Kit used for aided prediction on postoperative survival time of esophageal squamous cell carcinoma patients

A technology for esophageal squamous cell carcinoma and survival time, which is applied in the field of kits to assist in predicting postoperative survival time of patients with esophageal squamous cell carcinoma, and can solve problems such as troubles

Active Publication Date: 2015-07-08
CANCER INST & HOSPITAL CHINESE ACADEMY OF MEDICAL SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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  • Kit used for aided prediction on postoperative survival time of esophageal squamous cell carcinoma patients
  • Kit used for aided prediction on postoperative survival time of esophageal squamous cell carcinoma patients
  • Kit used for aided prediction on postoperative survival time of esophageal squamous cell carcinoma patients

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Embodiment 1

[0038] Embodiment 1, establishment of method

[0039] The cancer tissues and adjacent normal tissues of 119 esophageal squamous cell carcinoma (ESCC) patients with at least 5-year follow-up information were collected to detect the expression of lncRNA. All patients underwent esophagectomy in the Cancer Hospital of Chinese Academy of Medical Sciences from December 2005 to December 2007, and all of them were proved to be primary tumors after operation. Follow-up information was obtained through telephone follow-up. The last follow-up date was December 15, 2012. 46 people survived and 73 died. All samples obtained the informed consent of the patients. No patient underwent chemoradiotherapy before surgery. Tissue samples were quickly frozen and stored in liquid nitrogen at -80°C after resection. A small part of each specimen was taken out for paraffin embedding, sectioning, routine HE staining, and pathological examination. Tumor histology was assessed by two independent patho...

Embodiment 2

[0049] Embodiment 2, the application of method

[0050]The first group of samples: the cancer tissue and adjacent normal tissue of 60 patients with esophageal squamous cell carcinoma (ESCC) were collected; all patients underwent esophagectomy at the Cancer Hospital of the Chinese Academy of Medical Sciences from December 2005 to December 2007. It was proved that they were all primary tumors; the follow-up information was obtained through telephone follow-up, and the last follow-up date was 2012-12-15; all samples obtained the patient's informed consent; no patient underwent radiotherapy and chemotherapy before surgery; tissue samples were quickly collected after resection Frozen and stored in liquid nitrogen at -80°C, a small part of each specimen was taken out for paraffin embedding, sectioning, conventional HE staining, and pathological examination. Tumor histology was identified by two independent pathologists. The ratio of cells was greater than 60%, and no tumor cells wer...

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Abstract

The invention discloses a kit used for aided prediction on postoperative survival time of esophageal squamous cell carcinoma (ESCC) patients. The kit comprises a substance used for detecting lncRNA 1 expression quantity, a substance used for detecting lncRNA 2 expression quantity, and a substance used for detecting lncRNA 3 expression quantity; the sequence of lncRNA 1 is represented by sequence 1 in a sequence table; the sequence of lncRNA 2 is represented by sequence 2 in the sequence table; and the sequence of lncRNA 3 is represented by sequence 3 in the sequence table. A plurality of ESCC patients are investigated; expression characteristics of lncRNA in cancer tissue and near cancer normal tissue are analyzed; it is observed that expression profile of a plurality of lncRNA in cancer tissue is obviously different from that of near cancer normal tissue; a model is established based on three lncRNA relative expression quantity; and the model can be used for aided prediction on postoperative survival time of esophageal squamous cell carcinoma patients.

Description

technical field [0001] The invention relates to a kit for assisting in predicting postoperative survival time of patients with esophageal squamous cell carcinoma. Background technique [0002] Esophageal cancer is a common malignancy and the sixth leading cause of cancer death worldwide. There are two main pathological types of esophageal cancer: adenocarcinoma (Esophagus Adenocarcinoma, EAC) and squamous cell carcinoma (ESCC). Pathological types vary in different regions of the world. Esophageal cancer is mainly adenocarcinoma in Western countries. In my country, 90% of esophageal cancer is squamous cell carcinoma, occupying the fourth cause of cancer death in my country. ESCC is highly invasive and has a poor prognosis. A deeper understanding of its genetic and molecular abnormal mechanisms is of great significance for early diagnosis, treatment and improvement of prognosis of the disease. [0003] Abnormal expression of genes plays an important role in the occurrence,...

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Application Information

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IPC IPC(8): C12Q1/68
CPCC12Q1/6886C12Q2600/158C12Q2600/178
Inventor 赫捷陈润生程京李嘉根陈照丽
Owner CANCER INST & HOSPITAL CHINESE ACADEMY OF MEDICAL SCI
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