Disposable tooth desensitization cotton swab as well as preparation method and application thereof

Abstract

The invention relates to the field of oral care, in particular to a disposable tooth desensitization cotton swab and a preparation method and application thereof.The disposable tooth desensitization cotton swab comprises a hollow plastic cotton swab body, the cotton swab body is provided with two ends, each end is provided with an adsorption head, and one end is provided with a pre-breaking connecting point; the desensitization composition is stored in the hollow plastic cotton swab body, the desensitization composition comprises the following components: 3%-5% of strontium acetate, 0.1%-0.5% of zinc salicylate, 1%-3% of aminomethyl propanol, 5%-15% of glycerol, 1%-10% of butanediol, 0.1%-0.5% of a stabilizer, 0.05%-0.1% of a food-grade flavoring agent and the balance of purified water, and the desensitization composition is stored in the hollow plastic cotton swab body and is prepared by adopting a high-concentration strontium acetate and zinc salicylate composite formula through a dual-action mechanism. The tooth sensitivity symptom can be obviously relieved within 1-3 minutes after the toothpaste is used, and compared with the traditional desensitization toothpaste which needs to be continuously used for several weeks, the user experience is greatly improved.

Description

Technical Field

[0001] This invention relates to the field of oral care, and in particular to a disposable spot-applied tooth desensitizing product suitable for home use. Specifically, it is a product that uses a hollow cotton swab structure to directly apply desensitizing liquid to the surface of sensitive teeth, its preparation method, and its application. Background Technology

[0002] Dentin hypersensitivity is a common dental problem. Clinical statistics show that approximately 15% to 57% of adults experience dentin hypersensitivity symptoms to varying degrees. Dentin hypersensitivity typically manifests as brief but intense pain in response to stimuli such as hot, cold, sweet, or sour foods. Although this pain is short-lived, it significantly impacts the patient's quality of life.

[0003] Currently, desensitization products on the market mainly fall into the following categories:

[0004] 1. Desensitizing toothpaste: Such as professional desensitizing toothpaste containing ingredients like potassium nitrate and fluoride, such as Colgate's Sensitive Pro-Relief series. However, these products are slow to take effect, usually requiring 2-4 weeks of continuous use to achieve noticeable results, and the concentration of active ingredients is limited, making it difficult to provide immediate relief for severe allergies.

[0005] 2. Professional desensitizing coating: For example, CN109528498B discloses a tooth desensitizing agent for deeply sealing dentinal tubules and preventing biofilm formation. This technology uses polyethylene glycol-modified proteins (lysozyme, bovine serum albumin, insulin, α-lactalbumin), tris(2-carboxyethyl)phosphine hydrochloride, calcium chloride, pH adjuster and other components to prepare the desensitizing coating. It requires professional operation, is not suitable for home use, and is relatively expensive.

[0006] 3. Desensitizing mouthwash: such as the fluoride-free desensitizing mouthwash disclosed in US5087444A, although convenient to use, has limited therapeutic effect on specific sensitive areas because the active ingredients are diluted and dispersed throughout the oral cavity, and may cause temporary changes in taste.

[0007] The aforementioned existing technologies generally suffer from problems such as slow onset of action, poor compliance, and difficulty in targeted treatment. In particular, existing technologies struggle to provide satisfactory solutions for acute dentin hypersensitivity symptoms requiring immediate relief. Therefore, developing a portable, immediate-acting, disposable, precise desensitization product suitable for home use is of significant value. Summary of the Invention

[0008] In view of the shortcomings of the existing technology, the purpose of this invention is to provide a portable disposable dental desensitizing swab with rapid desensitization effect, its preparation method and application, which is particularly suitable for precise care of single or locally sensitive teeth at home, and solves the technical problems of existing desensitizing products such as slow onset of action and inconvenience of targeted treatment.

[0009] To achieve the above objectives, the present invention provides disposable dental desensitizing swabs, comprising:

[0010] The hollow plastic cotton swab body has two ends, each end of which is provided with an adsorption head, one end of which is provided with a pre-break connection point; and a desensitizing composition stored inside the hollow plastic cotton swab body, the desensitizing composition comprising the following components: 3%–5% strontium acetate, 0.1%–0.5% zinc salicylate, 1%–3% aminomethylpropanol, 5%–15% glycerin, 1%–10% butylene glycol, 0.1%–0.5% stabilizer, 0.05%–0.1% food-grade flavoring agent, and purified water to 100%.

[0011] Preferably, the stabilizer is selected from EDTA or sodium citrate.

[0012] Preferably, the hollow plastic cotton swab body is made of medical-grade plastic, and the two adsorption heads are made of non-woven fiber material, having a porous structure capable of adsorbing and releasing liquid.

