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Method of purifying and preparing momordica grosvenori alcohol

A technique for mogrosolic alcohol and extract, applied in the field of purification and preparation of high-purity substances, can solve the problems of unfavorable mass preparation of mogrosolic alcohol, cumbersome operation, high cost, and achieve the effects of no toxic and side effects, simplified process and improved efficiency

Inactive Publication Date: 2010-05-19
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The yield of this method is very low, less than 5 / 100,000, and the operation is cumbersome and the cost is high, which is not conducive to the large-scale preparation of mogrosanol

Method used

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  • Method of purifying and preparing momordica grosvenori alcohol

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] This embodiment 1 is implemented under the following conditions of implementation and technical requirements:

[0026] 1) 100g of dried Luo Han Guo, crushed into a very coarse powder, added 600mL of 70% industrial ethanol for reflux extraction for 3 hours, filtered, recovered ethanol from the filtrate (which can be used again for medicinal material extraction), and obtained 9.5g of alcoholic extract.

[0027] 2) Take the alcoholic extract, add 100mL of water to suspend, then extract with 50mL of water-saturated ethyl acetate, separate the ethyl acetate layer, and recover ethyl acetate under reduced pressure (which can be used again for extraction) to obtain ethyl acetate Ester extract 1.1g.

[0028] 3) Add hydrochloric acid solution to the aqueous solution extracted with ethyl acetate to make the concentration of hydrochloric acid reach 5%, then add 100 mL of ethyl acetate, and heat to reflux for 8 hours. Cool to room temperature, separate the ethyl acetate solution, a...

Embodiment 2

[0032] This embodiment 2 is implemented under the following conditions of implementation and technical requirements:

[0033] 1) Grind 100 g of dried Luo Han Guo into a coarse powder, add 800 mL of 95% industrial ethanol to reflux for extraction for 6 hours, filter, and recover ethanol from the filtrate (which can be used again for extracting medicinal materials) to obtain an extract. Repeat the above operation, combine the extracted extracts obtained twice to obtain 17.2 g of alcoholic extracts.

[0034] 2) Take the alcohol extract, add 200mL of water to suspend it, then extract with 150mL of water-saturated ethyl acetate, separate the ethyl acetate layer, recycle the ethyl acetate (which can be used again for extraction), and obtain the extract. The above operation was repeated once, and the extract obtained from the two extractions was combined to obtain 2.2 g of ethyl acetate extract.

[0035] 3) Add hydrochloric acid solution to the aqueous solution extracted with ethyl ...

Embodiment 3

[0039] This embodiment 3 is implemented under the following conditions of implementation and technical requirements:

[0040] 1) 100g of dried Luo Han Guo, crushed into very coarse powder, added 750mL of 80% industrial ethanol to reflux for extraction for 4 hours, filtered, recovered ethanol from the filtrate (which can be used again for medicinal material extraction) to obtain extract. Repeat the above operation once, and combine the extracted extracts obtained twice to obtain 13.0 g of alcoholic extracts.

[0041] 2) Take the alcoholic extract, add 100mL of water to suspend it, then extract with 100mL of water-saturated ethyl acetate, separate the ethyl acetate layer, and recover the ethyl acetate under reduced pressure (which can be used again for extraction) to obtain the extract. The above operation was repeated once, and the extracts obtained from the two extractions were combined to obtain 1.6 g of ethyl acetate extract.

[0042] 3) Add hydrochloric acid solution to th...

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Abstract

A purified preparation of Mangosteen alcohol, which includes steps: (1) first crush Mangosteen and add ethanol to get alcohol extract, (2) suspend the extract in water, extract by ethyl acetate, recover ethyl acetate to get ethyl acetate extract and take the mother liquor, (3) add HCL into the mother liquor and ethyl acetate for acid hydrolysis with heating, separate the layer of ethyl acetate after hydrolysis and adjust it neutral with lye, abstract ethyl acetate, decompress and recycle the solvent to get the extract containing Mangosteen alcohol, (4) conduct silica gel column chromatography,chloroform elution, and recovery, chloroform-methanol elution, collect the elutes, recycle the solvents to get the crude, (5) conduct re-crystallization on the crude to get Mangosteen alcohol with purity morn than 95%.

Description

technical field [0001] The invention belongs to a method for purifying and preparing high-purity substances, in particular to a method for purifying and preparing mogrosvenol. Background technique [0002] Mogrosanol is a cucurbitane-type tetracyclic triterpenoid compound, which is currently only distributed in the dried fruit of the Cucurbitaceae plant Momordica grosvenori Swingle. Its structural formula is shown in the figure below: [0003] [0004] Monk fruit alcohol is a characteristic component of Luo Han Guo plants, and high-purity monk fruit alcohol can be used as a chemical reference for the identification and quality control of Luo Han Guo medicinal materials and preparations containing Luo Han Guo. Mogroside has pharmacological effects such as anti-tumor, and at the same time, mogroside can be synthesized into high-sweetness mogroside through structural modification, such as a series of sweeteners such as mogroside V and mogroside IV, so the preparation of mog...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07J9/00C07J75/00
Inventor 李晓波王梦月
Owner SHANGHAI JIAO TONG UNIV
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