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Composition containing hyaluronic acid substances and ectoine substances

A technology of ectoine and hyaluronic acid, which is applied in drug combinations, skin care preparations, medical preparations containing active ingredients, etc., can solve the problem of hyaluronic acid and ectoine substances that have not yet been seen, and synergistic effects To achieve the effect of protecting the skin immune barrier, repairing skin wounds, and reducing radiation skin damage

Active Publication Date: 2018-10-23
BLOOMAGE BIOTECHNOLOGY CORP LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there have been no reports of synergistic effects of hyaluronic acid and ectoine on whitening, anti-inflammatory, moisturizing, sun protection, and post-sun damage repair

Method used

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  • Composition containing hyaluronic acid substances and ectoine substances
  • Composition containing hyaluronic acid substances and ectoine substances
  • Composition containing hyaluronic acid substances and ectoine substances

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Anti-inflammatory effect of embodiment 1 composition

[0022] The anti-inflammatory repair experiment is a human patch test for inflammation induced by sodium dodecyl sulfate (SDS), and the patch test is carried out by conventional methods (24-hour human patch).

[0023] 1. Experimental materials

[0024] Sodium hyaluronate (Mw 0.83×10 4 Da, Bloomage Freda Biomedical Co., Ltd.), potassium hyaluronate (Mw 0.83×10 4 Da, Bloomage Freda Biopharmaceutical Co., Ltd.), calcium hyaluronate (Mw 0.83×10 4 Da, Bloomage Freda Bio-Pharmaceutical Co., Ltd.), acetylated hyaluronic acid (Bloomage Freda Bio-Pharmaceutical Co., Ltd.), alkylated hyaluronic acid (Bloomage Freda Bio-Pharmaceutical Co., Ltd.), cross-linked Hyaluronic acid (Bloomage Freda Bio-Pharmaceutical Co., Ltd.), ectoine (sigma), hydroxyl ectoine (sigma), sodium dodecylsulfonate (Sinopharm Group).

[0025] 2. Experimental method

[0026] 2.1 Solution preparation

[0027] 5% SDS solution: prepare 5% SDS solution...

Embodiment 2

[0046] Moisturizing effect of embodiment 2 composition

[0047] Moisturizing effect Use a skin moisture meter to measure the moisture content of the skin before and after applying the sample to investigate its short-term moisturizing effect, and investigate whether it has a synergistic effect with HA.

[0048] 1. Experimental materials

[0049] Sodium hyaluronate (Mw 0.83×10 4 Da, Bloomage Freda Biomedical Co., Ltd.), potassium hyaluronate (Mw 0.83×10 4 Da, Bloomage Freda Biopharmaceutical Co., Ltd.), calcium hyaluronate (Mw 0.83×10 4 Da, Bloomage Freda Bio-Pharmaceutical Co., Ltd.), acetylated hyaluronic acid (Bloomage Freda Bio-Pharmaceutical Co., Ltd.), alkylated hyaluronic acid (Bloomage Freda Bio-Pharmaceutical Co., Ltd.), cross-linked Hyaluronic acid (Bloomage Freda Bio-Pharmaceutical Co., Ltd.), ectoine (sigma), hydroxyl ectoine (sigma), basic moisturizing lotion (Bloomage Freda Bio-Pharmaceutical Co., Ltd.).

[0050] 2. Instruments and equipment

[0051] Skin M...

Embodiment 3

[0066] Example 3 Effect of composition on melanin production

[0067] 1. Experimental materials

[0068] Sodium hyaluronate (Mw 0.83×10 4 Da, Bloomage Freda Biomedical Co., Ltd.), potassium hyaluronate (Mw 0.83×10 4 Da, Bloomage Freda Biopharmaceutical Co., Ltd.), calcium hyaluronate (Mw 0.83×10 4 Da, Bloomage Freda Bio-Pharmaceutical Co., Ltd.), acetylated hyaluronic acid (Bloomage Freda Bio-Pharmaceutical Co., Ltd.), alkylated hyaluronic acid (Bloomage Freda Bio-Pharmaceutical Co., Ltd.), cross-linked Hyaluronic acid (Bloomage Freda Biomedicine Co., Ltd.), ectoine (sigma), hydroxyectoine (sigma), B16 mouse melanoma cell line, 1640 medium (Gibco), fetal bovine serum (Gibco ), NaOH (Sinopharm Group).

[0069] 2. Instruments and equipment

[0070] Inverted microscope (OLYMPUS, CKX41), ultra-clean bench (Beijing Donglian Haer Instrument Manufacturing Co., Ltd., SCB-1520), carbon dioxide incubator (SANYO), digital constant temperature water bath (Jintan Zhongda Instrument...

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Abstract

The invention provides a composition containing hyaluronic acid substances and ectoine substances. The composition comprises the two substances according to a mass ratio of 50:1 to 1:50, and the masspercentage of the composition is 0.001% to 100%. The hyaluronic acid salt includes but not limited to sodium salt, potassium salt, calcium salt, zinc slat or magnesium salt, and the molecular weight is smaller than 106Da; the ectoine substance is ectoine or salt or / and ester acceptable in cosmetic or medicine field, hydroxyl ectoine or salt or / and ester acceptable in cosmetic or medicine field, and the combination thereof. The composition can be used as whitening, anti-inflammatory, moisturizing, and after-sun injured skin repair components in cosmetics or medicines. The composition can reachsynergistic function in moisturizing, whitening, inflammation diminishing, sun screening, and after-sun injured skin repair.

Description

technical field [0001] The present invention relates to the fields of cosmetics and medicine, in particular to a composition of hyaluronic acid substances and ectoine substances with the functions of moisturizing, whitening, anti-inflammation, sun protection and after-sun repairing, and its application in cosmetics and skin diseases application in pharmaceuticals. Background technique [0002] Skin is the largest organ in the human body, composed of epidermis, dermis and subcutaneous tissue, and contains appendages. As the body's first barrier to the external environment, the skin is constantly affected by various microbial, chemical and physical factors. Photoaging caused by light, environmental pollution in modern society, and radiation from electronic products have caused more and more people to suffer from pigmentation disorders. Whitening, sun protection, and post-sun repair have become one of the research hotspots. Inflammatory skin Diseases, especially chronic infla...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/73A61K8/49A61Q19/02A61Q19/00A61Q17/04A61K31/728A61K31/505A61P17/00A61P17/16
CPCA61K8/4953A61K8/735A61K31/505A61K31/728A61K2800/10A61Q17/04A61Q19/00A61Q19/004A61Q19/02A61P17/00A61P17/16A61P29/00A61K2300/00
Inventor 董艳美石艳丽王冠凤钱晓路陈晨张晓鸥栾贻宏郭学平
Owner BLOOMAGE BIOTECHNOLOGY CORP LTD
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