30results about How to "High clinical promotion value" patented technology

The invention discloses a DTC prognosis marker and application thereof, and a construction method of a DTC prognosis evaluation model, and belongs to the technical field of cancer prognosis evaluation. The prognosis condition of a DTC patient can be predicted by detecting the expression quantity of the glycolysis-related genes, so that the reagent for detecting the expression quantity of the glycolysis-related genes can be used for preparing a reagent or a kit for predicting DTC prognosis, and the glycolysis-related genes comprise ADM, CD44, MKI67 and TYMS. The invention also provides a method for screening the glycolysis-related gene, and a DTC prognosis evaluation system is constructed based on the glycolysis-related gene, so that prognosis risk layering of patients with differentiated thyroid cancer is realized, patients with high and low risks are obviously separated, and clinical results of differentiated thyroid cancer can be predicted. The method can guide individualized treatment and has high clinical application value.

An application of pepperweed seed in preparing the medicines for preventing and treating myocardial hypertrophy and / or ventricular hypertrophy, and in turn preventing heart failure, arrhythmia and sudden death is disclosed.

The invention discloses an ointment for treating rotavirus enteritis, which is prepared from the following raw materials: 10-15g of Huoxiang, 12-18g of Cangzhu, 10-15g of Tangerine Peel, 10-15g of Amomum, and 28-32g of Poria , Magnolia officinalis 12 ~ 18g, big belly skin 12 ~ 18g, grain buds 22 ~ 26g, coix seed 28 ~ 32g, myrobalan meat 12 ~ 18g. The invention also provides its preparation method. The ointment of the present invention is pasted on Shenque, spleen acupoints and stomach acupoints after being heated, so that the medicine can exert therapeutic effect through direct subcutaneous absorption and indirect stimulation to stimulate meridian qi at the acupoints. After treatment, children with abdominal pain and diarrhea, nausea and vomiting, loss of appetite, abdominal fullness, fatigue and fatigue are significantly better than oral montmorillonite powder, and are significantly better than Ding Guier umbilical patch in terms of comprehensive curative effect, syndrome curative effect, and RV negative conversion rate. . The ointment of the invention has remarkable curative effect, convenient use, good safety, low price and simple medicine, and has high clinical popularization value.

The invention discloses an ointment for treating rotavirus enteritis. The ointment is prepared from the following raw material medicines: 10-15g of agastache rugosus, 12-18g of rhizoma atractylodis, 10-15g of pericarpium citri reticulatae, 10-15g of fructus amomi, 28-32g of poria cocos, 12-18g of cortex magnoliae officinalis, 12-18g of pericarpium arecae, 22-26g of rice sprouts, 28-32g of coix seeds and 12-18 g of myrobalan pulp. The invention also provides a preparation method of the ointment. The ointment disclosed by the invention is applied to the Shenque acupoint, the spleen acupoint andthe stomach acupoint after being heated, so that the ointment plays a role in treatment through direct subcutaneous absorption and indirect stimulation to stimulate meridian Qi of the acupoints. Aftertreatment, abdominal pain, diarrhea, nausea, vomiting, inappetence, abdominal distension, tiredness, fatigue and the like of a sick child are obviously superior to those of oral montmorillonite powder, and are obviously superior to those of a Dingguier navel patch in the aspects of comprehensive curative effect, syndrome curative effect, RV negative conversion rate and the like. The ointment is remarkable in curative effect, convenient to use, good in safety, low in price, simple in medicine and high in clinical popularization value.

The invention discloses an auxiliary circumcision device for circumcision at the root of the penis. The front pressing piece, the rear pressing piece, the guide nail piece and the thrust assembly all adopt a semi-ring structure. The ends pass through the thrust assembly, the guide nail piece, the rear pressure piece and the front pressure piece in turn; the two clamping arms are connected by a guide rod assembly, which includes an outer tube and a push rod that is movably installed in the outer tube. There is a chute in lateral symmetry, and the two sides of the push rod are respectively hinged with the inner sides of the two clamping arms through the movable assembly. The movable assembly includes a connecting rod and a mounting piece. The push rod is welded, and the spring assembly is sleeved on the push rod. The present invention can overcome the disadvantages of traditional penile root circumcision surgery, reduce the difficulty of penile root circumcision surgery, realize the idealized effect of "minimum scar + minimum impact on penile function" in penile circumcision surgery, and finally achieve precise excision and improve medical treatment. purpose of quality.

The invention relates to a medical facility, and discloses an internal medicine examination bed. A protective pad is laid on a bed body, the protective pad is composed of a plurality of layers of isolation films stacked in sequence, a film uncovering recovery assembly is arranged on the outside of the bed body, the film uncovering recovery assembly includes a recovery box and a film uncovering mechanism, and a box opening is formed in the upper end of the recovery box; the film uncovering mechanism includes a support seat, a swing arm, a suction cup, a reset device, and a vent valve; the filmuncovering mechanism can adsorb a corner of the isolation film on the uppermost layer and gradually lift up, gradually uncover, and finally strip off the isolation film, and finally the separated isolation film falls into the recovery box. According to the internal medicine examination bed, a delicate structural design and scientific protection mechanism are adopted, in clinical use, each patientcan use a separate layer of isolation film, the uncovering and recovery of the isolation film is completed with the help of the film uncovering recovery assembly, the possibility of cross-infection caused by the internal medicine examination bed is greatly decreased, using is convenient and quick, the medical efficiency is guaranteed, the production cost of the internal medicine examination bed islow, and the internal medicine examination bed has great clinical promotion value.

