121 results about "Bone mineral content" patented technology

Methods and devices for reducing the mineral content of a region of non-intimal vascular tissue are provided. In the subject methods, an isolated local environment that includes the region to be demineralized is produced. The pH of the local environment is then reduced to a subphysiologic level, e.g. by flushing with an acidic dissolution fluid, for a period of time sufficient for the mineral content of the region to be reduced. The devices of the subject invention are characterized by comprising a means for producing an isolated local environment that includes a non-intimal region of vascular tissue. Also provided are kits for practicing the subject methods.

Methods and devices are provided for at least reducing the mineral content of a vascular calcified lesion, i.e. a calcified lesion present on the vascular tissue of a host. In the subject methods, the local environment of the lesion is maintained at a subphysiologic pH for a period of time sufficient for the mineral content of the lesion to be reduced, e.g. by flushing the lesion with a fluid capable of locally increasing the proton concentration in the region of the lesion. Also provided are systems and kits for practicing the subject methods. The subject methods and devices find particular use in the treatment of vascular diseases associated with the presence of calcified lesions on vascular tissue.

The present invention relates to antibodies against sclerostin and compositions and methods of use for said antibodies to treat disease related to bone abnormalities such as osteoporosis. An embodiment of the invention herein provides an antibody or a functional protein comprising an antigen-binding portion of said antibody for a target in sclerostin polypeptide, characterized in that the antibody or functional protein specifically binds to sclerostin polypeptide and can increase at least one of bone formation, bone mineral density, bone mineral content, bone mass, bone quality and bone strength in a mammal.

The invention relates to a spectral reflectance peak decomposition based quantitative inversion method of the hyperspectral remote sensing mineral content. The method comprises the seven steps of: 1. reading data in; 2. intercepting a reflection peak band; 3. converting a reflectance spectrum and an absorption spectrum; 4. carrying out continuum removal on the spectrums; 5. linearly decomposing the spectrums to obtain the mineral spectrum decomposition content; 6. establishing a statistical relationship between the mineral spectrum decomposition content and the real content; and 7. converting the calculated mineral spectrum decomposition content in the step 5 into the real mineral content according to the established statistical relationship in the step 6. The invention can not only be applied to hyperspectral data which is not covered by a mineral absorption spectrum band, but also can be used for hyperspectral data which is covered by the mineral absorption spectrum band in the spectrum band range, carries out quantitative mineral content inversion by comprehensively applying a spectral reflectance peak and an absorption spectrum band and improves the inversion precision and the inversion accuracy. The invention has practical value and broad application potential in the field of hyperspectral remote sensing mineral identification.

The present invention relates to methods for prevention and / or treatment of metabolic disorders, post-menopausal obesity and conditions associated with high fat diet consumption including, obesity, body weight gain, fat mass formation, bone mineral content reduction, white adipose tissue weight gain, increased cholesterol levels, increased leptin levels, insulin resistance, type II diabetes, increased blood glucose levels, inflammatory diseases, cardiovascular diseases, fatty liver condition (accumulation of fat in the liver), decreased uncoupling protein-1 (UCP-1) levels and increased lipogenesis.

The present invention relates to a nutritional composition for infants and / or toddlers comprising a lipid component which has a large lipid globule size, having a volume weighted mode diameter above 1.0 μm and / or with a diameter of 2 to 12 μm in a amount of at least 45 volume % based on total lipid. The composition can be used to increase bone mineral content and / or bone mass density, to prevent osteoporosis and / or osteopenia and for the further prevention of obesity.

A wearable apparatus for the treatment or prevention of osteopenia or osteoporosis, stimulating bone growth, preserving or improving bone mineral density, and inhibiting adipogenesis is disclosed where the apparatus may generally comprise one or more vibrating elements configured for imparting repeated mechanical loads to the hip, femur, and / or spine of an individual at a frequency and acceleration sufficient for therapeutic effect. These vibrating elements may be secured to the upper body of an individual via one or more respective securing mechanisms, where the securing mechanisms are configured to position the one or more vibrating elements in a direction lateral to the individual, and the position, tension, and efficacy of these vibrating elements may be monitored and / or regulated by one or more accelerometers.

The invention provides a method for predicting a brittle mineral content in a gas reservoir layer of shale. The method comprises: carrying out pre-stack elastic parametric inversion; on the basis of log data, calculating a brittleness index logging curve; constructing anisotropic rock physical model of a gas reservoir layer of shale; and on the basis of a pre-stack elastic parametric inversion result and the anisotropic rock physical model of the gas reservoir layer of shale, carrying out inversion of a brittle mineral content of the gas reservoir layer of shale. Therefore, a problem that the conventional brittleness index indirectly calculated based on the Young modulus and Poisson's ratio can not describe the brittleness of the shale effectively can be solved. The invention provides a direct inversion method for a brittle mineral content in a gas reservoir layer of shale, so that the brittleness of the gas reservoir layer of shale can be predicted accurately and reliably based on the brittle mineral content of the shale.

The invention discloses a mineral ingredient content and porosity calculating method for a shale gas stratum. The method comprises the following steps that routine integrated logging data is used to calculate the total clay mineral content, calculate contents of three different types of clay materials by decomposition, calculate the content of organic matters, and calculate the content of pyrite; a logging value of a logging curve is corrected; if there is no element capture logging result, a regional relation is established according to the integrated logging data, and the content of a carbonatite mineral is calculated; if there is an element capture logging result, the carbonatite mineral content in the element capture logging accomplishment is used directly; quartz, feldspar, calcite and dolomite minerals and the porosity are optimized and constrained; and a calculation result is normalized. According to the invention, contents of different mineral ingredients of the shale gas stratum are calculated according to the logging data, the mineral ingredient content and porosity calculating precision of the shale gas stratum are improved, and basis is provided for accurate calculation of the brittleness index and gas content of the shale gas stratum.

The invention relates to a composition for increasing bone mineral density, a preparation agent containing the composition, and the preparation method of same. The composition comprises the following raw materials according to the weight portions: 0.5 to 35 portions of calcium carbonate, 0.5 to 30 portions of sulfuric acid dextrosamine, 0.05 to 2 portions of sulfuric acid chondroitin, 0.1 to 10 portions of collagen, and 0.08 to 5 portions of turmeric yellow extractive. In the composition, except a calsium supplement and a calcium absorbing promoting agent, the composition further comprises nutrients and anti-inflammatory mitigative, and can be used for preventing and treating osteoporotic symptom from multiply angles and ways.

The invention discloses an CT image-based osteoporosis parameter automatic measurement method. The method comprises the following steps: 1) constructing a clinical data taking DXA diagnosis as astandard, and constructing a corresponding relation between a CT value of a to-be-measured vertebral body layer and bone mineral density measured through the DXA diagnosis; 2) carrying out bone mineral density measurement method correction: carrying out CT scanning on a body membrane with known density, establishing a linear corresponding relationship between a CT value and the bone mineral density of the body membrane, and then carrying out correction to obtain a corresponding relationship between the CT value and the real bone mineral density; 3) performing lumbar vertebra segmentation on the CT scanning image of the to-be-measured object, and then 4) performing bone mineral density calculation. According to the method, three-dimensional measurement is carried out from the three-dimensional CT image. The osteoporosis sensitivity is high. An examiner does not have extra X-rays. The measurement process is automatically and objectively quantified. In addition, bone trabecula morphological parameters and rubbing parameters can be additionally obtained.

Detection of epigenetic alteration, especially methylation, of a gene or a combination of genes, preferably in a perinatal tissue sample such as umbilical cord, for predicting diverse phenotypic characteristics such as propensity for obesity, altered body composition, impaired cognition, low bone mineral content, neuro-behavioural problems and altered cardiovascular structure and function occurring in an individual.

The invention discloses an ultrasonic probe of bone-ore density, which consists of detecting probe and two directional probes, wherein the detecting probe and directional probe are composed of case, delaying block in the case, wafer, acoustic layer, copper foil and adsorbing block. The invention can meter the spreading time and speed in the bone, which is relative to bone-ore to judge bone quality.

The invention discloses a spectrum analysis method for calculating mineral content and brittleness index of shale reservoir in imaging logging. The method comprises the steps that 1) imaging logging data is preprocessed; 2) a histogram of preprocessed data of different electrodes of original imaging logging is analyzed; 3) the histogram of the data of the different electrodes of imaging logging isstandardized; 4) the standardized imaging data is enhanced; 5) static imaging data is described as an imaging mineral spectrum; 6) the standard histogram and imaging spectrum are used, rock core analysis data is used to describe logging, a spectrum of minerals is unfolded according to spectral distribution positions, and content of clay mineral, quartz and calcite mineral is obtained; and 7) theproportion of the quartz in the total mineral content is calculated to obtain the brittleness index in the shale gas. The method has a higher precision is practical calculation, micro change of the content of the stratum minerals can be reflected accurately, and the calculated brittleness index Brite can reflect the stratum brittleness change effectively.

