The invention discloses a method for establishing a polygenic liver cancer prognosis grading system and its application, which can be used to predict the survival period and recurrence probability of liver cancer patients after surgery, regardless of the patient's age and tumor size. The samples came from a total of 378 clinical patients with liver cancer surgery in an affiliated hospital of Zhejiang University School of Medicine in 2012-2018. After strict quality control, the samples were subjected to multi-gene quantitative real-time polymerase chain reaction (qRT-PCR) , and further analyzed the correlation between each gene and the survival period, and finally screened out the high-risk genes related to the prognosis of patients with clinical liver cancer surgery, and constructed a prognosis grading system. Beneficial effects of the patented technology of the present invention: the present invention constructs a prognosis grading system that can predict postoperative survival and recurrence probability of patients with clinical liver cancer, regardless of patient age and tumor size. It can be used to evaluate the postoperative survival of patients with liver cancer surgery, and assist in formulating postoperative treatment plans for patients.