55results about How to "Promote bone metabolism" patented technology

The invention relates to the field of medical food and discloses an aquatic collagen peptide food used for adjuvant therapy of osteoporosis and arthritis. Every 100g of the food contains multiple nutritional ingredients as follows: 9-11g of cod skin collagen protein peptide powder, 4-6g of squid skin collagen protein peptide powder, 2-3g of whey protein powder, 2-3g of soybean protein powder, 9-11g of MCT fat, 2-3g of soybean oil, 58-62g of carbohydrate and other vitamins and microelements. The aquatic collagen peptide food takes cod skin collagen protein peptide powder, squid skin collagen protein peptide powder and whey protein powder as main raw materials and has relatively high digestive absorptivity, and collagen protein peptide can promote bone formation and reinforce a bone collagen structure at low calcium level, so that bone strength is improved; bone metabolism can be improved, and ossification can be enhanced; and bone diseases such as the osteoporosis, hyperostosis and swelling and pain of bone joints can be prevented.

The invention discloses a bone joint health-care product capable of increasing body weight, body length, calcium content of bone and bone density. The health-care product is prepared from the following raw materials in parts by weight: 80-160 parts of collagen, 80-160 parts of D-glucosamine hydrochloride, 200-400 parts of milk calcium, 10-40 parts of casein phosphopeptides, and 30-70 parts of rhizoma drynariae. The raw materials are reasonable in formula, and the effective components of the raw materials take a synergetic effect under a specific proportioning condition, bone metabolism is improved, absorption of bone to calcium is promoted, and calcium content of the bone can be remarkably increased, the bone density can be increased, and the body weight and the body length can be obviously increased, osteoporosis caused by various reasons can be effectively prevented and treated, the product safety is good, and the product can be eaten for a long time.

The invention discloses a diethylstilbestrol compound and application thereof in preparation of a drug for treating osteoporosis and/or hyperlipemia. The structural formula of the diethylstilbestrol compound is shown in the specification. The data of a cellular level pharmacodynamic test show that cajanstilbene H (R is H, and X is Cl) can promote multiplication and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) of an SD rat. After an ob/ob obese mice orally takes the cajanstilbene H (20 mg/kg/d) continuously for 21 days, the results are as follows: (1) no obvious effect on weight is generated; (2) the bone density of the mice is obviously increased; serum alkaline phosphatase (ALP) and tartrate resistant acid phosphatase (TRACP) level are obviously reduced; and the serum calcium concentration is improved; and (3) levels of total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) in the serum of the mice are obviously reduced. The results show that the cajanstilbene H has positive significance in treatment of the osteoporosis caused by obesity and high blood sugar, and has a clear curative effect on the aspect of improvement of lipid metabolism of the obese mice. The cajanstilbene H has a clear treatment effect on the osteoporosis caused by obesity and high blood sugar and simultaneously can improve lipid metabolism; and metabasis of hyperlipemia to diabetes mellitus to chronic complication of diabetes mellitus to osteoporosis can be avoided to a certain extent.

The invention discloses a composition for improving the immunity. In the composition, a weight ratio of Ossotide to bone marrow peptide is 1-5:1; and a certain weight part of zinc lactate can be added. A preparation method for the composition comprises the following steps of: collecting fetal bovine marrow, washing and sterilizing the fetal bovine marrow, separating fat from the fetal bovine marrow, and separating protein from active substances; performing enzymolysis on the fetal bovine marrow twice, concentrating and drying the fetal bovine marrow to obtain the bone marrow peptide; collecting beef bones, washing and crushing the beef bones, and allowing the beef bones to enter a distillation retort to perform extraction; separating the fat from an extract, separating a supernatant, performing enzymolysis on the supernatant twice, and concentrating and drying the supernatant to obtain the Ossotide; and mixing the bone marrow peptide, the Ossotide and the zinc lactate uniformly in a proportion to obtain a formulation which is acceptable by a human body. The composition can improve the immunity of the human body, effectively resist the attack of diseases outside, and slow the speed of aging.

