41 results about "Functional diarrhea" patented technology

This invention relates to novel compounds which are inhibitors of the Rearranged during Transfection (RET) kinase, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy, alone or in combination, for the normalization of gastrointestinal sensitivity, motility and / or secretion and / or abdominal disorders or diseases and / or treatment related to diseases related to RET dysfunction or where modulation of RET activity may have therapeutic benefit including but not limited to all classifications of irritable bowel syndrome (IBS) including diarrhea-predominant, constipation-predominant or alternating stool pattern, functional bloating, functional constipation, functional diarrhea, unspecified functional bowel disorder, functional abdominal pain syndrome, chronic idiopathic constipation, functional esophageal disorders, functional gastroduodenal disorders, functional anorectal pain, inflammatory bowel disease, proliferative diseases such as non-small cell lung cancer, hepatocellular carcinoma, colorectal cancer, medullary thyroid cancer, follicular thyroid cancer, anaplastic thyroid cancer, papillary thyroid cancer, brain tumors, peritoneal cavity cancer, solid tumors, other lung cancer, head and neck cancer, gliomas, neuroblastomas, Von Hippel-Lindau Syndrome and kidney tumors, breast cancer, fallopian tube cancer, ovarian cancer, transitional cell cancer, prostate cancer, cancer of the esophagus and gastroesophageal junction, biliary cancer, adenocarcinoma, and any malignancy with increased RET kinase activity.

This invention relates to novel compounds which are inhibitors of the Rearranged during Transfection (RET) kinase, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy, alone or in combination, for the normalization of gastrointestinal sensitivity, motility and / or secretion and / or abdominal disorders or diseases and / or treatment related to diseases related to RET dysfunction or where modulation of RET activity may have therapeutic benefit including but not limited to all classifications of irritable bowel syndrome (IBS) including diarrhea-predominant, constipation-predominant or alternating stool pattern, functional bloating, functional constipation, functional diarrhea, unspecified functional bowel disorder, functional abdominal pain syndrome, chronic idiopathic constipation, functional esophageal disorders, functional gastroduodenal disorders, functional anorectal pain, inflammatory bowel disease, proliferative diseases such as non-small cell lung cancer, hepatocellular carcinoma, colorectal cancer, medullary thyroid cancer, follicular thyroid cancer, anaplastic thyroid cancer, papillary thyroid cancer, brain tumors, peritoneal cavity cancer, solid tumors, other lung cancer, head and neck cancer, gliomas, neuroblastomas, Von Hippel-Lindau Syndrome and kidney tumors, breast cancer, fallopian tube cancer, ovarian cancer, transitional cell cancer, prostate cancer, cancer of the esophagus and gastroesophageal junction, biliary cancer, adenocarcinoma, and any malignancy with increased RET kinase activity.

The invention belongs to the field of Chinese traditional medicine preparations and particularly relates to an externally-applied Chinese traditional medicine preparation for treating chronic functional diarrhea and a preparation method thereof. The Chinese traditional medicine preparation is prepared from the following materials: 2-4 parts of radix codonopsis, 1-3 parts of bighead atractylodes rhizome, 1-3 parts of poria cocos, 1-2 parts of radix glycyrrhizae, 1-2 parts of pericarpium citri reticulatae, 1-2 parts of rhizoma pinelliae, 1-2 parts of prepared common monkshood daughter root, 1-3 parts of cortex cinnamomi, 1-3 parts of dried ginger and 1-3 parts of rhizoma cimicifugae. The Chinese traditional medicine preparation is applied externally; compared with an oral traditional Chinese medicine, the Chinese traditional medicine preparation has the advantages as follows: the dosage is small, the cost is low, treatment is convenient, a patient is liable to persist with the treatment and has high compliance, toxic and side effects of the oral medicine are avoided, the curative effect is reliable and can last for a long time, the medicine takes effect quickly, the cure rate is high, and oral administration is not needed.

The invention relates to a method of decreasing intestinal motility in a subject in need of treatment. The method comprises administering to the subject a therapeutically effective amount of a compound that has 5-HT3 receptor antagonist activity and NorAdrenaline Reuptake Inhibitor (NARI) activity. The invention further relates to a method of decreasing intestinal motility in a subject in need thereof, comprising coadministering to said subject a first amount of a 5-HT3 antagonist and a second amount of a NARI, wherein the first and second amounts together comprise a therapeutically effective amount or are each present in a therapeutically effective amount. In addition, the method of the invention comprises administering a NARI alone. In certain embodiments, the subject is a subject with a functional bowel disorder, such as IBS, functional abdominal bloating, or functional diarrhea.

