33results about How to "Realize smart release" patented technology

The invention relates to a chlorambucil multi-targeting medicine carrying system and a preparation method and application thereof in the aspect of anti-tumor medicines. The chlorambucil multi-targeted medicine carrying system is prepared by mixing a PEG-HA-CHL (polyethylene glycol-hyaluronic acid-chlorambucil) component with an Fe3O4 magnetofluid component in weigh ratio of 1:(1-5), wherein the PEG-HA-CHL comprises the following components in parts by weight: 20-100 parts of chlorambucil, 500-1500 parts of PEG, 100-500 parts of HA, 10-50 parts of DCC (dicyclohexylcarbodiimide), 1-10 parts of DMAP (dimethylamino pyridine), 100-500 parts of butanedioic anhydride, 10-50 parts of EDC (dichloroethane) and 20-100 parts of sodium hydrogensulfite. The invention has the advantages of intelligent medicine release, multiple targeting and better reverse medicine resistance, controlled medicine release, better blood circulation stability, better invisibility and wide applicability.

The invention provides a kind of preparation method of the nano gel of tumor cell targeting, comprises the following steps: A) the initiator with phenylboronic acid group and L-glutamic acid oligomer glycol monomethyl ether-N The acid anhydride in the ring is dissolved in an organic solvent and reacted to obtain a mixed solution; B) the compound with the structure of formula (I) and the compound with the structure of formula (II) are mixed with the mixed solution obtained in step A) and reacted to obtain Reaction solution; C) mixing the reaction solution obtained in step B) with an organic solvent, and filtering to obtain a tumor cell-targeted nanogel; using the tumor cell-targeted nanogel drug-loaded particles provided by the present invention is non-toxic to the human body Side effects, and has good water solubility, stability and biocompatibility.

The invention discloses a gemcitabine prodrug compound, a biomimetic nano-drug carrier and a preparation method thereof. PEI is first reacted with a reductively responsive prodrug segment to obtain a PEI with a positive charge on the surface and partially reacted amino groups, and then the Then react with the phosphorylcholine segment with aldehyde group, put it into a dialysis bag with MW=3500, and dialyze for 2 days to remove organic solvents and unreacted small molecules, and finally get a pH / GSH multi-level response biomimetic nano-drug carriers. The preparation method of the nano-microcarrier in the present invention is simple and novel, and the multi-level response is compared with the previously reported drug carrier. The charged PEI promotes the endocytosis of the prodrug molecule by the cell. After the prodrug molecule enters the cancer cell, a large amount of GSH in the cancer cell further decomposes the disulfide bond in the prodrug, precisely controls the release of the drug, and realizes the release of the drug. effective release and treatment of tumor cells.

The invention discloses a preparation method of a pH-responsive organic-inorganic composite bone cement, which generates pH-responsive calcium carbonate nanoparticles through the reaction of calcium ions and carbonate ions, and adds antibiotics in the preparation process so that the calcium carbonate is loaded with antibiotics; The drug calcium carbonate nanoparticles are used as the core, and a layer of polydimethylaminoethyl methacrylate hydrogel shell is formed on the surface of calcium carbonate, and then the pH-responsive core-shell microspheres are obtained by washing, freeze-drying, and ball milling; the pH-responsive core The shell microspheres are mixed with polymethyl methacrylate and barium sulfate to obtain a pH-responsive organic-inorganic composite bone cement solid phase, and the pH-responsive organic-inorganic composite bone cement solid phase and liquid phase are mixed, stirred, and solidified to obtain a pH-responsive type Organic-inorganic composite bone cement. It solves the problem that the expandable bone cement in the prior art cannot perform pH-responsive drug release.

The invention discloses a slow-release drug. The slow-release drug is prepared from a mesoporous silicon sphere, a drug, a guest molecule and a host molecule; the mesoporous silicon sphere has a mesopore, and the drug is loaded in the mesopore; the guest molecule is combined with the outer surface of the mesoporous silicon sphere; the host molecule is combined with the guest molecule through interaction between a host and a guest, at least partially blocks the opening of the mesopore, and can be separated from the mesoporous silicon sphere under the action of force. The invention also discloses a preparation method and application of the slow-release drug.

The invention provides a nanogel, its preparation method and anti-tumor drug-carrying nanogel. The nanogel provided by the present invention is shown in formula (I), wherein, m, x, y, n are degrees of polymerization, 40≤m≤120, 1≤x≤50, 1≤y≤50, 1≤n≤ 50; CPPs are cell membrane-penetrating peptides modified by cysteine ​​at the end. The nanogel with the structure of formula (I) provided by the present invention can be used as an anti-tumor drug carrier to target enrichment at the tumor site, and can improve the adhesion and deep penetration to tumor cells, so that the drug-loaded particles are easy to be absorbed by the tumor. Cell endocytosis; at the same time, it also has response sensitivity. Under the high concentration of optical glutathione in tumor cells, the disulfide bond in its structure can be broken quickly, realizing the intelligent release of drugs inside tumor cells. Swallow-release works together in many ways to improve the anti-tumor effect.

