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Internal fixing device aiming at osteoporotic fracture treatment and preparation method thereof

A fixation device and osteoporosis technology, applied in the field of medical devices, can solve the problems of not being able to provide a stable environment for fracture healing, increase secondary fractures, accelerate bone mass, etc., achieve excellent biological functions, reduce burden, and promote fracture healing Effect

Pending Publication Date: 2018-01-09
SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to solve the shortcomings that the implants currently used for fracture fixation may accelerate bone loss, increase secondary fractures, fail to provide a stable environment for fracture healing, and require reoperation to remove implants. Mg–Nd–Zn– Zr alloy is used as the substrate of the internal plant, and zoledronic acid (zoledronic acid, C 5 h 10 N 2 o 7 P 2 ) coating to achieve fracture reduction and fixation while shortening the fracture healing time and improving the quality of fracture healing

Method used

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  • Internal fixing device aiming at osteoporotic fracture treatment and preparation method thereof
  • Internal fixing device aiming at osteoporotic fracture treatment and preparation method thereof
  • Internal fixing device aiming at osteoporotic fracture treatment and preparation method thereof

Examples

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Embodiment 1

[0032] Take 24 micrograms of zoledronate (purchased from Chia Tai Tianqing Pharmaceutical Group Co., Ltd.) and dissolve it (250 microliters) in polylactic acid solution to make a solution. The polylactic acid solution was formed by dissolving (600 mg) polylactic acid (purchased from Jinan Daigang Bioengineering Co., Ltd.) in a solvent (10 ml ethyl acetate).

[0033] Soak the magnesium alloy intramedullary nail processed into the required shape in zoledronate solution for 24 hours, take out the intramedullary nail, dry it, and irradiate it with ultraviolet light for 3-5 minutes.

[0034] Soak the intramedullary nail coated with zoledronate in supersaturated Ca(H 2 PO 4 ) 2 •H 2 O solution for 12 hours; the intramedullary nail was taken out, cleaned with deionized water, and dried under nitrogen environment to obtain an internal fixation device.

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Abstract

The invention discloses an internal fixing device aiming at osteoporotic fracture treatment and a preparation method thereof. The internal fixing device comprises an internal implant matrix, wherein the cross section of the internal implant matrix is in a round shape or a quasi-circular shape, the internal implant matrix comprises a tip portion, and a zoledronic acid coating layer and a calcium phosphate coating layer are sequentially arranged on the internal implant matrix from inside to outside. The internal fixing device provided by the invention utilizes magnesium alloy with an elasticitymodulus which is perfectly matched with bone of an osteoporosis patient as the internal implant matrix, zoledronic acid is loaded by the surface of the matrix, fracture reduction fixation is achieved,fracture healing time is shortened at the same time, and fracture healing quality is improved; the zoledronic acid coating layer is further covered by the calcium phosphate coating layer, so that notonly is a corrosion rate of the magnesium alloy matrix material effectively reduced, but also a slow release effect of loading medicine (the zoledronic acid) is further achieved; furthermore, the internal fixing device need not be taken out after operation, so that pain of the patient is reduced, and the application prospect is good.

Description

technical field [0001] The invention belongs to the field of medical devices, relates to a medical device, in particular to an internal fixation device for treating osteoporotic fractures and a preparation method thereof. Background technique [0002] Osteoporosis is a systemic skeletal disease characterized by reduced bone mass, destruction of bone microstructure, and significantly increased incidence of fractures. Reduction, immobilization, functional exercise and anti-osteoporosis are the basic principles in the treatment of osteoporotic fractures. Osteoporotic fractures are mostly comminuted fractures, difficult to reduce, maintain reduction and fixation, fracture healing, bed rest and fixation time are longer, and the incidence of refracture is high. [0003] The surgical treatment of osteoporotic fractures is based on the treatment of osteoporosis, the restoration and fixation of fractures, and the restoration of the function of the fracture site. Osteoporosis patien...

Claims

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Application Information

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IPC IPC(8): A61L31/12A61L31/02A61L31/14A61L31/16A61B17/72
Inventor 李国远郝永强王磊谢凯郭煜赵双贺超
Owner SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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