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Formulation for increasing bone density

A technology for increasing bone density and preparations, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pill delivery, etc. It can solve problems such as difficult absorption, high toxicity, and difficult absorption of calcium supplements by the human body.

Inactive Publication Date: 2008-12-17
王冰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Domestic and foreign medical circles agree that the main cause of osteoporosis and bone hyperplasia is the long-term calcium deficiency in the human body. For this disease, calcium supplementation is mainly used for prevention and treatment at present. The existing calcium supplementation in China is active. Calcium is ionized calcium, calcium gluconate, calcium lactate, calcium tablets, etc. These calcium supplements are used to treat osteoporosis and hyperplasia, but there are the following problems: First, some calcium supplements are not easily absorbed by the body, such as oysters, mussels, etc. The shell is used as a raw material, which is calcined at high temperature to make a calcium mixture. Its main components are calcium oxide, calcium hydroxide and a small amount of calcium carbonate. These inorganic calcium are not easy to be absorbed by the human body, and their toxicity is relatively high; Lower, such as calcium gluconate with 9% calcium and calcium lactate with 12%
And a small number of calcium supplement products contain calcium depositin, although it can accelerate the deposition of calcium on the bone, but it cannot restore the calcified soft tissue to its original state

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Calcium acetate 220.0g

[0021] Glucosamine Hydrochloride 40.0g

[0022] Casein Phosphopeptide 20.0g

[0023] Soy Isoflavones 20.0g

[0024] Magnesium Stearate 2.5g

[0025]

[0026] Makes 1000 pieces

[0027] Preparation method: Mix calcium acetate, glucosamine hydrochloride, casein phosphopeptide, soybean isoflavones, and microcrystalline cellulose evenly, dry granulate, add magnesium stearate, mix evenly, press into tablets or coat with film according to conventional coating operations , that is.

Embodiment 2

[0029] Calcium acetate 325.0g

[0030] Glucosamine Hydrochloride 125.0g

[0031] Casein Phosphopeptide 20.0g

[0032] Soy Isoflavones 31.25g

[0033] Microcrystalline Cellulose 84.0g

[0034] Povidone K30 12.0g

[0035] Magnesium Stearate 2.5g

[0036]

[0037] Makes 1000 pieces

[0038] Preparation method: mix calcium acetate, glucosamine hydrochloride, casein phosphopeptide, soybean isoflavone, and microcrystalline cellulose evenly, add 10% povidone K30 aqueous solution, make soft material, granulate, 80±10°C Drying, granulation, adding magnesium stearate and mixing, pressing into tablets or coating with film according to conventional coating operations, to obtain.

Embodiment 3

[0040] Calcium acetate 800.0g

[0041] Glucosamine Hydrochloride 300.0g

[0042] Casein Phosphopeptide 160.0g

[0043] Soy Isoflavones 20.0g

[0044] Microcrystalline Cellulose 530g

[0045] Povidone K30 52g

[0046] Magnesium Stearate 18g

[0047]

[0048] Makes 1000 pieces

[0049] Preparation method: mix calcium acetate, glucosamine hydrochloride, casein phosphopeptide, soybean isoflavone, and microcrystalline cellulose evenly, add 10% povidone K30 aqueous solution, make soft material, granulate, 80±10°C Drying, granulation, adding magnesium stearate and mixing, pressing into tablets or coating with film according to conventional coating operations, to obtain.

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Abstract

A preparation for increasing the bone density, which is provided by the invention, relates to a calcium supplement product, in particular to a calcium supplement preparation which can increase the bone density. The calcium supplement preparation of the invention is mainly prepared by main raw materials of calcium acetate, glucosamine hydrochloride, CPPs and soy isoflavones. The ratio of the main raw materials is 11 portions to 40 portions of calcium acetate, 2 portions to 15 portions of glucosamine hydrochloride, 1 portion to 8 portions of CPPs, 1 portion to 3 portions of soy isoflavones and 0.1 portion to 30 portions of auxiliary material. In the preparation for increasing the bone density of the invention, the calcium acetate is a common calcium supplement preparation and can increase the bone density through the direct calcium supplement; the CPPs can promote the calcium absorption; the soy isoflavones has the estrogen-like effect and can reduce the calcium loss and the glucosamine hydrochloride can improve bone metabolism and bone nutrition. The formula of the invention can realize the effects of promoting calcium absorption, reducing calcium loss, improving bone metabolism and bone nutrition and increasing the bone density through the direct calcium supplement.

Description

technical field [0001] The invention relates to a calcium supplement product, in particular to a calcium supplement preparation for increasing bone density. Background technique [0002] Domestic and foreign medical circles agree that the main cause of osteoporosis and bone hyperplasia is the long-term calcium deficiency in the human body. For this disease, calcium supplementation is mainly used for prevention and treatment at present. The existing calcium supplementation in China is active. Calcium is ionized calcium, calcium gluconate, calcium lactate, calcium tablets, etc. These calcium supplements are used to treat osteoporosis and hyperplasia, but there are the following problems: First, some calcium supplements are not easily absorbed by the body, such as oysters, mussels, etc. The shell is used as a raw material, which is calcined at high temperature to make a calcium mixture. Its main components are calcium oxide, calcium hydroxide and a small amount of calcium carbo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/16A61K38/10A61K9/48A61K9/20A61K9/10A61K9/16A61K9/28A61K47/24A61K47/14A61K47/38A61K47/36A61K47/46A61P19/10A61P3/02A61K31/19A61K31/7008A61K36/48
Inventor 王冰刘晓凯张永胜杜元英
Owner 王冰
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