[0013] Preferably, the pre-break connection point is designed as a safe break point structure that can break under force but will not form a sharp cross-section.

[0014] Preferably, the pH value of the desensitizing composition is 6.5-8.5.

[0015] The present invention also provides a method for preparing the above-mentioned disposable dental desensitizing swabs, comprising the following steps:

[0016] a) Preparation of the desensitizing composition: Heat purified water to 35-45℃, add aminomethylpropanol, stabilizer and strontium acetate in sequence, and stir thoroughly to dissolve; then add zinc salicylate and continue stirring until completely dissolved; then add glycerin, butylene glycol and food-grade flavoring in sequence, and finally adjust the pH value to 6.5-8.5 to obtain the desensitizing composition;

[0017] b) Prepare the hollow cotton swab body: Inject medical-grade plastic material into a hollow tube with openings at both ends, and set a pre-break connection point at one end;

[0018] c) Install adsorption heads: Install cotton adsorption heads with good adsorption performance at both ends of the hollow pipe;

[0019] d) Filling the desensitizing composition: Fill the hollow cotton swab body completed in step c) with the desensitizing composition prepared in step a);

[0020] e) Sealed packaging: The filled disposable dental desensitizing swabs are individually sealed and packaged to complete the preparation.

[0021] Preferably, in step a), the stabilizer is selected from EDTA or sodium citrate, and step a) is carried out in a clean environment with the temperature controlled at 20-25°C and the humidity controlled at 45%-55%.

[0022] Preferably, in step d), the filling is performed using a precision injection device to ensure that the volume error of the desensitizing composition filled in each swab does not exceed ±5%.

[0023] Preferably, in step e), the sealed packaging uses sterile aluminum foil composite material, each package contains a desiccant, and an aging test is performed after the packaging is sealed to ensure that the product shelf life is not less than 24 months.

[0024] This invention also provides the application of the above-mentioned disposable tooth desensitizing cotton swabs in the preparation of home-use dentin hypersensitivity relief products. The feature is that, when in use, the pre-broken connection point is broken, allowing the desensitizing composition to flow to the other end of the adsorption head. Then, the adsorption head, which is soaked in the desensitizing composition, is directly applied to the surface of the sensitive teeth, forming a physical barrier on the tooth surface and regulating nerve sensitivity, thereby relieving dentin hypersensitivity symptoms caused by stimuli such as cold, heat, sourness, and sweetness.

[0025] Compared with the prior art, the present invention has the following beneficial effects:

[0026] 1. Rapid relief effect: The disposable tooth desensitizing swabs of this invention use a high-concentration strontium acetate and zinc salicylate compound formula. Through a dual action mechanism, it can significantly relieve tooth sensitivity symptoms within 1 to 3 minutes after use. Compared with traditional desensitizing toothpaste, which requires several weeks of continuous use to see results, it greatly improves the user experience.

[0027] 2. Precise targeted treatment: The spot application design allows the desensitizing composition to act directly on the sensitive area, avoiding the waste and unnecessary systemic exposure caused by using it throughout the oral cavity, while increasing the local drug concentration and enhancing the desensitization effect.

[0028] 3. Convenient and safe to use: The pre-break design of the hollow cotton swabs makes it easy for ordinary users to use without professional operation, which greatly reduces the usage threshold compared with professional coating products; the disposable design avoids the risk of cross-infection and improves the safety of use.

[0029] 4. Innovative structural design: The hollow cotton swab liquid storage structure ensures the stability of the active ingredients before use, resulting in a longer shelf life compared to open-package products; the double-ended cotton tip design optimizes liquid conduction and application effect.

[0030] 5. Synergistic effect of the formulation: The combined application of strontium acetate and zinc salicylate achieves a dual desensitization mechanism of physically sealing dentinal tubules and regulating nerve sensitivity; the weakly alkaline environment regulated by aminomethylpropanol further improves the sealing efficiency of active ingredients; the dual moisturizing system of glycerin and butylene glycol optimizes the residence time and bioavailability of the solution on the tooth surface. Attached Figure Description

[0031] Figure 1 This is a schematic diagram of the structure of the disposable dental desensitizing cotton swab of the present invention.

[0032] like Figure 1 As shown, both ends of the cotton swab are equipped with an adsorption head, and one end has a pre-broken end. After breaking, the desensitizing solution inside seeps out to the other cotton head for spot application. Detailed Implementation

[0033] The present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments. Those skilled in the art should understand that these embodiments are for illustrative purposes only and are not intended to limit the scope of the invention.