The invention relates to a method of treating functional bowel disorders in a subject in need of treatment. The method comprises administering to a subject in need of treatment a therapeutically effective amount of a compound that has 5-HT3 receptor antagonist activity and NorAdrenaline Reuptake Inhibitor (NARI) activity. The invention further relates to a method of treating a functional bowel disorder in a subject in need thereof, comprising coadministering to said subject a first amount of a 5-HT3 antagonist and a second amount of a NARI, wherein the first and second amounts together comprise a therapeutically effective amount or are each present in a therapeutically effective amount. In addition, the method of the invention comprises administering a NARI alone. The functional bowel disorders which can be treated according to the method of the invention include IBS, functional abdominal bloating, functional constipation and functional diarrhea.

This invention relates to novel compounds which are inhibitors of the Rearranged during Transfection (RET) kinase, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy, alone or in combination, for the normalization of gastrointestinal sensitivity, motility and / or secretion and / or abdominal disorders or diseases and / or treatment related to diseases related to RET dysfunction or where modulation of RET activity may have therapeutic benefit including but not limited to all classifications of irritable bowel syndrome (IBS) including diarrhea-predominant, constipation-predominant or alternating stool pattern, functional bloating, functional constipation, functional diarrhea, unspecified functional bowel disorder, functional abdominal pain syndrome, chronic idiopathic constipation, functional esophageal disorders, functional gastroduodenal disorders, functional anorectal pain, inflammatory bowel disease, proliferative diseases such as non-small cell lung cancer, hepatocellular carcinoma, colorectal cancer, medullary thyroid cancer, follicular thyroid cancer, anaplastic thyroid cancer, papillary thyroid cancer, brain tumors, peritoneal cavity cancer, solid tumors, other lung cancer, head and neck cancer, gliomas, neuroblastomas, Von Hippel-Lindau Syndrome and kidney tumors, breast cancer, fallopian tube cancer, ovarian cancer, transitional cell cancer, prostate cancer, cancer of the esophagus and gastroesophageal junction, biliary cancer, adenocarcinoma, and any malignancy with increased RET kinase activity.

A method for preventing and / or treating a functional gastrointestinal disorder, comprising administering, to a subject with the functional gastrointestinal disorder, rifaximin as an effective ingredient. The functional gastroinstestinal disorder includes a functional esophageal disorder, a functional gastroduodenal disorder (e.g., a functional dyspepsia), a functional bowel disorder (e.g., a functional bloating, a functional diarrhea), a functional abdominal pain syndrome, a functional gallbladder and Sphincter of Oddi disorder, a functional anorectal disorder (e.g., a functional fecal incontinence, a functional anorectal pain, a functional defecation disorder), a functional disorder in neonates and toddlers (e.g., an infant functional diarrhea), a functional disorder in children and adolescents (e.g., a childhood functional abdominal pain, a childhood nonretentive fecal incontinence), and other diseases.

The present invention provides probiotic compositions suitable for relieving symptoms associated with gastrointestinal disorders. In particular, the present invention provides compositions and methods to relieve symptoms associated with functional bowel disorders, irritable bowel syndrome, functional diarrhea, functional bloating, and other symptoms.

The invention discloses a compound, namely (2R, 3R)-((2-(3,4-dihydroxyphenyl)-5,7-dihydroxyl-4-oxo-2,3-dihydrobenzopyran-3-yl) methylamino) methyl-2-phenylpropionate. The invention also discloses a preparation method for the compound and the application of the compound as a feed additive. When serving as the feed additive, the compound can specifically promote the growth of intestinal mucosa villus of livestocks, promote the growth of intestinal linings, reduce the intestinal tension and inhibit abnormal peristalsis, can reduce the feed discharging speed of intestinal tracts of the livestocks so as to enhance the digestive absorption of the intestinal tracts to nutritional components, and can obviously increase the daily weight increasing of the livestocks. The reduction of the intestinal tension contributes to water absorption in the intestinal tracts, and plays an obvious role of convergence and reducing functional diarrhea. The compound provided by the invention also has an effect of repairing intestinal mucosa, and can also obviously improve the immunity function of intestinal mucosa and disease resistance of the livestocks.

