Preparation method of pH-responsive organic-inorganic composite bone cement

An inorganic composite, bone cement technology, applied in medical science, tissue regeneration, prosthesis, etc., can solve the problem of pH-responsive drug release of expandable bone cement, to prevent drug resistance, good application prospects, and achieve The effect of smart release

Active Publication Date: 2021-08-20
XIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The purpose of the present invention is to provide a method for preparing a pH-responsive organic-inorganic composite bone cement, which solves the problem that the expandable bone cement in the prior art cannot perform pH-responsive drug release

Method used

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  • Preparation method of pH-responsive organic-inorganic composite bone cement

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Embodiment 1

[0038] Dissolve calcium chloride, potassium carbonate and gentamycin in deionized water respectively, stir evenly, pour the gentamicin solution and calcium chloride solution into the potassium carbonate solution, stir with magnetic force to react, and centrifuge the obtained product Obtain drug-loaded calcium carbonate nanoparticles; the mol ratio of calcium chloride to potassium carbonate is 0.8:1; the ratio of gentamicin to the total mass of calcium chloride and potassium carbonate is 1:40; the stirring speed is 800 rpm ; The reaction time is 10min. Disperse drug-loaded calcium carbonate nanoparticles in deionized water and ultrasonically homogenize drug-loaded calcium carbonate suspension; dissolve N,N'-methylenebisacrylamide in deionized water; dissolve azobisisobutyronitrile in In water and ethanol; add drug-loaded calcium carbonate suspension, dimethylaminoethyl methacrylate, N,N'-methylenebisacrylamide aqueous solution and azobisisobutyronitrile ethanol solution in the ...

Embodiment 2

[0040] Dissolve calcium chloride, potassium carbonate and neomycin in deionized water respectively, stir evenly, pour neomycin solution and calcium chloride solution into potassium carbonate solution, magnetically stir for reaction, and centrifuge the obtained product to obtain Drug calcium carbonate nanoparticles; the molar ratio of calcium chloride to potassium carbonate is 0.9:1; the ratio of neomycin to the total mass of calcium chloride and potassium carbonate is 1:45; the stirring speed is 1000 rpm; the reaction time for 20min. Disperse drug-loaded calcium carbonate nanoparticles in deionized water and ultrasonically homogenize drug-loaded calcium carbonate suspension; dissolve N,N'-methylenebisacrylamide in deionized water; dissolve azobisisobutyronitrile in In water and ethanol; add drug-loaded calcium carbonate suspension, dimethylaminoethyl methacrylate, N,N'-methylenebisacrylamide aqueous solution and azobisisobutyronitrile ethanol solution in the reaction vessel, 6...

Embodiment 3

[0042] Dissolve calcium chloride, potassium carbonate and vancomycin in deionized water respectively, stir evenly, pour vancomycin solution and calcium chloride solution into potassium carbonate solution, and react with magnetic stirring, and centrifuge the obtained product to obtain Drug calcium carbonate nanoparticles; the molar ratio of calcium chloride to potassium carbonate is 1:1; the ratio of vancomycin to the total mass of calcium chloride and potassium carbonate is 1:50; the stirring speed is 1200 rpm; the reaction time for 30min. Disperse drug-loaded calcium carbonate nanoparticles in deionized water and ultrasonically homogenize drug-loaded calcium carbonate suspension; dissolve N,N'-methylenebisacrylamide in deionized water; dissolve azobisisobutyronitrile in In water and ethanol; Add drug-loaded calcium carbonate suspension, dimethylaminoethyl methacrylate, N,N'-methylenebisacrylamide aqueous solution and azobisisobutyronitrile ethanol solution in the reaction ves...

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Abstract

The invention discloses a preparation method of pH-responsive organic-inorganic composite bone cement. The method comprises the following steps: reacting calcium ions with carbonate ions to generate pH-responsive calcium carbonate nanoparticles, and adding antibiotics in the preparation process to load the antibiotics in calcium carbonate; by taking drug-loaded calcium carbonate nanoparticles as a core, forming a poly (dimethylaminoethyl methacrylate) hydrogel shell layer on the surface of calcium carbonate, and then washing, freeze-drying and ball-milling to obtain pH response core-shell microspheres; and mixing the pH-responsive core-shell microspheres with polymethyl methacrylate and barium sulfate to obtain a pH-responsive organic-inorganic composite bone cement solid phase, mixing the pH-responsive organic-inorganic composite bone cement solid phase with a liquid phase, stirring, and curing to obtain the pH-responsive organic-inorganic composite bone cement. The problem that the expandable bone cement in the prior art cannot perform pH response drug release is solved.

Description

technical field [0001] The invention belongs to the technical field of preparation of biomedical materials, and relates to a preparation method of a pH-responsive organic-inorganic composite bone cement. Background technique [0002] Polymethylmethacrylate (PMMA) bone cement has been widely used in vertebroplasty and joint replacement due to its good histocompatibility and fast retentive mechanical strength. Aseptic loosening and postoperative infection caused by volume shrinkage are the main causes of prosthetic failure. Aiming at the problem of volume shrinkage, the current improvement methods are mainly: adding hydrophilic materials to PMMA bone cement to give it the ability to absorb water and expand. In order to reduce the risk of postoperative infection, antibiotic-loaded bone cement is widely used in the world. Bone cement with slow-release antibiotics has been widely studied internationally. The slow-release system of antibiotics improves the cumulative release rat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/16A61L27/02A61L27/54A61L27/50A61L27/56
CPCA61L27/16A61L27/025A61L27/54A61L27/50A61L27/56A61L2300/406A61L2300/602A61L2430/02A61L2300/41A61L2300/412A61L2300/102C08L33/12
Inventor 汤玉斐蒋吓树吴子祥张诗彤梁倩
Owner XIAN UNIV OF TECH
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