33results about How to "Realize smart release" patented technology

The invention discloses a monolayer molybdenum disulfide-zinc ferrite nanocomposite material and a preparing method and application thereof, and relates to the field of novel nanocomposite materials. The material is composed of a molybdenum disulfide nanosheet and zinc ferrite nanoparticles, wherein the surface of the molybdenum disulfide nanosheet is evenly modified with the zinc ferrite nanoparticles, and the molybdenum disulfide nanosheet is of a layer-peeled structure. The zinc ferrite nanoparticles are assembled on the surface of the molybdenum disulfide nanosheet by means of the reaction of amino and carboxyl to form an amido bond. The method has the advantages that energy consumption is low, the cost is low, and the yield is high. The obtained composite material can serve as a magnetic resonance imaging contrast agent and a controllable drug carrier. A drug can reach and be gathered at the position of a focus under the guidance of a magnetic field, intelligent drug release and real-time curative effect evaluation can be achieved under the guidance of magnetic resonance imaging, and controllable adjustment of the magnetic resonance imaging effect and the drug loading capacity can be achieved by changing the relative content of molybdenum disulfide and zinc ferrite in the composite material.

The invention discloses a pH responsive nanometer carrier as well as a preparation method and application thereof, and belongs to the field of medicine delivery. Biomacromolecule is loaded to a pore canal of pH responsive mesoporous silica nanoparticles, a hole plugging agent is used for plugging the pore canal of the mesoporous silica nanoparticles, and the pH responsive mesoporous silica nanoparticles are mesoporous silica nanoparticle surface grafted acidic sensitivity molecules, wherein the diameter of the nanoparticle pore canal is 5-50nm. Under the condition that the pH value is smallerthan or equal to threshold, an acidic sensitivity chemical bond is ruptured, and charge on the surfaces of the nanoparticles is turned into positive charge from negative charge; and under the action of electrostatic repulsion, the hole plugging agent with the positive charge is separated from the surfaces of the mesoporous silica nanoparticles, the pore canal is exposed, and the biomacromolecule is quickly released. The pH responsive nanometer carrier can effectively solve the problems that the biomacromolecule leaks before arriving at target cells or cannot be controllably released under thespecific condition in cells, and controlled release under the specific pH condition of the loaded biomacromolecule is realized.

The invention provides an intelligent lubricating particle releasing wear-resisting material and a preparation method thereof, belongs to the technical field of wear-resisting materials, and is intended to solve the technical problems in the prior art that outer and inner performances of a polyurethane resin material are different and are not stable, the initial-stage wear-resisting performance is good, the later-period wear-resisting performance is suddenly reduced after surface lubricating particles are consumed, the material has no intelligent releasing function and a preparation process is complicated. The intelligent lubricating particle releasing wear-resisting material provided by the invention is prepared from 2wt%-40wt% of a polyurethane microcapsule and 60wt%-98wt% of polyurethane resin, wherein the grain diameter of the polyurethane microcapsule is 12-20 microns and the polyurethane microcapsule is composed of a capsule core and a capsule wall for packaging the capsule core; the capsule core is made of solid paraffin wax and/or liquid paraffin wax; and the capsule wall is made of polyurethane resin. The wear-resisting material provided by the invention has good wear-resisting performance and storage stability and also has an intelligent releasing function; and a phenomenon that performances of the material are not stable because the local temperature is too high when the polyurethane material is abraded, can be avoided.

The invention provides a preparation method of convertible surface charge nano-gel. The preparation method includes the steps: A) dissolving an initiating agent with a morpholinyl group and L-glutamic acid polyethylene glycol single methyl ether-N-carboxyanhydride into an organic solvent for reaction to obtain mixed solution; B) mixing a compound with a formula (I) structure, a compound with a formula (II) structure and the mixed solution obtained in the step A) for reaction to obtain reaction solution; C) mixing and filtering the reaction solution obtained in the step B) and the organic solvent to obtain the convertible surface charge nano-gel. A convertible surface charge nano-gel drug-loaded particle has no toxic and side effects on human bodies and has excellent water solubility, stability and biocompatibility.

The invention belongs to the fields of intelligent materials, high polymer materials and biomedical engineering and specifically relates to a cell-packaged thermo-sensitive hydrogel material with response temperature adjusted as well as a preparation method and application thereof. Cell-packaged thermo-sensitive hydrogel comprises the following raw ingredients by weight percentage: 12wt% of methylcellulose, 7.4wt% of PEG (polyethylene glycol)-20000, 1.4wt% of non-toxic inorganic sodium salt, 0-16wt% of xylitol and the balance of water. The non-toxic inorganic sodium salt is Na2HPO3.12H2O. According to the cell-packaged thermo-sensitive hydrogel material with response temperature adjusted, the thermo-sensitivity response temperature can be adjusted by adjusting the content of the xylitol,and the material has no biotoxicity. When the temperature is low, the material keeps a transparent liquid state; when the temperature is risen to phase inversion temperature, the material can be changed into a gel state. Additionally, the material has no biotoxicity, so that the material can be used for packaging and protecting a cell, and the packaged cell is then injected into a human body.

