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Fat emulsion injection liquid containing soybean oil, medium chain triglyceride, olive oil and fish oil and method for preparing the same

A medium-chain triglyceride and olive oil technology, which is applied in the field of fat emulsion, can solve the problems of affecting the body's immune system and adverse effects of inflammatory reactions, and achieve the effects of maintaining vitamin E levels, preventing antioxidant depletion, and ensuring stability

Inactive Publication Date: 2007-05-23
费森尤斯卡比华瑞制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these fat emulsion injections can better meet the clinical needs of general patients, due to the relatively high content of omega-6 polyunsaturated fatty acids in these products, especially linoleic acid, clinical research suspects that long-term application may affect the body's immune system , especially have adverse effects on the body's inflammatory response

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] 60 grams of soybean oil, 60 grams of medium chain triglycerides, 50 grams of olive oil, 30 grams of fish oil, 135 mg of dl-α-tocopherol, 12 grams of refined lecithin, 22.5 grams of anhydrous glycerin, 300 mg of sodium oleate, hydrogen Sodium oxide 20 mg, appropriate amount of water for injection, to a total volume of 1 liter. This formula is a standard formula.

[0071] Add 60 grams of soybean oil, 60 grams of medium-chain triglycerides, 50 grams of olive oil, 30 grams of fish oil, and 135 mg of dl-α-tocopherol into a container, stir and heat to about 70°C under nitrogen filling. This is the oil phase.

[0072] Add about 600 grams of water for injection into another container, stir and heat to about 70°C under nitrogen gas, add 12 grams of egg yolk lecithin, 25 grams of anhydrous glycerin, and 300 mg of sodium oleate in sequence, and stir until it is completely dispersed. This is water box.

[0073] Slowly add the oil phase to the vigorously stirred water phase, and ...

Embodiment 2

[0081] 48 grams of soybean oil, 48 grams of medium chain triglycerides, 40 grams of olive oil, 24 grams of fish oil, 108 mg of dl-α-tocopherol, 9.6 grams of egg yolk lecithin, 25 grams of anhydrous glycerin, 240 mg of sodium oleate, hydrogen About 18 mg of sodium oxide, appropriate amount of water for injection, to a total volume of 1 liter.

[0082] Add 48 grams of soybean oil, 48 grams of medium-chain triglycerides, 40 grams of olive oil, 24 grams of fish oil, and 108 mg of dl-α-tocopherol into a container, stir and heat to about 70°C under nitrogen, which is oily phase.

[0083] Add about 600 grams of water for injection into another container, stir and heat to about 70°C under nitrogen gas, add 9.6 grams of egg yolk lecithin, 22.5 grams of anhydrous glycerin, and 240 mg of sodium oleate in sequence, and stir until it is completely dispersed. This is water box.

[0084] Slowly add the oil phase to the vigorously stirred water phase, and continue vigorously stirring for 10...

Embodiment 3

[0093] 72 grams of soybean oil, 72 grams of medium chain triglycerides, 60 grams of olive oil, 36 grams of fish oil, 162 mg of dl-α-tocopherol, 9.6 grams of egg yolk lecithin, 25 grams of anhydrous glycerin, 240 mg of sodium oleate, hydrogen Sodium oxide 22 mg, appropriate amount of water for injection, to a total volume of 1 liter.

[0094] Add 72 grams of soybean oil, 72 grams of medium-chain triglycerides, 60 grams of olive oil, 36 grams of fish oil, and 162 mg of dl-α-tocopherol into a container, stir and heat to about 70°C under nitrogen filling. This is the oil phase.

[0095] Add about 600 grams of water for injection into another container, stir and heat to about 70°C under nitrogen gas, add 9.6 grams of egg yolk lecithin, 25 grams of anhydrous glycerin, and 240 mg of sodium oleate in sequence, and stir until it is completely dispersed. This is water box.

[0096] Slowly add the oil phase to the vigorously stirred water phase, and continue vigorously stirring for 10 ...

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Abstract

The invention relates to an intralipid injection which contains soya oil, middle chain triglyceride, olive oil, and fish oil, wherein it comprises 48-72g.L soya oil, 48-72g / L middle chain triglyceride, 40-60g / L olive oil, and 24-36g / L fish oil, 108-162 mg / L dl-alpha-tocofecol, 9.6-14.4g / L lipovitellin, 22.5-27.5g / L pure glycerin, 240-360mg / L sodium oleate, 18-22mg / L caustic soda, and 1L injection water. The ratio between w-6 and w-3 aliphatic acid is 3.0-2.2:1. The invention optimizes and balances the aliphatic acid mode.

Description

technical field [0001] The present invention belongs to a kind of fat emulsion containing soybean oil, medium-chain triglyceride, olive oil and fish oil and its preparation method. The number of carbon atoms is 6-24). Background technique [0002] Fat emulsions are ideal for intravenous administration to provide energy and essential fatty acids. Its osmotic pressure is similar to that of blood, has no stimulation to the vein wall, can be infused through peripheral veins, has the advantages of high calorie, does not require insulin to participate in metabolism, and has no hyperosmolar diuresis. In clinical parenteral nutrition, it can be used together with glucose infusion to provide patients with double energy supply and prevent a series of complications caused by glucose alone. At present, there are two types of fat emulsion injection widely used clinically, which are soybean oil and medium-chain triglyceride (C 6 -C 8 ) as raw material to provide triglycerides prepared...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K36/63A61P3/02A61K35/60A61K31/232
Inventor (要求不公开姓名)
Owner 费森尤斯卡比华瑞制药有限公司
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