Sophorae flavescentis seed flavone sustained-release pellets for veterinary use and preparation

Abstract

The invention belongs to the technical field of veterinary drug preparations, in particular to a traditional Chinese medicine sustained-release drug preparation capable of substituting antibiotics to have a prevention and sterilization effect, and particularly relates to sophorae flavescentis seed flavone sustained-release pellets for veterinary use and having a by-pass rumen protection for ruminants and a preparation process of the sophorae flavescentis seed flavone sustained-release pallet. The pellets are prepared from the following raw materials: 40 to 45 percent of main herbs, 15 to 30 percent of wax materials, 15 to 20 percent of Carbomer, 10 to 20 percent of ethyecellulose and 1 to 5 percent of anti plastering agent and flavoring agent. By utilizing the characteristic of pH sensitivity of the Carbomer, the swelling of the Carbomer is controlled by virtue of the variation of a pH environment of rumen and abomasum so as to achieve drug sustained-release and positioned release purposes, so that a coating process is omitted, the preparation process is simple and fast, and the repeatability is good. The invention also provides a method for preparing the sustained-release pellets by virtue of a melt high-speed stirring technology. The preparation method has the advantages of high production efficiency, good pellet stability, and time and labor conservation.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine preparations, and in particular relates to a slow-release traditional Chinese medicine preparation which can replace antibiotics to prevent and kill bacteria, in particular to a slow-release flavonoids from flavescens seeds for ruminants with rumen protection Pellets and their preparation process. Background technique [0002] Most of the antibacterial drugs on the market are western antibacterial drugs represented by antibiotics. Because of their remarkable antibacterial and bactericidal effects, antibiotics are usually used as the first choice of antibacterial drugs. However, antibiotics have their defects that cannot be ignored: large side effects, easy to produce drug resistance . At present, the abuse of antibiotics is serious, especially in the field of veterinary medicine. A large amount of antibiotics are often added to animal feed to prevent infectious diseases in animals. T...

AI Technical Summary

Problems solved by technology

[0002] Most of the antibacterial drugs on the market are western antibacterial drugs represented by antibiotics. Because of their remarkable antibacterial and bactericidal effects, antibiotics are usually used as the first choice of antibacterial drugs. However, antibiotics have their defects that cannot be ignored: large side effects, easy to produce drug resistance

[0007] Among the existing patents, the patents with application number 201610585227.6 and application number 201510606163.9 respectively disclose a rumen-passed aureomycin pellet and a preparation method thereof, and a rumen-passed enrofloxacin pellet and a preparation method thereof However, the main ingredients of these two pellets are antibiotics, which still cannot avoid the disadvantages caused by the long-term use of antibiotics, and the core of the pellets needs to be prepared first, and then coated, the process is complicated and the cost is high

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