Porous tantalum

A technology of porous tantalum and cavities, which is applied in the field of porous tantalum for medical implant materials, can solve the problems that human bone tissue cannot grow normally, cannot achieve bone tissue regeneration, cannot be used as a bone repair material, etc., so as to maintain normal physiological functions. , Good bone regeneration effect, avoid implant and bone tissue damage and structural collapse effect

Inactive Publication Date: 2018-03-27
CHONGQING RUNZE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the medical implant materials produced by this series of research results have always had poor practical application effects.
At present, regardless of the porous tantalum medical implant materials reported in the literature or seen on the market, after being implanted into the human body, human bone tissue cannot grow into the implant material normally, that is, the implant material cannot achieve bone tissue regeneration, and cannot become a real bone repair material

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] The porous tantalum of this embodiment is connected between the cavity and the cavity, and the cavity is also connected with the outside world. The pore diameter of the porous tantalum is 400 μm-600 μm, and the porosity is 90%. The preparation method is as follows:

[0018] Take tantalum powder with a particle size of 800±50nm and polymethyl methacrylate with a particle size of 500-700μm as a pore-forming agent, mix tantalum powder: polymethyl methacrylate powder at a volume ratio of 1:10, and stir repeatedly Make it uniform, put the mixed powder into a cemented carbide mold, apply 500MPa pressure for compaction, hold the pressure for 20s, take out the compacted sample, put it in a vacuum furnace, and start low-temperature exhaust: use FF-160 / 620 molecular Pump+mechanical pump vacuum system reaches 10 -4 Pa, rise from room temperature to 300°C at a rate of 1°C / min, and hold for 90 minutes; then rise to 400°C at the same heating rate, and hold for 60 minutes; then rise t...

Embodiment 2

[0027] The cavity of the porous tantalum in this embodiment is connected with the cavity, and the cavity of the porous tantalum is also connected with the outside world. The diameter of the cavity of the porous tantalum is 400-600 μm, and the porosity is 85%. The preparation method is similar Example 1, wherein the porosity and pore size are controlled by the content and particle size of the pore-forming agent. The difference in the sintering temperature is: after the temperature rises to 1500°C, it is kept for 30 minutes, and then raised to 2100°C at a rate of 10°C / min. 140min.

[0028] With reference to the same method test of Example 1, the absorbed energy per unit volume was 0.365×10 when the strain of this example reached 50%. -2 J / mm 3 .

[0029] The dog implantation test was carried out with reference to the same method as in Example 1, and the porous tantalum was implanted into the lumbar spine. The results showed that there were no defects such as cracks and breaka...

Embodiment 3

[0031] The cavity of the porous tantalum in this embodiment is connected with the cavity, and the cavity of the porous tantalum is also connected with the outside world. The diameter of the cavity of the porous tantalum is 400-600 μm, and the porosity is 80%. The preparation method is similar Example 1, in which the porosity and pore size are controlled by the content and particle size of the pore-forming agent. The difference in the sintering temperature is: after the temperature rises to 1500°C, it is kept for 30 minutes, and then raised to 2250°C at a rate of 10°C / min. 140min.

[0032] With reference to the same method test of Example 1, the absorbed energy per unit volume was 0.61×10 when the strain of this example reached 50%. -2 J / mm 3 .

[0033] The dog implantation test was carried out with reference to the same method as in Example 1, and the porous tantalum was implanted into the lumbar spine. The results showed that there were no defects such as cracks and breakag...

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Abstract

The invention discloses medical porous tantalum. The material body of the porous tantalum is composed of a bore cavity and a cavity wall surrounding the bore cavity, wherein the bore cavity is through. The porous tantalum is still in a plateau stress stage when strain reaches 50%; and the absorption energy of the porous tantalum per unit volume is no less than 0.13*10<-2> J / mm<3> when strain reaches 50%. The medical porous tantalum has good energy absorption capability, can meet the demands of ingrowth of human bone tissue, is especially applicable to cancellous bone-repairing implantation material capable of bearing medium-grade load, and allows good osteanagenesis effect to be obtained after implantation.

Description

technical field [0001] The present invention relates to porous materials, in particular to a porous tantalum used in medical implant materials. Background technique [0002] Tantalum metal is a transition metal (element No. 73, atomic weight 180.05), which remains inert in the body and has excellent corrosion resistance in strong acids. As early as the 1940s, this metal was widely used in medical equipment, including skull patches, electrodes, imaging markers, ligament holders and so on. Human implants based on tantalum metal have been widely used in orthopedic surgery, craniofacial surgery and dentistry, and have shown excellent biocompatibility and safety. However, due to the shortcomings of dense tantalum metal such as large specificity and high elastic modulus, the effect of direct implantation into the human body is not good. Therefore, people began to develop porous tantalum. The basic structure of porous tantalum metal has the characteristics of high overall volume ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/56A61L27/04
CPCA61L27/047A61L27/56A61L2430/02
Inventor 叶雷
Owner CHONGQING RUNZE PHARM CO LTD
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