Therapeutic combinations comprising selective estrofen receptor modulator and parathyroid hormone

A parathyroid hormone and composition technology, applied in the direction of medical preparations containing active ingredients, drug combinations, organic active ingredients, etc., to increase bone mass, inhibit osteoporosis and related bone diseases, and reduce fracture rates

A parathyroid hormone and composition technology, applied in the direction of medical preparations containing active ingredients, drug combinations, organic active ingredients, etc., to increase bone mass, inhibit osteoporosis and related bone diseases, and reduce fracture rates

CN1305373AInactive Publication Date: 2001-07-25PFIZER PRODS ETAT DE CONNECTICUT
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] 6.5-month-old S-D female rats were subjected to mock surgery (n=18) or ovariectomized (OVX) (n=42), and 6 days after surgery, 9-day mock-surgery rats and 7 OVX rats were killed As a control group before treatment, while the remaining OVX rats were treated with PTH (40 μg / kg / day, subcutaneously injected (s.c.) with 0.1% bovine serum (BAS) solution), (-)-cis-6-phenyl-5- [4-(2-Pyrrolidin-1-yl-ethoxy)-phenyl]-5,6,7,8-tetralin-2-ol (0.1 mg / kg / day in 5% ethanol / Oral gavage (o.g.) in water) or a combination of both (40 μg / kg / day, s.c. injection of PTH and 0.1 mg / kg / day, oral gavage (o.g.) of (-)-cis-6-phenyl-5-[ 4-(2-Pyrrolidin-1-yl-ethoxy)-phenyl]-5,6,7,8-tetralin-2-ol) for 60 days. All rats were injected subcutaneously with 10 mg / kg calcein (Sigma Chemical Co., St. Louis, MO) 12 and 2 days before necropsy. The small tibial metaphysis was determined by standard static and dynamic histomorphometry techniques (Parfitt A.M. et al., Bone histomorphometry: Standardization of no...

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Abstract

This invention is directed to pharmaceutical combination compositions and methods comprising (-)-cis-6-phenyl-5-(4-(2-pyrrolidin-1-yl-ethoxy)-phenyl)-5,6,7,8-tetrahydronaphthalene-2-ol or a pharmaceutically acceptable salt thereof and parathyroid hormone or a biologically active fragment thereof, methods of using such compositions and kits containing such compositions. The compositions are useful for treating musculoskeletal frailty, including osteoporosis, osteoporotic fracture, low bone mass and frailty.

Description

Background of the invention [0001] The present invention relates to therapeutic compositions comprising a selective estrogen receptor modulator (SERM) and parathyroid hormone (PTH) or a biologically active fragment thereof, which stimulate bone formation, increase bone mass and enhance the bone healing effects of PTH. The present invention also relates to a kit containing the composition and the use of the composition in the treatment of muscular and skeletal frailty, including osteoporosis, osteoporotic fractures, low bone quality, frailty, etc., in mammals, including humans. More specifically, the present invention relates to (-)-cis-6-phenyl-5-(4-(2-pyrrolidin-1-yl-ethoxy)-phenyl)-5,6,7,8 - a composition of tetralin-2-ol or a pharmaceutically acceptable salt thereof and parathyroid hormone or a bioactive fragment thereof, a kit containing the composition, and the composition for treating muscular dystrophy in mammals, including humans Applications in fragile bones, includi...

Claims

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Application Information

Patent Timeline
25 Jul 2001
Publication
CN1305373A
IPC
A61K38/22; A61K; A61K31/40; A61K31/402; A61K31/435; A61K38/29; A61P5/32; A61P19/00; A61P19/08; A61P19/10; C07C; C07D
CPC
A61K38/29; A61P19/00; A61P19/08; A61P19/10; A61P5/32; A61K2300/00; A61K31/40
Inventors
柯华珠; 戴维·D·汤普森