A kind of extraction and preparation method of active ingredient of rhubarb saltpeter decoction

An active ingredient, the technology of rhubarb, which is applied in the field of extraction and preparation of active ingredients of rhubarb saltpeter soup, can solve the problems of reduced active ingredients, low solubility, and reduced drug efficacy, so as to avoid chemical changes, reduce the use, and solve the problem of active ingredients Reduced effect

Inactive Publication Date: 2011-12-28
SHANXI UNIV OF CHINESE MEDICINE
View PDF0 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, studies have found that the solubility of this double salt in artificial gastric juice and intestinal juice is very low, and pharmacological experiments have verified that the bioavailability of macromolecular double salt is very low (Pei Miaorong, et al. Research on the Compatibility Chemistry of Acid-base Drugs in Traditional Chinese Medicine Prescriptions [J]. Chinese Journal of Traditional Chinese Medicine, 2009, 34(15): 1989-1993, Pei Miaorong, et al. A study on the structure of complexes formed by co-decoction of acid-base components contained in acid-base medicines [J]. Chinese Medicine, 2009 ,34(23):3054-3059)
[0008] Therefore, in the existing decoction preparation method of rhubarb saltpetre decoction, there is an association reaction between the alkaline components contained in Phellodendron Phellodendri and the acidic components contained in rhubarb during the decoction process to form insoluble precipitates (this precipitates cannot be absorbed and utilized by the body) , the problem of reducing the active ingredients and reducing the efficacy of the drug

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of extraction and preparation method of active ingredient of rhubarb saltpeter decoction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0018] Take about 1000g of rhubarb, add 7L of water to decoct for 40min, filter the decoction while it is hot, concentrate to 0.53g of crude drug per ml, and load 0.73g of rhubarb per 1ml of resin into the D-101 macropore Resin column, washed with water until clarified, then eluted with 75% ethanol until colorless, collected 75% ethanol eluate, recovered solvent, dried at low temperature, and pulverized into fine powder to obtain rhubarb extract fraction.

[0019] Take about 1000g of Cortex Phellodendri, add 7L of 50% ethanol, and extract under reflux for 1 hour. After recovering the solvent from the extract, dry it at low temperature, and grind it into fine powder to obtain the extract component of Phellodendron Phellodendri.

[0020] Take about 1000g of gardenia, add 7L of water to decoct for 40min, then add the same volume of water to decoct for 30min, filter each decoction while it is hot, combine the two decoctions, and concentrate to 0.65g of crude drug per ml. Resin loa...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

A method for extracting and preparing the active ingredient of rhubarb saltpeter decoction. After concentrating the water decoction obtained by decocting rhubarb, refining it on a macroporous resin column to obtain the rhubarb extract component, extracting the phellodendron with ethanol to obtain the phellodendron extract component, and After the water decoction obtained by decocting gardenia is concentrated, it is refined with macroporous resin to obtain gardenia extract components, and finally rhubarb extract components, cork extract components, gardenia extract components and mirabilite are mixed to make rhubarb saltpeter decoction medicine active ingredient. The invention effectively solves the problems of decocting the whole prescription of the rhubarb saltpeter decoction to reduce the effective components and reduce the medicinal effect.

Description

technical field [0001] The invention belongs to the technical field of preparation of traditional Chinese medicines, and relates to a method for extracting and preparing active ingredients of traditional Chinese medicines, in particular to a method for extracting and preparing active ingredients of rhubarb saltpeter decoction. Background technique [0002] Rhubarb Saltpeter Decoction originated from "Synopsis of the Golden Chamber" by Zhang Zhongjing in the Han Dynasty. It is composed of rhubarb, Glauber's salt, Cortex Phellodendron, and Gardenia. The combination of Rhubarb and Glauber's Salt enhances the power of clearing away heat, dredging the internal organs and removing blood stasis, and the combination of Gardenia and Cortex Phellodendri strengthens the power of clearing away heat and dampness. After defecating, the "inside stuff" will be eliminated, and urination will be natural and refreshing. Damp heat from the Sanjiao comes out from the two stools, and plays the ro...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/756A61P1/04A61P1/16A61P1/18A61P31/20A61K33/04
Inventor 裴妙荣高宝益李翠红李慧峰
Owner SHANXI UNIV OF CHINESE MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap