82 results about "Metronizole" patented technology

The invention discloses a Metronidazole, Clotrimazole and Chlorhexidine Acetate Effervescent Tablet and the preparation method. Each tablet has the following proportion of contents: metronidazole 0.2 gram, clotrimazole 0.16 gram, acetic acid chlorhexidine acetate 0.008 gram, fumaric acid 0.108 to 0.162 gram, tartaric acid 0.012 to 0.018 gram, solium bicarbonate 0.12 to 0.18 gram, starch 0.02 to 0.04 gram, dextrin 0.003 to 0.007 gram, hydroxypropyl cellulose 0.007 to 0.013 gram, talc 0.01 to 0.017 gram, sodium dodecyl sulfate 0.01to 0.02 gram, and proper proportion of povidone K30 water solution. According to the preparation method, the components are mixed to produce granule (1) and granule (2); the talc, sodium dodecyl sulfate and the granule (1) and granule (2) are mixed uniformly; granule content is tested and according to the granule content, the tablet weight is identified for tabletting. The invention overcomes the shortages with prior art, enables the acetic acid chlorhexidine acetate to perform functions normally, performs synergistic effects of the three drugs, and greatly enhances the cure rate. Besides, the frothing volume is high, and within storage period, the quality is stable and the drug effects are not affected.

A ssDNA aptamer for specifically identifying metronidazole and an application thereof belongs to the fields of biochemistry, molecular biology, analytical chemistry and combinatorial chemistry. In thepresent invention, a ssDNA initial library containing 35 random nucleotides is amplified by PCR through a magnetic beads-SELEX technology, and then immobilized on magnetic beads modified with streptavidin, added with metronidazole to separate ssDNAs with affinity by competition, and amplified for next screening. After ten rounds of screening and clone sequencing, 39 metronidazole aptamer sequences are obtained. After further affinity evaluation, four sequences with higher affinity including ap2, ap19, ap21, and ap32 are selected, wherein, the ap32 is selected as an optimal metronidazole aptamer due to the advantages of high affinity, high specificity and stable structure. The invention provides an identification element with excellent performance for metronidazole detection.

The invention discloses a sprayable metronidazole gel composition. The composition comprises metronidazole, water, a water-miscible solvent, carboxymethylcellulose, gamma-type carrageen glycan and 2000-20000 parts of PEG1 (polyethylene glycol 1). The gel composition is high in physical stability, high in salt-resistant capacity and convenient to use.

The invention relates to a method for detecting chloramphenicol, thiamphenicol, metronidazole residuals in prawns by using a pressurized capillary electrochromatographic instrument, which comprises the following steps of: preparing a sample; preparing standard chloramphenicol, thiamphenicol, metronidazole solutions; carrying out analysis on the solutions by using the pressurized capillary electrochromatographic instrument, namely, under the process conditions that a capillary electrochromatographic column taking phase reversal keys and C18 as packing is taken as a detecting column, a mobile phase is a mixed solution of a hydrogen diamine phosphate buffer solution (11-13 mmol/L, pH = 4-6) and acetonitrile, the volume ratio of the hydrogen diamine phosphate buffer solution to the acetonitrile is (90-70): (10-30), the applied voltage is minus 3-minus 5 kv, the pressure of the column is 9.6-9.8 MP, the temperature of the column is room temperature, the flow velocity of the mobile phase is 40- 60 mu L/min, and the sample size is 0.9-1.1 mu L, carrying out detection at a position (wavelength: 275 nm) by using an ultraviolet detector, and drawing standard curves; and after the sample is detected and analyzed, carrying out quantitative analysis on the sample according to the retention time of the sample, and carrying out quantitative analysis on the sample according to the peak area of the sample by using an external standard method. The method disclosed by the invention is efficient, accurate, less in organic reagent consumption, and high in sensitivity, and can satisfy the demands of daily detection on chloramphenicol, thiamphenicol, metronidazole drugs.