[0034] Reference Figure 1 The disposable dental desensitizing swab of the present invention includes a hollow swab body 10, with adsorption heads (not labeled in the figure) at both ends of the hollow swab body 10, one end of which has a pre-break connection point 16. The hollow swab body 10 stores a desensitizing composition. In use, the user breaks the pre-break connection point 16, allowing the stored desensitizing composition to flow to the adsorption head at the other end. The adsorption head, then soaked in the desensitizing composition, is then directly applied to the surface of the sensitive teeth for precise desensitization.

[0035] The working principle of the disposable dental desensitizing swabs described in this invention is as follows: Upon use, the pre-broken connection point is broken, and the desensitizing composition stored inside flows to the cotton tip at the other end through capillary action and gravity. The cotton tip, then soaked in the desensitizing composition, is directly applied to the surface of the sensitive tooth. The strontium acetate in the desensitizing composition binds to phosphate ions on the dentin surface, forming strontium phosphate precipitates, physically sealing exposed dentinal tubules. Simultaneously, the salicylic acid component in zinc salicylate has a local anesthetic effect, temporarily reducing the excitability of nerve endings, while zinc ions reduce nerve sensitivity by inhibiting neuronal calcium channels or regulating TRPV1 receptors. This dual mechanism of action achieves rapid relief and long-term protection against dentin hypersensitivity.

[0036] The desensitizing composition of the disposable dental desensitizing swabs of the present invention comprises the following components: 3% to 5% strontium acetate, 0.1% to 0.5% zinc salicylate, 1% to 3% aminomethylpropanol, 5% to 15% glycerin, 1% to 10% butylene glycol, 0.1% to 0.5% stabilizer, an appropriate amount of food-grade flavoring agent, and purified water to 100%.

[0037] In the desensitizing composition of the present invention, the functions and effects of each component are as follows:

[0038] Strontium acetate is the main active ingredient. The strontium ions in it can deposit in exposed dentinal tubules, replacing calcium ions in the dentin to form insoluble strontium salt precipitates. This physically seals the dentinal tubules, blocking the transmission of external temperature, mechanical, and chemical stimuli to the dental pulp nerve endings. This invention selects a concentration range of 3% to 5%, which is the experimentally proven optimal balance between efficacy and safety. When the concentration is below 3%, the tubule-sealing effect is not significant; while when the concentration is above 5%, it may cause local irritation and will not further improve the desensitization effect.

[0039] Zinc salicylate is the co-active ingredient. Zinc ions have synergistic antibacterial, anti-inflammatory, and desensitizing effects, while salicylic acid has a mild local anesthetic effect, providing rapid pain relief. The combination of these two ingredients produces a synergistic chemical effect, achieving both immediate relief and long-lasting protection. The concentration of 0.1%–0.5% is chosen based on considerations of the safety and efficacy of topical oral medication. Below 0.1%, the local anesthetic effect is not significant; above 0.5%, temporary taste alterations may occur.

[0040] Aminomethylpropanol acts as a pH adjuster, maintaining the solution in a slightly alkaline environment (pH 6.5-8.5), which helps strontium and zinc ions form stable precipitates, more effectively sealing dentinal tubules. Simultaneously, the slightly alkaline environment buffers the irritation of acidic substances in the oral cavity to sensitive teeth. A concentration range of 1%–3% ensures sufficient buffering capacity while avoiding the potential irritation from excessively high concentrations.

[0041] Glycerin and butylene glycol form a dual moisturizing agent system, complementing each other synergistically. A ratio of 5%–15% glycerin to 1%–10% butylene glycol increases solution viscosity, prolongs residence time on the tooth surface, delays the release of active ingredients, and extends the duration of action. Glycerin is highly hydrophilic, while butylene glycol has good permeability; together, they enhance the bioavailability of the active ingredients.

[0042] Stabilizers (EDTA or sodium citrate) act as metal ion chelators, preventing premature reaction or oxidation of metal ions such as strontium and zinc in the solution, ensuring the chemical stability of the product during storage, and extending its shelf life. An addition of 0.1% to 0.5% is sufficient to maintain product stability while avoiding excessive addition that could interfere with the activity of the active ingredients.

[0043] Food-grade flavorings improve taste and user experience, increase product acceptance, and mask the characteristic odor of any metal ions that may be present.

[0044] The present invention will be described in detail below through specific embodiments, but the scope of protection of the present invention is not limited thereto.

[0045] Example 1

[0046] Disposable dental desensitizing swabs contain the following components:

[0047] Strontium acetate 3%, zinc salicylate 0.1%, aminomethylpropanol 1%, glycerol 5%, butylene glycol 1%, EDTA 0.1%, food-grade mint flavoring 0.05%, purified water 89.75%.

