New application of statin compound as topical medicine for preventing and curing osteoporotic fracture
An osteoporosis and compound technology, applied in the field of medicine, can solve the problems that bones are difficult to ensure the efficacy of surgery, difficult to exert osteogenesis, obstacles to successful bone surgery, etc., to enhance the attachment and convenience, improve the microstructure of bone tissue, The effect of promoting mechanical strength
An osteoporosis and compound technology, applied in the field of medicine, can solve the problems that bones are difficult to ensure the efficacy of surgery, difficult to exert osteogenesis, obstacles to successful bone surgery, etc., to enhance the attachment and convenience, improve the microstructure of bone tissue, The effect of promoting mechanical strength
CN103169972APending Publication Date: 2013-06-26PEKING UNIV THIRD HOSPITAL
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Experimental program
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Effect test
Embodiment 1
[0048] Preparation of simvastatin topical injection
[0049] Dissolve 1000 mg of simvastatin in 10 ml of PBS phosphate buffer (purchased from Beijing Zhongshan Jinqiao Biotechnology Co., Ltd.), containing 2% dimethyl sulfoxide (Dimethyl Sulfoxide, DMSO, purchased from Sigma company) and 0.1 % bovine serum albumin (Bovine Serum Albumin, BSA, purchased from Sigma Company), and homogenize the obtained solution to obtain the final product.
Embodiment 2
[0051] Preparation of pravastatin topical injection
[0052] Suspend 1000 mg of pravastatin sodium in 10 ml of fat emulsion (Intralipid), and homogenize the obtained solution.
Embodiment 3
[0054] Fluvastatin topical injection preparation
[0055] Dissolve 1000 mg of fluvastatin sodium in 10 ml of physiological saline containing 3% paloxamer 188 (BSF, Germany), and homogenize the obtained solution.
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The invention discloses a new application of statin compound as topical medicine for preventing and curing osteoporotic fracture and enhancing bone plant strength in osteoporotic bone, particularly, discloses a topical statin composite for bone. The topical statin composite can increase bone mass, improve bone density, improve bone tissue microstructure and enhance bone mechanical property, thereby being used for preventing and curing osteoporotic fracture and enhancing the bone plant strength in osteoporotic bone.
Description
technical field [0001] The present invention relates to the field of medical technology, more specifically, relates to the local application of HMG-CoA reductase inhibitors (statins) to prevent and treat osteoporotic fractures, enhance the internal fixation strength of osteoporotic bones, and promote new uses such as fracture healing, and Its topical composition. Background technique [0002] Osteoporosis is a systemic disease characterized by low bone mass and microarchitectural disruption of bone tissue, leading to increased bone fragility and susceptibility to fractures. [0003] With the extension of human life span and the increase of postmenopausal women, osteoporosis and its associated fractures have become a serious public health problem worldwide. Taking the most serious hip fracture as an example, the global incidence in 1990 was 1.66 million, and it is expected to reach 6.26 million in 2050, of which Asia accounts for about 51%. [0004] Although osteoporosis is...
Claims
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Patent Timeline
26 Jun 2013
Publication
CN103169972A
- IPC
- A61K45/00; A61K31/22; A61K31/366; A61K31/40; A61K31/405; A61K31/4418; A61K31/505; A61P19/10
- Inventors
- 宋纯理; 杨宁