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33results about How to "Realize smart release" patented technology
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Monolayer molybdenum disulfide-cobalt ferrite nanocomposite material as well as preparation method and application thereof
ActiveCN106344937ARealize smart releaseIncrease concentrationInorganic non-active ingredientsNMR/MRI constrast preparationsCobalt ferrite nanoparticlesTherapeutic effect
The invention discloses a monolayer molybdenum disulfide-cobalt ferrite nanocomposite material and a preparation method and application thereof, and particularly relates to the field of novel nanocomposite materials. The monolayer molybdenum disulfide-cobalt ferrite nanocomposite material consists of molybdenum disulfide nanonanosheets and cobalt ferrite nanoparticles, wherein the surfaces of the molybdenum disulfide nanonanosheets are uniformly modified by the cobalt ferrite nanoparticles; the molybdenum disulfide nanonanosheets adopt layered stripping structures. The cobalt ferrite nanoparticles are assembled on the surfaces of the molybdenum disulfide nanonanosheets through a reaction in which amino groups and carboxyl groups form amide bonds; the preparation method has the advantages of low energy consumption, low cost and high yield; the obtained composite material can be used as a magnetic resonance imaging contrast agent and a controllable medicine carrier at the same time; under the guidance of a magnetic field, a medicine can reach and be enriched on a lesion site so as to achieve intelligent medicine release and real-time therapeutic effect assessment under the guidance of magnetic resonance imaging; through change of the relative contents of molybdenum disulfide and cobalt ferrite in the composite material, controllable adjustment of the magnetic resonance imaging effect and the medicine loading capacity can be achieved.
Owner:HEBEI UNIV OF ENG
Monolayer molybdenum disulfide-zinc ferrite nanocomposite material and preparing method and application thereof
ActiveCN107029251ARealize smart releaseReal-timeEnergy modified materialsNMR/MRI constrast preparationsCurative effectDrug carrier
The invention discloses a monolayer molybdenum disulfide-zinc ferrite nanocomposite material and a preparing method and application thereof, and relates to the field of novel nanocomposite materials. The material is composed of a molybdenum disulfide nanosheet and zinc ferrite nanoparticles, wherein the surface of the molybdenum disulfide nanosheet is evenly modified with the zinc ferrite nanoparticles, and the molybdenum disulfide nanosheet is of a layer-peeled structure. The zinc ferrite nanoparticles are assembled on the surface of the molybdenum disulfide nanosheet by means of the reaction of amino and carboxyl to form an amido bond. The method has the advantages that energy consumption is low, the cost is low, and the yield is high. The obtained composite material can serve as a magnetic resonance imaging contrast agent and a controllable drug carrier. A drug can reach and be gathered at the position of a focus under the guidance of a magnetic field, intelligent drug release and real-time curative effect evaluation can be achieved under the guidance of magnetic resonance imaging, and controllable adjustment of the magnetic resonance imaging effect and the drug loading capacity can be achieved by changing the relative content of molybdenum disulfide and zinc ferrite in the composite material.
Owner:HEBEI UNIV OF ENG
Injection type pH sepsitive chitin quarternary ammonium salt aquagel and its preparation method
InactiveCN1830420ARealize smart releaseRetain biocompatibilityPharmaceutical delivery mechanismPharmaceutical non-active ingredientsPhosphateReaction temperature
An injectable pH-sensitive chitosan quaternary ammonium salt hydrogel is prepared through reaction between chitosan and 2.3-epoxypropyl ammonium trimethylchloride, depositing in acetone, washing, baking to obtain chitosan quatemary ammonium salt, dissolving it in acidic solution, dripping the solution of glycerine phosphate while stirring, and heating for gelatinizing.