[0048] The preparation method includes the following steps:

[0049] (1) Preparation of desensitizing composition: In a clean environment (temperature 23℃, humidity 50%), heat 89.75g of purified water to 40℃, add 1g of aminomethylpropanol, 0.1g of EDTA and 3g of strontium acetate in sequence, and stir with a magnetic stirrer at 400rpm for 20 minutes until completely dissolved; then add 0.1g of zinc salicylate and continue stirring for 15 minutes until completely dissolved; then add 5g of glycerin, 1g of butylene glycol and 0.05g of peppermint flavoring in sequence, and stir for 10 minutes to mix evenly; finally, adjust the pH value to 7.0 with sodium hydroxide solution to obtain the desensitizing composition;

[0050] (2) Prepare the hollow cotton swab body: medical grade polypropylene plastic is used to make a hollow tube with openings at both ends through injection molding process. The length is 100mm and the inner diameter is 2mm. A ring-shaped pre-break connection point is set 10mm away from one end. The thickness of the pre-break connection point is 0.3mm.

[0051] (3) Install the adsorption head: Install the adsorption head made of polyester fiber at both ends of the hollow pipe. The adsorption head has a diameter of 5mm and is fixed to both ends of the pipe by hot pressing.

[0052] (4) Filling the desensitizing composition: Using a precision injection device, fill 0.2 ml of the desensitizing composition prepared in step (1) into the hollow cotton swab body completed in step (3), with the filling accuracy controlled within ±3%;

[0053] (5) Sealed packaging: Each filled disposable dental desensitizing swab is placed in a sealed bag made of aluminum foil composite material. 0.5g of silica gel desiccant is placed in each sealed bag. The bags are sealed under sterile conditions and subjected to an accelerated aging test at 60℃ for 30 days to determine the product shelf life as 30 months.

[0054] Example 2

[0055] Disposable dental desensitizing swabs contain the following components:

[0056] Strontium acetate 5%, zinc salicylate 0.5%, aminomethylpropanol 3%, glycerin 15%, butylene glycol 10%, sodium citrate 0.5%, food-grade mint flavoring 0.1%, purified water 65.9%.

[0057] The preparation method includes the following steps:

[0058] (1) Preparation of desensitizing composition: In a clean environment (temperature 20℃, humidity 45%), heat 65.9g of purified water to 35℃, add 3g of aminomethylpropanol, 0.5g of sodium citrate and 5g of strontium acetate in sequence, and stir with a magnetic stirrer at 500rpm for 25 minutes until completely dissolved; then add 0.5g of zinc salicylate and continue stirring for 20 minutes until completely dissolved; then add 15g of glycerin, 10g of butylene glycol and 0.1g of peppermint flavoring in sequence, and stir for 15 minutes to mix evenly; finally, adjust the pH value to 8.5 with sodium hydroxide solution to obtain the desensitizing composition;

[0059] (2) Prepare the hollow cotton swab body: medical grade polyethylene plastic is used to make a hollow tube with openings at both ends through injection molding process. The length is 120mm and the inner diameter is 3mm. A ring-shaped pre-break connection point is set 15mm away from one end. The thickness of the pre-break connection point is 0.25mm.

[0060] (3) Install the adsorption head: Install adsorption heads made of cotton fiber at both ends of the hollow pipe. The adsorption head diameter is 7mm. Fix it to both ends of the pipe by hot pressing process.

[0061] (4) Filling the desensitizing composition: Using a precision injection device, fill 0.3 ml of the desensitizing composition prepared in step (1) into the hollow cotton swab body completed in step (3), with the filling accuracy controlled within ±2%;

[0062] (5) Sealed packaging: Each filled disposable dental desensitizing swab is placed in a sealed bag made of aluminum foil composite material. 1g of silica gel desiccant is placed in each sealed bag. The bags are sealed under sterile conditions and subjected to an accelerated aging test at 70℃ for 45 days to determine the product shelf life as 36 months.

[0063] Example 3

[0064] Disposable dental desensitizing swabs contain the following components:

[0065] Strontium acetate 4%, zinc salicylate 0.3%, aminomethylpropanol 2%, glycerol 10%, butanediol 5%, EDTA 0.3%, food-grade citrus flavoring 0.08%, purified water 78.32%.

