54 results about "Metronizole" patented technology

The invention provides a preparation method of artificial bezoar-metronidazole capsules. The capsules contain 2 parts of artificial bezoar, 80 parts of metronidazole, and 30-40 parts of starch in parts by weight. The preparation method comprises the steps of preparing raw materials and auxiliary materials, premixing, wet processing, and filling. The prepared artificial bezoar-metronidazole capsules have small weight variation, high content uniformity, and stable quality after accelerated storage for 6 months.

The invention discloses metronidazole particles, a preparation containing the metronidazole particles and a preparation method of the metronidazole particles. The metronidazole particle comprises a drug core and a coating layer, wherein the coating layer is coated on the outer surface of the drug core; the medicine core comprises metronidazole; the coating layer comprises a film-forming material, and the film-forming material comprises gastric-soluble acrylic resin and ethyl cellulose. The metronidazole granule has low dissolution rate in water and a medium with high pH (such as pH 6.8), especially the dissolution rate in 15 minutes is less than or equal to 10%, the dissolution rate at low pH (such as pH 1.2-4.5) is consistent with the dissolution rate of commercially available tablets, and the metronidazole granule is rapidly dissolved out.

The present invention relates to the technical field of metronidazole, and specifically discloses a method for recovering materials from a crude metronidazole mother liquor. The present invention first adjusts acid for neutralization, then concentrates and distills water, and adds low-carbon alcohol to remove salt (sodium sulfate), thereby avoiding the "first concentration and then neutralization" treatment mode in which acid adjustment generates salt in the subsequent process, which is mixed into the recovered material, affecting the recovery rate and purity of the material; low-carbon alcohol is added to dissolve organic matter, so as to achieve effective separation of organic matter and sodium sulfate, and the obtained sodium sulfate is of high quality, meets the quality standard of industrial-grade sodium sulfate, can be sold as a by-product or directly used, and reduces the cost of solid waste treatment; carbon disulfide is used to extract the first filtrate for removing low-carbon alcohol, so as to achieve effective separation of 2-methyl-5-nitroimidazole and metronidazole, improve the recovery rate of materials 2-methyl-5-nitroimidazole and metronidazole, solve the use problem of recovered materials, significantly improve economic benefits and environmental benefits, and is suitable for large-scale production.

The invention discloses a continuous flow synthesis method of metronidazole, which comprises the following steps: by taking glyoxal and acetaldehyde as starting raw materials, continuously synthesizing a high-purity metronidazole product through a cyclization reaction, a nitration reaction and a hydroxyethylation reaction by utilizing a micro-mixer, a micro-reactor and a self-developed vaporization separation and recovery device. And effective recycling of glyoxal, acetaldehyde, nitric acid, formic acid and the like is realized, the removal efficiency is high, continuous synthesis is ensured, the production efficiency is greatly improved, and the stability of product quality is ensured.

The utility model discloses a packaging device for metronidazole tablet manufacturing, and relates to the technical field of packaging, the packaging device comprises a slow pushing mechanism and a base station, the top of the slow pushing mechanism is provided with a conveying and packaging mechanism, and the top of the base station is fixedly connected with a fixing block. A rotating block drives a moving rod to move through a third fixing shaft, a second limiting disc limits the position of the moving rod, the moving rod drives a rotating rod to move through a second fixing shaft while moving, a driving rod is driven to rotate through a motor, the rotating block can be matched with the rotating rod connected with a fixing block, and the rotating rod is driven to move through a second limiting disc. According to the metronidazole tablet packaging device, the metronidazole tablets can be pushed by the push plate through the connecting rod, and the effects that the metronidazole tablets are gradually and slowly pushed, the metronidazole tablets are fully collected in the packaging box, the packaging box is convenient to replace, and the packaged metronidazole tablets are convenient to package are achieved.

1. The name of the product of this design: Packaging box (metronidazole chlorhexidine lotion). 2. Purpose of this design product: used for product packaging. 3. The key design point of this product lies in the combination of pattern and color. 4. The picture or photo that best illustrates the key points of the design: Main view of Design 1. 5. The design for which protection is sought includes color. 6. Designate Design 1 as the base design.

