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DTC prognosis marker and application thereof, and construction method of DTC prognosis evaluation model

A construction method and biomarker technology, applied in the construction of DTC prognostic evaluation model, DTC prognostic markers and their application fields, can solve the problems of model design not included, achieve high clinical promotion value, high clinical application value, solve The effect of difficult sample collection

Pending Publication Date: 2022-04-01
XIANGYA HOSPITAL CENT SOUTH UNIV
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Problems solved by technology

However, the model design did not incorporate clinical information, and it is necessary to find a more reasonable mRNA construction model that facilitates changes in clinical stages

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  • DTC prognosis marker and application thereof, and construction method of DTC prognosis evaluation model
  • DTC prognosis marker and application thereof, and construction method of DTC prognosis evaluation model
  • DTC prognosis marker and application thereof, and construction method of DTC prognosis evaluation model

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Embodiment Construction

[0022] In order to make the technical problems, technical solutions and advantages to be solved by the present invention clearer, the following will describe in detail in conjunction with specific embodiments.

[0023] The construction of the DTC recurrence risk assessment system specifically includes the following steps:

[0024] 1) Retrieve data and process RNA-seq data: Confirm and download RNA-seq data of tissue samples from 183 THCA cohort patients from the TCGA public database (The Cancer Genome Atlas, https: / / portal.gdc.cancer.gov / ); Confirm and download the expression profile of GSE28735 containing thyroid cancer-related tissue and normal tissue information from the GEO public database (Gene Expression Omnibus, https: / / www.ncbi.nlm.nih.gov / geo / ), which contains 45 Tumor samples and 45 normal thyroid tissues;

[0025] 2) Define the set of oncogenic glycolysis differential genes: search on the GeneCard website (http: / / www.genecards.org / ) with the keyword "glycolysis", a...

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Abstract

The invention discloses a DTC prognosis marker and application thereof, and a construction method of a DTC prognosis evaluation model, and belongs to the technical field of cancer prognosis evaluation. The prognosis condition of a DTC patient can be predicted by detecting the expression quantity of the glycolysis-related genes, so that the reagent for detecting the expression quantity of the glycolysis-related genes can be used for preparing a reagent or a kit for predicting DTC prognosis, and the glycolysis-related genes comprise ADM, CD44, MKI67 and TYMS. The invention also provides a method for screening the glycolysis-related gene, and a DTC prognosis evaluation system is constructed based on the glycolysis-related gene, so that prognosis risk layering of patients with differentiated thyroid cancer is realized, patients with high and low risks are obviously separated, and clinical results of differentiated thyroid cancer can be predicted. The method can guide individualized treatment and has high clinical application value.

Description

technical field [0001] The invention belongs to the technical field of cancer prognosis assessment, and in particular relates to a DTC prognosis marker and its application, and a method for constructing a DTC prognosis assessment model. Background technique [0002] Thyroid cancer is one of the most common malignant tumors in the endocrine system. The incidence rate in my country is increasing year by year, and new cases each year account for 5% to 7% of all malignant tumors. Differentiated thyroid cancer is a less malignant type of thyroid cancer, but due to the lack of serological indicators with high sensitivity and specificity, it is easy to be missed and misdiagnosed in the early stage of the disease. Surgical resection combined with 131 radioactive particle therapy is currently the main treatment for thyroid cancer; however, related studies have shown that 20% to 30% of patients with differentiated thyroid cancer may develop lymph node metastasis or distant metastasis ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16B25/10G16B20/00G16B40/20G16B45/00G16B50/30G16B15/30G16H50/30G16H10/20
Inventor 黄鹏常实吴敏谭海龙欧阳登洁刘绵陈佩赵鑫雅魏波
Owner XIANGYA HOSPITAL CENT SOUTH UNIV
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