The invention relates to a chewing gum capable of removing bad breath. The chewing gum is characterized by comprising the following components in parts by weight: 18 parts of synthetic gum base, 25 parts of xylitol, 3 parts of cocoa powder, 0.5 part of metronidazole, 1.5 parts of maltodextrin, 1 part of glycerol, 0.1 part of soybean phospholipid, 0.5 part of spearmint essential oil, 0.2 part of titanium dioxide and 0.2 part of carnauba wax. The chewing gum is a coffee-flavored metronidazole chewing gum. The bad breath removing effect of the coffee-flavored metronidazole chewing gum lasts for 4 to 8 hours, but the bad breath removing effect of the common chewing gum does not exceed 1 hour. The coffee-flavored metronidazole chewing gum also can be applied to oral care of critical patients. The metronidazole is used for killing odor producing bacteria of an oral cavity, so that the bad breath value is reduced; the oral cavity is cleaned by chewing the chewing gum; the bad odor of the oral cavity is covered by the perfume ingredient of the chewing gum. The chewing gum is organic combination of mechanical therapy and chemical therapy, achieves a synergistic effect of removing bad breath and obviously improves the effect of removing bad breath. The screened formula of the chewing gum can obviously cover the bitter taste of the metronidazole, so people can easily accept the chewing gum.

The invention relates to the field of metronidazole medicaments, and discloses a metronidazole and sodium chloride injection as well as a preparation method and application thereof. Based on the totalweight of the injection, the metronidazole and sodium chloride injection is prepared from the following components in percentage by weight: (1) 0.2 to 0.9 percent of metronidazole, (2) 0.1 to 0.9 percent of sodium chloride, (3) 0.01 to 0.1 percent of citric acid, (4) 0.05 to 0.3 percent of sodium dihydrogen phosphate, (5) 0.1 to 2 percent of disodium hydrogen phosphate, and (6) 96 to 99 percent of water for injection. The metronidazole and sodium chloride injection provided by the invention has good stability.

Disclosed is a colon positioning and adhering preparation and its preparing process which comprises mixing Metronidazole, starch, dextrin and bletilla striata, charging starch grout and preparing particles, obtaining wet micro-pullet, drying, pressing into tablet, mixing dressing material, ethanol, castor-oil, dibutyl phthalate into dressing liquid, preparing dressed micro-pullet or dressed tablet, and loading the dressed micro-pullet into capsule or directly split charging into micro-pullet pills.

The invention provides a method, a device for formic acid solvent recycling in metronidazole production and an application thereof. In a metronidazole synthesis process, the recycling of formic acid is realized, and the production cost is saved. In a metronidazole production process, sulfur trioxide consumes water to generate sulfuric acid, the water in formic acid solution is gradually consumed,and the sulfuric acid needed for the metronidazole synthesis is generated. The reduction of the water is beneficial to a follow-up synthetic process of the metronidazole. The device is capable of introducing the sulfur trioxide into an injector by using the injector and mixing with solution, and improving the mixing efficiency. Because of the action of the injector, the sulfuric acid concentrationof liquid at the bottom of a negative pressure tank is greater than the sulfuric acid concentration of the liquid at the top, the liquid at the top is replaced in a storage tank for recycling by using a hose and a floating head, and pumped back by a power pump, thereby the sulfuric acid concentration of the liquid mixed with the sulfur trioxide is the lowest, and beneficial to the high-efficientmixing. Alkaline liquor in a liquid seal tank is used for absorbing an acid gas, and the pollution is prevented.