The invention discloses a method for detecting nitrite in a metronidazole bulk drug. According to the method, an ultraviolet spectrophotometric method is adopted, diazotization with sulfanilamide is carried out, then color development with N-(1-naphthyl) ethylenediamine hydrochloride is carried out, and the content of nitrite is detected at the wavelength of 530-534 nm. According to the detection method, the content of nitrite in the metronidazole bulk drug can be rapidly and accurately detected, and the method is high in recovery rate and sensitivity and good in precision, repeatability and linearity.

The invention provides a preparation method of a high-stability metronidazole suppository, and relates to the technical field of metronidazole suppository preparation. The high-stability metronidazole suppository is prepared from metronidazole, ginseng stem and leaf saponin, vitamin E, a polyethylene glycol composition, polyoxyethylene stearate, distilled water and vitamin C palmitate, and the high-stability metronidazole suppository is prepared by the following steps: dissolving the vitamin E, the polyethylene glycol composition, the polyoxyethylene stearate and the distilled water as matrixes; the metronidazole suppository is obtained by mixing metronidazole and ginseng stem and leaf saponin with vitamin C palmitate, then mixing the mixture with part of the matrix, dropwise adding the remaining matrix in a nitrogen atmosphere, and then performing stirring treatment by adopting carbon dioxide to obtain the final metronidazole suppository. The metronidazole suppository overcomes the defects in the prior art, the disintegration time of the metronidazole suppository in a human body can be effectively shortened, meanwhile, the stability of the metronidazole suppository is improved, and the safety of medicine storage is guaranteed.

The utility model discloses a tablet conveying device for metronidazole tablet manufacturing, and relates to the technical field of medicine production, the tablet conveying device comprises a support frame, the inner wall of the support frame is fixedly connected with a plurality of connecting rods, the outer wall of the top of the support frame is provided with a conveying seat, the inner wall of the conveying seat is rotatably connected with a rotating rod, and the rotating rod is fixedly connected with the support frame. By means of the screening plate, complete tablets can be naturally conveyed in a sliding mode along the inclination angle of the screening plate, incomplete tablets and disintegrating slag can directly pass through the interior of screening holes and naturally fall off, and therefore the tablets and the disintegrating slag can be completely conveyed. Then, the tablets naturally slide on the surface of a second screening plate and fall on the surface of a conveying belt through a discharging opening, and crushed materials fall into a crushed material collecting box, so that the tablets can be reasonably screened, and the complete tablets are conveyed to the subsequent working procedures; and incomplete tablets and disintegrating slag are screened out for subsequent dumping or recycling treatment.

The invention provides a method for separating and detecting impurities in a metronidazole-ursodesoxycholic acid conjugate and application of the metronidazole-ursodesoxycholic acid conjugate. The method comprises the following steps: preparing a metronidazole-ursodesoxycholic acid conjugate solution to obtain a test solution; performing high performance liquid chromatography detection on the test solution by adopting a high performance liquid chromatograph with an electrified spray detector; wherein the chromatographic conditions of the high performance liquid chromatography detection are as follows: a mobile phase is a mixed solution of a 0.1% formic acid aqueous solution, methanol and acetonitrile in a volume ratio of 40: 35: 25; and the power law of the electrospray detector is 1.4. According to the application, an electrospray detector is adopted for detection, so that the problem of low sensitivity under an ultraviolet detector due to few conjugated systems in an ursodesoxycholic acid structure and large terminal absorption interference is solved; the electrospray detector serves as a mass type detector, the detection of the electrospray detector is irrelevant to the molecular structure of a detected substance, the response value of the detected substance is determined by the absolute mass of a detected sample, and the detection requirements of ursodesoxycholic acid and metronidazole can be met.

This invention discloses a method for synthesizing a terbium complex fluorescent probe and its application in the detection of metronidazole, belonging to the field of food safety technology. This invention utilizes 2,6-difluorobenzoic acid and 1,10-phenanthroline as ligands to synthesize a luminescent rare earth complex [Tb2(2,6-dfba)6(phen)2] with Tb(NO3)3·6H2O. The crystal structure shows that it is a binuclear terbium complex, which exhibits strong Tb2 fluorescence at 489, 545, 584, and 621 nm. 3+ The complex exhibits characteristic emission peaks and good time stability of its fluorescence intensity. It specifically and sensitively recognizes metronidazole, demonstrating rapid response (<1 min), a low limit of detection (43.7 nM), and a wide linear detection range (0–100 μM). It can be used for the quantitative detection of metronidazole in animal feed.