A preparation for increasing the calcium absorption, which is provided by the invention, relates to a calcium supplement product, in particular to a preparation which can supplement calcium. The calcium supplement preparation of the invention is mainly prepared by main raw materials of calcium acetate, glucosamine hydrochloride, CPPs, extracts of epimedium and extracts of rhizoma drynariae, and is characterized in that the ratio of the main raw materials is 5 portions to 40 portions of calcium acetate, 1 portion to 20 portions of glucosamine hydrochloride, 0.5 portion to 3 portions of CPPs, 1 portion to 5 portions of extracts of epimedium, 1 portion to 5 portions of extracts of rhizoma drynariae and 0.1 portion to 25 portions of auxiliary material. The preparation of the invention can realize the effects of promoting calcium absorption, improving bone metabolism and bone nutrition and increasing the bone density.

The invention relates to a traditional Chinese medicine pill for curing amenorrhea resulted from psychotropic drugs and a preparation method thereof. The traditional Chinese medicine pill is prepared from the following bulk drugs in parts by weight: 80-100 parts of salvia miltiorrhiza bunge, 80-100 parts of peach kernel, 80-100 parts of safflower, 30-40 parts of cinnamon, 30-40 parts of fennel, 40-60 parts of folium artemisiae argyi, 40-60 parts of rhizoma cyperi, 40-60 parts of radix linderae, 40-60 parts of angelica sinensis, 40-60 parts of szechuan lovage rhizome, 40-60 parts of twotooth achyranthes root, 40-50 parts of rhizoma corydalis, 40-60 parts of bighead atractylodes rhizome and 40-60 parts of poria. The preparation method is as follows: weighting and processing 900g of the bulk drugs in parts by weight; taking 600g of the processed bulk drugs, adding 1200ml of water in the 600g of the processed bulk drugs, decocting for 40 minutes, removing dregs, decocting once again until the decoction liquid boils, decocting by slow fire and concentrating until the volume of the decoction solution is 400ml for later use; and grinding the rest 300g of the bulk drugs into fine powder, and placing the fine powder in a pelleting container, spraying the concentrated liquid in the pelleting container to prepare into water pills, taking the water pills out of the container and drying to obtain the concentrated pills. The traditional Chinese medicine pill is a pure traditional Chinese medicine preparation, has no toxic or side effect, is convenient to take and has low price.

The invention provides a doped bone repairing material, comprising the following main ingredients according to weight proportion: 9 to 9.9 portions of calcium polyphosphate body and 0.1 to 1 portion of alkali polyphosphate. The preparation method thereof is as follows: calcium biphosphate and alkali dihydric phosphate are formed at first, then mixed according to the required preparation ratio of the calcium polyphosphate and the portion of alkali polyphosphate in the materials, and forged at high temperature to generate polyreaction; then the material forged at high temperature is quickly cooled and quenched; then the forged material is converted into amorphous calcium polyphosphate and the alkali polyphosphate; then the amorphous calcium polyphosphate and the alkali polyphosphate are dried and ground into powder and then sintered at high temperature, thus manufacturing the crystallized doped bone repairing material. The doped bone repairing material provided by the invention has the characteristics of inorganic and organic characteristics, combination between doped element and calciumn element as well as combination of rigidity and toughness; moreover, the material also has excellent degrading controllable performances. The alkali metal ions released after degrading are innoxious to inner environments; and the inorganic irons can also promote the bone metabolizing, growing and nutrition absorption.

The invention discloses codfish peptide and an enzymolytic extraction method thereof. The enzymolytic extraction method comprises the following steps of: (S1) selecting fresh codfish skin and cuttinginto codfish skin chips; (S2) adopting lipase for enzymolysis; (S3) adopting papain for enzymolysis; (S4) mixing active carbon and enzymolysis liquid, and removing fishy smell; (S5) carrying out ultrafiltration on decoloring liquid by using an ultrafiltration membrane with the cutoff molecular weight being 50-140kD, and carrying out vacuum freezing and drying to obtain the codfish peptide. The codfish peptide and the enzymolytic extraction method disclosed by the invention have the beneficial effects that the codfish skin is used as a main raw material, so that the safety and the naturality ofthe source are ensured; the prepared codfish peptide has higher activity and digestible absorptivity, has multiple functions of metabolism and physiological regulation of a human body, is easily digested and absorbed, has the effects of promoting immunity, regulating hormone, resisting bacteria and viruses, reducing blood pressure and blood fat, lubricating joints, heeling wounds and resisting aging and the like, and also has the functions of improving the elasticity and activity of the skin of the human body, enhancing the bone strength, improving bone metabolism, enhancing the bone-formingaction, preventing the bone diseases such as osteoporosis, osteoproliferation and swelling and pain of bone joints.