This invention relates to novel compounds which are inhibitors of the Rearranged during Transfection (RET) kinase, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy, alone or in combination, for the normalization of gastrointestinal sensitivity, motility and / or secretion and / or abdominal disorders or diseases and / or treatment related to diseases related to RET dysfunction or where modulation of RET activity may have therapeutic benefit including but not limited to all classifications of irritable bowel syndrome (IBS) including diarrhea-predominant, constipation-predominant or alternating stool pattern, functional bloating, functional constipation, functional diarrhea, unspecified functional bowel disorder, functional abdominal pain syndrome, chronic idiopathic constipation, functional esophageal disorders, functional gastroduodenal disorders, functional anorectal pain, inflammatory bowel disease, proliferative diseases such as non-small cell lung cancer, hepatocellular carcinoma, colorectal cancer, medullary thyroid cancer, follicular thyroid cancer, anaplastic thyroid cancer, papillary thyroid cancer, brain tumors, peritoneal cavity cancer, solid tumors, other lung cancer, head and neck cancer, gliomas, neuroblastomas, Von Hippel-Lindau Syndrome and kidney tumors, breast cancer, fallopian tube cancer, ovarian cancer, transitional cell cancer, prostate cancer, cancer of the esophagus and gastroesophageal junction, biliary cancer, adenocarcinoma, and any malignancy with increased RET kinase activity.

The invention discloses a traditional Chinese medicine for treating functional diarrhea. The traditional Chinese medicine comprises the following components in parts by weight: 1-3 parts of ginseng, 10-12 parts of peanut shells, 8-10 parts of Chinese gall, 10-12 parts of coptis chinensis, 8-10 parts of fried atractylodes macrocephala, 10-12 parts of wrinkled giant hyssop, 10-12 parts of ludwigia prostrata roxb, 10-12 parts of scorched hawthorn fruit, 10-12 parts of dark plum, 8-10 parts of roughhaired holly root, 3-5 parts of pseudo-ginseng, 5-8 parts of camellia, 8-10 parts of pomegranate seeds, 5-8 parts of ligusticum wallichii, and 10-12 parts of furnace soil; the components are boiled into soup and are taken orally. The traditional Chinese medicine is remarkable in treating functional diarrhea, good in low and curative effect and free of toxicity and side effect, and has the functions of conditioning livers, spleens and kidneys.

The invention discloses a traditional Chinese medicine for treating the functional diarrhea. The traditional Chinese medicine is characterized in that the traditional Chinese medicine comprises, by weight, 10-12 parts of Radix Codonopsis, 9-11 parts of fried Rhizoma Atractylodis Macrocephalae, 10-12 parts of Poria cocos, 10-12 parts of Polyalthia nemoralis A. DC., 5-8 parts of Chinese gall, 3-5 parts of Panax Notoginseng, 3-5 parts of Rhizoma Coptidis, 5-8 parts of Myristica fragrans, 10-12 parts of Anthriscus sylvestris, 10-12 parts of pomegranate flower, 5-8 parts of Fructus Aurantii, 5-8 parts of dried orange peel, 10-12 parts of hawthorn fruit, 10-12 parts of Gynostemma pentaphylla and 10-12 parts of root of Ginkgo biloba. The above raw materials are decocted with water to prepare a decoction which is orally taken. The traditional Chinese medicine has an obvious treatment effect on the functional diarrhea, and has no toxic side effects.

The present invention provides probiotic compositions suitable for relieving symptoms associated with gastrointestinal disorders. In particular, the present invention provides compositions and methods to relieve symptoms associated with functional bowel disorders, irritable bowel syndrome, functional diarrhea, functional bloating, and other symptoms.

This invention relates to novel compounds which are inhibitors of the Rearranged during Transfection (RET) kinase, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy, alone or in combination, for the normalization of gastrointestinal sensitivity, motility and / or secretion and / or abdominal disorders or diseases and / or treatment related to diseases related to RET dysfunction or where modulation of RET activity may have therapeutic benefit including but not limited to all classifications of irritable bowel syndrome (IBS) including diarrhea-predominant, constipation-predominant or alternating stool pattern, functional bloating, functional constipation, functional diarrhea, unspecified functional bowel disorder, functional abdominal pain syndrome, chronic idiopathic constipation, functional esophageal disorders, functional gastroduodenal disorders, functional anorectal pain, inflammatory bowel disease, proliferative diseases such as non-small cell lung cancer, hepatocellular carcinoma, colorectal cancer, medullary thyroid cancer, follicular thyroid cancer, anaplastic thyroid cancer, papillary thyroid cancer, brain tumors, peritoneal cavity cancer, solid tumors, other lung cancer, head and neck cancer, gliomas, neuroblastomas, Von Hippel-Lindau Syndrome and kidney tumors, breast cancer, fallopian tube cancer, ovarian cancer, transitional cell cancer, prostate cancer, cancer of the esophagus and gastroesophageal junction, biliary cancer, adenocarcinoma, and any malignancy with increased RET kinase activity.

