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Antibacterial restorative functional dressing and preparation method thereof

A functional and bacterial cellulose technology, applied in the field of biomedical materials, can solve the selection defects of collagen types, functions and molecular weight refinement of functional materials, fail to obtain ideal composite multifunctional medical dressings, fail to form composite Multi-functional medical dressings and other problems, to achieve the effect of reducing pigmentation, promoting wound healing, and promoting wound healing

Active Publication Date: 2017-06-09
北京福庆堂医药有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The purpose of the present invention is to provide a novel antibacterial and repairing functional dressing, which is used to solve the problem that the existing dressing product has a single function and cannot form a composite multifunctional medical dressing; the type, function and Defects in the selection of molecular weight refinement; the problem of high endotoxin in the bacterial cellulose membrane purification step; solving the technical problem that the prior art fails to obtain an ideal composite multifunctional medical dressing

Method used

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  • Antibacterial restorative functional dressing and preparation method thereof
  • Antibacterial restorative functional dressing and preparation method thereof
  • Antibacterial restorative functional dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] This example provides an antibacterial and repairing functional dressing, preparation requirements: specification: 5cm×5cm; quantity: 100 pieces

[0053] Preparation steps:

[0054] Step 1: Purification of bacterial cellulose membrane: select 10 large pieces of fresh bacterial cellulose membrane, put them in a beaker and wash them three times with distilled water, squeeze about 70% of the water each time, remove the impurities on the surface of the bacterial cellulose membrane, and set aside. Prepare 6L of 1mol / L NaOH solution, pour the above solution into a beaker equipped with a bacterial cellulose membrane, start heating and keep stirring. Control the temperature at 95°C and time it for 2 hours.

[0055] After the completion, rinse the bacterial cellulose membrane with distilled water repeatedly until the pH is between 5 and 7, and pass ozone for 1 hour, and the ozone concentration is 1.5mg / L; after the ozone is passed, stir for 2 hours, After passing the test, squ...

Embodiment 2

[0064] This example provides an antibacterial and repairing functional dressing, preparation requirements: specification: 10cm×15cm; quantity: 100 pieces

[0065] Preparation steps:

[0066] Step 1: Purification of bacterial cellulose membrane: select 25 large pieces of fresh bacterial cellulose membrane, put them in a stainless steel bucket and wash them three times with purified water, squeeze about 70% of the water each time, remove the impurities on the surface of the bacterial cellulose membrane, and set aside. Prepare 12L of 2mol / L KOH solution, pour the above solution into a stainless steel bucket equipped with a bacterial cellulose membrane, start heating and keep stirring. Control the temperature at 70°C and count for 24 hours.

[0067] After the completion, rinse the bacterial cellulose membrane with purified water repeatedly until the pH is between 5 and 7, and pass ozone for 2 hours, and the ozone concentration is 0.5mg / L; after the ozone is passed, stir and count...

Embodiment 3

[0073] This example provides an antibacterial and repairing functional dressing, preparation requirements: specification: 10cm×20cm; quantity: 60 pieces

[0074] Preparation steps:

[0075] Step 1: Purification of bacterial cellulose membrane: select 20 large pieces of fresh bacterial cellulose membrane, put them in a beaker and wash them three times with distilled water, squeeze about 70% of the water each time, remove the impurities on the surface of the bacterial cellulose membrane, and set aside. Prepare 10L of 2mol / L NaOH solution, pour the above solution into a beaker equipped with a bacterial cellulose membrane, start heating and keep stirring. Control the temperature at 50°C and count for 36 hours.

[0076] After the completion, rinse the bacterial cellulose membrane with distilled water repeatedly until the pH is between 5 and 7, and pass ozone for 2.5 hours, and the ozone concentration is 1.0 mg / L; after the ozone is passed, stir for 2 hours, After passing the test...

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Abstract

The invention relates to novel antibacterial restorative functional dressing and a preparation method thereof. The novel antibacterial restorative functional dressing is formed by crosslinking and compounding chitosan and collagen on a bacterial cellulose membrane through a cross-linking agent, wherein a mass ratio of the chitosan to the bacterial cellulose membrane is (0.001-5) to 100; a mass ratio of collagen to the bacterial cellulose membrane is (0.5-20) to 100; a mass ratio of the chitosan to the collagen is (0.001-5) to (20-0.5); and the collagen is a mixture of collagen with small molecular weight and collagen with large molecular weight according to a ratio of 1 to 1. The antibacterial restorative functional dressing has very good biocompatibility, cellular affinity and mechanical property, has excellent water-permeable, gas-permeable or drainage and moisture absorption effect, has the effects of realizing antisepsis and anti-inflammation, reducing wound infection and quickly relieving pain of the wound, and has the effects of relieving chromatosis and promoting the wound to heal during a wound healing period. Meanwhile, the dressing can naturally drop along with epithelial regeneration, so that the treatment time and cost is reduced, and the wound infection probability is reduced.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to an antibacterial repair functional dressing and a preparation method thereof. Background technique [0002] With the rapid development of modern science and technology, the research on medical dressings has achieved rapid development. Various new types of medical dressings continue to appear, and their performance is getting better and better. However, medical dressings are a type of clinical medical supplies that temporarily cover wounds such as burns, ulcers, and wounds. It has the function of promoting the recovery of wound skin function. my country's medical dressing industry is mainly based on low-end and mid-range products. Most enterprises are small in scale, have little investment in research and development, and have weak product technology capabilities. As a result, they lack competitiveness in high-end products, and the market competition for low-end and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/32A61L15/44A61L27/20A61L27/24A61L27/54A61L27/60A61L31/04A61L31/16A61K8/65A61K8/73A61Q19/00
Inventor 潘海江
Owner 北京福庆堂医药有限责任公司
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