The invention relates to a health preserving wine, and the ingredients comprise: sorghum 1-1.5 kg, rhizome of Longspur epimedium 30-40 g, Rosa roxburghii 10-20 g and distillation liquor 1 kg; the ingredients are fermented, distilled and extracted according to the production process of sauce-flavor type liquor. The invention employs Guizhou high-quality sorghum, and is added with wild Rosa roxburghii and traditional Chinese medicinal material rhizome of Longspur epimedium, and the wine is prepared by fermentation and distillation extraction according to production process of sauce-flavor type liquor. The wine is crystal clear and transparent with mellow sauce flavor, and the alcoholic strength is 52%. The product is detected by the traditional Chinese medicine modernization high and new technology business incubation center important analysis laboratory in Guiyang city of Guizhou province, and the result is as follows: the vitamin C content is 116 mg/100 ml, the total ketone content is 21.42 mg/100 ml, and the rhizome of Longspur epimedium content is 0.42 mg/100 ml.

A preparation for increasing the bone density, which is provided by the invention, relates to a calcium supplement product, in particular to a calcium supplement preparation which can increase the bone density. The calcium supplement preparation of the invention is mainly prepared by main raw materials of calcium acetate, glucosamine hydrochloride, CPPs and soy isoflavones. The ratio of the main raw materials is 11 portions to 40 portions of calcium acetate, 2 portions to 15 portions of glucosamine hydrochloride, 1 portion to 8 portions of CPPs, 1 portion to 3 portions of soy isoflavones and 0.1 portion to 30 portions of auxiliary material. In the preparation for increasing the bone density of the invention, the calcium acetate is a common calcium supplement preparation and can increase the bone density through the direct calcium supplement; the CPPs can promote the calcium absorption; the soy isoflavones has the estrogen-like effect and can reduce the calcium loss and the glucosamine hydrochloride can improve bone metabolism and bone nutrition. The formula of the invention can realize the effects of promoting calcium absorption, reducing calcium loss, improving bone metabolism and bone nutrition and increasing the bone density through the direct calcium supplement.

The invention relates to a traditional Chinese medicine composition for treating chronic prostatitis and a preparation method thereof. The traditional Chinese medicine composition is prepared from thefollowing raw materials in parts by weight: 8 to 12 parts of cortex eucommiae chlorogenic acid, 6 to 10 parts of cortex cinnamomi polyphenol, 13 to 17 parts of oyster peptide, 8 to 12 parts of maca,8 to 12 parts of cordyceps militaris, 13 to 17 parts of silk peptide, 2 to 6 parts of herba abelmoschi esculenti, 2 to 6 parts of cortex pausinystaliae macroceras, 2 to 6 parts of catuaba, 2 to 6 parts of herba epimedii, 2 to 6 parts of herba gynostemmatis, 2 to 6 parts of herba rhodiolae, 2 to 6 parts of radix salviae miltiorrhizae and 2 to 6 parts of semen persicae. The traditional Chinese medicine composition disclosed by the invention is simple in preparation and remarkable in curative effect, has no side effect, is safe and effective, is low in cost and is suitable for oral administration.

A preparation for improving the bone metabolism, which is provided by the invention, relates to a calcium supplement product, in particular to a calcium supplement preparation which can improve the bone metabolism. The calcium supplement preparation of the invention is mainly prepared by main raw materials of calcium acetate and CPPs. The ratio of the main raw materials is 10 portions to 60 portions of calcium acetate, 1 portion of CPPs and 1 portion to 500 portions of auxiliary material. The calcium supplement preparation of the invention can promote calcium absorption and improve bone metabolism through the direct calcium supplement to cure and prevent diseases caused by the calcium deficiency.

The invention discloses a medicinal preparation for treating the stress-related diseases of Chinese soft-shelled turtles and a preparing method thereof. The medicinal preparation is medicine powder comprising, by weight, 7% to 13% of uncaria rhynchophylla, 7% to 13% of rhizoma corydalis, 5% to 11% of jujube kernels, 5% to 11% of salvia miltiorrhiza, 5% to 11% of radix bupleuri, 5% to 11% of radix rehmanniae,2% to 8% of motherwort herbs, 2% to 8% of medical stone, 5% to 11% of rhizoma polygonati, 5% to 11% of astragalus membranaceus, 5% to 11% of herba epimedii, 5% to 11% of schisandra chinensis, 2% to 8% of liquorice and 0.5% to 1.5% of vitamins C, wherein the sum of the components is 100%. The preparing method of the medicinal preparation includes the steps that the vitamins C are weighed according to the weight percent and pulverized; the medicinal materials are weighed according to the weight percents to be mixed and smashed to pass through a 80-mesh sieve, the product is dried to be mixed with the vitamins C powder, and the medicinal preparation is obtained. The medicinal preparation for treating the stress-related diseases of Chinese soft-shelled turtles has the advantages of being good in treatment effect and free of medicine residuals when used for treating the stress-related diseases of Chinese soft-shelled turtles.