1. Name of the product in this design: Packaging Box (Metronidazole Gel). 2. Purpose of this design: For use in pharmaceutical packaging. 3. The key design features of this product are the combination of shape and pattern. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The invention discloses a metronidazole tablet and a preparation method thereof. The metronidazole tablet is prepared from the following components in parts by mass: 55 to 60 parts of metronidazole, 35 to 40 parts of a filling agent, 5 to 10 parts of sorbitol, 1 to 5 parts of povidone K30, 5 to 15 parts of an adhesive, 0.2 to 0.5 part of magnesium stearate and 2 to 6 parts of a coating agent. By using sorbitol and povidone K30 in the auxiliary materials, the brittleness of the tablet can be improved, and the hardness and stability of the tablet are improved, so that the tablet is not easy to break in the production and storage processes. In addition, the dissolution rate of the tablet can be improved through the synergistic effect of the sorbitol and the povidone K30, so that the bioavailability of the medicine is improved.

A metronidazole derivative of formula I, a preparation method, and a use in preparation of a drug. The metronidazole derivative can effectively ameliorate the symptoms of rosacea. Moreover, compared with metronidazole, the metronidazole derivative has less medication dosage and low medication frequency, but still can achieve a better improvement effect. Therefore, the metronidazole derivative has the prospect of being developed into a drug for ameliorating the symptoms of rosacea. The preparation method for the metronidazole derivative involves simple steps and mild conditions, and is easy for industrial production.

The invention discloses a method for removing light-sensitive impurities in metronidazole disodium phosphate. The method comprises the following steps: dissolving; decoloring treatment; crystallizing and purifying; and drying. According to the method for removing the light-sensitive impurities in the metronidazole disodium phosphate, through activated carbon adsorption and organic solvent devitrification, the impurities which cause deepened product color in the metronidazole disodium phosphate are effectively removed, and the purity of the metronidazole disodium phosphate is improved.

The invention relates to the technical field of pharmaceutical preparations, and particularly discloses a metronidazole tablet and a preparation method thereof. The preparation method comprises the following steps: micronizing metronidazole to obtain pretreated metronidazole; mixing the pretreated metronidazole, corn starch, cane sugar, carboxymethyl starch sodium and an adhesive, granulating, drying, and finishing to obtain a core material; and mixing the core material, carboxymethyl starch sodium and magnesium stearate, and tabletting to obtain the metronidazole tablet. The micronization treatment comprehensively improves the physical and chemical properties of metronidazole by regulating and controlling the particle size, form and crystal form. The carboxymethyl starch sodium has a relatively high expansion rate, and can cooperate with particle pores formed by the adhesive by adopting a specific internal and external addition mode, so that the dissolution rate is improved; the cane sugar assists in dissolving, so that the dissolution peak reaching time is shortened, and the medicine takes effect quickly; the corn starch and the adhesive enhance the compressibility of the particles, and the magnesium stearate controls the amount and prevents sticking, so that the formability is improved, and the loss is reduced.

The invention discloses a composition for toothache and application thereof.The composition is prepared from 2-6 parts of anisodamine, 4-12 parts of dexamethasone, 200-600 parts of naproxen and 200-500 parts of metronidazole. Through reasonable raw material matching, the composition can treat toothache caused by pulpitis, apical apitis, periodontal abscess, tooth oscillation trauma or periodontal disease and the like; rapid pain relieving can be achieved within 10-20 min for the first time, the pain relieving effect is rapid, and toothache can be treated fundamentally and efficiently; in addition, the traditional Chinese medicine composition is also beneficial to restoring the activity of dental pulp and has an effective treatment effect on tooth renaturation pulpitis; in addition, the root canal can be assisted in treating non-recupable pulpitis or apicitis, and the root canal treatment effect is improved.

1. The name of the product of this design: packaging box (metronidazole chlorhexidine lotion). 2. Purpose of this design product: used for product packaging. 3. The design key point of this appearance design product lies in the combination of shape and pattern. 4. The picture or photo that best illustrates the design points: expanded state diagram.

