Method for preparing high-purity carnosic acid from rosemary oil paste byproduct

Abstract

The invention discloses a method for preparing carnosic acid from a rosemary oil paste byproduct, and the method comprises the following steps: preparing an R67 extract, preparing the rosemary oil paste byproduct, preparing rosemary oil paste particle powder, carrying out solid-liquid extraction on the rosemary oil paste powder, concentrating the extract, and crystallizing to prepare crude carnosic acid dry powder, remove impurities from the crude carnosic acid product by activated carbon adsorbing, and refining carnosic acid to prepare a carnosic acid product with carnosic acid content of 95-98%. The method has the characteristics of simplicity in operation, high efficiency, recyclability of the extract, environmental friendliness, high product yield and the like.

Description

Technical field [0001] The invention belongs to the technical field of plant component extraction, and specifically relates to a method for preparing high-purity carnosic acid from rosemary ointment. Background technique [0002] Rosemary (Rosmarinusofficinalis L.) is an evergreen shrub of Labiatea (Labiatea). It is native to the Mediterranean area and is currently cultivated in Xinjiang, Yunnan, Guizhou and other places in China. It is warm in nature and pungent in taste. The main part used is the leaves. It has the effects of aromatic stomach, refreshing, sedative and soothing. It has certain therapeutic effects on nerve, digestive and respiratory diseases. It is also a traditional spice and food additive. [0003] Rosemary is rich in a variety of antioxidants and has strong antioxidant capacity. It is currently recognized as a plant with high-efficiency antioxidant effects. The Institute of Botany, Chinese Academy of Sciences successfully introduced rosemary in 1981. 2 The supe...

AI Technical Summary

Problems solved by technology

The defect of this method is: (1) preparation process is loaded down with trivial details, and energy consumption is bigger, and organic solvent consumption is big; (2) rosemary essential oil and rosmarinic acid two kinds of active components are not prepared; The extraction rate of oxalic acid is low, and the single extraction rate is lower than 20%, which cannot be used in large-scale production

The disadvantages of this method are: (1) the two active ingredients of rosemary essential oil and rosmarinic acid are not prepared; (2) two low-temperature ultrasonic extraction preparations, n-hexane liquid-liquid extraction, the preparation process is cumbersome; (3) The extraction rate of normal hexane to carnosic acid is low, and the single extraction rate is lower than 20%, and energy consumption is bigger, and organic solvent consumption is big, can not be used for large-scale production; (3) lye separation, carnosic acid A series of total phenolic acid components can be produced under aqueous conditions; (4) silica gel column chromatography, using silica gel adsorption separation, the o-diphenolic hydroxyl and carboxyl groups of carnosic acid may undergo oxidation reactions when they are distributed with silica gel, Lead to degradation, and the long residence time of the chromatography process also leads to structural changes; (5) high cost, low product purity, no industrial production, and no actual economic benefits

At present, there are no literature and patent reports on the preparation of carnosic acid by the by-product of rosemary ointment

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