The invention discloses a monolayer molybdenum disulfide-zinc ferrite nanocomposite material and a preparing method and application thereof, and relates to the field of novel nanocomposite materials. The material is composed of a molybdenum disulfide nanosheet and zinc ferrite nanoparticles, wherein the surface of the molybdenum disulfide nanosheet is evenly modified with the zinc ferrite nanoparticles, and the molybdenum disulfide nanosheet is of a layer-peeled structure. The zinc ferrite nanoparticles are assembled on the surface of the molybdenum disulfide nanosheet by means of the reaction of amino and carboxyl to form an amido bond. The method has the advantages that energy consumption is low, the cost is low, and the yield is high. The obtained composite material can serve as a magnetic resonance imaging contrast agent and a controllable drug carrier. A drug can reach and be gathered at the position of a focus under the guidance of a magnetic field, intelligent drug release and real-time curative effect evaluation can be achieved under the guidance of magnetic resonance imaging, and controllable adjustment of the magnetic resonance imaging effect and the drug loading capacity can be achieved by changing the relative content of molybdenum disulfide and zinc ferrite in the composite material.

The invention relates to a tumor cell multi-targeted drug carrying system, and a preparation method of the drug carrying system and application of the drug carrying system in the aspect of antitumor drugs. The drug carrying system is prepared by mixing a PEG (Polyethylene Glycol)-HA (Hyaluronic Acid)-MEL (Melamine) component and a Fe3O4 magnetic fluid component according to a weight ratio of 1:1-5, wherein the PEG-HA-MEL component comprises the following components in parts by weight: 20-100 parts of melphalan, 500-1500 parts of PEG, 100-500 parts of HA, 10-50 parts of DCC (dicyclohexylcarbodiimide), 1-10 parts of DMAP (Dimethylamino Pyridine), 100-500 parts of succinic anhydride, 10-50 parts of EDC (ethylene dichloride) and 20-100 parts of sodium hydrogensulfite. The invention has the advantages of drug release intelligence of the system, multi-targeted property and good reverse drug resistance action of the system, drug release control of the system, good blood circulation stabilityof the system, good invisibility of the system, and wide applicability of the system.

The invention relates to an intelligent anti-aging composition, a preparation process thereof, and application thereof in cosmetics. According to the composition, camellia oil, components such as a radix angelicae sinensis extract and a citrus extract are inserted into a lipidosome bilayer, an intelligent anti-aging component is wrapped, and the intelligent slow release of anti-aging function components is realized through the change of illumination intensity; the anti-aging components wrapped by lipidosome is innovatively compounded aiming at multiple mechanisms produced by skin aging, has the efficacies of moisturizing and protecting skin, promoting cell proliferation, resisting ultraviolet light, scavenging free radical, inhibiting MMPs expression, moisturizing, complementing extracellular matrix and the like, and produces a synergistic interaction effect. The intelligent anti-aging composition provided by the invention realizes the aims of intelligently slow releasing the anti-aging function components, improving the product efficacy and the safety, prolonging the action time, reducing the skin load, and the like; the composition can be widely applied in cream milk agents, emulsion and solution cosmetics.

The invention discloses a pH responsive nanometer carrier as well as a preparation method and application thereof, and belongs to the field of medicine delivery. Biomacromolecule is loaded to a pore canal of pH responsive mesoporous silica nanoparticles, a hole plugging agent is used for plugging the pore canal of the mesoporous silica nanoparticles, and the pH responsive mesoporous silica nanoparticles are mesoporous silica nanoparticle surface grafted acidic sensitivity molecules, wherein the diameter of the nanoparticle pore canal is 5-50nm. Under the condition that the pH value is smallerthan or equal to threshold, an acidic sensitivity chemical bond is ruptured, and charge on the surfaces of the nanoparticles is turned into positive charge from negative charge; and under the action of electrostatic repulsion, the hole plugging agent with the positive charge is separated from the surfaces of the mesoporous silica nanoparticles, the pore canal is exposed, and the biomacromolecule is quickly released. The pH responsive nanometer carrier can effectively solve the problems that the biomacromolecule leaks before arriving at target cells or cannot be controllably released under thespecific condition in cells, and controlled release under the specific pH condition of the loaded biomacromolecule is realized.