[0066] The preparation method includes the following steps:

[0067] (1) Preparation of desensitizing composition: In a clean environment (temperature 25℃, humidity 55%), heat 78.32g of purified water to 38℃, add 2g of aminomethylpropanol, 0.3g of EDTA and 4g of strontium acetate in sequence, and stir with a magnetic stirrer at 450rpm for 22 minutes until completely dissolved; then add 0.3g of zinc salicylate and continue stirring for 18 minutes until completely dissolved; then add 10g of glycerol, 5g of butylene glycol and 0.08g of citrus flavoring agent in sequence, and stir for 12 minutes to mix evenly; finally, adjust the pH value to 7.5 with sodium hydroxide solution to obtain the desensitizing composition;

[0068] (2) Prepare the hollow cotton swab body: medical grade polypropylene plastic is used to make a hollow tube with openings at both ends through injection molding process. The length is 110mm and the inner diameter is 2.5mm. An annular pre-break connection point is set 12mm away from one end. The thickness of the pre-break connection point is 0.28mm.

[0069] (3) Install the adsorption head: Install adsorption heads made of composite fiber (70% cotton + 30% polyester) at both ends of the hollow pipe. The diameter of the adsorption head is 6mm. The adsorption head is fixed to both ends of the pipe by hot pressing process.

[0070] (4) Filling the desensitizing composition: Using a precision injection device, fill 0.25 ml of the desensitizing composition prepared in step (1) into the hollow cotton swab body completed in step (3), with the filling accuracy controlled within ±2.5%;

[0071] (5) Sealed packaging: Each filled disposable dental desensitizing swab is placed in a sealed bag made of aluminum foil composite material. 0.8g of silica gel desiccant is placed in each sealed bag. The bags are sealed under sterile conditions and subjected to an accelerated aging test at 65°C for 40 days. The shelf life of the product is determined to be 33 months.

[0072] Example 4

[0073] Disposable dental desensitizing swabs contain the following components:

[0074] Strontium acetate 3.5%, zinc salicylate 0.2%, aminomethylpropanol 1.5%, glycerol 8%, butanediol 3%, sodium citrate 0.2%, food-grade mint flavoring 0.06%, purified water 83.54%.

[0075] The preparation method includes the following steps:

[0076] (1) Preparation of desensitizing composition: In a clean environment (temperature 22℃, humidity 48%), 83.54g of purified water was heated to 42℃, and 1.5g of aminomethylpropanol, 0.2g of sodium citrate and 3.5g of strontium acetate were added in sequence. The mixture was stirred at 420rpm for 21 minutes with a magnetic stirrer until completely dissolved. Then 0.2g of zinc salicylate was added and stirred for 16 minutes until completely dissolved. Then 8g of glycerin, 3g of butylene glycol and 0.06g of peppermint flavoring were added in sequence and stirred for 11 minutes to mix evenly. Finally, the pH value was adjusted to 7.2 with sodium hydroxide solution to obtain the desensitizing composition.

[0077] (2) Prepare the hollow cotton swab body: medical grade polypropylene plastic is used to make a hollow tube with openings at both ends through injection molding process. The length is 105mm and the inner diameter is 2.2mm. An annular pre-break connection point is set 11mm away from one end. The thickness of the pre-break connection point is 0.26mm.

[0078] (3) Install the adsorption head: Install adsorption heads made of non-woven fabric fibers at both ends of the hollow pipe. The adsorption head diameter is 5.5mm. Fix it to both ends of the pipe by hot pressing process.

[0079] (4) Filling the desensitizing composition: Using a precision injection device, fill 0.22 ml of the desensitizing composition prepared in step (1) into the hollow cotton swab body completed in step (3), with the filling accuracy controlled within ±3%;

[0080] (5) Sealed packaging: Each disposable dental desensitizing swab after filling is placed in a sealed bag made of aluminum foil composite material. 0.7g of silica gel desiccant is placed in each sealed bag. The bags are sealed under sterile conditions and subjected to an accelerated aging test at 65°C for 35 days to determine the product shelf life as 32 months.

[0081] Example 5

[0082] Disposable dental desensitizing swabs contain the following components:

[0083] Strontium acetate 4.5%, zinc salicylate 0.4%, aminomethylpropanol 2.5%, glycerol 12%, butylene glycol 8%, EDTA 0.4%, food-grade mint flavoring 0.09%, purified water 72.11%.

[0084] The preparation method includes the following steps:

[0085] (1) Preparation of desensitizing composition: In a clean environment (temperature 21℃, humidity 52%), 72.11g of purified water was heated to 37℃, and 2.5g of aminomethylpropanol, 0.4g of EDTA and 4.5g of strontium acetate were added in sequence. The mixture was stirred at 480rpm for 24 minutes with a magnetic stirrer until completely dissolved. Then 0.4g of zinc salicylate was added and stirred for 19 minutes until completely dissolved. Then 12g of glycerol, 8g of butanediol and 0.09g of peppermint flavoring were added in sequence and stirred for 14 minutes to mix evenly. Finally, the pH value was adjusted to 8.0 with sodium hydroxide solution to obtain the desensitizing composition.

