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Application of radix scrophulariae in preparing medicament for preventing and controlling myocardial hypertrophy, hypertrophic cardiomyopathy and chronic heart failure

A technology for chronic heart failure and hypertrophic cardiomyopathy, which is applied to drugs for hypertrophic cardiomyopathy and chronic heart failure. In the field of preparation and prevention of myocardial hypertrophy, the traditional Chinese medicine Scrophulariaceae achieves the effect of improving the quality of life and reducing the incidence rate

Inactive Publication Date: 2008-09-24
SHANGHAI UNIV OF T C M
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the prevention and treatment of ventricular remodeling, myocardial hypertrophy and chronic heart failure

Method used

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  • Application of radix scrophulariae in preparing medicament for preventing and controlling myocardial hypertrophy, hypertrophic cardiomyopathy and chronic heart failure
  • Application of radix scrophulariae in preparing medicament for preventing and controlling myocardial hypertrophy, hypertrophic cardiomyopathy and chronic heart failure
  • Application of radix scrophulariae in preparing medicament for preventing and controlling myocardial hypertrophy, hypertrophic cardiomyopathy and chronic heart failure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1 (observation of ventricle remodeling in mice induced by Scrophulariaceae anti-isoproterenol)

[0029] 20-22g mice were selected and randomly divided into 5 groups: normal control group, model group, metoprolol group and Scrophulariaceae high and low dose groups. Except for the normal control group, each group was subcutaneously injected with isoproterenol 2 mg / kg / d in the back for 7 consecutive days, once a day to create a model of myocardial hypertrophy. The mice in the normal group were subcutaneously injected with the same volume of normal saline on the back for 7 consecutive days. The treatment group was given 39g / (kg.d)×7d, 19.5g / (kg.d)×7d and metoprolol 60mg / (kg.d)× 7d; The normal group and the model group were given the same volume of normal saline by intragastric administration. After the last administration, no food or drink was allowed for 12 hours, and then blood and myocardium were collected for various analyses.

[0030] 1.1 Determination of my...

Embodiment 2

[0049] Example 2 (Observation on the effect of Radix Scrophulariae on anti-thyroxine-induced myocardial hypertrophy in rats)

[0050] Male SD rats of 220-250 g were randomly divided into 5 groups (11 rats in each group): normal control group, model group, captopril 40 mg / kg, high-dose group of Scrophulariae Scrophulariae (27 g / kg Scrophulariae) , Scrophulariaceae low dose group (13.5g / kg). Except for the normal control group, each group was intraperitoneally injected L-thyroxine 0.25 mg / kg / d for 7 consecutive days, once a day, to prepare a model of myocardial hypertrophy. The normal group was intraperitoneally injected with the same volume of normal saline for 7 consecutive days. Scrophulariaceae high-dose and low-dose groups were given L-thyroxine and 27g / kg and 13.5g / kg of Scrophulariaceae water decoction by intragastric administration for 9 days continuously; the normal group was given the same volume of normal saline by intragastric administration; The topril group was a...

Embodiment 3

[0064] Example 3 (Observation of Scrophulariae Scrophulariae Anti-abdominal Aortic Constriction-induced Ventricular Remodeling in Rats)

[0065] Rats were anesthetized by intraperitoneal injection of 3% pentobarbital sodium 0.1ml / 100g, fixed in the supine position, the abdominal cavity was opened, the abdominal aorta was bluntly separated, and the abdominal area between the left and right renal arteries was incompletely ligated with a silver clip with an inner diameter of 0.5mm. The outer diameter of the aorta was narrowed to 0.5 mm to prepare a pressure overload ventricular remodeling model. Animals in the sham operation group were only separated from the abdominal aorta without ligation. Intramuscular injection of penicillin 1×104U·kg-1·d-1 after operation for 3 days to prevent infection.

[0066]Two weeks after modeling, the rats in the operation group were randomly divided into 11 rats in each group. Administration once a day, 20ml / kg / d, continuous administration for 8 w...

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Abstract

The invention belongs to the traditional Chinese pharmaceutics field, and relates to an application of traditional Chinese medicine radix scrophulariae to the preparation of a drug for preventing and curing cardiac hypertrophy, hypertrophic cardiomyopathy and chronic heart failure. The invention researches the effect of the cardiac hypertrophy and ventricle reconstruction model of a plurality of mice and rats on the traditional Chinese medicine radix scrophulariae. The experimental results show that the radix scrophulariae water or the alcohol abstracts has evident function for preventing the cardiac hypertrophy, the ventricular remodeling and the chronic heart failure caused by various reasons, the mechanism is obviously related with the excessive activation of the neuroendocrine system such as a suppressing renin-angiotensin-aldosterone system and is related with the functions of blood pressure reduction, heart beat slowing and hemodynamics improvement. The figwort can be used for preparing the drug for preventing the diseases of cardiac hypertrophy, hypertrophic cardiomyopathy and chronic heart failure and for reducing the possibility of the incidence rate of arrhythmia and the sudden death of patients with cardiac hypertrophy, hypertrophic cardiomyopathy and chronic heart failure.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and relates to the use of Chinese medicine Scrophulariaceae in the preparation of drugs for preventing and treating ventricular remodeling. chronic heart failure) medicine. Background technique [0002] Chronic cardiac insufficiency, also known as congestive heart failure (CHF), is a clinical syndrome in which the pumping function of the heart is reduced due to various etiologies and cannot discharge enough blood to meet the metabolic needs of tissues and organs throughout the body. The fatality rate is high. [0003] In the past, the clinical treatment of CHF focused on the use of cardiac glycosides, inotropic drugs and diuretics. After the 1970s, CHF also advocated the use of new non-digital positive inotropic drugs, mainly phosphodiesterase inhibitors and β-receptor agonists. At present, the long-term basic treatment drugs for chronic heart failure include ① diuretics, ②...

Claims

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Application Information

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IPC IPC(8): A61K36/808A61P9/04A61P9/00
Inventor 陈长勋顾伟梁金若敏王樱
Owner SHANGHAI UNIV OF T C M
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