Ceramic-based dental department bone powder and preparation method thereof

A technology based on dental and bone powder, applied in the field of ceramic-based dental bone powder and its preparation, can solve the problems of poor hydrophilicity, unfavorable cell adhesion and proliferation, and poor biocompatibility, so as to improve water absorption performance, improve bone repair effect, The effect of low production cost

Active Publication Date: 2018-06-05
BEIJING ALLGENS MEDICAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] Aiming at the problems of poor biocompatibility and hydrophilicity of the existing dental bone powder, which is not conducive to the adhesion and proliferation of cells on the bone powder material, the present invention provides a dental dental bone powder with good biocompatibility and excellent hydrophilic effect. Ceramic-based dental bone powder can improve the effect of bone repair, but also has a lower production cost and is convenient for clinical application

Method used

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  • Ceramic-based dental department bone powder and preparation method thereof
  • Ceramic-based dental department bone powder and preparation method thereof
  • Ceramic-based dental department bone powder and preparation method thereof

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preparation example Construction

[0079] In some embodiments, the preparation method of the porous hydroxyapatite includes:

[0080] (a) preparing hydroxyapatite suspension;

[0081] (b) adding the first PMMA particles and the second PMMA particles to the hydroxyapatite suspension to obtain a sintered base liquid;

[0082] (c) placing the sintering base liquid in a sintering device for sintering to obtain a sintered material;

[0083] (d) crushing and sieving the sintered material to obtain the porous hydroxyapatite.

[0084] Preferably, the step (a) is carried out as follows:

[0085] Mix 15-20g of hydroxyapatite in batches (for example, the hydroxyapatite can be divided into 3-10 parts, so that the hydroxyapatite can be added in 3-10 times) and 20-35mL of PBS solution are mixed, Then add 1.5-2.5 mL of polyvinyl alcohol solution with a concentration of 0.05-0.1 g / mL, stir evenly, and prepare the hydroxyapatite suspension. The PBS solution here is a commonly used phosphate buffered saline solution with a p...

Embodiment 1

[0116] A kind of ceramic base dental bone powder, its preparation component comprises:

[0117] Porous hydroxyapatite;

[0118] Type I collagen, the mass is 1% of the mass of porous hydroxyapatite;

[0119] Wherein, the preparation component of porous hydroxyapatite comprises hydroxyapatite, the first PMMA particle and the second PMMA particle, the mass ratio is 5:2.5:1.5, and the particle diameter of the first PMMA particle is 50 μ m, the second PMMA particle The particle size of the particles is 500 μm; and

[0120] Porous hydroxyapatite is prepared by sintering, and the sintering process is shown in Table 1

[0121] Table 1

[0122]

Embodiment 2

[0124] A kind of ceramic base dental bone powder, its preparation component comprises:

[0125] Porous hydroxyapatite;

[0126] Type I collagen, the mass is 10% of the mass of porous hydroxyapatite;

[0127]Wherein, the preparation component of porous hydroxyapatite comprises hydroxyapatite, the first PMMA particle and the second PMMA particle, the mass ratio is 5:3.5:2.5, and the particle diameter of the first PMMA particle is 100 μ m, the second PMMA particle The particles have a particle size of 1000 μm; and

[0128] Porous hydroxyapatite is prepared by sintering, and the sintering process is shown in Table 2:

[0129] Table 2

[0130]

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Abstract

The invention relates to a ceramic-based dental department bone powder and a preparation method thereof. The powder comprises preparation components, namely porous hydroxyapatite and type-I collagen,wherein the porous hydroxyapatite comprises preparation components, namely hydroxyapatite of a specific mass ratio, first PMMA (Polymethyl Methacrylate) granules and second PMMA granules; the particlesizes of the first PMMA granules are 50-100mu m; the particle sizes of the second PMMA granules are 500-1000mu m; the porous hydroxyapatite is made through sintering preparation; the sintering preparation comprises the following stages: at stage I, the heating velocity is 5-10 DEG C, the target temperature is 500-600 DEG C, and the constant temperature time is 20-30 minutes; at stage II, the heating velocity is 5-10 DEG C/minute, the target temperature is 1200-1500 DEG C, and the constant temperature time is 200-300 minutes; at stage III, heating is stopped, and the temperature is reduced naturally. The ceramic-based dental department bone powder is excellent in water absorption property and bone repairing effect and relatively low in production cost.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a ceramic-based dental bone powder and a preparation method thereof. Background technique [0002] In dental surgery, there are many situations that may cause bone defect or bone deficiency in patients after surgery, such as bone defect after periodontal cyst extraction, and bone deficiency caused by alveolar ridge atrophy after tooth extraction. These conditions often limit the patient's postoperative bone healing and the effect of subsequent dental implants, so bone implants are required. The current gold method is mainly to use autologous bone for transplantation, but its application is limited due to its limited source and certain postoperative complications in the donor site. Allogeneic bone grafts have potential antigenicity and risk of disease transmission. Therefore, artificial bone repair materials have become the research direction of many scholars because of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/24A61L27/12A61L27/10A61L27/50A61L27/56
CPCA61L27/10A61L27/12A61L27/24A61L27/50A61L27/56A61L2430/12
Inventor 胡艳丽宋天喜崔云朱金亮何志敏仇志烨崔菡
Owner BEIJING ALLGENS MEDICAL SCI & TECH
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