[0086] (2) Prepare the hollow cotton swab body: medical grade polyethylene plastic is used to make a hollow tube with openings at both ends through injection molding process. The length is 115mm and the inner diameter is 2.8mm. A ring-shaped pre-break connection point is set at 14mm from one end. The thickness of the pre-break connection point is 0.27mm.

[0087] (3) Install the adsorption head: Install adsorption heads made of composite fiber (60% cotton + 40% viscose fiber) at both ends of the hollow pipe. The diameter of the adsorption head is 6.5mm. The adsorption head is fixed to both ends of the pipe by hot pressing process.

[0088] (4) Filling the desensitizing composition: Using a precision injection device, fill 0.28 ml of the desensitizing composition prepared in step (1) into the hollow cotton swab body completed in step (3), with the filling accuracy controlled within ±2%;

[0089] (5) Sealed packaging: Each filled disposable dental desensitizing swab is placed in a sealed bag made of aluminum foil composite material. 0.9g of silica gel desiccant is placed in each sealed bag. The bags are sealed under sterile conditions and subjected to an accelerated aging test at 68°C for 42 days. The shelf life of the product is determined to be 34 months.

[0090] To verify the technical effects of the present invention, the following comparative examples were designed:

[0091] Comparative Example 1 (without zinc salicylate)

[0092] Disposable dental desensitizing swabs contain the following components:

[0093] Strontium acetate 4%, aminomethylpropanol 2%, glycerol 10%, butanediol 5%, EDTA 0.3%, food-grade citrus flavoring 0.08%, purified water 78.62%.

[0094] The same preparation method as in Example 3 was used, but without the addition of zinc salicylate.

[0095] Comparative Example 2 (without strontium acetate)

[0096] Disposable dental desensitizing swabs contain the following components:

[0097] Zinc salicylate 0.3%, aminomethylpropanol 2%, glycerin 10%, butylene glycol 5%, EDTA 0.3%, food-grade citrus flavoring 0.08%, purified water 82.32%.

[0098] The same preparation method as in Example 3 was used, but without the addition of strontium acetate.

[0099] Comparative Example 3 (without aminomethylpropanol)

[0100] Disposable dental desensitizing swabs contain the following components:

[0101] Strontium acetate 4%, zinc salicylate 0.3%, glycerol 10%, butylene glycol 5%, EDTA 0.3%, food-grade citrus flavoring 0.08%, purified water 80.32%.

[0102] The same preparation method as in Example 3 was used, but without the addition of aminomethylpropanol, and the final pH value was 5.2.

[0103] Comparative Example 4 (without hollow cotton swab structure, applied using ordinary cotton swabs).

[0104] A desensitizing composition with the same components as in Example 3 was prepared, but instead of using a hollow cotton swab structure, a regular cotton swab was used to apply the desensitizing composition by dotting it.

[0105] To evaluate the technical effects of the present invention, the following tests were conducted:

[0106] Test Experiment 1: Immediate Desensitization Effect Test

[0107] One hundred patients with dentin hypersensitivity (aged 20-60 years, half male and half female) were selected. All patients had symptoms of sensitivity to cold stimuli and a tooth sensitivity score of 7-9 (out of 10, with higher scores indicating higher sensitivity). The patients were randomly divided into 7 groups, and each group was tested using the products from Examples 1-5 and Comparative Examples 1-2, respectively.

[0108] Test Method: A standard airflow stimulator (cold airflow temperature 0±1℃, air pressure 30±2psi) was used to stimulate sensitive teeth for 10 seconds, and the patient's pain score was recorded (0-10 points, 0 points indicating no pain, 10 points indicating extreme pain). Then, each group of products was used to treat the sensitive teeth, and airflow stimulation tests were performed again at 1 minute, 5 minutes, 30 minutes, and 60 minutes after treatment, and the patient's pain score was recorded. The test results are shown in Table 1:

[0109] Table 1. Results of immediate desensitization test (mean pain score ± standard deviation)

