Production technology for acquiring two antioxidant agents from Rosmarinus officinalis L.
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An anti-oxidant and production process technology, which is applied in the production of bulk chemicals, separation/purification of carboxylic acid compounds, organic chemistry, etc., can solve the problems of large size, difficult immersion, high concentration, etc., and achieve simple process, accelerated dissolution, The effect of low energy consumption
Inactive Publication Date: 2011-09-28
YUZHOU SENYUAN BENCAO NATURAL PRODS
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Problems solved by technology
Ultrasonic countercurrent technology is used to solve the problem that the fresh rosemary raw material is not easy to extract. Increasing the solid-liquid ratio of the material can obtain a higher concentration difference, which is conducive to the diffusion and dissolution of the target component, and is conducive to the process at a lower temperature environment.
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Embodiment example 1
[0030] 100 kg of fresh rosemary leaves, ultrasonic countercurrent extraction, the extraction solvent is 65% alcohol, the extraction temperature is 40°C, the solid-liquid ratio is 1:25, the extract is centrifuged, filtered with a 50nm pore size membrane, and the filtrate is passed through a molecular weight of 50000 and a molecular weight of 10000. Then to 500 molecular weight, the unpermeable liquid is concentrated under reduced pressure until it has no alcohol smell, the solid and liquid are separated, and an appropriate amount of deionized water is washed. Rosemary fat-soluble antioxidant (crude product) 3.5 kg, crude product with CO 2 1.1 kg of rosemary fat-soluble antioxidants with carnosic acid content of 60-80% were obtained by supercritical extraction.
[0031] The above-mentioned standby liquid is adsorbed with macroporous resin, desorbed with gradients of 40, 50, 60, 70, and 80% ethanol, the desorbed liquid is concentrated under reduced pressure, spray-dried, and recr...
Embodiment example 2
[0033] 200 kg of fresh branches and leaves of rosemary, cut into sections of 0.5-5 cm, ultrasonic countercurrent extraction, the extraction solvent is 65% alcohol, the extraction temperature is 40°C, the solid-liquid ratio is 1:30, the extract is centrifuged, filtered with a 50nm pore size membrane, and the filtrate is passed through 50,000 molecular weight and 10,000 molecular weight, and then to 500 molecular weight, the unpermeated liquid is concentrated under reduced pressure until it has no alcohol smell, the solid and liquid are separated, washed with an appropriate amount of deionized water, the obtained liquid is saved for future use, and the solid is spray-dried to obtain the content of carnosic acid It is 3.5 kilograms of rosemary fat-soluble antioxidant (crude product) of 20~40%, crude product uses CO 2 1.1 kg of rosemary fat-soluble antioxidants with carnosic acid content of 60-80% were obtained by supercritical extraction.
[0034] The above-mentioned standby liqu...
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Abstract
The invention discloses a production technology employing a ultrasonic countercurrent extraction process and a membrane separation (molecular sieve) process to acquire two antioxidants from Rosmarinus officinalis L. The production technology comprises adding 30 to 85% of edible alcohol into fresh rosemary branches and leaves, carrying out a ultrasonic counter current extraction process for a mixture of the edible alcohol and the fresh rosemary branches and leaves to obtain an extracted liquid with a solid-to-liquid ratio of from 1:10 to 1:30, and carrying out a membrane separation (molecular sieve) process to separate two antioxidant agents consisting of a rosemary fat-soluble antioxidant agent (comprising carnosic acid as a representative) and a rosemary water-soluble antioxidant agent (comprising rosmarinic acid as a representative) from the extracted liquid, wherein a heating time of the extracted liquid can be reduced through the membrane separation (molecular sieve) process thus a conversion ratio of rosmarinic acid to carnosol is reduced. A content of carnosic acid in the rosemary fat-soluble antioxidant agent is increased through a CO2 supercritical extraction process. The rosemary water-soluble antioxidant agent (comprising rosmarinic acid as a representative) is separated from a liquid obtained through a concentration process under reduced pressure and a solid-liquid separation process, and a content of rosmarinic acid in the rosemary water-soluble antioxidant agent is increased through recrystallization from ethanol. The production technology has the advantages of simple processes, low energy consumption, high production efficiency, production safety, and no harmful residual solvent due to single edible alcohol usage during all production processes.
Description
Technical field: [0001] The invention belongs to the field of extraction, separation and manufacture of highly active natural antioxidant substances, and particularly designs a production process for separating and obtaining two kinds of antioxidants from the Lamiaceae plant rosemary. Background technique: [0002] Rosemary (Rosmarinus officinalis L) is a plant of the Labiatae family. It is a perennial evergreen shrub. Its origin is in Europe, North Africa and the Mediterranean coast. The main producing countries are France, Spain, Yugoslavia and Italy. Now it is widely cultivated in various countries around the world. . [0003] According to literature records, during the period of Emperor Wen of the Three Kingdoms, rosemary was introduced into my country from the Western Regions. Cao Zhi's "Fu on Rosemary" is a good proof. The Beijing Institute of Botany, Chinese Academy of Sciences successfully introduced rosemary in 1981. The plant has very low requirements on soil and...
Claims
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