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Metronidazole tablet for pets and preparation method thereof

A technology for metronidazole tablets and metronidazole, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, drug combinations, etc. It can improve the compressibility and content uniformity and ensure the effect of disintegration.

Pending Publication Date: 2020-12-15
河北远征药业有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the bitter nature of metronidazole makes it extremely inconvenient for dogs and cats to use it clinically. At present, there is no pet-specific metronidazole tablet on the market that can induce dogs and cats to take it actively and achieve the purpose of treating diseases.
[0003] The traditional preparation process of metronidazole tablets is to mix raw materials and excipients and press them into tablets. Although the quality of the compressed tablets meets the standard requirements, the bitter taste of metronidazole itself is difficult to be recognized when it is used in the veterinary drug market, especially in pet clinics. Accepted by dogs and cats, it is very difficult to use clinically
Even though some preparation processes are tablet coating, the pet chewing process makes the coating on the outer layer of the tablet unable to function

Method used

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  • Metronidazole tablet for pets and preparation method thereof
  • Metronidazole tablet for pets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] (A), preparation of metronidazole coated pellets

[0026] Select 30 parts of metronidazole, 5 parts of microcrystalline vitamins, 5 parts of dextrin, 2.5 parts of crospovidone and 0.5 parts of hypromellose E5 in a 1% aqueous solution and mix evenly to make a soft material, which is extruded Metronidazole pellets were prepared by spheronization, and the metronidazole pellets had a particle size of 0.3 mm. The metronidazole pellets were coated with Killcoat SmartSeal 30D by a fluidized bed coating process, and the weight gain was 10%. Nitazole coated pellets;

[0027] (B), preparation of auxiliary material granules

[0028] Take 15 parts of microcrystalline vitamins, 12.5 parts of dextrin, 2.5 parts of crospovidone, 5 parts of chicken liver hydrolyzate and 1.5 parts of hypromellose E5 and mix them with 1% aqueous solution, add water to make soft material, wet Granulation by law, drying, and sizing with a 50-mesh sieve to obtain auxiliary material granules;

[0029] (C)...

Embodiment 2

[0032] (A), preparation of metronidazole coated pellets

[0033] Choose to take 30 parts of metronidazole, 5 parts of corn starch, 5 parts of crospovidone and 0.5 parts of hypromellose E5 in a 1% aqueous solution and mix evenly to make a soft material, and prepare metronidazole by extrusion spheronization Micropills, the metronidazole pellets have a particle size of 0.5mm, and the fluidized bed coating process is used to select Killcoat SmartSeal 30D to coat the metronidazole pellets, and the weight gain is 15%, to obtain metronidazole coated pellets ;

[0034] (B), preparation of auxiliary material granules

[0035] Mix 15 parts of microcrystalline vitamins, 15 parts of dextrin, 3 parts of crospovidone, 5 parts of pig liver hydrolyzate and 2 parts of 1% aqueous solution of hypromellose E5, add water to make soft material, and wet granulate , drying, and sizing with a 40-mesh sieve to obtain auxiliary material granules;

[0036] (C), preparation of tablet

[0037] Take met...

Embodiment 3

[0039] (A), preparation of metronidazole coated pellets

[0040] Choose to get 30 parts of metronidazole, 8 parts of sucrose and 2 parts of crospovidone and mix evenly, add 20 parts of water to make a soft material, and prepare metronidazole pellets by extrusion and spheronization to obtain metronidazole pellets The particle size is 0.4mm, and the metronidazole pellets are coated with Killcoat SmartSeal 30D by a fluidized bed coating process, and the weight gain is 20% to obtain metronidazole coated pellets;

[0041] (B), preparation of auxiliary material granules

[0042] Mix 35 parts of corn starch, 5 parts of crospovidone, 8 parts of yeast extract and 1 part of hypromellose E3 in a 1% aqueous solution, add water to make a soft material, wet granulate, dry, and sieve 50 mesh Whole grains to obtain excipient granules;

[0043] (C), preparation of tablet

[0044] Take metronidazole-coated pellets and auxiliary material granules, mix them evenly, add 1.5 parts of talcum powd...

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Abstract

The invention belongs to the field of pet medicines, and relates to a metronidazole tablet for pets and a preparation method of the metronidazole tablet. The metronidazole tablet is coated by adding adisintegrating agent, a diluent and an adhesive when metronidazole coated pellets are prepared, and auxiliary material particles added with a phagostimulant, the disintegrating agent, the diluent andthe adhesive are prepared. The metronidazole coated pellets and the auxiliary material particles are mixed to prepare the metronidazole tablet, so that the bitter taste of metronidazole is masked, the purpose of inducing pets to take the metronidazole tablet actively is achieved, the compliance of pets is improved, and the convenience of clinical medication is also improved.

Description

technical field [0001] The invention belongs to the field of pet medicine, and in particular relates to a metronidazole tablet for pets and a preparation method thereof. Background technique [0002] Metronidazole is a synthetic nitroimidazole antibacterial and antiprotozoal drug, widely used in the treatment of diseases caused by Giardia, amoeba, trichomonas, etc. Treatment of infections in the mouth, throat, gastrointestinal tract and urinary tract. However, the bitter nature of metronidazole makes it extremely inconvenient for dogs and cats to use it clinically. At present, there is no pet-specific metronidazole tablet on the market that can induce dogs and cats to take it actively and achieve the purpose of treating diseases. [0003] The traditional preparation process of metronidazole tablets is to mix raw materials and excipients and press them into tablets. Although the quality of the compressed tablets meets the standard requirements, the bitter taste of metronidaz...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K9/50A61K47/12A61K47/32A61K47/38A61K47/36A61K31/4164A61P31/04A61P33/02
CPCA61K9/2013A61K9/2081A61K9/5026A61K31/4164A61K47/36A61K47/38A61P31/04A61P33/02
Inventor 贾国宾瞿红颖刘欣魏丽娟魏占勇宋婷婷贾兴耿智霞刘静郭李珉李金明李红园李卓伟
Owner 河北远征药业有限公司
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