Owner:INST OF PROCESS ENG CHINESE ACAD OF SCI
PH responsive nanometer carrier as well as preparation method and application thereof
ActiveCN109549933ASolve the technical problem of being unable to efficiently carry large biomacromolecules such as proteinsAchieve controlled releaseNervous disorderPeptide/protein ingredientsControl releaseNanoparticle
The invention discloses a pH responsive nanometer carrier as well as a preparation method and application thereof, and belongs to the field of medicine delivery. Biomacromolecule is loaded to a pore canal of pH responsive mesoporous silica nanoparticles, a hole plugging agent is used for plugging the pore canal of the mesoporous silica nanoparticles, and the pH responsive mesoporous silica nanoparticles are mesoporous silica nanoparticle surface grafted acidic sensitivity molecules, wherein the diameter of the nanoparticle pore canal is 5-50nm. Under the condition that the pH value is smallerthan or equal to threshold, an acidic sensitivity chemical bond is ruptured, and charge on the surfaces of the nanoparticles is turned into positive charge from negative charge; and under the action of electrostatic repulsion, the hole plugging agent with the positive charge is separated from the surfaces of the mesoporous silica nanoparticles, the pore canal is exposed, and the biomacromolecule is quickly released. The pH responsive nanometer carrier can effectively solve the problems that the biomacromolecule leaks before arriving at target cells or cannot be controllably released under thespecific condition in cells, and controlled release under the specific pH condition of the loaded biomacromolecule is realized.
Owner:HUAZHONG UNIV OF SCI & TECH
Intelligent lubricating particle releasing wear-resisting material and preparation method thereof
InactiveCN106751718ARealize smart releaseInhibit wearMicroballoon preparationMicrocapsule preparationState of artParaffin wax
The invention provides an intelligent lubricating particle releasing wear-resisting material and a preparation method thereof, belongs to the technical field of wear-resisting materials, and is intended to solve the technical problems in the prior art that outer and inner performances of a polyurethane resin material are different and are not stable, the initial-stage wear-resisting performance is good, the later-period wear-resisting performance is suddenly reduced after surface lubricating particles are consumed, the material has no intelligent releasing function and a preparation process is complicated. The intelligent lubricating particle releasing wear-resisting material provided by the invention is prepared from 2wt%-40wt% of a polyurethane microcapsule and 60wt%-98wt% of polyurethane resin, wherein the grain diameter of the polyurethane microcapsule is 12-20 microns and the polyurethane microcapsule is composed of a capsule core and a capsule wall for packaging the capsule core; the capsule core is made of solid paraffin wax and / or liquid paraffin wax; and the capsule wall is made of polyurethane resin. The wear-resisting material provided by the invention has good wear-resisting performance and storage stability and also has an intelligent releasing function; and a phenomenon that performances of the material are not stable because the local temperature is too high when the polyurethane material is abraded, can be avoided.
Owner:CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
Convertible surface charge nano-gel, preparation method thereof and convertible surface charge nano-gel drug-loaded particle
ActiveCN104817688AGood biocompatibilityRealize smart releasePharmaceutical non-active ingredientsSolubilityBiocompatibility Testing
The invention provides a preparation method of convertible surface charge nano-gel. The preparation method includes the steps: A) dissolving an initiating agent with a morpholinyl group and L-glutamic acid polyethylene glycol single methyl ether-N-carboxyanhydride into an organic solvent for reaction to obtain mixed solution; B) mixing a compound with a formula (I) structure, a compound with a formula (II) structure and the mixed solution obtained in the step A) for reaction to obtain reaction solution; C) mixing and filtering the reaction solution obtained in the step B) and the organic solvent to obtain the convertible surface charge nano-gel. A convertible surface charge nano-gel drug-loaded particle has no toxic and side effects on human bodies and has excellent water solubility, stability and biocompatibility.
Owner:CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
Cell-packaged thermo-sensitive hydrogel material with response temperature adjusted as well as preparation method and application thereof
InactiveCN109232995ASolve the problem of low retention rate and large lossIncrease gel speedPharmaceutical delivery mechanismProsthesisLiquid statePolyethylene glycol
The invention belongs to the fields of intelligent materials, high polymer materials and biomedical engineering and specifically relates to a cell-packaged thermo-sensitive hydrogel material with response temperature adjusted as well as a preparation method and application thereof. Cell-packaged thermo-sensitive hydrogel comprises the following raw ingredients by weight percentage: 12wt% of methylcellulose, 7.4wt% of PEG (polyethylene glycol)-20000, 1.4wt% of non-toxic inorganic sodium salt, 0-16wt% of xylitol and the balance of water. The non-toxic inorganic sodium salt is Na2HPO3.12H2O. According to the cell-packaged thermo-sensitive hydrogel material with response temperature adjusted, the thermo-sensitivity response temperature can be adjusted by adjusting the content of the xylitol,and the material has no biotoxicity. When the temperature is low, the material keeps a transparent liquid state; when the temperature is risen to phase inversion temperature, the material can be changed into a gel state. Additionally, the material has no biotoxicity, so that the material can be used for packaging and protecting a cell, and the packaged cell is then injected into a human body.
