41 results about "Functional diarrhea" patented technology

This invention relates to novel compounds which are inhibitors of the Rearranged during Transfection (RET) kinase, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy, alone or in combination, for the normalization of gastrointestinal sensitivity, motility and/or secretion and/or abdominal disorders or diseases and/or treatment related to diseases related to RET dysfunction or where modulation of RET activity may have therapeutic benefit including but not limited to all classifications of irritable bowel syndrome (IBS) including diarrhea-predominant, constipation-predominant or alternating stool pattern, functional bloating, functional constipation, functional diarrhea, unspecified functional bowel disorder, functional abdominal pain syndrome, chronic idiopathic constipation, functional esophageal disorders, functional gastroduodenal disorders, functional anorectal pain, inflammatory bowel disease, proliferative diseases such as non-small cell lung cancer, hepatocellular carcinoma, colorectal cancer, medullary thyroid cancer, follicular thyroid cancer, anaplastic thyroid cancer, papillary thyroid cancer, brain tumors, peritoneal cavity cancer, solid tumors, other lung cancer, head and neck cancer, gliomas, neuroblastomas, Von Hippel-Lindau Syndrome and kidney tumors, breast cancer, fallopian tube cancer, ovarian cancer, transitional cell cancer, prostate cancer, cancer of the esophagus and gastroesophageal junction, biliary cancer, adenocarcinoma, and any malignancy with increased RET kinase activity.

The invention belongs to the field of Chinese traditional medicine preparations and particularly relates to an externally-applied Chinese traditional medicine preparation for treating chronic functional diarrhea and a preparation method thereof. The Chinese traditional medicine preparation is prepared from the following materials: 2-4 parts of radix codonopsis, 1-3 parts of bighead atractylodes rhizome, 1-3 parts of poria cocos, 1-2 parts of radix glycyrrhizae, 1-2 parts of pericarpium citri reticulatae, 1-2 parts of rhizoma pinelliae, 1-2 parts of prepared common monkshood daughter root, 1-3 parts of cortex cinnamomi, 1-3 parts of dried ginger and 1-3 parts of rhizoma cimicifugae. The Chinese traditional medicine preparation is applied externally; compared with an oral traditional Chinese medicine, the Chinese traditional medicine preparation has the advantages as follows: the dosage is small, the cost is low, treatment is convenient, a patient is liable to persist with the treatment and has high compliance, toxic and side effects of the oral medicine are avoided, the curative effect is reliable and can last for a long time, the medicine takes effect quickly, the cure rate is high, and oral administration is not needed.

The invention relates to a method of treating functional bowel disorders in a subject in need of treatment. The method comprises administering to a subject in need of treatment a therapeutically effective amount of a compound that has 5-HT₃ receptor antagonist activity and NorAdrenaline Reuptake Inhibitor (NARI) activity. The invention further relates to a method of treating a functional bowel disorder in a subject in need thereof, comprising coadministering to said subject a first amount of a 5-HT₃ antagonist and a second amount of a NARI, wherein the first and second amounts together comprise a therapeutically effective amount or are each present in a therapeutically effective amount. In addition, the method of the invention comprises administering a NARI alone. The functional bowel disorders which can be treated according to the method of the invention include IBS, functional abdominal bloating, functional constipation and functional diarrhea.

The invention discloses a compound, namely (2R, 3R)-((2-(3,4-dihydroxyphenyl)-5,7-dihydroxyl-4-oxo-2,3-dihydrobenzopyran-3-yl) methylamino) methyl-2-phenylpropionate. The invention also discloses a preparation method for the compound and the application of the compound as a feed additive. When serving as the feed additive, the compound can specifically promote the growth of intestinal mucosa villus of livestocks, promote the growth of intestinal linings, reduce the intestinal tension and inhibit abnormal peristalsis, can reduce the feed discharging speed of intestinal tracts of the livestocks so as to enhance the digestive absorption of the intestinal tracts to nutritional components, and can obviously increase the daily weight increasing of the livestocks. The reduction of the intestinal tension contributes to water absorption in the intestinal tracts, and plays an obvious role of convergence and reducing functional diarrhea. The compound provided by the invention also has an effect of repairing intestinal mucosa, and can also obviously improve the immunity function of intestinal mucosa and disease resistance of the livestocks.

The present invention provides probiotic compositions suitable for relieving symptoms associated with gastrointestinal disorders. In particular, the present invention provides compositions and methods to relieve symptoms associated with functional bowel disorders, irritable bowel syndrome, functional diarrhea, functional bloating, and other symptoms.

