Application of radix scrophulariae in preparing medicament for preventing and controlling myocardial hypertrophy, hypertrophic cardiomyopathy and chronic heart failure

A technology for chronic heart failure and hypertrophic cardiomyopathy, which is applied to drugs for hypertrophic cardiomyopathy and chronic heart failure. In the field of preparation and prevention of myocardial hypertrophy, the traditional Chinese medicine Scrophulariaceae achieves the effect of improving the quality of life and reducing the incidence rate
CN101269151AInactive Publication Date: 2008-09-24SHANGHAI UNIV OF T C M
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANGHAI UNIV OF T C M
Publication Date
2008-09-24
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the traditional Chinese pharmaceutics field, and relates to an application of traditional Chinese medicine radix scrophulariae to the preparation of a drug for preventing and curing cardiac hypertrophy, hypertrophic cardiomyopathy and chronic heart failure. The invention researches the effect of the cardiac hypertrophy and ventricle reconstruction model of a plurality of mice and rats on the traditional Chinese medicine radix scrophulariae. The experimental results show that the radix scrophulariae water or the alcohol abstracts has evident function for preventing the cardiac hypertrophy, the ventricular remodeling and the chronic heart failure caused by various reasons, the mechanism is obviously related with the excessive activation of the neuroendocrine system such as a suppressing renin-angiotensin-aldosterone system and is related with the functions of blood pressure reduction, heart beat slowing and hemodynamics improvement. The figwort can be used for preparing the drug for preventing the diseases of cardiac hypertrophy, hypertrophic cardiomyopathy and chronic heart failure and for reducing the possibility of the incidence rate of arrhythmia and the sudden death of patients with cardiac hypertrophy, hypertrophic cardiomyopathy and chronic heart failure.
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Description

technical field

[0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and relates to the use of Chinese medicine Scrophulariaceae in the preparation of drugs for preventing and treating ventricular remodeling. chronic heart failure) medicine. Background technique

[0002] Chronic cardiac insufficiency, also known as congestive heart failure (CHF), is a clinical syndrome in which the pumping function of the heart is reduced due to various etiologies and cannot discharge enough blood to meet the metabolic needs of tissues and organs throughout the body. The fatality rate is high.

[0003] In the past, the clinical treatment of CHF focused on the use of cardiac glycosides, inotropic drugs and diuretics. After the 1970s, CHF also advocated the use of new non-digital positive inotropic drugs, mainly phosphodiesterase inhibitors and β-receptor agonists. At present, the long-term basic treatment drugs for chronic heart failure include ① diuretics, ②...

Claims

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