The invention belongs to the technical field of bone tissue engineering, and particularly relates to a method for promoting osteogenic differentiation of mesenchymal stem cells and application. The invention provides the method for promoting osteogenic differentiation of the mesenchymal stem cells (MSCs), that is, N-acetyltransferase 10 (NAT10) is overexpressed in vivo by a biological method, through overexpression of NAT10 in mice by adenovirus according to the method, it is found that NAT10 can reverse bone mass loss of osteoporosis mice, enhance osteogenic differentiation potential of the MSCs, effectively increase local bone mass, increase bone mineral density, enhance bone strength, improve local osteoporosis and improve bone metabolism, and it is indicated that NAT10 can be used forconstructing a novel stem cell osteogenic material. Therefore, the method can provide a new treatment scheme for osteoporosis treatment.

The invention relates to a ceramic-based dental department bone powder and a preparation method thereof. The powder comprises preparation components, namely porous hydroxyapatite and type-I collagen,wherein the porous hydroxyapatite comprises preparation components, namely hydroxyapatite of a specific mass ratio, first PMMA (Polymethyl Methacrylate) granules and second PMMA granules; the particlesizes of the first PMMA granules are 50-100mu m; the particle sizes of the second PMMA granules are 500-1000mu m; the porous hydroxyapatite is made through sintering preparation; the sintering preparation comprises the following stages: at stage I, the heating velocity is 5-10 DEG C, the target temperature is 500-600 DEG C, and the constant temperature time is 20-30 minutes; at stage II, the heating velocity is 5-10 DEG C/minute, the target temperature is 1200-1500 DEG C, and the constant temperature time is 200-300 minutes; at stage III, heating is stopped, and the temperature is reduced naturally. The ceramic-based dental department bone powder is excellent in water absorption property and bone repairing effect and relatively low in production cost.

The invention discloses a traditional Chinese medicine preparation for treating stress diseases of Chinese softshell turtles and a preparation method of the preparation. The traditional Chinese medicine preparation is powder prepared from the following medicinal materials in percentage by weight: 5-11% of ligusticum chuanxiong hort, 5-11% of salvia miltiorrhiza, 2-8% of angelicae sinensis, 2-8% of leonurus, 7-13% of uncaria rhynchophylla, 7-13% of rhizoma corydalis, 5-11% of jujube seed, 5-11% of radix bupleuri, 5-11% of polygonatum sibiricum, 5-11% of astragalus membranaceus, 5-11% of epimedium, 5-11% of schisandra chinensis, 2-8% of radix glycyrrhizae, and 0.5-1.5% of vitamin C; the total percentage of all components is 100%. The traditional Chinese medicine preparation for treating stress diseases of Chinese softshell turtles, provided by the invention, has the characteristics of being good in curative effect on treating the white spot disease of the Chinese softshell turtles and free of drug residues.

The invention is applicable to the technical field of traditional Chinese medicine preparation and provides a traditional Chinese medicine composition for treating collum femoris fracture. The traditional Chinese medicine composition is prepared from, by weight, 100-200 parts of herbs of tuberculate speranskia, 50-120 parts of sanguis draxonis, 50-120 parts of frankincense, 50-120 parts of myrrh, 50-120 parts of radix angelica sinensis, 50-150 parts of ground beetles, 50-150 parts of lignum sappan, 50-150 parts of pheretima, 50-80 parts of scorpio, 50-80 parts of ippocampus, 50-80 parts of zaocys, 50-80 parts of cortex eucommiae, 50-80 parts of ramulus cinnamomi, 50-80 parts of radix dipsaci, 50-80 parts of radix paeoniae rubra, 20-80 parts of flos carthami, 20-60 parts of radix achyranthis bidentatae and 10-50 parts of radix saposhnikoviae. The cure rate reaches 95%. The invention further relates a preparation method of the composition, the process is simple and scientific, mechanical operation is achieved easily, both symptoms and root causes of diseases are treated through the pesticide effect, treatment time is reduced, treatment cost is lowered, and side effects brought by western medicine are also lowered.