The invention provides a shale rock-phase plane distribution compilation method and a shale exploration system, which belong to the technical field of petroleum exploration. The method comprises the following steps: using a mineral component content of a shale sample, and performing compilation of a 3-end-mumber graph of the silicon mineral content, carbonate mineral content and the clay mineral content; using the mineral component content and the organic matter content, performing compilation of a plane distribution map of an organic matter, silicon mineral, clay mineral and carbonate mineral; according to the 3-end-mumber graph and the plane distribution map of the organic matter, the silicon mineral, the clay mineral and carbonate mineral, dividing the rock phase of the shale; performing superposition intersection on an organic matter plane distribution map, a silicon mineral plane distribution map, a clay mineral plane distribution map, and a carbonate plane distribution map, and determining the shale rock-phase plane distribution according to a rock-phase dividing standard. The shale exploration system has the above shale rock-phase plane distribution compilation method, whichis simple and easy to use and realizes quantitative operation.

The invention is suitable for the field of nutrition and health care and provides a health food capable of enhancing bone mineral density and immunity and a preparation method of the health food. The health food comprises the following components in percentage by weight: 20%-40% of D-glucosamine, 20%-40% of calcium, 8%-15% of a kudzuvine root extract, 5%-10% of chondroitin sulfate, 2%-5% of casein phosphopeptides, 0.5%-3.3% of colostrum basic protein and the balance of auxiliary materials. According to the health food, bone metabolism is promoted by the modes of restoring or improving the normal physiological functions of the organism, such as regulating the hormone level in the organism, improving the capacity of a bone tissue for actively absorbing osteoblast nutrients, stimulating osteoblast proliferation, self-synthesizing ossein, repairing bones and joints and bone tissues, improving the skeleton micro-structure and improving the bone immunity; the bone health is maintained; and the condition of the bone mineral density is fundamentally improved.

The invention provides a composition for increasing the bone mineral density. The composition mainly comprises the following raw materials in parts by weight: 180-540 percent of calcium carbonate, 23-69 percent of D-glucosamine hydrochloride and 15-45 percent of collagen. The invention also provides a preparation method of the composition. The raw materials adopted by the composition for increasing the bone mineral density have no toxic and side effects, health and safety, has the effects of promoting calcium absorption and relieving osteoporosis and can safely and effectively supplement calcium of the human body and ensure that the calcium level is improved so as to prevent fractures and bone loss and has improvement effect on bone formation. Moreover, the invention adopts scientific andreasonable production process and better retains active constituents in various raw materials.

A composition for improving osteoporosis and increasing bone mineral density, a preparation method of the same and an application of the same in preparation of a health-caring product. The composition comprises an active ingredient and auxiliary materials and is characterized in that the active ingredient includes following components, by weight, 65-85 parts of a raw medicine in an extract of epimedium, 5-15 parts of glucosamine, 5-15 parts of chondroitin sulfate, 1.5-3.5 parts of collagen and a proper amount of vitamin D3; and the auxiliary materials include following components, by weight, 1.5-4.5 parts of an excipient and 0.2-1.5 parts of a lubricant. The composition is designed especially for middle-aged and elderly people and is strong in targeted performance. In the invention, the composition is prepared through integration of Chinese and western medicines, not only is traditional Chinese medicine guide theory inherited but also modern medicinal treatment methods are referenced. An experimental result proves that epimedium in the formula can increases the bone mineral density and the chondroitin sulfate, the glucosamine, the collagen and the vitamin D3 have an effect of improving the osteoporosis. The composition has excellent effects of increasing the bone mineral density and promoting absorption of calcium.

A method and apparatus for using a flat panel detector to determine bone mineral density are provided. The apparatus includes a dual energy X-ray emitter, a flat panel detector for receiving X-rays sent from the X-ray emitter, and may optionally include an image corrector, adapted to emit corrected image information. The apparatus also includes a basis material decomposer that includes a calibration database, the decomposer being adapted to create a bone image and a soft tissue image. The apparatus further includes a bone mineral density calculator that is adapted to compute bone mineral density from the first image, and a display for displaying at least the computed bone mineral density. A method for using a flat panel detector to detect multiple disease states is also provided. The method includes emitting X-rays from a dual energy X-ray source through an area of a patient's body sought to be imaged and receiving X-rays with a flat panel detector. The method also includes generating multiple images, using dual energy X-ray absorptiometry, to detect for a first disease state and a second disease state and analyzing the images for the first and second disease states. The first disease state includes lung cancer, breast cancer, pneumonia, chronic obstructive pulmonary disease, tuberculosis, bone fracture or an abnormally sized or shaped organ and the second disease state comprises osteoporosis.

The present invention relates to a nutritional composition for infants and / or toddlers comprising a lipid component which has a lipid globules coated with phospholipids. The composition is used for increasing bone mineral content, bone mineral density, preventing osteoporosis, and / or preventing ostopenia.