[0110] test group Before processing 1 minute after processing 5 minutes after treatment 30 minutes after treatment 60 minutes after treatment Example 1 7.8±0.6 4.2±0.8 3.3±0.7 2.8±0.6 2.5±0.5 Example 2 7.9±0.7 3.0±0.6 2.1±0.5 1.6±0.4 1.4±0.4 Example 3 7.7±0.5 3.5±0.7 2.6±0.6 2.0±0.5 1.8±0.4 Example 4 7.8±0.6 3.8±0.8 2.9±0.7 2.3±0.6 2.0±0.5 Example 5 7.6±0.5 3.2±0.6 2.3±0.5 1.8±0.4 1.6±0.4 Comparative Example 1 7.7±0.6 6.8±0.9 6.1±0.8 5.7±0.7 5.5±0.7 Comparative Example 2 7.8±0.7 5.6±0.8 5.3±0.7 5.1±0.7 5.0±0.6

[0111] Test results showed that Examples 1-5 of the present invention all exhibited significant immediate desensitization effects, with Example 2 (high concentration of strontium acetate and zinc salicylate) showing the best effect, reducing pain scores by approximately 82% 60 minutes after treatment. In contrast, Comparative Example 1 (lacking zinc salicylate) and Comparative Example 2 (lacking strontium acetate) showed significantly poorer desensitization effects, confirming the importance of the synergistic effect of strontium acetate and zinc salicylate for rapid desensitization.

[0112] Test Experiment 2: Long-lasting Desensitization Duration Test

[0113] Sixty patients with dentin hypersensitivity were selected and divided into 6 groups of 10 each. The products from Examples 3 and Comparative Examples 1-4 were used twice daily (once in the morning and once in the evening) for 7 consecutive days. Tooth sensitivity was assessed using a standard cold water stimulation test (rinsing sensitive teeth with 5°C cold water for 10 seconds) before use, after 3 days of use, and after 7 days of use. The results are shown in Table 2.

[0114] Table 2 Results of the long-term desensitization persistence test (mean pain score ± standard deviation)

[0115] test group Before use After 3 days of use Use for 7 days Example 3 7.8±0.7 2.3±0.5 1.1±0.3 Comparative Example 1 7.7±0.6 4.5±0.7 3.2±0.6 Comparative Example 2 7.9±0.7 5.2±0.8 4.1±0.7 Comparative Example 3 7.8±0.6 3.8±0.6 2.5±0.5 Comparative Example 4 7.7±0.7 3.6±0.7 2.8±0.6

[0116] Test results show that Example 3 of the present invention exhibits the best desensitization durability after long-term use, with pain scores decreasing by approximately 86% after 7 days of use. In contrast, the long-term desensitization effects of Comparative Examples 1-4 are significantly worse. Comparative Example 3 (without aminomethylpropanol, slightly acidic pH) showed some desensitization effect, but it was significantly weaker than Example 3, confirming the importance of a slightly alkaline environment for improving desensitization efficacy. Comparative Example 4 (using ordinary cotton swabs for application) also showed a less effective desensitization effect than the hollow cotton swab structure of the present invention due to the inability to precisely control the dosage and ensure the stability of the active ingredient.

[0117] Test Experiment 3: User Experience and Product Stability Testing

[0118] Fifty volunteers were selected to use the product of Example 3 and complete a user experience questionnaire after use. Simultaneously, the product of Example 3 was stored for 6 months under different temperature conditions (4℃, 25℃, 40℃), and the stability of the desensitization composition (pH value, active ingredient content, appearance, etc.) was periodically tested. The results are shown in Tables 3 and 4:

[0119] Table 3 User Experience Test Results (Percentages represent the proportion of users who selected "satisfied" or "very satisfied")

[0120] Evaluation Project Satisfaction rate (%) Ease of use 92 Dot application accuracy 88 Immediate relief 86 Comfort of use 90 taste 82 Overall satisfaction 88

[0121] Table 4 Product stability test results

[0122] Storage conditions initial pH value pH value after 6 months Initial strontium acetate content (%) Strontium acetate content (%) after 6 months Appearance changes 4℃ 7.5 7.4 4 3.9 No significant changes 25℃ 7.5 7.3 4 3.8 No significant changes 40℃ 7.5 7.1 4 3.7 Slight yellowing

[0123] Test results show that the product of this invention has received high praise from users, especially for its ease of use and immediate relief effect. Furthermore, after being stored for 6 months under different temperature conditions, the content of the main active ingredients and the pH value remained stable, demonstrating that the product of this invention has good storage stability.

[0124] Based on the above test results, the disposable dental desensitizing cotton swabs of the present invention have the following outstanding technical effects:

[0125] 1. Dual desensitization mechanism: Strontium acetate physically seals dentinal tubules, while zinc salicylate regulates nerve sensitivity. The synergistic effect of the two achieves rapid (within 1 minute) and long-lasting (more than 7 days) desensitization.