The invention provides compound partridge tea polyphenol concentrated powder and a preparation method thereof. The preparation method comprises the steps of raw material crushing, extract liquid preparation, extract liquid filtration, concentration and extraction, freeze-dried powder preparation, proportioning and mixing and the like, and proportioning and mixing comprise the steps of weighing 40-50 parts of partridge tea freeze-dried powder, 15-35 parts of morinda officinalis freeze-dried powder and 25-35 parts of fructus alpiniae oxyphyllae freeze-dried powder for proportioning; the mixed freeze-dried powder is divided into 2-4 equal parts by mass, then 2-4 parts of the mixed freeze-dried powder are put into a stirring device for stirring in multiple times, the adding amount of the mixed freeze-dried powder is 1 part each time, and after stirring is completed, the compound partridge tea polyphenol concentrated powder is obtained. Through morinda officinalis polysaccharide, osteoblast proliferation is promoted, and bone metabolism is improved; contraction and relaxation of bladder detrusor muscles are adjusted through effective components such as sharpleaf galangal fruit sterol, the urination frequency is reduced, absorption and metabolism of morinda officinalis polysaccharide and effective components in sharpleaf galangal fruit are promoted through mallotus oblongifolius polyphenol, and the effects of improving bone metabolism and relieving urinary incontinence are better achieved.

The invention relates to a drug for treatment of osteoporosis, wherein the drug consists of oysters, premna fulva craib, dracaena cochinchinensis, soft-shelled turtle, herba lespedezae cuneatae, davallia formosana, tuber dioscoreae persimilis, membranaceous beautyleaf root, fennel and a pearl powder. The drug has the effect for relief and treatment of osteoporosis, and has the advantages of low price, and no toxic or side effects, and is safe and reliable.

The invention relates to an application of an STAT3 agonist ColivelinTFA in treatment of HIES and osteoporosis. An osteoblast specific Stat3 knockout mouse is constructed through a Cre-loxp system, it is found that the mouse shows HIES-related bone deformity such as maxillofacial bone development deformity, spontaneous fracture and osteoporosis, and the mechanism that STAT3 inactivation causes HIES-related bone development deformity and osteoporosis by regulating osteogenic activity is proved. On the basis, it is proved that the STAT3 agonist ColivelinTFA can be used for treating osteoporosis caused by insufficient single dosage of STAT3 and stress loss. Compared with a diphosphate drug, the ColivelinTFA increases the bone mass by promoting bone metabolism instead of inhibiting bone metabolism, which may avoid a series of complications such as jaw bone necrosis caused by diphosphate to a certain extent.

The invention relates to osteoporosis prevention food of a bone strengthening tea granule and belongs to the field of nutrition food. The bone strengthening tea granule aims at realizing the goals of good effect and fast effect taking and is prepared from ingredients including herba epimedii, rhizoma drynariae, soybean, lucid ganoderma, prepared rehmannia roots, black tea and the like. The bone strengthening tea granule has the effects of supporting body resistance, reinforcing qi, nourishing blood, tonifying the liver, nourishing yin, strengthening the bone and alleviating the pain, and has the advantages of good effect and high effect taking speed.

The invention discloses formula milk powder for promoting height development of children and a preparation method thereof, and relates to the technical field of milk powder manufacturing, according to the formula milk powder for promoting height development of children and the preparation method thereof, the formula milk powder comprises whole milk powder, the preparation method comprises the steps: firstly, performing raw and auxiliary material acceptance inspection: unpacking milk powder, additives, raw materials and auxiliary materials, and performing tunnel sterilization on the inner bag, unpacking the inner back of the raw materials and the auxiliary materials, pre-mixing and weighing raw materials and auxiliary materials, then mixing the raw materials and the auxiliary materials, bagging after mixing, and finally performing same outer packaging on bagged finished products, adding 50 mg of walnut peptide, 50 mg of hydrolyzed egg yolk powder, 80 mg of colostrum basic protein and balance of lactoferrin in the raw materials and the auxiliary materials to 100 mg/100g in total, and mixing the materials according to the dosage so that after children eat the product, the content of the milk patch protein contained in the body can be increased, the iron balance of the children in the body can be regulated, and the generation of bone marrow cells can be regulated.