Owner:TONGJI UNIV
Tumor cell targeted nano gel and preparation method thereof as well as tumor cell targeted drug-loaded nano-particles
ActiveCN104761732ATumor suppressionProlong blood circulation timeAerosol deliveryOintment deliveryChemistryWater soluble
The invention provides a preparation method of a tumor cell targeted nano gel. The preparation method comprises the following steps: (A) dissolving an initiator with a phenylo boric acid radical and L-glutamic acid oligomeric ethylene glycol monomethyl ether-N-anhydride in an organic solvent to perform reaction, thereby obtaining a mixed solution; (B) mixing a compound with a structure shown by a formula (I) and a compound with a structure shown by a formula (II) with the mixed solution obtained in the step (A), and reacting to obtain a reaction solution; and (C) mixing the reaction solution obtained in the step (B) with an organic solvent, and filtering to obtain the tumor cell targeted nano gel. The drug-loaded particles adopting the tumor cell targeted nano gel provided by the invention do not have toxic or side effects on human bodies and have good water solubility, stability and biocompatibility. The formulae are as shown in the specification.
Owner:CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
Preparation method of pH-responsive core-shell structure dendrimer drug carrier
InactiveCN110496226ASimple reaction conditionsThe synthesis steps are simpleOrganic active ingredientsPharmaceutical non-active ingredientsDendrimerFifth generation
The invention relates to a preparation method of a pH-responsive core-shell structure dendrimer drug carrier. The fifth generation dentrimer modified by beta-cyclodextrin is taken as a core, the thirdgeneration dentrimer modified by benzimidazole-2-acetic acid is taken as a shell, and a pH-responsive core-shell super structure dendrimer is constructed by the self-assembly function of a supramolecule of host and guest molecules. When the prepared pH-responsive core-shell structure dendrimer is used as an anticancer drug carrier, the advantages of low toxicity, safety, high loading rate, intelligent release in tumor microenvironment and the like are achieved, and potential application prospects are achieved in aspects of chemotherapy and the like.
Owner:DONGHUA UNIV
Intelligent release-type protein metal ion antibacterial nanoparticle and preparation method thereof
ActiveCN111990643AGive full play to the superiorityImprove targetingFood shapingNatural extract food ingredientsBiotechnologyEscherichia coli
The invention belongs to the field of food antibacterial additives, and particularly relates to an intelligent release-type protein metal ion antibacterial nanoparticle and a preparation method thereof. The yarrow essential oil is wrapped in zein by adopting a nano precipitation method, the pH value of the solution is adjusted, so that the surface is negatively charged, and positively charged zincmetal ions are chelated through electrostatic interaction. The characteristics of bacterial metalloproteinase are utilized, the bacterial metalloproteinase is used as a biological switch, and when bacteria containing Zn<2+> metalloproteinase encounter chelated nanoparticles, the protease activity is activated, so that proteins on the surfaces of the nanoparticles are hydrolyzed, the wrapped yarrow essential oil is released, and the bacteria are killed. The novel antibacterial nanoparticle can effectively inhibit various bacteria such as escherichia coli O157:H7, staphylococcus aureus and Listeria monocytogenes, and can intelligently release an antibacterial agent.
Owner:JIANGSU UNIV
Melphalan multi-targeted drug carrying system, and preparation method and application thereof
ActiveCN102038652AInhibition releaseRealize smart releaseOrganic active ingredientsPowder deliveryPolyethylene glycolEthylene Dichloride
The invention relates to a tumor cell multi-targeted drug carrying system, and a preparation method of the drug carrying system and application of the drug carrying system in the aspect of antitumor drugs. The drug carrying system is prepared by mixing a PEG (Polyethylene Glycol)-HA (Hyaluronic Acid)-MEL (Melamine) component and a Fe3O4 magnetic fluid component according to a weight ratio of 1:1-5, wherein the PEG-HA-MEL component comprises the following components in parts by weight: 20-100 parts of melphalan, 500-1500 parts of PEG, 100-500 parts of HA, 10-50 parts of DCC (dicyclohexylcarbodiimide), 1-10 parts of DMAP (Dimethylamino Pyridine), 100-500 parts of succinic anhydride, 10-50 parts of EDC (ethylene dichloride) and 20-100 parts of sodium hydrogensulfite. The invention has the advantages of drug release intelligence of the system, multi-targeted property and good reverse drug resistance action of the system, drug release control of the system, good blood circulation stability of the system, good invisibility of the system, and wide applicability of the system.
