Composition with effects of increasing bone mineral density, preventing inflammation and easing pain and preparation method thereof

A technology to increase bone density, anti-inflammatory and analgesic, applied in the fields of application, food science, and the function of food ingredients, etc., can solve the problems of not being able to meet the actual needs of patients, and the effect is not significant, so as to increase the weight of the femur and reduce the infiltration of joints Liquid, improve the effect of joints

Active Publication Date: 2016-11-09
SHANDONG MINGREN FURUIDA PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The drugs for increasing bone density and anti-inflammatory and analgesic effects disclosed in the prior art are mainly made of chondroitin sulfate, glucosamine hydrochloride, calcium carbonate, and sodium hyaluronate. Articular cartilage, relieve osteoporosis and osteoarticular cartilage tissue damage or degeneration, but the effect is not significant and cannot meet the actual needs of patients

Method used

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  • Composition with effects of increasing bone mineral density, preventing inflammation and easing pain and preparation method thereof
  • Composition with effects of increasing bone mineral density, preventing inflammation and easing pain and preparation method thereof
  • Composition with effects of increasing bone mineral density, preventing inflammation and easing pain and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0120] Embodiment 1, increase the functional evaluation of bone density

[0121] Compositions made of chondroitin sulfate, glucosamine hydrochloride, sodium hyaluronate, calcium carbonate, dimethyl sulfone, and kudzu root extract in different ratios have certain differences in their effects on increasing bone density. In order to show the effectiveness of the present invention in increasing bone density, investigate the effects of prescriptions with different proportions on increasing bone density, the following correlation tests have been carried out on the present invention.

[0122] The experimental method used in this embodiment is the same as the above-mentioned "Functional Evaluation Experiment of Increasing Bone Density with Single Component Calcium Carbonate" method, and the low calcium control in the formulation of the low-calcium control group and "Functional Evaluation Experiment of Increasing Bone Density with Single Component Calcium Carbonate" The formulations of...

Embodiment 2

[0163] Example 2, Functional Evaluation of Osteoarthritis Therapeutic Effect

[0164] 1 Materials and methods

[0165] 1.1 Animals: SD rats, clean grade, 150-180g, half male and half male, 96 rats.

[0166] 1.2 Test group setting and test administration method

[0167] 1.2.1 Sample preparation and test grouping

[0168] All tested samples are all ground with 0.3% xanthan gum and made into a uniform suspension for subsequent use, and the tested samples are made of tablets made from prescription 1, prescription 2, prescription 3 and comparison 1 as test samples (preparation ratio settings see Table 20).

[0169] Table 20 The different proportioning settings of the composition of the present invention

[0170]

[0171]

[0172] 96 rats were purchased and fed for 1 week. After body weight was measured, they were randomly divided into the following 6 groups, 16 rats in each group: (1) control group (0.3% xanthan gum); (2) model group (0.3% xanthan gum); Raw gum); (3) rec...

Embodiment 3

[0199] Example 3, functional evaluation of analgesic effect

[0200] 1. Effect on writhing response of mice induced by acetic acid

[0201] 1.1 Dose and grouping

[0202] Select 60 healthy ICR kind mice, half male and half female, body weight 18~22g, test establishes 6 groups altogether, is respectively model group (0.5%CMC-Na), positive medicine group (aspirin 200mg / kg), composition of the present invention group (the ratio of the three compositions is shown in Table 24), with 10 animals in each group, and each group was prepared with a corresponding concentration suspension, and the administration volume was 10ml / kg.

[0203] Table 24 Different proportioning settings of the composition of the present invention

[0204]

Chondroitin Sulfate

Glucosamine Hydrochloride

Pueraria Root Extract

calcium carbonate

hyaluronic acid

Dimethyl sulfone

Recipe 1

16.2％

37.8％

10.9％

30.1％

3.7％

1.3％

Formation 2

27％

27％

1...

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Abstract

The invention relates to composition with effects of increasing bone mineral density, preventing inflammation and easing pain and a preparation method thereof. The composition with the effects of increasing bone mineral density, preventing inflammation and easing pain is prepared from the following bulk pharmaceutical chemicals ingredients of chondroitin sulfate, glucosamine hydrochloride, calcium carbonate, sodium hyaluronate, dimethyl sulfone and radix puerariae extract. The invention further relates to a film-coated tablet prepared from the composition and a preparation method of the film-coated tablet. The composition has a better curing effect of increasing bone mineral density, and all ingredients have a synergistic effect, can easily improve calcium absorption and can well increase bone mineral density; animal function experiments prove that the composition can obviously improve the thighbone weight, the bone calcium content, the thighbone middle point density and the thighbone telecentric end bone mineral density of a rat.

Description

technical field [0001] The invention relates to a composition with bone density increasing, anti-inflammatory and analgesic effects and a preparation method thereof, belonging to the technical field of health food. Background technique [0002] Osteoporosis and osteoarthritis are common diseases of middle-aged and elderly people. The affected population accounts for a large proportion in our country, and has become an important issue affecting the health of our people. There are about 200 million osteoporosis patients in the world, and its incidence rate ranks seventh among common diseases and frequently-occurring diseases, and the average annual growth rate shows a rapid growth trend. The clinical treatment of this disease is mainly oral calcium and vitamin D supplementation. Calcium intake can slow down bone loss and improve bone mineralization. However, clinical studies have shown that in addition to calcium supplementation, patients should also improve Comprehensive tre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/105A23L33/16A23L33/125
CPCA23V2002/00A23V2200/30A23V2200/306
Inventor 吴世德徐传彬吴维群贾美春许敏韩苗苗谭倩徐鑫
Owner SHANDONG MINGREN FURUIDA PHARMA
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