The invention belongs to the technical field of high polymer materials, particularly relates to a preparation process of a persistent antibacterial and antiviral additive, and provides the following scheme aiming at the problem that an additive does not have antibacterial and antiviral functions: the preparation process comprises the following steps: S1, preparing all raw materials in parts by weight; S2, mixing a carrier and water to form a suspension; S3, mixing silver chloride and a cosolvent to obtain a silver ion solution; S4, mixing zinc sulfate, copper sulfate and water to obtain a zinc-copper ion solution; S5, mixing an organic matter with water to obtain an organic matter solution; S6, adding a silver ion solution and the zinc-copper ion solution into the suspension, and adding a dispersing agent to obtain a solution A; S7, adding the organic matter solution into the solution A, and then adding a defoaming agent to obtain a solution B; and S8, finally adding a stabilizer into the solution B. The raw materials using the additive have autonomous antibacterial and antiviral functions, subsequent manual sterilization and disinfection are not needed, the stability of the additive is improved, and the persistent antibacterial and antiviral effects are guaranteed.