Diethylstilbestrol compound and application thereof in preparation of drug for treating osteoporosis and hyperlipemia

Abstract

The invention discloses a diethylstilbestrol compound and application thereof in preparation of a drug for treating osteoporosis and/or hyperlipemia. The structural formula of the diethylstilbestrol compound is shown in the specification. The data of a cellular level pharmacodynamic test show that cajanstilbene H (R is H, and X is Cl) can promote multiplication and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) of an SD rat. After an ob/ob obese mice orally takes the cajanstilbene H (20 mg/kg/d) continuously for 21 days, the results are as follows: (1) no obvious effect on weight is generated; (2) the bone density of the mice is obviously increased; serum alkaline phosphatase (ALP) and tartrate resistant acid phosphatase (TRACP) level are obviously reduced; and the serum calcium concentration is improved; and (3) levels of total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) in the serum of the mice are obviously reduced. The results show that the cajanstilbene H has positive significance in treatment of the osteoporosis caused by obesity and high blood sugar, and has a clear curative effect on the aspect of improvement of lipid metabolism of the obese mice. The cajanstilbene H has a clear treatment effect on the osteoporosis caused by obesity and high blood sugar and simultaneously can improve lipid metabolism; and metabasis of hyperlipemia to diabetes mellitus to chronic complication of diabetes mellitus to osteoporosis can be avoided to a certain extent.

Description

technical field [0001] The present invention relates to a class of organic compounds and applications thereof, in particular to the preparation of a medicine for treating osteoporosis and / or hyperlipidemia and the benefit of osteoporosis and / or hyperlipidemia. Application in health food. Background technique [0002] Osteoporosis is a common disease that mainly affects middle-aged and elderly people. With the advent of an aging society, osteoporosis has become a public health problem that cannot be ignored, threatening the health of middle-aged and elderly people and seriously affecting their quality of life. Osteoporosis (osteoporosis) is a metabolic bone disease, which can be divided into two types: primary and secondary, among which primary osteoporosis accounts for 90% of osteoporosis, and can be divided into There are two subtypes, among which type I is called postmenopausal osteoporosis, and type II is senile osteoporosis. Secondary osteoporosis can be secondary to ...

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