Sophorae flavescentis seed flavone sustained-release pellets for veterinary use and preparation

A technology of seed flavonoids and sustained-release pellets, which is applied to medical preparations containing no active ingredients, medical preparations containing active ingredients, and pill delivery, etc., which can solve problems such as large side effects, high cost, and easy drug resistance

Inactive Publication Date: 2017-06-23
QINGDAO UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Most of the antibacterial drugs on the market are western antibacterial drugs represented by antibiotics. Because of their remarkable antibacterial and bactericidal effects, antibiotics are usually used as the first choice of antibacterial drugs. However, antibiotics have their defects that cannot be ignored: large side effects, easy to produce drug resistance
[0007] Among the existing patents, the patents with application number 201610585227.6 and app...

Method used

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  • Sophorae flavescentis seed flavone sustained-release pellets for veterinary use and preparation
  • Sophorae flavescentis seed flavone sustained-release pellets for veterinary use and preparation
  • Sophorae flavescentis seed flavone sustained-release pellets for veterinary use and preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Taking the production of Sophora flavescens seed flavonoid sustained-release pellets 100g as an example, the used principal agent and auxiliary material quality proportioning are as follows:

[0025]

[0026] Preparation method: pass the main drug and auxiliary materials through 100-mesh sieve respectively, weigh them according to the prescription amount, sieve and mix them evenly, pour them into the melting pot, start the instrument, set the initial temperature to 50°C, and the initial speed to 250rpm, then Raise the temperature at a rate of 1°C / 4min, increase the speed at a rate of 50r / 5min until it reaches 75°C, stop heating and stirring after 2min, and pass through a 14-18 mesh sieve while it is still hot.

Embodiment 2

[0028] Taking the production of Sophora flavescens seed flavonoid sustained-release pellets 100g as an example, the used principal agent and auxiliary material quality proportioning are as follows:

[0029]

[0030] Preparation method is the same as embodiment 1

Embodiment 3

[0032] Taking the production of Sophora flavescens seed flavonoid sustained-release pellets 100g as an example, the used principal agent and auxiliary material quality proportioning are as follows:

[0033]

[0034] Preparation method is the same as embodiment 1

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PUM

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Abstract

The invention belongs to the technical field of veterinary drug preparations, in particular to a traditional Chinese medicine sustained-release drug preparation capable of substituting antibiotics to have a prevention and sterilization effect, and particularly relates to sophorae flavescentis seed flavone sustained-release pellets for veterinary use and having a by-pass rumen protection for ruminants and a preparation process of the sophorae flavescentis seed flavone sustained-release pallet. The pellets are prepared from the following raw materials: 40 to 45 percent of main herbs, 15 to 30 percent of wax materials, 15 to 20 percent of Carbomer, 10 to 20 percent of ethyecellulose and 1 to 5 percent of anti plastering agent and flavoring agent. By utilizing the characteristic of pH sensitivity of the Carbomer, the swelling of the Carbomer is controlled by virtue of the variation of a pH environment of rumen and abomasum so as to achieve drug sustained-release and positioned release purposes, so that a coating process is omitted, the preparation process is simple and fast, and the repeatability is good. The invention also provides a method for preparing the sustained-release pellets by virtue of a melt high-speed stirring technology. The preparation method has the advantages of high production efficiency, good pellet stability, and time and labor conservation.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine preparations, and in particular relates to a slow-release traditional Chinese medicine preparation which can replace antibiotics to prevent and kill bacteria, in particular to a slow-release flavonoids from flavescens seeds for ruminants with rumen protection Pellets and their preparation process. Background technique [0002] Most of the antibacterial drugs on the market are western antibacterial drugs represented by antibiotics. Because of their remarkable antibacterial and bactericidal effects, antibiotics are usually used as the first choice of antibacterial drugs. However, antibiotics have their defects that cannot be ignored: large side effects, easy to produce drug resistance . At present, the abuse of antibiotics is serious, especially in the field of veterinary medicine. A large amount of antibiotics are often added to animal feed to prevent infectious diseases in animals. T...

Claims

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Application Information

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IPC IPC(8): A61K36/489A61K9/20A61K47/32A61K47/38A61P31/04A61P31/00
Inventor 赵文英徐艳丽朱庆书
Owner QINGDAO UNIV OF SCI & TECH
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