Owner:WUHAN NUOAN PHARMACY
Microcapsule soil conditioner and preparation method thereof
ActiveCN112794775AGood biocompatibilityPromote degradationMagnesium fertilisersAlkali orthophosphate fertiliserNatural sourceSoil treatment
The invention relates to a microcapsule soil conditioner and a preparation method thereof, and the preparation method comprises the following steps: preparing a mixed solution containing nutrient substances and capsule forming raw materials, and treating the mixed solution by a spray drying method to obtain the microcapsule soil conditioner. Compared with the prior art, the soil conditioner with the microcapsule structure is prepared by taking natural source macromolecules as a coating material and loading nutrient substances required by soil treatment and plant growth; and through coating of natural source macromolecules, the release period of nutrient substances can be effectively prolonged, the use efficiency of effective components is improved, and the fertilizer has a wide application prospect in the aspects of soil improvement and environmental governance.
Owner:河北新启力肥业有限公司
Gemcitabine prodrug compound, bionic nano medicament carrier and preparation method of carrier
ActiveCN109970831AAchieving covalent loadingOvercome the premature leak problemOrganic active ingredientsSugar derivativesCancer cellPhosphorylcholine
The invention discloses a gemcitabine prodrug compound, a bionic nano medicament carrier and a preparation method of the carrier. The method comprises the following steps: allowing PEI to react with aprodrug chain segment with reductive response so as to obtain PEI with positive charges on the surface and partial-reacted amino, allowing the obtained PEI to react with a phosphorylcholine chain segment with an aldehyde group, putting the just-obtained PEI into a dialysis bag with MW of 3500, and performing dialyzing for 2 days to remove organic solvent and unreacted small molecules so as to finally obtain the bionic nano medicament carrier with pH / GSH multi-level response. The preparation method of the nano microcarrier is simple and novel. Compared with drug carriers reported in the priorart, in terms of the multi-level response, the phosphorylcholine hydrophilic chain bonded by the carrier is broken under the tumor sourish environment, the PEI with positive charges is exposed, the endocytosis of cells on prodrug molecules is promoted, a large amount of GSH in the cancer cells further decomposes disulfide bonds in the prodrug after the prodrug molecules enter the cancer cells, therelease of the drug is accurately controlled, and the effective release of the drug and the treatment of the tumor cells are realized.
Owner:WEST CHINA HOSPITAL SICHUAN UNIV
Slow-release drug, and preparation method and application thereof
ActiveCN109806399AInhibition releaseQuick releaseOrganic active ingredientsSkeletal disorderSiliconChemistry
The invention discloses a slow-release drug. The slow-release drug is prepared from a mesoporous silicon sphere, a drug, a guest molecule and a host molecule; the mesoporous silicon sphere has a mesopore, and the drug is loaded in the mesopore; the guest molecule is combined with the outer surface of the mesoporous silicon sphere; the host molecule is combined with the guest molecule through interaction between a host and a guest, at least partially blocks the opening of the mesopore, and can be separated from the mesoporous silicon sphere under the action of force. The invention also discloses a preparation method and application of the slow-release drug.
Owner:TSINGHUA UNIV
Chlorambucil multi-targeting medicine carrying system and preparation method and application thereof
InactiveCN102100915BInhibition releaseRealize smart releaseOrganic active ingredientsPowder deliveryPolyethylene glycolPyridine
The invention relates to a chlorambucil multi-targeting medicine carrying system and a preparation method and application thereof in the aspect of anti-tumor medicines. The chlorambucil multi-targeted medicine carrying system is prepared by mixing a PEG-HA-CHL (polyethylene glycol-hyaluronic acid-chlorambucil) component with an Fe3O4 magnetofluid component in weigh ratio of 1:(1-5), wherein the PEG-HA-CHL comprises the following components in parts by weight: 20-100 parts of chlorambucil, 500-1500 parts of PEG, 100-500 parts of HA, 10-50 parts of DCC (dicyclohexylcarbodiimide), 1-10 parts of DMAP (dimethylamino pyridine), 100-500 parts of butanedioic anhydride, 10-50 parts of EDC (dichloroethane) and 20-100 parts of sodium hydrogensulfite. The invention has the advantages of intelligent medicine release, multiple targeting and better reverse medicine resistance, controlled medicine release, better blood circulation stability, better invisibility and wide applicability.
