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Knee joint prosthesis and hyaluronate compositions for treatment of osteoarthritis

a technology of hyaluronate compositions and joints, applied in the field of therapies, can solve the problems of limiting patient's mobility, reducing and limiting the mobility of the knee joint, so as to reduce the number of injections, improve the effect of lubrication duration, and reduce pain

Inactive Publication Date: 2008-04-24
INTERSECT PARTNERS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0058] The primary goal for treatment of osteoarthritis using hyaluronate compositions are to increase the duration of effectiveness in lubrication and pain reduction, and to reduce the number of injections required.
[0059] The secondary goal for treatment of osteoarthritis using hyaluronate compositions are to improve the effectiveness (i.e. reduce the coefficient of friction) in lubrication and pain reduction, and to provide a therapy which can have applicability in joints with relatively healthy (and therefore stiffer) cartilage as well as older and degenerated (and therefore softer) cartilage.
[0060] These objectives can be attained by increasing the residence time (half life) of the injected HA in the joint space; improving / supplementing the lubrication efficacy of HA in the joint space; and / or increasing the amount of HA per the injection.

Problems solved by technology

The knee is very complex and includes many components with many functions.
The medial meniscus is also attached to the medial collateral ligament, which limits its mobility.
As the bone surfaces become less well protected by cartilage, the patient experiences pain upon weight bearing, including walking and standing.
Due to decreased movement because of the pain, regional muscles may atrophy, and ligaments may become more lax.
The main symptom is chronic pain, causing loss of mobility and often stiffness.
Humid weather increases the pain in many patients.
As a person ages, the water content of the cartilage decreases, and the protein composition in it degenerates, thus degenerating the cartilage through repetitive use or misuse.
Sufferers find their every movement so painful and debilitating that it can also affect them emotionally and psychologically.
Although injections appear to be effective, these products require multiple injections (usually 3-5) and the effectiveness lasts only for 3-6 months.

Method used

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  • Knee joint prosthesis and hyaluronate compositions for treatment of osteoarthritis
  • Knee joint prosthesis and hyaluronate compositions for treatment of osteoarthritis
  • Knee joint prosthesis and hyaluronate compositions for treatment of osteoarthritis

Examples

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example no.1

Example No. 1 Meniscal Wafer Manufacturing

[0130] A meniscal wafer (MW) is a medical device implanted via an arthroscope into the knee joint space (see FIG. 1) to act as a support and bearing wear surface between the femoral condyle and the meniscus / tibial plateau. It is for (1) use in partial or total meniscectomy to supplement or provide meniscus function and articulating surface (to minimize joint degradation), (2) use in place of partial or total meniscectomy (to delay joint degradation), (3) use after arthroscopic clean-up of osteoarthritis (OA) joint to provide fresh articulating surface and improve biomechanics (to delay total knee replacement, for example), and / or (4) to adjust the alignment of the joint though height supplementation. Meniscal wafers can be used on the medial, lateral or both sides of one or both joints. Meniscal wafers can (i) cover the meniscus (only), (ii) cover the tibial plateau (only) or (iii) cover both. FIG. 5 (B-D) shows placement of a meniscal wafer...

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Abstract

A medical device and methods to relieve joint pain and adapted for knee joint repair, replacement and augmentation. The invention discloses joint lubricant, particularly hyaluronate compositions and methods for treatment of osteoarthritis.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS [0001] The application claims the priority benefits of U.S. Provisional Application No. 60 / 852,885 filed Oct. 19, 2006 and U.S. Provisional Application No. 60 / 919,305 filed Mar. 20, 2007.FIELD OF THE INVENTION [0002] The present invention is generally related to therapies for treating a joint or other body parts of a patient. More particularly, the present invention is related to a medical device, hyaluronic compositions, and methods for treatment of osteoarthritis or relieving joint pain adapted for knee joint repair, replacement and augmentation. BACKGROUND OF THE INVENTION [0003] The knee is very complex and includes many components with many functions. The knee problems may be related to meniscus, pain, cartilage, shock absorption, synovial fluids, articular cartilage, ligaments / tendons and / or preserving normal biomechanics. Available therapy currently includes chronic synovial lubrication, acute synovial lubrication, meniscal protection, ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61F2/08A61B17/58
CPCA61F2/3872A61F2/461A61F2002/4635A61L27/20A61F2/30756A61L27/52A61L27/50C08L5/08
Inventor CRAGG, ANDREW H.GREFF, RICHARD J.WALLACE, GEORGESOCCI, JR., ROBERT J.KAGAN, JONATHANQUIJANO, RODLOFO C.TU, HOSHENG
Owner INTERSECT PARTNERS
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