The invention provides a preparation method of a tumor cell targeted nano gel. The preparation method comprises the following steps: (A) dissolving an initiator with a phenylo boric acid radical and L-glutamic acid oligomeric ethylene glycol monomethyl ether-N-anhydride in an organic solvent to perform reaction, thereby obtaining a mixed solution; (B) mixing a compound with a structure shown by a formula (I) and a compound with a structure shown by a formula (II) with the mixed solution obtained in the step (A), and reacting to obtain a reaction solution; and (C) mixing the reaction solution obtained in the step (B) with an organic solvent, and filtering to obtain the tumor cell targeted nano gel. The drug-loaded particles adopting the tumor cell targeted nano gel provided by the invention do not have toxic or side effects on human bodies and have good water solubility, stability and biocompatibility. The formulae are as shown in the specification.

The invention relates to a preparation method of a pH-responsive core-shell structure dendrimer drug carrier. The fifth generation dentrimer modified by beta-cyclodextrin is taken as a core, the thirdgeneration dentrimer modified by benzimidazole-2-acetic acid is taken as a shell, and a pH-responsive core-shell super structure dendrimer is constructed by the self-assembly function of a supramolecule of host and guest molecules. When the prepared pH-responsive core-shell structure dendrimer is used as an anticancer drug carrier, the advantages of low toxicity, safety, high loading rate, intelligent release in tumor microenvironment and the like are achieved, and potential application prospects are achieved in aspects of chemotherapy and the like.

The invention belongs to the field of food antibacterial additives, and particularly relates to an intelligent release-type protein metal ion antibacterial nanoparticle and a preparation method thereof. The yarrow essential oil is wrapped in zein by adopting a nano precipitation method, the pH value of the solution is adjusted, so that the surface is negatively charged, and positively charged zincmetal ions are chelated through electrostatic interaction. The characteristics of bacterial metalloproteinase are utilized, the bacterial metalloproteinase is used as a biological switch, and when bacteria containing Zn<2+> metalloproteinase encounter chelated nanoparticles, the protease activity is activated, so that proteins on the surfaces of the nanoparticles are hydrolyzed, the wrapped yarrow essential oil is released, and the bacteria are killed. The novel antibacterial nanoparticle can effectively inhibit various bacteria such as escherichia coli O157:H7, staphylococcus aureus and Listeria monocytogenes, and can intelligently release an antibacterial agent.

The invention discloses a gemcitabine prodrug compound, a bionic nano medicament carrier and a preparation method of the carrier. The method comprises the following steps: allowing PEI to react with aprodrug chain segment with reductive response so as to obtain PEI with positive charges on the surface and partial-reacted amino, allowing the obtained PEI to react with a phosphorylcholine chain segment with an aldehyde group, putting the just-obtained PEI into a dialysis bag with MW of 3500, and performing dialyzing for 2 days to remove organic solvent and unreacted small molecules so as to finally obtain the bionic nano medicament carrier with pH/GSH multi-level response. The preparation method of the nano microcarrier is simple and novel. Compared with drug carriers reported in the priorart, in terms of the multi-level response, the phosphorylcholine hydrophilic chain bonded by the carrier is broken under the tumor sourish environment, the PEI with positive charges is exposed, the endocytosis of cells on prodrug molecules is promoted, a large amount of GSH in the cancer cells further decomposes disulfide bonds in the prodrug after the prodrug molecules enter the cancer cells, therelease of the drug is accurately controlled, and the effective release of the drug and the treatment of the tumor cells are realized.

The invention discloses a slow-release drug. The slow-release drug is prepared from a mesoporous silicon sphere, a drug, a guest molecule and a host molecule; the mesoporous silicon sphere has a mesopore, and the drug is loaded in the mesopore; the guest molecule is combined with the outer surface of the mesoporous silicon sphere; the host molecule is combined with the guest molecule through interaction between a host and a guest, at least partially blocks the opening of the mesopore, and can be separated from the mesoporous silicon sphere under the action of force. The invention also discloses a preparation method and application of the slow-release drug.

The invention relates to a pharmacosome hydrogel patch for GSH concentration responsive treatment of hyperthyroidism and a preparation method thereof. The patch comprises a polymer matrix, a methimazole pharmacosome and auxiliary materials. The methimazole pharmacosome hydrogel patch provided by the invention can be used for transdermal drug delivery through thyroid lesion sites, and the pharmacosome in the patch has good GSH responsiveness, and can respond to intracellular glutathione concentration stimulation and realize intelligent release of drugs.