The invention belongs to the traditional Chinese pharmaceutics field, and relates to an application of traditional Chinese medicine radix scrophulariae to the preparation of a drug for preventing and curing cardiac hypertrophy, hypertrophic cardiomyopathy and chronic heart failure. The invention researches the effect of the cardiac hypertrophy and ventricle reconstruction model of a plurality of mice and rats on the traditional Chinese medicine radix scrophulariae. The experimental results show that the radix scrophulariae water or the alcohol abstracts has evident function for preventing thecardiac hypertrophy, the ventricular remodeling and the chronic heart failure caused by various reasons, the mechanism is obviously related with the excessive activation of the neuroendocrine system such as a suppressing renin-angiotensin-aldosterone system and is related with the functions of blood pressure reduction, heart beat slowing and hemodynamics improvement. The figwort can be used for preparing the drug for preventing the diseases of cardiac hypertrophy, hypertrophic cardiomyopathy and chronic heart failure and for reducing the possibility of the incidence rate of arrhythmia and the sudden death of patients with cardiac hypertrophy, hypertrophic cardiomyopathy and chronic heart failure.

The invention relates to a gene chip, and discloses an integrated detection gene chip of an mtDNA mutation site related to Leber genetic optic neuropathy, as well as the preparation and the application thereof. A specific oligonucleotide detecting probe of the mtDNA mutational site related to the Leber genetic optic neuropathy and a specific oligonucleotide detecting probe of a mononucleotide polymorphyism site mtDNA 11719G>A are fixed on the carrier surface lattice of the gene chip. The gene chip has the advantages of time saving, low cost, simple operation and the like, has 32 mutation sites related to the Leber genetic optic neuropathy in a specific detecting clinical sample only through one-time PCR amplification and one-time crossing reaction, and is suitable for the gene diagnosis of the Leber genetic optic neuropathy.

The present invention provides a polypeptide compound with HER2 targeting function, which is composed of a HER2 affinity body and a bifunctional chelating agent connected through a polypeptide sequence; the polypeptide sequence is Met-Val-Lys; the polypeptide compound has a general structure The formula is shown in the following formula (I), wherein, R is a HER2 affinity body molecule, and X is a bifunctional chelating agent group. The present invention also provides a HER2-targeted radiolabeled complex using the polypeptide compound as a ligand. The radiolabeled complexes of the present invention can be used as radioactive diagnostic probes for the evaluation of HER2 receptors in breast cancer. The probes can reduce kidney accumulation while keeping tumor uptake unchanged, thereby improving tumor target and HER2 receptors. Non-target ratio, while reducing the radiation dose to the kidney. The present invention also provides the preparation method of the polypeptide compound and radiolabeled complex, and its application in the preparation of HER2-positive breast cancer radiodiagnostic and therapeutic probes for humans or animals.

The invention discloses an injury control external fixator, comprising a proximal fixing plate, a distal fixing plate, a plurality of connection rods and a plurality of clamps. The proximal fixing plate and the distal fixing plate are provided respectively with a plurality of screw holes having an internal thread, and grooves for fitting the connection rods; each clamp includes an upper clamping portion and a lower clamping portion; the clamps enable the connection rods on the proximal fixing plate and the distal fixing plate to be jointly fixed to a point. The injury control external fixatorhas the advantages that higher structural rigidity is gained via the use of single-side long-span structure, surgical fixation is simple to perform, a limb with severe injury can be quickly stabilized, and hemorrhage and secondary injury can be lessened; screws are mounted on the fixator far away from the injured part, so that iatrogenic injury and infection risk of soft tissues due to traditionalscrew holes can be avoided; the fixator is well compatible with steel plates, intramedullary nails and otherness in terms of internal fixation and is highly worthy of clinical popularization.

A Chinese medicine in the form of pill for making eye muscle stronger, nourishing liver, preventing the retrograde lesion of eye, improving vision, etc is prepared from 36 Chinese-medicinal materials including pilose asiabell root, rehmannia root, Chinese angelica root, yam, etc.

The invention belongs to the field of traditional Chinese medicine and particularly relates to traditional Chinese medicine liniment for treating stage 2 and stage 3 bedsores in clinical nursing. The traditional Chinese medicine liniment is prepared by yellow angledtwig magnoliavine root stem and leaf, herba violae acuminatae, all-grass of Nippon Cinquefoil, serrate clubmoss herb, serrate rabdosia herb, radix lithospermi, radix polygoni cuspidati and Chinese ilex leaf according to a certain weight proportion. The traditional Chinese medicine liniment has effects of promoting blood circulation to remove blood stasis, clearing away heat and toxic materials, relieving swelling and pain, resisting bacteria and diminishing inflammation and eliminating necrotic tissues and promoting granulation, can firmly adhere to an affected part, can isolate bacterial and benefit wound surface cleaning through self-dissolution, can directly reach lesions through absorption by skin soft tissues, can produce relatively advantaged medicine concentration locally, does not stick to the skin, and is easy to remove, free of secondary damage, good in breathability, convenient to use and worthy of clinical popularization.