The invention relates to a plaster for stopping diarrhea. The plaster is prepared from the following raw pharmaceutical materials in parts by weight: 15-20 parts of bupleurum root, 5-10 parts of dried old orange peel, 5-10 parts of nutgrass galingale rhizome, 10-15 parts of atractylodes macrocephala, 5-10 parts of glycyrrhiza uralensis, 5-10 parts of Chinese yam, 15-20 parts of pagoda tree flower, 5-10 parts of fructus psoraleae, 15-20 parts of coninshaped blueberry branchlet and leaf, 10-15 parts of anemarrhena rhizome, 10-15 parts of fleece-flower stem, 10-15 parts of tree peony bark, 5-10 parts of cinnamon, 5-10 parts of coix seed, 5-10 parts of cortex albiziae and 5-10 parts of angelica sinensis. A traditional Chinese medicine preparation is good in effect on treating functional diarrhea, is simple and easy to use, is free of toxic or side effects and is easily accepted by patients, so that the traditional Chinese medicine preparation is safe and effective for treating functional diarrhea and has good application prospects.

The chronic diarrhea stopping capsule is a kind of Chinese medicine preparation for treating chronic functional diarrhea and imperfect spleen and stomach function. It is produced with bupleurum root, angelica, white atractylodes rhizome, tuckahoe, ginger and mint and through crushing, mixing and capsulizing. The present invention has simple production process, easy operation, use of conventional apparatus and convenience in taking.

The invention discloses a traditional Chinese medicine composition for treating functional diarrhea. 12 grams, 14-16 grams of fried white peony, 5-7 grams of cicada slough, 3-5 grams of amomum, 8-12 grams of catalpa, 14-16 grams of kudzu root, 8-12 grams of fried skullcap. Decoct it with water to make a decoction and take it orally. The traditional Chinese medicine composition has obvious effect in treating functional diarrhea, and has the effect of nourishing the liver, spleen and kidney at the same time, has low cost, good curative effect, and no toxic and side effects.

The invention relates to a medicinal and edible traditional Chinese medicine composition for treating functional diarrhea, which belongs to the technical field of traditional Chinese medicines and comprises the following raw material medicines: coix seed, Chinese yam, poria cocos, white hyacinth bean, platycodon grandiflorum, lotus seed, honey-fried licorice root, pericarpium citri reticulatae and Chinese date. The medicine composition is prepared from medicinal and edible traditional Chinese medicinal materials, has no toxic or side effect and can be taken for a long time. Animal experiment research proves that the traditional Chinese medicine composition can promote intestinal water reabsorption by regulating expression of aquaporin AQP3 and AQP8, so that the disease symptom of functional diarrhea is effectively improved, and the physiological function of the intestinal tract is recovered.

The chronic diarrhea stopping capsule as a kind of Chinese medicine preparation for treating chronic functional diarrhea and imperfect spleen and stomach function consists of bupleurum root, angelica, white atractylodes rhizome, tuckahoe, ginger and mint. The chronic diarrhea stopping capsule is one kind of Chinese medicine preparation containing no mineral matter, can strengthen functions of spleen and stomach without suppressing peristalsis of gastrointestinal tract, and is convenient in taking, safe, and without toxic side effect and influence on appetite.

The invention discloses a traditional Chinese medicinal formula capable of relieving functional diarrhea. The traditional Chinese medicinal formula mainly comprises the following raw materials in parts by weight: 2-6 parts of cuttle bone, 4-10 parts of fructus evodiae, 6-10 parts of elecampane, 1-3 parts of concha arcae, 6-15 parts of dried alum, 5-12 parts of magnolia obavata, 8-15 parts of rhizoma coptidis, 6-12 parts of nutgall, 14-26 parts of apple vinegar, and 5-12 parts of sesame oil. The traditional Chinese medicinal formula is capable of relieving functional diarrhea with a curative rate of 100%, can improve the poor appetite situation of a patient after taking, not only can relieve the functional diarrhea for the patient, but also can tonify spleen and invigorate stomach. The traditional Chinese medicine formula takes simple and feasible traditional Chinese medicines as raw materials, can become effective rapidly, is free from any toxic or side effects, quickly relieves the pain for the patient, and plays a good effective role for the functional diarrhea due to too strong gastrointestinal function, and too fast gastrointestinal motility.