[0126] 2. Synergistic effect of formulation: The weakly alkaline environment (pH 6.5-8.5) regulated by aminomethylpropanol significantly improves the deposition efficiency and sealing effect of strontium acetate; the dual moisturizing system of glycerin and butylene glycol optimizes the residence time and bioavailability of the solution on the tooth surface.

[0127] 3. Innovative structural design: The pre-breakable hollow cotton swab design not only ensures ease of use but also guarantees the stability of the desensitizing composition before use, improving the desensitizing effect by about 30% compared to the ordinary cotton swab application method.

[0128] 4. Targeted and precise care: The spot-applied design allows the desensitizing composition to act directly on sensitive areas, resulting in more significant and faster effects compared to traditional products used throughout the entire mouth (such as desensitizing toothpaste and mouthwash).

[0129] 5. Product stability: Through reasonable formula design and sealing packaging technology, the product of this invention can maintain stability for at least 24 months at room temperature, meeting commercialization requirements.

[0130] The disposable dental desensitizing swabs of this invention, through the above-mentioned multiple technological innovations, successfully solve the technical problems of existing desensitizing products such as slow onset of action, poor compliance, and inconvenience in positioning and processing, providing a fast, convenient, and precise self-care solution for patients with dentin hypersensitivity.

Claims

1. A disposable dental desensitizing swab, characterized in that, include: The hollow plastic cotton swab body has two ends, each end of which is provided with an adsorption head, one end of which is provided with a pre-break connection point; and a desensitizing composition stored inside the hollow plastic cotton swab body, the desensitizing composition comprising the following components: 3%–5% strontium acetate, 0.1%–0.5% zinc salicylate, 1%–3% aminomethylpropanol, 5%–15% glycerin, 1%–10% butylene glycol, 0.1%–0.5% stabilizer, 0.05%–0.1% food-grade flavoring agent, and purified water to 100%.

2. The disposable dental desensitizing swab according to claim 1, characterized in that, The stabilizer is selected from EDTA or sodium citrate.

3. The disposable dental desensitizing swab according to claim 1, characterized in that, The hollow plastic cotton swab body is made of medical-grade plastic, and the two adsorption heads are made of non-woven fiber material, which has a porous structure that can adsorb and release liquid.

4. The disposable dental desensitizing swab according to claim 1, characterized in that, The pre-break connection point is designed as a safe break point structure that can break under stress but will not form a sharp cross-section.

5. The disposable dental desensitizing swab according to claim 1, characterized in that, The pH value of the desensitizing composition is 6.5-8.

5.

6. A method for preparing disposable dental desensitizing swabs according to any one of claims 1-5, characterized in that, Includes the following steps: a) Preparation of the desensitizing composition: Heat purified water to 35-45℃, add aminomethylpropanol, stabilizer and strontium acetate in sequence, and stir thoroughly to dissolve; then add zinc salicylate and continue stirring until completely dissolved; then add glycerin, butylene glycol and food-grade flavoring in sequence, and finally adjust the pH value to 6.5-8.5 to obtain the desensitizing composition; b) Prepare the hollow cotton swab body: Inject medical-grade plastic material into a hollow tube with openings at both ends, and set a pre-break connection point at one end; c) Install adsorption heads: Install cotton adsorption heads with good adsorption performance at both ends of the hollow pipe; d) Filling the desensitizing composition: Fill the hollow cotton swab body completed in step c) with the desensitizing composition prepared in step a); e) Sealed packaging: The filled disposable dental desensitizing swabs are individually sealed and packaged to complete the preparation.

7. The method according to claim 6, characterized in that, In step a), the stabilizer is selected from EDTA or sodium citrate. Step a) is carried out in a clean environment with the temperature controlled at 20-25℃ and the humidity controlled at 45%-55%.

8. The method according to claim 6, characterized in that, In step d), a precision injection device is used for filling to ensure that the volume error of the desensitizing composition filled in each swab does not exceed ±5%.

9. The method according to claim 6, characterized in that, In step e), the sealed packaging uses sterile aluminum foil composite material, and each package contains a desiccant. After the packaging is sealed, an aging test is conducted to ensure that the product shelf life is not less than 24 months.

10. The use of the disposable dental desensitizing swabs according to any one of claims 1-5 in the preparation of a home-use dentin hypersensitivity relief product, characterized in that, When using, break the pre-break connection point to allow the desensitizing composition to flow to the other end of the adsorption head. Then, apply the adsorption head, which is soaked in the desensitizing composition, directly to the surface of the sensitive teeth. This forms a physical barrier on the tooth surface and regulates nerve sensitivity, thereby relieving dentin hypersensitivity symptoms caused by stimuli such as cold, heat, sourness, and sweetness.

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