The invention discloses a drug for shortening a sow labor process and a preparation method thereof. The preparation method comprises the following steps of adding 88.8806-88.8810% of injection water into a concentration tank, carrying out stirring, slowly adding 0.1-0.3% of metronidazole into the concentration tank, carrying out heating boiling, adding 9-11% of weighed glucose, 0.008-0.012% of triphosadenine, 0.006-0.01% of dexamethasone and 0.8-1.0% of common salt into the boiling solution until complete dissolution, adding active carbon of which humidity is pre-adjusted into the mixed solution for decoloration, filtering the hot mixed solution by a concentration and filtration titanium rod, collecting the filtrate by a dilution tank, carrying out stirring by the dilution tank, diluting the filtrate by injection water until the diluent filtrate volume is 90% of the total dilution tank volume, adjusting a pH value to 6.0-7.0 by a sodium hydroxide solution having the content of 0.1mol/L, carrying out dilution until the diluent filtrate volume is equal to the total dilution tank volume, adding active carbon of which humidity is pre-adjusted into the diluent filtrate for decoloration, carrying out filtration by a filter membrane until the filtrate is clear and transparent, feeding the filtrate to a soft bag liquid-conveying production line by a delivery pump, and carrying out loading.

The invention relates to a liquid fertilizer and a preparation method thereof. The liquid fertilizer is composed of an inorganic nutrient substance, an organic nutrient substance and water, and is characterized by containing metronidazole. The liquid fertilizer and the preparation method thereof have the advantages that the liquid fertilizer can be prevented from swelling out of a bottle, the fertilizer loss is reduced, the quality of the fertilizer is stable, and the utilization rate of the fertilizer in soil is also increased.

Relating to the field of medicinal chemistry, the invention discloses a synthesis method of sodium glycididazole. According to the method, iminodiacetic acid as a starting material reacts with acethlchloride/anhydrous sodium acetate in DMF (dimethyl formamide), and then reacts with metronidazole to generate imido bisazolyl ester which is further condensed with chloroacetic acid into acid glycididazole. And finally, an ethanol solution with 40 wt% of sodium hydroxide is added to generate sodium glycididazole salt trihydrate. According to the invention, the synthesis method of sodium glycididazole, without using pyridine and acetic anhydride, is environmentally friendly. With an overall yield of 34.5%, the method is suitable for industrial production.

The invention belongs to the field of pet medicines, and relates to a metronidazole tablet for pets and a preparation method of the metronidazole tablet. The metronidazole tablet is coated by adding adisintegrating agent, a diluent and an adhesive when metronidazole coated pellets are prepared, and auxiliary material particles added with a phagostimulant, the disintegrating agent, the diluent andthe adhesive are prepared. The metronidazole coated pellets and the auxiliary material particles are mixed to prepare the metronidazole tablet, so that the bitter taste of metronidazole is masked, the purpose of inducing pets to take the metronidazole tablet actively is achieved, the compliance of pets is improved, and the convenience of clinical medication is also improved.

The invention discloses a composite nano-material, a preparation method and application thereof, and belongs to the technical field of mass spectrometric detection.The composite nano-material comprises a gold colloidal solution and ferronickel-layered double hydroxides, the volume ratio of the gold colloidal solution to the ferronickel-layered double hydroxides is (1-3):(1-3), and according to the preparation method, an improved Frens method is used for synthesizing a nano-gold material; and NiFe-LDHs and AuNPs are self-assembled to form the composite nano material, the composite nano material is used for detecting metronidazole and metabolite thereof, the detection result repeatability is good, the linear relation is good, and the composite nano material can be used for quantification.

The invention discloses an anti-inflammatory drug for a postpartum sow and a preparation method thereof. The preparation method comprises the following steps of crushing 9-11% of naproxen and 28-32% of metronidazole, sieving the crushed naproxen and metronidazole to obtain naproxen and metronidazole of 100 meshes, pouring 9-11% of the crushed naproxen, 28-32% of the crushed metronidazole, 1.8-2.2% of gentamycin sulfate, 1.0-1.4% of metoclopramide, 17.4-17.8% of motherwort, 27.36-27.40% of pottery clay and 9-11% of Daditian into a wet granulation machine, carrying out uniform mixing, adding 1.80-1.84% of starch into the mixture, carrying out stirring for 8min, pouring the stirred mixture into an oscillating granulator, carrying out granulation, feeding the granules into a fluidized bed by a negative pressure pipe, carrying out drying, and carrying out sieving and packaging.