and a chromogenic part of the side chain; wherein, the The response assembly retention part includes a response sequence and an assembly sequence, the response sequence is SEQ ID NO.1, the assembly sequence is SEQ ID NO.2, and the molecular imaging probe recognizes tumor cells through a specific targeting part, through "Assembly retention effect" assembles and stays in the tumor microenvironment to achieve high-quantity and long-term imaging in tumor tissue. Through near-infrared light excitation, stable and long-term intraoperative imaging and navigation at tumor lesions can be achieved, and tumor positioning can be visualized, improving The accuracy of tumor resection greatly improves the success rate of surgery, reduces the recurrence rate after surgery, and improves the quality of life of patients after surgery.

The invention provides a biomarker long-chain non-coding RNA LINC01728 and a kit for predicting the prognosis of colon cancer, which are used for predicting the prognosis survival time of a patient with colon cancer. A preparation for predicting the prognosis of colon cancer is a real-time fluorescent quantitative PCR detection kit, and the kit contains a specific primer h used for detecting the expression of a target gene LINC01728 and the specific primer used for detecting the expression of a reference gene TUBA1A, and further contains real-time fluorescent quantitative SYBR dye and RNase-free water, wherein the volume ratio of the real-time fluorescent quantitative SYBR dye to the target gene LINC01728-specific prime to the reference gene TUBA1A-specific primer to the RNase-free water in the kit is 10 to 1 to 1 to 6. This method provides a strong technical support for predicting the prognosis survival time of a patient with colon cancer, facilitates the improvements on the postoperative life quality of the patients with colon cancer and the development of postoperative treatment plans, improves the survival rate, and has a far-reaching clinical significance.

The invention belongs to the biotechnical field, and discloses a glioma prognostic marker circ15:98707562|98708107 and applications, namely a reagent for detecting the expression quantity of circRNA circRNA circ15:98707562|98708107; and the glioma prognostic marker is used for preparing a prognostic preparation for patients with glioma. Study proves that patients with glioma having higher expression quantity of circ15:98707562|98708107 have higher postoperative survival rate. The prognostic prediction on the patients with glioma can be made by detecting the expression level of circRNA circ15:98707562|98708107 in glioma tissues of patients with glioma.

The invention discloses medical porous tantalum. The material body of the porous tantalum is composed of a bore cavity and a cavity wall surrounding the bore cavity, wherein the bore cavity is through. The porous tantalum is still in a plateau stress stage when strain reaches 50%; and the absorption energy of the porous tantalum per unit volume is no less than 0.13*10<-2> J / mm<3> when strain reaches 50%. The medical porous tantalum has good energy absorption capability, can meet the demands of ingrowth of human bone tissue, is especially applicable to cancellous bone-repairing implantation material capable of bearing medium-grade load, and allows good osteanagenesis effect to be obtained after implantation.

The invention relates to polypropylene / polylactic acid interwoven composite pelvic floor mesh and a preparation method thereof. The mesh is in a meshwork structure. Preparation of the mesh includes: weaving medical-grade polypropylene monofilaments and medical-grade polylactic acid monofilaments to obtain a mesh in the meshwork structure; flushing the mesh, naturally air-drying at normal temperature, and carrying out thermal setting, cooling, cutting and sterilizing to obtain the mesh. The mesh has the advantages such as low sense of foreign matters, high porosity, structural stability and good biocompatibility.

The invention discloses a traditional Chinese medicine powder, and a preparation method and an application thereof. The powder comprises the following components, by mass: 15-30 parts of betel nut, 10-20 parts of rhubarb, 10-20 parts of stir-fried hawthorn, 10-20 parts of black pharbitis seed, 10-20 parts of white pharbitis seed, 25-50 parts of common phellinus fungus, 10-20 parts mix-fried licorice root, 10-20 parts of panax notoginseng, and 1-5 parts of purging croton seed. The traditional Chinese medicine powder is orally taken, and can be used for treating digestive system diseases. With the powder, gastroenteritis can be eliminated, gastrointestinal tract garbage can be removed, and internal toxins can be discharged. The medicine powder has the advantages of clear formula, simple preparation process, short treatment course, simple application method, and easy implementation by patients. More importantly, compared with existing Western medicines and traditional Chinese medicines, the medicine powder provided by the invention has a fast and reliable effect in treating the digestive system diseases, and has prevention and treatment effect against tumor or cancer.

The invention relates to application, a kit and a detection method of novel molecular marker non-coding RNA LINC00922 for prognosis of kidney cancer. Real-time fluorescence quantitative PCR (Polymerase Chain Reaction) and survival curve analysis show that the non-coding RNA LINC00922 derived from kidney cancer tissues is related with a survival rate of a patient, the content is higher and the survival rate is higher. The method provides powerful technical support for predicting prognosis survival rate of kidney cancer patients, the postoperative life quality of the kidney cancer patients is facilitated, the developing of a postoperative treatment scheme is facilitated, the survival rate is increased, and the application, the kit and the detection method of the novel molecular marker non-coding RNA LINC00922 for prognosis of the kidney cancer disclosed by the invention have profound clinical significance.

The invention discloses a cardiac interventional left ventricular electromagnetic assisting device, which mainly includes: an external control device and a blood pump, the external control device and the blood pump are separated through the skin layer, and the external control device and the blood pump are connected through an electromagnetic field The in vitro control device is a box with a rectangular cross section, and the outer front of the box is sequentially provided with a power adjustment knob, a current adjustment knob, a power switch, an electromagnetic auxiliary switch, a liquid crystal display, a charging holes; the present invention uses electromagnetic induction control technology, does not need to drill wire holes under the patient's skin, prevents infection, is easy to operate, and can be controlled and adjusted continuously for a long time; adopts a new type of magnetic levitation axial flow blood pump, which has high control precision and makes the artificial heart The gravity balance of the magnetic field can maintain the balance of the magnetic field force on the artificial heart and improve the life of the artificial heart, which can be widely used clinically.