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Immunogene adherence and method of making and using the same

A technology of immunogens and inhibitors, applied in fermentation, antibodies, etc., can solve problems such as reduced feed intake

Active Publication Date: 2006-08-16
彼得·纳什 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Furthermore, since monensin cannot be incorporated into syrup-based additions to conventional additives in cattle feed, feed intake is initially reduced

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0038] Example 1: Selection of Laying Poultry Hens

[0039]Breeds of laying hens vary with needs and uses. Any laying bird hen can be vaccinated, including chicks, turkeys, ducks, geese, pigeons, quail, ostriches, emus or any other bird. Common breeds of laying hens are preferred, and are usually chosen based on the number of eggs laid per year, egg size and housing comfort. Lowe Island Reds, White Leghorns, and RedSex Linked hybrids were the animals selected based on egg size (Large to Extra Large, 50-65gm) and used in the immunization protocol. Ease of handling the animals and egg size and consistency were observed, as well as, the number of eggs laid per hen per year. Although any poultry layer hen can be used, these chickens have proven to be the best considering cost and ease of use. The White Leghorn, W98 hybrid had the best consistency and produced a greater number of eggs per animal. These animals produce large to jumbo grade eggs (50-65gm) and...

example 2

[0040] Example 2: Preparation of PM antigens for use in immunogens

[0041] Pasteurella Multicoda (ATCC 15743) was used as a model bacterium. The microorganisms were isolated from cattle. The ATCC method used to rehydrate the stock is as follows. Bacteria were rehydrated in 1.0 ml of TSB. Brain Heart Infusion (BHI, Acumedia) was used to stimulate PM antigens on bacteria. The stock TSB was inoculated into BHI broth and incubated at 37°C for 18-24 hours. This stimulates the development of somatic and attached antigens on the bacteria. Inoculate the flask containing the BHI broth with the BHI broth broth. While stirring slowly, the flask was incubated at 37°C. Blood agar plates were streaked to isolate colonies for morphology determination. Good growth was seen after 22 hours. The flasks were combined and the resulting material was harvested using centrifugation and sterile saline (0.9%) at approximately 3000 rpm for 30 minutes. Harvest products were col...

example 3

[0042] Example 3: Preparation of PH antigens for use in immunogens

[0043] Stock P. Haemolytica (ATCC 14000) was used as stock for PH antigen. Microorganisms isolated from cattle. Follow ATCC method for rehydration stock. Bacteria were rehydrated in 1.0 ml of TSB. Brain heart infusion (BHI, Acumedia) was used to stimulate PM antigens on bacteria. Inoculate stock TSB in BHI broth and incubate at 37°C for 18-24 hours. This stimulates the development of somatic and attached antigens on the bacteria. Inoculate the flask containing the BHI broth with the BHI broth broth. While stirring slowly, the flask was incubated at 37°C. Good growth was seen after 22 hours. Colonies were isolated by streaking blood agar plates to determine morphology. Flasks were combined and material was harvested using centrifugation and sterile saline (0.9%) at approximately 3000 rpm for 30 minutes. Harvest products were collected in test tubes. Density was checked using spectr...

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PUM

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Abstract

The present invention discloses microbial adhesion inhibitors in the form of egg antibodies, and methods for their preparation and use. The inhibitors act by substantially preventing the adherence or attachment of the colony forming immunogen in the airways of host animals and humans. The suppressor is produced by inoculating female birds with the immunogen, harvesting the eggs containing antibodies against the immunogen, and separating the yolk and white from the eggshell. The yolk and egg white contents are administered to animals or humans by directly dispensing or entraining the contents in the air.

Description

technical field [0001] The present invention relates to microbial adhesion inhibitors in the form of avian egg antibodies, which are useful for substantially preventing the adhesion or attachment of immunogens causing colony-forming diseases in respiratory disease syndromes by inhibiting the adhesion of immunogens to the mucous membranes of animals Including host food animals, high value non-food animals, zoological animals, companion animals, laboratory animals or humans; and methods of making said adhesion inhibitors, and methods of using said inhibitors. Background technique [0002] A population of microorganisms forms very complex interactions within the airways of animals. The animals may be dairy cows, feeder cattle, pigs, poultry such as chickens and turkeys, and the like. Although the microbial communities vary between different animal groups, they are basically bacteria such as Pasteurellae, Mannhiemae and Haemophilus species, Mycoplasma bacteria, And respiratory...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/40A61K39/42A61K39/395C12P21/08
Inventor 彼得·纳什布拉德利·M·米特勒斯
Owner 彼得·纳什
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