Use of pepperweed seed in preparation of medicine for preventing and treating myocardial hypertrophia or/and ventricular hypertrophy

A technology for cardiac hypertrophy and ventricular hypertrophy, which is applied in the directions of drug combination, pharmaceutical formula, plant raw materials, etc., to reduce the incidence and improve the quality of life.

Inactive Publication Date: 2010-06-16
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report that Tinglizi, a traditional Chinese medicine, has the effect of preventing and treating myocardial hypertrophy and ventricular hypertrophy.

Method used

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  • Use of pepperweed seed in preparation of medicine for preventing and treating myocardial hypertrophia or/and ventricular hypertrophy
  • Use of pepperweed seed in preparation of medicine for preventing and treating myocardial hypertrophia or/and ventricular hypertrophy
  • Use of pepperweed seed in preparation of medicine for preventing and treating myocardial hypertrophia or/and ventricular hypertrophy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020]Tinglizi anti-isoproterenol-induced ventricular hypertrophy in mice

[0021] Experimental animals: Kunming mice, weighing 20-22 g; purchased from the Shanghai Experimental Animal Center of the Chinese Academy of Sciences, certificate number SCXK (Shanghai) 2002-0010, and bred in the SPF laboratory of the Experimental Animal Center of Shanghai University of Traditional Chinese Medicine.

[0022] Drugs and reagents: Tinglizi (batch number: 050102-5) was purchased from Shanghai Yanghetang Chinese Herbal Pieces Co., Ltd. (identified by the Pharmacy Teaching and Research Office of Shanghai University of Traditional Chinese Medicine, the species is correct, and it is DescurainiaSophia (L.) Webb ex prantl Dried mature seeds, commonly known as "Nan Tinglizi"); isoprenaline hydrochloride injection (isoprenaline hydrochloride injection), product of Shanghai Hefeng Pharmaceutical Co., Ltd., batch number: 5E20007; metoprolol tartrate tablets, AstraZeneca Pharmaceuticals Limited prod...

Embodiment 2

[0044] Anti-L-Thyroxine Sodium Induced Ventricular Hypertrophy in Rats

[0045] Experimental animals: SD rats, male, weighing 220-250 g, purchased from the Shanghai Experimental Animal Center of the Chinese Academy of Sciences, certificate number SCXK (Shanghai) 2002-0010, and raised in the SPF animal laboratory of the Experimental Animal Center of Shanghai University of Traditional Chinese Medicine.

[0046] Drugs and reagents: Tinglizi (batch number: 050102-5) was purchased from Shanghai Yanghetang Chinese Herbal Pieces Co., Ltd. (identified by the Pharmacy Teaching and Research Office of Shanghai University of Traditional Chinese Medicine, the species is correct, and it is DescurainiaSophia (L.) Webb ex prantl Dried mature seeds, commonly known as "Southern Tinglizi".); L-thyroxine sodium (L-Thy), product of Sigma Company, lot number: WA1331; Captopril (Captopril), product of Shanghai Hengshan Pharmaceutical Co., Ltd., lot number : 050102; angiotensin II (Ang II) kit, batch...

Embodiment 3

[0072] Acute Toxicity Test

[0073] The purpose of the experiment: To explore the possible toxic reaction and its severity of Tinglizi administered with a large dose at one time, so as to make a reasonable evaluation of the safety of the drug.

[0074] Preparation of the test drug: Take 200 g of Tinglizi, decoct 3 times with 8 times the amount of water, boil for 30 minutes each time, and concentrate the combined filtrate to 12 g / ml for later use.

[0075] Animals: 20 Kunming mice, weighing 18-22g, half male and half male, purchased from Shanghai Experimental Animal Center of Chinese Academy of Sciences, certificate number SCXK (Shanghai) 2002-0010, bred in SPF level experiment of Experimental Animal Center of Shanghai University of Traditional Chinese Medicine room.

[0076] Experimental methods and results: fasting (without water) for 12 hours before administration. Each animal was orally administered 0.4 ml / 10 g body weight of the above-mentioned Tinglizi concentrate. Aft...

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Abstract

An application of pepperweed seed in preparing the medicines for preventing and treating myocardial hypertrophy and / or ventricular hypertrophy, and in turn preventing heart failure, arrhythmia and sudden death is disclosed.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and relates to the use of the traditional Chinese medicine Tinglizi in the preparation of medicines for preventing and treating ventricular remodeling, in particular to the use of the traditional Chinese medicine Tinglizi in the preparation of medicines for preventing and treating myocardial hypertrophy and / or ventricular hypertrophy. use. Background technique [0002] Chronic cardiac insufficiency, also known as congestive heart failure (CHF), is a clinical syndrome in which the pumping function of the heart is reduced due to various etiologies and cannot discharge enough blood to meet the metabolic needs of tissues and organs throughout the body. The fatality rate is high. [0003] In the past, the clinical treatment of CHF focused on the use of cardiac glycosides, inotropic drugs and diuretics. After the 1970s, CHF also advocated the use of new non-digital positive inotro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61P9/06A61P9/00A61K36/31A61P9/04A61K131/00
Inventor 陈长勋郭娟金若敏沈云辉
Owner SHANGHAI UNIV OF T C M
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