Owner:WUHAN UNIV OF TECH
A tumor cell-targeted nanogel, a preparation method thereof, and a tumor cell-targeted nanogel drug-loaded particle
ActiveCN104761732BRealize smart releaseExtend cycle timeAerosol deliveryOintment deliverySolubilitySide effect
The invention provides a kind of preparation method of the nano gel of tumor cell targeting, comprises the following steps: A) the initiator with phenylboronic acid group and L-glutamic acid oligomer glycol monomethyl ether-N The acid anhydride in the ring is dissolved in an organic solvent and reacted to obtain a mixed solution; B) the compound with the structure of formula (I) and the compound with the structure of formula (II) are mixed with the mixed solution obtained in step A) and reacted to obtain Reaction solution; C) mixing the reaction solution obtained in step B) with an organic solvent, and filtering to obtain a tumor cell-targeted nanogel; using the tumor cell-targeted nanogel drug-loaded particles provided by the present invention is non-toxic to the human body Side effects, and has good water solubility, stability and biocompatibility.
Owner:CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
Gemcitabine prodrug compound, biomimetic nano drug carrier and preparation method thereof
ActiveCN109970831BAchieving covalent loadingOvercome the premature leak problemOrganic active ingredientsSugar derivativesDisulfide bondingCancer cell
The invention discloses a gemcitabine prodrug compound, a biomimetic nano-drug carrier and a preparation method thereof. PEI is first reacted with a reductively responsive prodrug segment to obtain a PEI with a positive charge on the surface and partially reacted amino groups, and then the Then react with the phosphorylcholine segment with aldehyde group, put it into a dialysis bag with MW=3500, and dialyze for 2 days to remove organic solvents and unreacted small molecules, and finally get a pH / GSH multi-level response biomimetic nano-drug carriers. The preparation method of the nano-microcarrier in the present invention is simple and novel, and the multi-level response is compared with the previously reported drug carrier. The charged PEI promotes the endocytosis of the prodrug molecule by the cell. After the prodrug molecule enters the cancer cell, a large amount of GSH in the cancer cell further decomposes the disulfide bond in the prodrug, precisely controls the release of the drug, and realizes the release of the drug. effective release and treatment of tumor cells.
Owner:WEST CHINA HOSPITAL SICHUAN UNIV
A kind of preparation method of pH-responsive organic-inorganic composite bone cement
ActiveCN113274547BSolve the problem of inability to perform pH-responsive drug releaseRealize smart releaseTissue regenerationProsthesisFreeze-dryingPolymethyl methacrylate
The invention discloses a preparation method of a pH-responsive organic-inorganic composite bone cement, which generates pH-responsive calcium carbonate nanoparticles through the reaction of calcium ions and carbonate ions, and adds antibiotics in the preparation process so that the calcium carbonate is loaded with antibiotics; The drug calcium carbonate nanoparticles are used as the core, and a layer of polydimethylaminoethyl methacrylate hydrogel shell is formed on the surface of calcium carbonate, and then the pH-responsive core-shell microspheres are obtained by washing, freeze-drying, and ball milling; the pH-responsive core The shell microspheres are mixed with polymethyl methacrylate and barium sulfate to obtain a pH-responsive organic-inorganic composite bone cement solid phase, and the pH-responsive organic-inorganic composite bone cement solid phase and liquid phase are mixed, stirred, and solidified to obtain a pH-responsive type Organic-inorganic composite bone cement. It solves the problem that the expandable bone cement in the prior art cannot perform pH-responsive drug release.
