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Taste-masked enrofloxacin soluble powder and preparation method thereof

An enrofloxacin and soluble technology, which is applied in the field of taste-masking enrofloxacin soluble powder and its preparation, can solve the problems of inability to achieve palatability and strong enrofloxacin bitterness, and achieve improved stability and taste-masking Good effect and high solubility

Active Publication Date: 2019-12-17
ZHEJIANG WANFANG BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the solution inclusion method has a certain masking effect on the bitterness of the drug, enrofloxacin has a very strong bitter taste. It has been proved by livestock experiments that the ideal palatability effect cannot be achieved only by inclusion and masking.

Method used

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  • Taste-masked enrofloxacin soluble powder and preparation method thereof
  • Taste-masked enrofloxacin soluble powder and preparation method thereof
  • Taste-masked enrofloxacin soluble powder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] If producing 100kg taste-masked enrofloxacin soluble powder, include the following steps:

[0027] (1) Weigh 10kg of enrofloxacin, 84.5kg of beta cyclodextrin (according to active ingredients), 3kg of sodium carbonate, 0.5kg of steviol glycoside, 0.5kg of sodium alginate, 1.5kg of sodium starch octenyl succinate, spare;

[0028] (2) Mix enrofloxacin and beta-cyclodextrin evenly, put them into hot water at 80-83°C and stir constantly, the ratio of water to material is 2:1, and it is molecular inclusion liquid;

[0029] (3) When the temperature of the molecular inclusion liquid in step (2) is stabilized in the range of 80-83°C, add sodium carbonate and steviol glycosides to clarify the solution, keep it warm for 1 hour, and then centrifugally spray dry it. The air inlet temperature is 175-180°C, 80±2°C, atomization disc rotation speed 3000-3200r / min, to obtain enrofloxacin powder preparation, the particle size is controlled at 120-160μm;

[0030] (4) Mix sodium alginate...

Embodiment 2

[0033] If producing 100kg taste-masked enrofloxacin soluble powder, include the following steps:

[0034] (1) Weigh 12kg of enrofloxacin, 81.4kg of beta cyclodextrin (according to active ingredients), 2kg of sodium carbonate and sodium bicarbonate, 0.6kg of steviol glycoside, sodium carboxymethylcellulose and hydroxypropyl methyl Each 0.25kg of base cellulose, 1.5kg of sodium starch octenyl succinate, spare;

[0035] (2) Mix enrofloxacin and beta-cyclodextrin evenly, put them into hot water at 80-83°C and stir constantly, the ratio of water to material is 2:1, and it is molecular inclusion liquid;

[0036] (3) Add sodium carbonate, sodium bicarbonate, neotame and aspartame to clarify the solution when the temperature of the molecular inclusion liquid in step (2) is stabilized in the range of 80-83°C, keep it warm for 1 hour, then centrifugally spray dry it, and let it air into The temperature is 175-180°C, the air outlet temperature is 80±2°C, and the rotation speed of the at...

Embodiment 3

[0040] If producing 100kg taste-masked enrofloxacin soluble powder, include the following steps:

[0041] (1) Weigh 15kg of enrofloxacin, 77.2kg of hydroxypropyl beta cyclodextrin (according to active ingredients), 2kg and 2.5kg of sodium carbonate and sodium bicarbonate, 0.8kg of steviol glycoside, hydroxypropyl methyl 0.5kg each of base cellulose and sodium alginate, 1.5kg of sodium starch octenyl succinate, spare;

[0042] (2) Mix enrofloxacin and hydroxypropyl beta-cyclodextrin evenly, put them into hot water at 80-83°C and stir continuously, the ratio of water to material is 2:1, and it is molecular inclusion liquid;

[0043](3) Add sodium carbonate, sodium bicarbonate, and steviol glycosides to clarify the solution when the temperature of the molecular inclusion liquid in step (2) is stabilized in the range of 80-83°C, keep it warm for 1 hour, and then centrifugally spray dry it, and the air inlet temperature is 175-180°C , the air outlet temperature is 80±2°C, the rota...

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Abstract

The invention discloses taste-masking enrofloxacin soluble powder and a preparation method thereof. The taste-masking enrofloxacin soluble powder comprises, by mass, 10-15 parts of enrofloxacin, 75.5-84.5 parts of inclusion agent, 3-5 parts of cosolvent, 0.5-1.5 parts of corrigent and 2-3 parts of film-forming release control agent. The enrofloxacin soluble powder has the advantages that the molecule inclusion and spray slow release double taste-masking technology is used to achieve a good masking effect on the bitter taste of the enrofloxacin, the enrofloxacin soluble powder can be dissolved in water through stirring, and content can be detected completely according to national-standard requirements; the problem that feed, stirred by a cultivation terminal, for feeding animals is poor in palatability, is solved, the drinking water problem of poultry is solved, drug bioavailability is increased, and evident social and economic benefits are achieved.

Description

Technical field: [0001] The invention relates to the technical field of veterinary drug preparations, in particular to a taste-masked enrofloxacin soluble powder and a preparation method thereof. Background technique: [0002] Enrofloxacin is a chemically synthesized third-generation quinolone antibacterial drug and the first fluoroquinolone drug for livestock and poultry. It was first successfully developed by Bayer in the 1980s. Enrofloxacin specifically inhibits the functions of bacterial DNA helicase and topoisomerase IV, and blocks the replication and transcription process of bacterial genetic material to achieve the purpose of sterilization. Enrofloxacin has broad-spectrum antibacterial activity and strong permeability, has a strong killing effect on Gram-negative bacteria, and has a good antibacterial effect on Gram-positive bacteria. However, the common enrofloxacin preparation has a bitter taste and low solubility, which seriously affects the feed intake and absorp...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K47/69A61K47/38A61K47/36A61K31/496A61P31/04
CPCA61K9/0053A61K9/0095A61K9/5036A61K9/5042A61K9/5047A61K31/496
Inventor 杨彩梅杨彪倪志兵刘金松
Owner ZHEJIANG WANFANG BIO TECH CO LTD
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