The invention is suitable for the technical field of medical image processing and applying, and provides a method and system for obtaining the value of the bone mineral density of the human body. The method includes the following steps: obtaining the high-low-energy image X ray injection strength, obtaining calibration parameters, collecting low-energy X ray images and high-energy X ray images of the bone area, preprocessing the collected images, receiving an interested area which is selected by a user and requires calculation of the value of the bone mineral density, locating an accurate area of the interested area which requires the calculation of the value of the bone mineral density, and calculating the value of the bone mineral density according to the Beer-Lambert law. By means of the method and system, dependence on hardware of a bone mineral density instrument can be reduced while the value of the bone mineral density is calculated; on the basis of a common digital X ray machine, the scheme of the method and system is applied, measurement and calculation of the bone mineral density of the human body can be achieved, the problem in the hardware is not required to be considered, and the production cost of the bone mineral density instrument is reduced to a certain degree. In addition, when the scheme is adopted for collecting the bone images, a standard body is not required, and the image collecting process is accordingly simplified.

The invention relates to composition with effects of increasing bone mineral density, preventing inflammation and easing pain and a preparation method thereof. The composition with the effects of increasing bone mineral density, preventing inflammation and easing pain is prepared from the following bulk pharmaceutical chemicals ingredients of chondroitin sulfate, glucosamine hydrochloride, calcium carbonate, sodium hyaluronate, dimethyl sulfone and radix puerariae extract. The invention further relates to a film-coated tablet prepared from the composition and a preparation method of the film-coated tablet. The composition has a better curing effect of increasing bone mineral density, and all ingredients have a synergistic effect, can easily improve calcium absorption and can well increase bone mineral density; animal function experiments prove that the composition can obviously improve the thighbone weight, the bone calcium content, the thighbone middle point density and the thighbone telecentric end bone mineral density of a rat.

A method of treating a mammal for a purpose selected from the group consisting of (a) increasing bone mineral density (BMD), (b) treating low BMD, (c) preventing and treatment of low impact fractures, (d)treatment of high impact fractures; (e) treating osteoporosis; (f) modulating a growth factor that influences bone metabolism; and (g) improving bone micro-architecture or connectivity of bone; the method comprising administering to the mammal an effective amount of a N-acylated-2-glucosamine derivative of the general formula (I):- wherein R is an alkyl radical of the general formula CnH2n+1 and n is selected from 2-12; or pharmaceutically-acceptable salts, esters and glucosides thereof; or pharmaceutically-acceptable compositions thereof.

The invention relates to combinations, particularly to a mineral oil-free natural skincare product and a preparation method thereof, and belongs to the field of household chemicals. The mineral oil-free natural skincare product abandons mineral oil and takes plant materials and plant derivatives as raw materials. The mineral oil-free natural skincare product is prepared through more scientific production processes and is a skin beautifying, caring and recovering cosmetic product more skin-friendly, higher in moisture preservation, more smooth, more charming, cleaner and more popular and acceptable among customers. The prepared mineral oil-free natural skincare product contains no mineral content, and through component selection, can be prepared skincare products with different effects. When applied to skincare, the mineral oil-free natural skincare product thoroughly solves the problems affecting skin appearance such as pore blocking, allergy, acnes and black spots. By completely replacing mineral oil-containing skincare products, the mineral oil-free natural skincare product is a major historical, conceptual and true-life revolution in the field of human skincare.

An apparatus, method, and computer program product for calibrating a CT scan without the use of an external calibration phantom, to enable quantitative assessment of internal body tissues and organs and additionally for any application that would benefit from a calibration of the scan attenuation data, such as viewing CT images in a consistent fashion. Embodiments are described with applications to quantitative assessment of bone density in the spine and hip, mineral content in blood vessels, hepatic-fat content in the liver, and gray-to-white matter ratio in the brain. The primary advantages of the method are that it does not require the use of an external calibration phantom, it is robust across different CT machines and scanner settings, and it is also highly precise, lending itself to a high degree of automation.

The invention discloses application of a maca amide compound and pharmaceutically acceptable salt thereof to preparation of bone mineral density improving products. A maca amide compound monomer is obtained by extracting and separating from Lepidiummeyenii Walp., and is found through in-vitro cell experiments and animal experiments to have an excellent ossification promoting effect and a bone mineral density improving effect; the natural maca amide compound is safe without toxic or side effects.

A method of treating a condition in a vertebrate animal characterized by bone having increased porosity and / or decreased bone mineral density. The porous bone is injected with an effective amount of a flowable bone composition. Also provided is a kit for the treatment of porous bone wherein a flowable bone composition is contained within an injectable delivery system.