Owner:XIAN UNIV OF TECH
Sustained-release drug, its preparation method and application
ActiveCN109806399BInhibition releaseQuick releaseOrganic active ingredientsSkeletal disorderCombinatorial chemistryBiochemistry
The invention discloses a slow-release drug. The slow-release drug is prepared from a mesoporous silicon sphere, a drug, a guest molecule and a host molecule; the mesoporous silicon sphere has a mesopore, and the drug is loaded in the mesopore; the guest molecule is combined with the outer surface of the mesoporous silicon sphere; the host molecule is combined with the guest molecule through interaction between a host and a guest, at least partially blocks the opening of the mesopore, and can be separated from the mesoporous silicon sphere under the action of force. The invention also discloses a preparation method and application of the slow-release drug.
Owner:TSINGHUA UNIV
Injection type pH sepsitive chitin quarternary ammonium salt aquagel and its preparation method
InactiveCN1830420BRealize smart releaseRetain biocompatibilityPharmaceutical delivery mechanismPharmaceutical non-active ingredientsReaction temperatureRoom temperature
The present invention discloses an injectable pH-sensitive chitosan quaternary ammonium salt hydrogel and a preparation method thereof, belonging to the medicine engineering pharmaceutic preparation field. The method adopts the chitosan hyamine and the glycerophosphate to prepare the injectable pH-sensitive chitosan quaternary ammonium salt hydrogel. The preparation method comprises the following steps: (1) the chitosan and the 2.3-epoxypropyl ammonium trimethylchloride are reacted at the reaction temperature, are deposited using acetone, washed, and dried to obtain chitosan hyamine; (2) the prepared chitosan hyamine is dissolved into an acid solution; (3) glycerophosphate is added dropwise into the chitosan hyamine acid solution to obtain uniform and clear mixed solution while stirring; (4) the temperature is rised to a gelatinization temperature, and an uniform and transparent chitosan hyamine hydrogel is obtained after keeping constant temperature. The hydrogel can happen gelatinization at a room temperature, and responds to the internal pH value variation to swelling, dissolve and realize intelligent release of the embedding drugs.
Owner:INST OF PROCESS ENG CHINESE ACAD OF SCI
A nanogel, its preparation method and anti-tumor drug-loaded nanogel
ActiveCN109966242BGood water solubilityImprove stabilityHeavy metal active ingredientsOrganic active ingredientsDisulfide bondingHigh concentration
The invention provides a nanogel, its preparation method and anti-tumor drug-carrying nanogel. The nanogel provided by the present invention is shown in formula (I), wherein, m, x, y, n are degrees of polymerization, 40≤m≤120, 1≤x≤50, 1≤y≤50, 1≤n≤ 50; CPPs are cell membrane-penetrating peptides modified by cysteine at the end. The nanogel with the structure of formula (I) provided by the present invention can be used as an anti-tumor drug carrier to target enrichment at the tumor site, and can improve the adhesion and deep penetration to tumor cells, so that the drug-loaded particles are easy to be absorbed by the tumor. Cell endocytosis; at the same time, it also has response sensitivity. Under the high concentration of optical glutathione in tumor cells, the disulfide bond in its structure can be broken quickly, realizing the intelligent release of drugs inside tumor cells. Swallow-release works together in many ways to improve the anti-tumor effect.
Owner:CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
Preparation method of pH-responsive organic-inorganic composite bone cement
ActiveCN113274547ASolve the problem of inability to perform pH-responsive drug releaseRealize smart releaseTissue regenerationProsthesisMicrosphereFreeze-drying
The invention discloses a preparation method of pH-responsive organic-inorganic composite bone cement. The method comprises the following steps: reacting calcium ions with carbonate ions to generate pH-responsive calcium carbonate nanoparticles, and adding antibiotics in the preparation process to load the antibiotics in calcium carbonate; by taking drug-loaded calcium carbonate nanoparticles as a core, forming a poly (dimethylaminoethyl methacrylate) hydrogel shell layer on the surface of calcium carbonate, and then washing, freeze-drying and ball-milling to obtain pH response core-shell microspheres; and mixing the pH-responsive core-shell microspheres with polymethyl methacrylate and barium sulfate to obtain a pH-responsive organic-inorganic composite bone cement solid phase, mixing the pH-responsive organic-inorganic composite bone cement solid phase with a liquid phase, stirring, and curing to obtain the pH-responsive organic-inorganic composite bone cement. The problem that the expandable bone cement in the prior art cannot perform pH response drug release is solved.