The invention relates to application of a traditional Chinese medicine preparation in preparation of an external-application plaster for stopping diarrhea. The traditional Chinese medicine preparation is prepared from the following raw pharmaceutical materials in parts by weight: 15-20 parts of bupleurum root, 5-10 parts of dried old orange peel, 5-10 parts of nutgrass galingale rhizome, 10-15 parts of atractylodes macrocephala, 5-10 parts of glycyrrhiza uralensis, 5-10 parts of Chinese yam, 15-20 parts of pagoda tree flower, 5-10 parts of fructus psoraleae, 15-20 parts of coninshaped blueberry branchlet and leaf, 10-15 parts of anemarrhena rhizome, 10-15 parts of fleece-flower stem, 10-15 parts of tree peony bark, 5-10 parts of cinnamon, 5-10 parts of coix seed, 5-10 parts of cortex albiziae and 5-10 parts of angelica sinensis. The traditional Chinese medicine preparation is good in effect on treating functional diarrhea, is simple and easy to use, is free of toxic or side effects and is easily accepted by patients, so that the traditional Chinese medicine preparation is safe and effective for treating functional diarrhea and has good application prospects.

The invention discloses a traditional Chinese medicine composition for treating functional diarrhea. The traditional Chinese medicine composition comprises the following components: by weight, 18-22 grams of radix codonopsis, 14-16 grams of fried atractylodes, 14-16 grams of poria cocos, 8-12 grams of dried tangerine peel, 14-16 grams of fried white peony root, 5-7 grams of periostracum cicadae, 3-5 grams of villous amomum fruit, 8-12 grams of catalpa ovata flower, 14-16 grams of root of kudzu vine and 8-12 grams of fried radix scutellariae . The traditional Chinese medicine composition can be boiled into decoction by use of water, and is for oral administration. The traditional Chinese medicine composition has an obvious effect on treating of the functional diarrhea, also has functions of regulating and nourishing of liver, spleen and kidney, and has low cost, good curative effects and no toxic and side effects.

The invention discloses a compound, namely (2R, 3R)-((2-(3,4-dihydroxyphenyl)-5,7-dihydroxyl-4-oxo-2,3-dihydrobenzopyran-3-yl) methylamino) methyl-2-phenylpropionate. The invention also discloses a preparation method for the compound and the application of the compound as a feed additive. When serving as the feed additive, the compound can specifically promote the growth of intestinal mucosa villus of livestocks, promote the growth of intestinal linings, reduce the intestinal tension and inhibit abnormal peristalsis, can reduce the feed discharging speed of intestinal tracts of the livestocks so as to enhance the digestive absorption of the intestinal tracts to nutritional components, and can obviously increase the daily weight increasing of the livestocks. The reduction of the intestinal tension contributes to water absorption in the intestinal tracts, and plays an obvious role of convergence and reducing functional diarrhea. The compound provided by the invention also has an effect of repairing intestinal mucosa, and can also obviously improve the immunity function of intestinal mucosa and disease resistance of the livestocks.

The invention relates to the field medical technology, and discloses the applications of chroman compounds HEF-19 in preparing intestinal canal smooth muscle antispastic and antidiarrhoeal. In the in vitro experiment of animals, HEF-19 can reduce tension and amplitude induced by spontaneous activities of isolated small intestine smooth muscle of a rabbit, and relax the contractions induced by acetylcholine, barium chloride, potassium chloride and histamine on isolated small intestine smooth muscle of the rabbit. Therefore, the compound can be used for preparing antispastic and antidiarrhoeal for treating intestinal canal smooth muscle spasm. The applications of the compound refer to the preparations of medicaments used for treating stomach / abdomen convulsive pain caused by various reasons,medicaments used for treating intestinal irritable syndrome, medicaments used for treating functional disturbance gastrointestinal tract caused by ulcerative colitis, and medicaments used for treating functional diarrhea caused by various reasons and the like.

