Florfenicol taste masking preparation and preparation method for same

A preparation technology of florfenicol, which is applied in the field of veterinary antibiotic preparations, can solve the problems of florfenicol bitter taste and poor palatability, etc., and achieve the effect of simple and reliable preparation process

Active Publication Date: 2013-07-17
SHANDONG LUKANG SHELILE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Aiming at the problem of florfenicol having a bitter taste and poor palatability, the invention provides a taste-masking preparation with good taste effect without affecting its efficacy

Method used

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  • Florfenicol taste masking preparation and preparation method for same

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Mix Florfenicol (10%), starch (37.5%), and microcrystalline cellulose (37.5%) evenly to obtain a physical mixture; then dissolve Eudragit E100 (15%) in 60% ethanol aqueous solution, Add to the physical mixture to make soft material, granulate with a swing granulator, pass through a 20-mesh sieve to obtain wet granules, dry at 50°C, and granulate with a 18-mesh sieve. The dissolution of the drug in water was 1.6% in 1 minute, and 7.2% in 10 minutes; the dissolution of the drug in 0.1mol / L hydrochloric acid was 81.5% in 2 minutes, and the dissolution was complete in 10 minutes.

[0051] With reference to the Chinese Pharmacopoeia 2010 edition two appendix X C the third method detects drug dissolution rate, draws dissolution curve, such as figure 1 shown. Dissolution medium: 250 ml deionized water or 0.1molL -1 Hydrochloric acid solution, speed: 100rpm / min, temperature: 37.0°C±0.5°C, sample 6ml at 0.33, 0.67, 1, 2, 5, 8, 10, 20, 30, 45, 60min, and supplement the same vol...

Embodiment 2

[0053] Mix Florfenicol (10%), starch (51%), and Eudragit EPO (30.5%) evenly to obtain a physical mixture; then dissolve Eudragit E100 (8.5%) in 70% ethanol aqueous solution, Add to the physical mixture to make soft material, granulate with a swing granulator, pass through a 65-mesh sieve to obtain wet granules, and dry at 50°C to obtain the product. The dissolution rate of the drug in water was 8.6% in 1 minute, 71.6% in 1 minute in 0.1 mol / L hydrochloric acid, and 94.7% in 5 minutes.

Embodiment 3

[0055] Mix florfenicol (10%), lactose (20%), low-substituted hydroxypropyl cellulose (10%), and microcrystalline cellulose (45%) to obtain a physical mixture; then Eudragit E100 ( 15%) dissolved in 60% ethanol aqueous solution, added to the physical mixture to make a soft material, passed through a 0.5mm aperture sieve, extruded through a screw extruder to make strips, and placed in a rounding equipment for 2 minutes to obtain pellets , 55 ℃ drying, that is. The dissolution of the drug in water was 3.0% in 1 minute, and 9.3% in 5 minutes; the dissolution of the drug in 0.1mol / L hydrochloric acid water reached 81.6% in 20 minutes, and was greater than 90% in 30 minutes.

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Abstract

The invention discloses a florfenicol taste masking preparation, which comprises the following components in percentage by weight: 5 to 75 percent of florfenicol, 5 to 40 percent of gastric-soluble high polymer material, 20 to 90 percent of filler, 0 to 10 percent of hydrophilic adhesive material and 0 to 5 percent of insoluble material. The invention also discloses a preparation method for the florfenicol taste masking preparation. The method is simple, convenient, and reliable; a coating and special equipment are not required; and the gastric-soluble high polymer material and the other minor ingredients are used together, so that the florfenicol achieves the dual effects of taste masking and fast action, and prepared taste masking particles or pellets have the characteristics of slow dissolution in an aqueous solution or saliva and quick dissolution in gastric juice.

Description

technical field [0001] The invention relates to a florfenicol taste-masking preparation and a preparation method thereof, in particular to a florfenicol taste-masking granule or pellet and a preparation method thereof, belonging to the field of veterinary antibiotic preparations. Background technique [0002] Florfenicol, also known as florfenicol, is a new generation of chloramphenicol-type veterinary-specific broad-spectrum antibiotics. It has the characteristics of broad-spectrum antibacterial, good absorption, wide distribution in the body, safety and high efficiency. The treatment effect of livestock bacterial diseases is remarkable, especially without potential aplastic anemia effect. Therefore, florfenicol has broad application prospects in the prevention and treatment of animal diseases, especially food animals. However, due to the bitter taste of florfenicol, its palatability is not good, and its oral administration has certain restrictions. Since the stomach-solu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/165A61K47/32A61P31/04
Inventor 董坤彭欣郭强
Owner SHANDONG LUKANG SHELILE PHARMA
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