Owner:XIAN UNIV OF TECH
A kind of monolayer molybdenum disulfide-zinc ferrite nanocomposite material and its preparation method and application
ActiveCN107029251BRealize smart releaseIncrease concentrationEnergy modified materialsInorganic non-active ingredientsCarboxyl radicalDrug release
Owner:HEBEI UNIV OF ENG
Melphalan multi-targeted drug carrying system, and preparation method and application thereof
ActiveCN102038652BInhibition releaseRealize smart releaseOrganic active ingredientsPowder deliveryPolyethylene glycolEthylene Dichloride
The invention relates to a tumor cell multi-targeted drug carrying system, and a preparation method of the drug carrying system and application of the drug carrying system in the aspect of antitumor drugs. The drug carrying system is prepared by mixing a PEG (Polyethylene Glycol)-HA (Hyaluronic Acid)-MEL (Melamine) component and a Fe3O4 magnetic fluid component according to a weight ratio of 1:1-5, wherein the PEG-HA-MEL component comprises the following components in parts by weight: 20-100 parts of melphalan, 500-1500 parts of PEG, 100-500 parts of HA, 10-50 parts of DCC (dicyclohexylcarbodiimide), 1-10 parts of DMAP (Dimethylamino Pyridine), 100-500 parts of succinic anhydride, 10-50 parts of EDC (ethylene dichloride) and 20-100 parts of sodium hydrogensulfite. The invention has the advantages of drug release intelligence of the system, multi-targeted property and good reverse drug resistance action of the system, drug release control of the system, good blood circulation stabilityof the system, good invisibility of the system, and wide applicability of the system.
Owner:WUHAN NUOAN PHARMACY
GSH concentration responsive pharmacosome for treating hyperthyroidism and preparation method
ActiveCN111939118AImprove permeabilityRealize smart releaseOrganic active ingredientsAerosol deliveryPharmaceutical drugPharmacology
The invention relates to a GSH concentration responsive pharmacosome for treating hyperthyroidism and a preparation method. The pharmacosome provided by the invention has good GSH responsiveness, canrespond to glutathione concentration stimulation in cells, and realizes intelligent release of drugs through a Michael elimination reaction. The pharmacosome is suitable for being made into a transdermal drug delivery system and is used for treating the hyperthyroidism.
Owner:WUHAN UNIV OF TECH
Electrolyte flame-retardant additive material with triphenyl phosphate and polydopamine microcapsule structure and synthesis method of electrolyte flame-retardant additive material
PendingCN114156538AInhibition releaseRealize smart releaseSecondary cells servicing/maintenanceOrganic electrolytesElectrolytic agentPhosphoric acid
The invention discloses an electrolyte flame-retardant additive material with a triphenyl phosphate and polydopamine microcapsule structure and a synthesis method, and relates to the technical field of battery flame-retardant materials, the flame-retardant additive material comprises the following components: triphenyl phosphate, absolute ethyl alcohol, deionized water, tris (hydroxymethyl) aminomethane and dopamine hydrochloride. The preparation method comprises the following steps: S1, weighing: dissolving triphenyl phosphate in absolute ethyl alcohol; s2, weighing tris (hydroxymethyl) aminomethane, and dissolving the tris (hydroxymethyl) aminomethane in deionized water; s3, adding the ethanol mixed solution into the deionized water mixed solution, and stirring to obtain a mixed solution; and S4, weighing dopamine hydrochloride, adding the dopamine hydrochloride into the mixed solution, and mechanically stirring to obtain the electrolyte flame-retardant additive material. According to the flame-retardant additive material prepared by the invention, surface modification can be carried out on a flame retardant through a capsule shell, and the application range of the flame retardant is expanded; the intelligent release of the flame retardant improves the application effect of the flame retardant.
