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Ointment for treating rotavirus enteritis and preparation method thereof

A technology of viral enteritis and ointment, which is applied in the field of ointment and preparation for the treatment of rotavirus enteritis, can solve the problems of unpalatable medicine, poor patient compliance, and inconvenient carrying of traditional Chinese medicine, achieving high clinical promotion value, good safety, Ease of use

Active Publication Date: 2021-08-27
THE AFFILIATED HOSPITAL OF SHANDONG UNIV OF TCM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A variety of traditional Chinese medicines and compound prescriptions can play an antiviral and antidiarrheal role through anti-RV, anti-inflammatory and antibacterial, improving immunity, and regulating gastrointestinal motility. However, the specific mechanism of action is still insufficiently explained, and basic research is relatively weak; , Difficulty in decocting and brewing, unpalatable medicine, difficult quality / cost control, poor patient compliance, etc.

Method used

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  • Ointment for treating rotavirus enteritis and preparation method thereof
  • Ointment for treating rotavirus enteritis and preparation method thereof
  • Ointment for treating rotavirus enteritis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1: prepare the ointment for the treatment of rotavirus enteritis

[0031] The prescription is: Huoxiang 12g, Atractylodes 15g, Chenpi 12g, Amomum 12g, Poria cocos 30g, Magnolia officinalis 15g, Dabupi 15g, Guya 24g, Coix seed 30g, Myrobalan meat 15g.

[0032] Proceed as follows:

[0033] (1) Take Huoxiang, Atractylodes atractylodes, Tangerine Peel and Amomum, add 8 times the amount of 50% ethanol solution, heat and reflux for extraction twice, each time for 1 hour, combine the extracts, filter, and recover the ethanol under reduced pressure at 50-60°C from the filtrate , concentrated into a thick paste (water content 18%, every 1g is equivalent to 4g of the original medicinal material);

[0034]Take Poria cocos, Magnolia officinalis officinale, Dabupi and Guya, add 8 times the amount of 80% ethanol solution, heat and reflux for extraction twice, each time for 1.5 hours, combine the extracts, filter, and recover the ethanol under reduced pressure at 50-60°C f...

Embodiment 2

[0039] Embodiment 2: prepare the ointment for the treatment of rotavirus enteritis

[0040] The prescription is: Huoxiang 10g, Atractylodes 12g, Chenpi 10g, Amomum 10g, Poria cocos 28g, Magnolia officinalis 12g, Dabupi 12g, Guya 22g, Coix seed 28g, Myrobalan meat 12g.

[0041] Proceed as follows:

[0042] (1) Take Huoxiang, Atractylodes atractylodes, Tangerine Peel and Amomum, add 8 times the amount of 50% ethanol solution, heat and reflux for extraction twice, each time for 1 hour, combine the extracts, filter, and recover the ethanol under reduced pressure at 50-60°C from the filtrate , concentrated into a thick paste;

[0043] Take Poria cocos, Magnolia officinalis officinale, Dabupi and Guya, add 8 times the amount of 80% ethanol solution, heat and reflux for extraction twice, each time for 1.5 hours, combine the extracts, filter, and recover the ethanol under reduced pressure at 50-60°C from the filtrate. concentrated into a thick paste;

[0044] Take coix seed and che...

Embodiment 3

[0048] Embodiment 3: prepare the ointment for the treatment of rotavirus enteritis

[0049] The prescription is: Huoxiang 15g, Atractylodes 18g, Chenpi 15g, Amomum 15g, Poria cocos 32g, Magnolia officinalis 18g, Dabupi 18g, Guya 26g, Coix seed 32g, Myrobalan meat 18g.

[0050] Proceed as follows:

[0051] (1) Take Huoxiang, Atractylodes atractylodes, Tangerine Peel and Amomum, add 8 times the amount of 50% ethanol solution, heat and reflux for extraction twice, each time for 1 hour, combine the extracts, filter, and recover the ethanol under reduced pressure at 50-60°C from the filtrate , concentrated into a thick paste;

[0052] Take Poria cocos, Magnolia officinalis officinale, Dabupi and Guya, add 8 times the amount of 80% ethanol solution, heat and reflux for extraction twice, each time for 1.5 hours, combine the extracts, filter, and recover the ethanol under reduced pressure at 50-60°C from the filtrate. concentrated into a thick paste;

[0053] Take coix seed and che...

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Abstract

The invention discloses an ointment for treating rotavirus enteritis, which is prepared from the following raw materials: 10-15g of Huoxiang, 12-18g of Cangzhu, 10-15g of Tangerine Peel, 10-15g of Amomum, and 28-32g of Poria , Magnolia officinalis 12 ~ 18g, big belly skin 12 ~ 18g, grain buds 22 ~ 26g, coix seed 28 ~ 32g, myrobalan meat 12 ~ 18g. The invention also provides its preparation method. The ointment of the present invention is pasted on Shenque, spleen acupoints and stomach acupoints after being heated, so that the medicine can exert therapeutic effect through direct subcutaneous absorption and indirect stimulation to stimulate meridian qi at the acupoints. After treatment, children with abdominal pain and diarrhea, nausea and vomiting, loss of appetite, abdominal fullness, fatigue and fatigue are significantly better than oral montmorillonite powder, and are significantly better than Ding Guier umbilical patch in terms of comprehensive curative effect, syndrome curative effect, and RV negative conversion rate. . The ointment of the invention has remarkable curative effect, convenient use, good safety, low price and simple medicine, and has high clinical popularization value.

Description

technical field [0001] The invention relates to an ointment for treating rotavirus enteritis and a preparation method thereof, belonging to the technical field of traditional Chinese medicine preparations. Background technique [0002] Rotavirus enteritis (RVE) is an acute intestinal infectious disease caused by infection with rotavirus (RV), ranking first among children with diarrhea. People in different regions are generally susceptible, and improving the standard of living hygiene cannot reduce the infection rate and morbidity rate. In sub-Saharan Africa and Asia, 500,000 to 600,000 infants die each year. The direct / indirect medical costs of preventing and treating such diseases in Europe and the United States are as high as several billion U.S. dollars. From 2010 to 2014, the average positive detection rate of RV in outpatients in many regions of my country was 12.9%. [0003] In recent years, although Western medicine has made a lot of progress in clinical and basic ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9064A61K9/70A61P1/12A61P31/14
CPCA61K9/7061A61K36/076A61K36/185A61K36/284A61K36/532A61K36/575A61K36/752A61K36/889A61K36/899A61K36/8994A61K36/9064A61K2236/331A61K2236/333A61K2236/39A61P1/12A61P31/14A61K2300/00
Inventor 王伟陈翰翰王佑辉王晓妍胡冬青陈婷
Owner THE AFFILIATED HOSPITAL OF SHANDONG UNIV OF TCM
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