Self-developing polymethacrylate used for bone cement and preparation method for self-developing bone cement

A technology of polymethacrylate and iodohydrin methacrylate is applied in dental preparations, pharmaceutical formulations, dental prostheses, etc. It can solve the problem that non-ionic developer cannot develop for a long time, and achieves prevention of circulation and rapid discharge. , to avoid toxic effects

Active Publication Date: 2015-12-09
山东明德生物医学工程有限公司
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  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

Using methacrylic acid and non-ionic developer to obtain self-imageable acrylate monomers, and then self-polymerized or copolymerized with other methacrylate monomers to obtain X-ray opaque materials—self-imageable polymethyl Iodohydryl acrylate, using iodine to impart developability to polymethacrylate, improves the shortcoming of non-ionic developers that cannot be developed for a long time in vivo

Method used

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  • Self-developing polymethacrylate used for bone cement and preparation method for self-developing bone cement
  • Self-developing polymethacrylate used for bone cement and preparation method for self-developing bone cement
  • Self-developing polymethacrylate used for bone cement and preparation method for self-developing bone cement

Examples

Experimental program
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Effect test

Embodiment 1-4

[0041] EDCI: DMAP: methacrylic acid: iohexol ratio is 1.2:0.5:1:2, dissolved in DMF, reacted at 40°C for 2h, washed and dried, concentrated and purified by column chromatography to obtain iodohydrin methacrylate, as Figure 1A shown.

[0042] Prepare purified methacrylate by dissolving in n-hexane, add 0.1% AIBN, 0.002% dodecyl mercaptan as a molecular weight regulator, stir and react at 60°C for 24h, the reaction process is as follows Figure 1B Shown, washed with water, dried and chromatographically purified to obtain self-imaging polyiodomethacrylate. figure 2 The infrared spectrum of self-imaged polyiodomethacrylate can be shown, 1493cm -1 、1600cm -1 The benzene ring skeleton belonging to iohexol appeared at 1710cm -1 A clear ester peak appears. The viscosity-average molecular weight of the self-developing polyiodomethacrylate is about 119,000 according to the calculation of the viscosity method.

[0043] Grind the self-developing polyiodomethacrylate for 2 hours, pas...

Embodiment 5-8

[0050] Example 5-8: Ioversol as a source of developer to prepare self-developing polyiodol methacrylate

[0051] EDCI: tetrabutyl titanate: methacrylic acid: ioversol with a ratio of 1.2:0.5:1:1, dissolved in DMF, reacted at 40°C for 4 hours, washed and dried, concentrated and purified by column chromatography to obtain iodohydrin methacrylate ester.

[0052] Prepare purified methacrylate by dissolving in n-hexane, add 0.1% BPO and 0.002% polythiol as molecular weight regulator, stir and react at 65°C for 24 hours, wash and dry with water, and then chromatographically purify to obtain self-imageable polymethylacrylate Iodooxyacrylate. Viscometry calculation shows that the viscosity-average molecular weight of self-developing polyiodomethacrylate is about 100,000.

[0053] Grind the self-imaged polyiodomethacrylate for 2 hours, pass through a 400-mesh sieve, and carry out refining treatment; take the self-imaged bone cement powder after sieving and BPO, etc. in a mixer, and m...

Embodiment 9-12

[0059] Examples 9-12: Preparation of self-developing polyiodomethacrylate with iodixanol as a source of developer

[0060] DCC: tetraisopropyl titanate: methacrylic acid: iodixanol with a ratio of 1.2:0.5:1:0.1, dissolved in DMF, reacted at 25°C for 4 hours, washed and dried, concentrated and purified by column chromatography to obtain methacrylic acid Iodine esters.

[0061] Prepare purified methacrylate by dissolving it in n-hexane, add 0.2% AIBN and 0.001% polythiol as molecular weight regulator, stir and react at 70°C for 24 hours, wash and dry with water, and chromatographically purify to obtain self-imageable polymethylacrylate Iodooxyacrylate. The viscosity-average molecular weight of self-developing polyiodomethacrylate is about 220,000 through viscosity measurement and calculation.

[0062] Grind the self-developing polyiodomethacrylate for 3 hours, pass through a 400-mesh sieve, and carry out refining treatment; take the sieved self-developing bone cement powder an...

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Abstract

The invention discloses self-developing polymethacrylate used for bone cement and a preparation method for the self-developing bone cement. The powder body of the bone cement consists of self-developing polymethyl iodine alcohol acrylate and benzoperoxide, wherein the self-developing polymethyl iodine alcohol acrylate is polymerized by methacrylic acid and non-ionic contrast agent, namely an iodine alcohol compound after esterification; a liquid consists of a methyl acrylate monomer, N,N-dimethyl-p-toluidine and hydroquinone; the polymethacrylate is endowed with the developing property by utilizing iodine, and meanwhile, the defect that the nonionic contrast agent cannot develop for a long time in vivo is improved. The bone cement can be used for plastic surgery, osteoporosis fracture fixation and bone defect filling, and can also be used as a denture base material.

Description

technical field [0001] The invention belongs to the field of medical materials for bone defect repair, and in particular relates to an autoimage bone cement and a preparation method thereof; in particular, an autoimage polymethacrylate used for bone cement and a preparation method of the autoimage bone cement. Background technique [0002] With the development of society, osteoporosis and osteoporotic fractures have become serious public health and social issues of worldwide concern. Various orthopedic diseases and bone injuries have also increased significantly. The market demand for orthopedic biomaterials is very considerable. Local treatment of osteoporosis and osteoporotic fractures is a new technique. In orthopedic surgery, percutaneous vertebroplasty (PVP) has become The minimally invasive treatment of vertebral body compression fractures caused by tumors and osteoporosis mainly achieves the therapeutic purpose by injecting PMMA bone cement into the vertebral body thr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F120/36C08F291/04C08F291/00C08F220/12A61L27/16A61L27/50A61K6/083
Inventor 李朝阳邸勋崔永顺吕维加
Owner 山东明德生物医学工程有限公司
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