Owner:JILIN UNIV
RNS-response-based 'nervous vascular unit' regulation and control targeted liposome drug delivery system and preparation method and application thereof
ActiveCN114081964AImprove stabilityReduce leakageOrganic active ingredientsOrganic compound preparationCholesterolCerebral ischaemia
The invention discloses an RNS-response-based 'nervous vascular unit' regulation and control targeted liposome drug delivery system and a preparation method and application thereof. The targeted drug delivery system is formed by hydrogenated soybean phospholipid (HSPC), cholesterol, c (RGDyK) grafted PEGylated phospholipid c (RGDyK)-PEG2000-DSPE and a neuroprotective agent caffeic acid phenethyl ester entrapped by lipid micromolecules with RNS responsiveness, wherein the lipid micromolecules with RNS responsiveness are prepared through an acid-base condensation reaction of o-phenylenediamine and tetradecanoic acid. The carrier system has the characteristics of good biocompatibility, capability of effectively prolonging in-vivo circulation time and the like, can be targeted to a cerebral ischemic stroke lesion part through the c (RGDyK) peptide, and responds to RNS accumulated in an ischemia reperfusion focus to release phenethyl caffeate, so that the drug is quickly released at the cerebral ischemia lesion part, and by remodeling the 'nerve vascular unit', the treatment effect on cerebral arterial thrombosis is enhanced, and toxic and side effects are reduced.
Owner:NANJING MEDICAL UNIV
A kind of anti-aging composition and its preparation process and its application in cosmetics
ActiveCN106860086BImprove anti-aging effectRealize smart releaseCosmetic preparationsToilet preparationsBiotechnologyCell-Extracellular Matrix
The invention relates to an intelligent anti-aging composition, a preparation process thereof, and application thereof in cosmetics. According to the composition, camellia oil, components such as a radix angelicae sinensis extract and a citrus extract are inserted into a lipidosome bilayer, an intelligent anti-aging component is wrapped, and the intelligent slow release of anti-aging function components is realized through the change of illumination intensity; the anti-aging components wrapped by lipidosome is innovatively compounded aiming at multiple mechanisms produced by skin aging, has the efficacies of moisturizing and protecting skin, promoting cell proliferation, resisting ultraviolet light, scavenging free radical, inhibiting MMPs expression, moisturizing, complementing extracellular matrix and the like, and produces a synergistic interaction effect. The intelligent anti-aging composition provided by the invention realizes the aims of intelligently slow releasing the anti-aging function components, improving the product efficacy and the safety, prolonging the action time, reducing the skin load, and the like; the composition can be widely applied in cream milk agents, emulsion and solution cosmetics.
Owner:康美氏(厦门)生物科技有限公司
A ph-responsive nanocarrier and its preparation method and application
ActiveCN109549933BAchieve effectivenessAchieve releaseNervous disorderPeptide/protein ingredientsNanocarriersEngineering
The invention discloses a pH responsive nanometer carrier as well as a preparation method and application thereof, and belongs to the field of medicine delivery. Biomacromolecule is loaded to a pore canal of pH responsive mesoporous silica nanoparticles, a hole plugging agent is used for plugging the pore canal of the mesoporous silica nanoparticles, and the pH responsive mesoporous silica nanoparticles are mesoporous silica nanoparticle surface grafted acidic sensitivity molecules, wherein the diameter of the nanoparticle pore canal is 5-50nm. Under the condition that the pH value is smallerthan or equal to threshold, an acidic sensitivity chemical bond is ruptured, and charge on the surfaces of the nanoparticles is turned into positive charge from negative charge; and under the action of electrostatic repulsion, the hole plugging agent with the positive charge is separated from the surfaces of the mesoporous silica nanoparticles, the pore canal is exposed, and the biomacromolecule is quickly released. The pH responsive nanometer carrier can effectively solve the problems that the biomacromolecule leaks before arriving at target cells or cannot be controllably released under thespecific condition in cells, and controlled release under the specific pH condition of the loaded biomacromolecule is realized.
Owner:HUAZHONG UNIV OF SCI & TECH
Pharmacosome hydrogel patch for GSH concentration responsive treatment of hyperthyroidism and preparation method thereof
ActiveCN111991371AEconomical and convenientNo drug lossOrganic active ingredientsAerosol deliveryDrug deliveryIntracellular glutathione
The invention relates to a pharmacosome hydrogel patch for GSH concentration responsive treatment of hyperthyroidism and a preparation method thereof. The patch comprises a polymer matrix, a methimazole pharmacosome and auxiliary materials. The methimazole pharmacosome hydrogel patch provided by the invention can be used for transdermal drug delivery through thyroid lesion sites, and the pharmacosome in the patch has good GSH responsiveness, and can respond to intracellular glutathione concentration stimulation and realize intelligent release of drugs.
Owner:WUHAN UNIV OF TECH
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