Suspensions of metronidazole or baclofen and / or salts or ester derivative thereof, such as metronidazole benzoate, are disclosed. The suspension my include metronidazole or baclofen, and / or a salt or ester derivative thereof a hydrocolloid stabilizer, simethicone emulsion, a buffer, such as sodium citrate, (dihydrate), a preservative, a thickening agent, a sweetener, and water.

1. The name of the design product: packaging box (metronidazole tablets). 2. The use of the design product: used for the outer packaging of products. 3. The design points of the design product: the combination of shape and pattern. 4. The picture or photo that best indicates the design points: unfolded state reference drawing.

The invention discloses a metronidazole derivative, a preparation method and application in medicine preparation. The invention provides a metronidazole derivative. The metronidazole derivative can effectively improve the symptoms of rosacea. Moreover, compared with metronidazole, the metronidazole derivative has the advantages that the dosage is reduced, the medication frequency is reduced, but a better improvement effect can be obtained, and the effect is unexpected. Therefore, the metronidazole derivative has the prospect of being developed into the medicine for improving the acne rosacea symptom. The invention also provides a preparation method of the metronidazole derivative, which has the advantages of simple steps, mild conditions and easiness in industrial production.

The application discloses a synthesis method of a stable isotope-labeled metronidazole, and belongs to the field of organic synthesis. The preparation steps are three hydrogen-deuterium exchanges: adding metronidazole and a deuterium source into a reaction container, adding a deuterium water solution of a catalyst under stirring, reducing to room temperature after reaction at 75 DEG C to 85 DEG C for 110 min to 130 min, and standing for 10 h to 15 h; adjusting pH to 6 to 7 by using a deuterated acid, and removing a solvent. Finally, recrystallization by using ethanol is performed to obtain the product. The application effectively improves the purity and abundance of the isotope-labeled metronidazole through multiple hydrogen-deuterium exchanges, ensures the quality and stability of the obtained product, and realizes high raw material utilization rate, and the obtained product has high purity and high abundance.

The invention relates to a production device and a production method, in particular to a production device and a production method of metronidazole vaginal effervescent tablets. The metronidazole vaginal effervescent tablet prepared by the production device and the production method can be rapidly disintegrated through matching of anhydrous citric acid, carboxymethyl starch sodium and sodium bicarbonate, on one hand, metronidazole can be rapidly released through rapid disintegration, the metronidazole vaginal effervescent tablet can rapidly act on a focus to digest inflammation, on the other hand, the metronidazole vaginal effervescent tablet can be rapidly dissolved into a solution through rapid disintegration, and the metronidazole vaginal effervescent tablet can be rapidly disintegrated. And foreign body sensation can be quickly eliminated. The tablets can be isolated from air through aluminum foil packaging, and the tablets are prevented from absorbing moisture. The problems that an existing effervescent tablet takes effect slowly and has foreign body sensation for a long time due to the fact that the existing effervescent tablet has a coating layer are solved.

The invention belongs to the technical field of organic compounds, and particularly relates to a binuclear macrocyclic metronidazole metal complex as well as a preparation method and application thereof. The preparation method comprises the following steps: (1) carrying out reflux reaction on 2-pyridine formylhydrazine, potassium hydroxide and carbon disulfide to prepare 5-(pyridine-2-yl)-1, 3, 4-oxadiazole-2-thiol; (2) respectively carrying out primary reflux on metronidazole, triethylamine and p-toluenesulfonyl chloride, and then carrying out secondary reflux on metronidazole and potassium iodide, so as to prepare 1-(2-iodoethyl)-2-methyl-5-nitro-1H-imidazole; and (3) carrying out reflux reaction on products prepared in the steps (1) and (2), and dissolving in an organic solvent containing silver salt to prepare the binuclear macrocyclic metronidazole metal complex. According to the binuclear macrocyclic metronidazole metal complex disclosed by the invention, the antibacterial effect of the current metronidazole metal complex can be further improved; the preparation method is simple and easy to implement, purification is convenient, and the prepared product is good in stability in air.

