Application of radix scrophulariae in preparing medicament for preventing and controlling myocardial hypertrophy, hypertrophic cardiomyopathy and chronic heart failure

Abstract

The invention belongs to the traditional Chinese pharmaceutics field, and relates to an application of traditional Chinese medicine radix scrophulariae to the preparation of a drug for preventing and curing cardiac hypertrophy, hypertrophic cardiomyopathy and chronic heart failure. The invention researches the effect of the cardiac hypertrophy and ventricle reconstruction model of a plurality of mice and rats on the traditional Chinese medicine radix scrophulariae. The experimental results show that the radix scrophulariae water or the alcohol abstracts has evident function for preventing thecardiac hypertrophy, the ventricular remodeling and the chronic heart failure caused by various reasons, the mechanism is obviously related with the excessive activation of the neuroendocrine system such as a suppressing renin-angiotensin-aldosterone system and is related with the functions of blood pressure reduction, heart beat slowing and hemodynamics improvement. The figwort can be used for preparing the drug for preventing the diseases of cardiac hypertrophy, hypertrophic cardiomyopathy and chronic heart failure and for reducing the possibility of the incidence rate of arrhythmia and the sudden death of patients with cardiac hypertrophy, hypertrophic cardiomyopathy and chronic heart failure.

Description

Application of Radix Scrophulariae in Preparation of Medicines for Prevention and Treatment of Myocardial Hypertrophy, Hypertrophic Cardiomyopathy and Chronic Heart Failure technical field The invention belongs to the field of traditional Chinese medicine pharmacy, and relates to the use of traditional Chinese medicine Scrophulariaceae in the preparation of medicines for preventing and treating ventricular remodeling, in particular to the use of Chinese medicine Scrophulariaceae in the preparation and prevention of myocardial hypertrophy, hypertrophic cardiomyopathy and chronic heart failure. Uses in medicine. Background technique Chronic cardiac insufficiency, also known as congestive heart failure (CHF), is a clinical syndrome in which the heart pumping function is reduced due to various etiologies and cannot discharge enough blood to meet the metabolic needs of tissues and organs throughout the body. very high. In the past, the clinical treatment of CHF focused on the...

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Problems solved by technology

However, there is no report on the prevention and treatment of ventricular remodeling, myocardial hypertrophy and chronic heart failure

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