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Use of lycopodium clavatum in preparation of medicament for treating bone diseases

A technology of Streptomyces vulgaris and medicine, which is applied in the application field of Streptomyces vulgaris or its extract in the preparation of medicines for treating bone diseases

Inactive Publication Date: 2011-05-11
TIANJIN PACIFIC PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there have been no literature reports on the use of traditional Chinese medicine Shenjin grassland crude drug powder, water extract of Shenjincao, and polysaccharide components of Shenjincao for the treatment and / or prevention of bone diseases. In view of this, the inventor discovered that the traditional Chinese medicine The original medicinal powder, water extract, and polysaccharides of Shenjincao have shown high pharmacological activity in the treatment of bone diseases.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: the preparation of the water extract of Streptococcus sinensis

[0023] Take 200g of Shenjincao powder and boil it with 2500ml of water for about 2 hours. After cooling to room temperature, the extract is centrifuged, the residue after extraction is boiled with water, cooled and then centrifuged, and the two supernatants are combined to obtain the water extract of C. sinensis.

Embodiment 2

[0024] Embodiment 2: Extraction of the polysaccharide of St.

[0025] Take 150g of Shenjincao powder and boil it with 3000ml of water for about 2 hours. After cooling to room temperature, the extract was centrifuged, and the residue after extraction was boiled with water, cooled and then centrifuged. The two supernatants were combined and concentrated to slightly viscous with a rotary evaporator. Add three times the amount of ethanol, let stand, and filter the precipitate. The precipitate was washed with a little ether and dried in vacuum to obtain the product polysaccharide.

Embodiment 3

[0027] Take 50.0g of the extract of Streptococcus sinensis, 30.0g of medicinal starch, 30.0g of dextrin, and an appropriate amount of 50% ethanol, stir and mix the above-mentioned raw materials to make granules, dry them at 60-70°C for 2-4 hours, and make 100 tablets , Each tablet contains 0.5g of Herba Grass Extract.

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PUM

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Abstract

The invention relates to the use of lycopodium clavatum in the preparation of a medicament for treating bone diseases. Lycopodium clavatum or active ingredients thereof can stimulate osteoblasts by activating the transmission path of a bone morphogenetic protein (BMP) signal and therefore specially promotes the formation of new bones. Pharmaceutical and clinic experiments show that the medicament and the active ingredients thereof can be used on various clinic occasions when new bones are needed to be formed. Lycopodium clavatum or active ingredients thereof can be applied on the whole body or partially for preventing and treating osteoporosis, and can be used for treating osteoporotic fracture and other fractures and obviously improving fracture repair rate.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and relates to the pharmaceutical development and utilization of shenjincao, more precisely, the application of shenjincao or its extracts in the preparation of medicines for treating bone diseases. Background technique [0002] Rheumatoid arthritis (RA) is an autoimmune disease, and its clinical treatment is difficult. Its lesion is characterized by invading the joint synovium, causing synovial hyperplasia and hypertrophy, and bone destruction on the articular surface, thereby causing irreversible damage to the joint. The purpose of treatment is to relieve pain, control the progression of the disease, prevent irreversible bone changes, and protect the function of joints and muscles as much as possible. Ankylosing spondylitis (AS) is a chronic progressive inflammatory disease that occurs in young adults with unknown cause. It mainly invades the axial joints and is one of the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/898A61P19/02A61P19/04A61P19/08A61P29/00
Inventor 宋德成
Owner TIANJIN PACIFIC PHARMA
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