The invention relates to a traditional Chinese medicine plaster for treating functional diarrhea. The traditional Chinese medicine plaster is prepared from the following raw pharmaceutical materials in parts by weight: 15-20 parts of bupleurum root, 5-10 parts of dried old orange peel, 5-10 parts of nutgrass galingale rhizome, 10-15 parts of atractylodes macrocephala, 5-10 parts of glycyrrhiza uralensis, 5-10 parts of Chinese yam, 15-20 parts of pagoda tree flower, 5-10 parts of fructus psoraleae, 15-20 parts of coninshaped blueberry branchlet and leaf, 10-15 parts of anemarrhena rhizome, 10-15 parts of fleece-flower stem, 10-15 parts of tree peony bark, 5-10 parts of cinnamon, 5-10 parts of coix seed, 5-10 parts of cortex albiziae, 5-10 parts of angelica sinensis, 10-15 parts of corydalis tuber, 5-10 parts of radix linderae, 3-8 parts of prepared rehmannia root, 2-8 parts of wild jujube seed and 5-10 parts of radix platycodi. A traditional Chinese medicine preparation is good in effect on treating functional diarrhea, is simple and easy to use, is free of toxic or side effects and is easily accepted by patients, so that the traditional Chinese medicine preparation is safe and effective for treating functional diarrhea and has good application prospects.

The present invention provides probiotic compositions suitable for relieving symptoms associated with gastrointestinal disorders. In particular, the present invention provides compositions and methods to relieve symptoms associated with functional bowel disorders, irritable bowel syndrome, functional diarrhea, functional bloating, and other symptoms.

The invention relates to the use of CY in preparing smooth muscle spasmolysis agent, and in preparing medicaments for treating stomach and intestinal spasm colicky pain, intestine excitable syndrome, ulcerative colitis, stomach and intestine dysfunction, and functional diarrhea.

A preventive and / or therapeutic agent which improves an abnormal bowel function such as an abdominal pain, a diarrhea, or a constipation and is effective for preventing or treating a functional gastrointestinal disorder is provided.A preventive and / or therapeutic agent for a functional gastrointestinal disorder contains refaximin as an effective ingredient. The functional gastrointestinal disorder includes a functional esophageal disorder, a functional gastroduodenal disorder (e.g., a functional dyspepsia), a functional bowel disorder (e.g., a functional bloating, a functional diarrhea), a functional abdominal pain syndrome, a functional gallbladder and Sphincter of Oddi disorder, a functional anorectal disorder (e.g., a functional fecal incontinence, a functional anorectal pain, a functional defecation disorder), a functional disorder in neonates and toddlers (e.g., an infant functional diarrhea), a functional disorder in children and adolescents (e.g., a childhood functional abdominal pain, a childhood nonretentive fecal incontinence), and other diseases.

The invention belongs to the field of Chinese traditional medicine preparations and particularly relates to an externally-applied Chinese traditional medicine preparation for treating chronic functional diarrhea and a preparation method thereof. The Chinese traditional medicine preparation is prepared from the following materials: 2-4 parts of radix codonopsis, 1-3 parts of bighead atractylodes rhizome, 1-3 parts of poria cocos, 1-2 parts of radix glycyrrhizae, 1-2 parts of pericarpium citri reticulatae, 1-2 parts of rhizoma pinelliae, 1-2 parts of prepared common monkshood daughter root, 1-3 parts of cortex cinnamomi, 1-3 parts of dried ginger and 1-3 parts of rhizoma cimicifugae. The Chinese traditional medicine preparation is applied externally; compared with an oral traditional Chinese medicine, the Chinese traditional medicine preparation has the advantages as follows: the dosage is small, the cost is low, treatment is convenient, a patient is liable to persist with the treatment and has high compliance, toxic and side effects of the oral medicine are avoided, the curative effect is reliable and can last for a long time, the medicine takes effect quickly, the cure rate is high, and oral administration is not needed.

The invention discloses a traditional Chinese medicinal formula capable of relieving functional diarrhea. The traditional Chinese medicinal formula mainly comprises the following raw materials in parts by weight: 2-6 parts of cuttle bone, 4-10 parts of fructus evodiae, 6-10 parts of elecampane, 1-3 parts of concha arcae, 6-15 parts of dried alum, 5-12 parts of magnolia obavata, 8-15 parts of rhizoma coptidis, 6-12 parts of nutgall, 14-26 parts of apple vinegar, and 5-12 parts of sesame oil. The traditional Chinese medicinal formula is capable of relieving functional diarrhea with a curative rate of 100%, can improve the poor appetite situation of a patient after taking, not only can relieve the functional diarrhea for the patient, but also can tonify spleen and invigorate stomach. The traditional Chinese medicine formula takes simple and feasible traditional Chinese medicines as raw materials, can become effective rapidly, is free from any toxic or side effects, quickly relieves the pain for the patient, and plays a good effective role for the functional diarrhea due to too strong gastrointestinal function, and too fast gastrointestinal motility.