The invention relates to a plaster for stopping diarrhea. The plaster is prepared from the following raw pharmaceutical materials in parts by weight: 15-20 parts of bupleurum root, 5-10 parts of dried old orange peel, 5-10 parts of nutgrass galingale rhizome, 10-15 parts of atractylodes macrocephala, 5-10 parts of glycyrrhiza uralensis, 5-10 parts of Chinese yam, 15-20 parts of pagoda tree flower, 5-10 parts of fructus psoraleae, 15-20 parts of coninshaped blueberry branchlet and leaf, 10-15 parts of anemarrhena rhizome, 10-15 parts of fleece-flower stem, 10-15 parts of tree peony bark, 5-10 parts of cinnamon, 5-10 parts of coix seed, 5-10 parts of cortex albiziae and 5-10 parts of angelica sinensis. A traditional Chinese medicine preparation is good in effect on treating functional diarrhea, is simple and easy to use, is free of toxic or side effects and is easily accepted by patients, so that the traditional Chinese medicine preparation is safe and effective for treating functional diarrhea and has good application prospects.

The chronic diarrhea stopping capsule is a kind of Chinese medicine preparation for treating chronic functional diarrhea and imperfect spleen and stomach function. It is produced with bupleurum root, angelica, white atractylodes rhizome, tuckahoe, ginger and mint and through crushing, mixing and capsulizing. The present invention has simple production process, easy operation, use of conventional apparatus and convenience in taking.

The chronic diarrhea stopping capsule as a kind of Chinese medicine preparation for treating chronic functional diarrhea and imperfect spleen and stomach function consists of bupleurum root, angelica, white atractylodes rhizome, tuckahoe, ginger and mint. The chronic diarrhea stopping capsule is one kind of Chinese medicine preparation containing no mineral matter, can strengthen functions of spleen and stomach without suppressing peristalsis of gastrointestinal tract, and is convenient in taking, safe, and without toxic side effect and influence on appetite.

The invention discloses a traditional Chinese medicine composition for treating functional diarrhea. The traditional Chinese medicine composition comprises the following components: by weight, 18-22 grams of radix codonopsis, 14-16 grams of fried atractylodes, 14-16 grams of poria cocos, 8-12 grams of dried tangerine peel, 14-16 grams of fried white peony root, 5-7 grams of periostracum cicadae, 3-5 grams of villous amomum fruit, 8-12 grams of catalpa ovata flower, 14-16 grams of root of kudzu vine and 8-12 grams of fried radix scutellariae . The traditional Chinese medicine composition can be boiled into decoction by use of water, and is for oral administration. The traditional Chinese medicine composition has an obvious effect on treating of the functional diarrhea, also has functions of regulating and nourishing of liver, spleen and kidney, and has low cost, good curative effects and no toxic and side effects.

The invention relates to the field medical technology, and discloses the applications of chroman compounds HEF-19 in preparing intestinal canal smooth muscle antispastic and antidiarrhoeal. In the in vitro experiment of animals, HEF-19 can reduce tension and amplitude induced by spontaneous activities of isolated small intestine smooth muscle of a rabbit, and relax the contractions induced by acetylcholine, barium chloride, potassium chloride and histamine on isolated small intestine smooth muscle of the rabbit. Therefore, the compound can be used for preparing antispastic and antidiarrhoeal for treating intestinal canal smooth muscle spasm. The applications of the compound refer to the preparations of medicaments used for treating stomach/abdomen convulsive pain caused by various reasons,medicaments used for treating intestinal irritable syndrome, medicaments used for treating functional disturbance gastrointestinal tract caused by ulcerative colitis, and medicaments used for treating functional diarrhea caused by various reasons and the like.

A preventive and/or therapeutic agent which improves an abnormal bowel function such as an abdominal pain, a diarrhea, or a constipation and is effective for preventing or treating a functional gastrointestinal disorder is provided.

A preventive and/or therapeutic agent for a functional gastrointestinal disorder contains refaximin as an effective ingredient. The functional gastrointestinal disorder includes a functional esophageal disorder, a functional gastroduodenal disorder (e.g., a functional dyspepsia), a functional bowel disorder (e.g., a functional bloating, a functional diarrhea), a functional abdominal pain syndrome, a functional gallbladder and Sphincter of Oddi disorder, a functional anorectal disorder (e.g., a functional fecal incontinence, a functional anorectal pain, a functional defecation disorder), a functional disorder in neonates and toddlers (e.g., an infant functional diarrhea), a functional disorder in children and adolescents (e.g., a childhood functional abdominal pain, a childhood nonretentive fecal incontinence), and other diseases.