The invention discloses a device for synthesizing metronidazole by simulating critical state atomized flow hydroxylation. It includes a hydroxylation kettle, a discharge valve, an EO feeding system, a sulfuric acid feeding system and a formic acid feeding system; the sulfuric acid feeding system and the formic acid feeding system are respectively connected to the feed end of the hydroxylation kettle; the discharge valve is located at the lower end of the discharge pipe, and one end of the discharge pipe is connected to the discharge end of the hydroxylation kettle; it also includes an external circulation loop system of the hydroxylation kettle; one end of the external circulation loop system of the hydroxylation kettle is connected to the feed end of the hydroxylation kettle through a process pipeline, and the other end is connected to the discharge end of the hydroxylation kettle through a process pipeline; the EO feeding system is connected to the external circulation loop system of the hydroxylation kettle through a process pipeline. The invention has the advantages of safe and reliable production, reduced EO loss, and improved EO utilization. The invention also discloses a method for synthesizing metronidazole by using the device for synthesizing metronidazole by simulating critical state atomized flow hydroxylation.

The utility model discloses a metronidazole filtering device, which is characterized in that a buffer unit, a flushing unit and a filtering unit are arranged in a filtering tank, and the impact force of mixed liquid on a filter screen due to the flow velocity and gravity action is weakened by utilizing a buffer slope, so that the loss of the filter screen is reduced; the holes are formed in the buffer slope and the platform, so that part of the mixed liquid can flow onto the filter screen through the holes, and the dispersion uniformity of the mixed liquid on the filter screen is improved; the flushing unit is arranged in the open groove below the supporting beam, so that the equipment structure is simplified while high-pressure flushing of the filter screen is realized; the filter screen is fixed to the supporting rod, the motor drives the supporting rod to rotate, the filter screen can rotate to any angle for high-pressure washing, and the service life of the filter screen is prolonged; the partition plate is arranged in the middle of the filter screen, and the upper surface of the partition plate is a convex surface, so that the mixed liquid can be shunted to the filter screens on two sides of the partition plate, unfiltered mixed liquid is prevented from remaining in a support rod area, and waste and raw material cost are reduced.

The invention discloses a preparation method of an anti-hair loss composition containing metronidazole. A production raw material formula comprises minoxidil, a regulator and pharmaceutically acceptable auxiliary materials, the mass ratio of minoxidil to the conditioning agent is 1: (0.1-0.4); the regulator comprises metronidazole. The minoxidil-containing anti-alopecia composition has the advantage that the inhibition effect of the minoxidil-containing anti-alopecia composition on scalp grease secretion of a seborrheic alopecia patient can be remarkably enhanced.

The utility model relates to a metronidazole sodium chloride injection storage rack which comprises a storage frame, a plurality of partition plates evenly distributed at equal intervals are fixed in the storage frame and divide the interior of the storage frame into a plurality of storage grooves, a plurality of L-shaped plates are fixed in the storage grooves, and every two adjacent L-shaped plates form a containing groove. A groove is formed between the L-shaped plate on the lowermost side and the storage frame, a plurality of rotating shafts in one-to-one correspondence with the L-shaped plates are rotationally connected to the storage frame, L-shaped supporting tables are arranged in the containing groove and the groove, the supporting tables are fixedly connected with the corresponding rotating shafts respectively, and the lower sides of the supporting tables make contact with the bottoms of the corresponding L-shaped plates. According to the device, bottled injection can be placed on the supporting table in the containing groove or the groove, the head of the bottled injection protrudes outwards by rotating the supporting table, so that the bottled injection can be conveniently taken or placed, and due to the fact that the supporting table is in an L shape, the bottled injection can be prevented from falling off when inclining.

1. Name of the product of this design: Pharmaceutical packaging box (metronidazole vaginal effervescent tablets). 2. Purpose of this design product: for packaging boxes. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

The application discloses a treatment method of metronidazole pharmaceutical wastewater. The treatment method comprises the following steps: S1, constructing a pulse electro-Fenton reactor: taking inert electrodes and iron electrodes as anodes, taking an air diffusion electrode as a cathode, and taking metronidazole pharmaceutical wastewater as an electrolyte; and S2, operation: alternately electrifying the inert electrodes and the iron electrodes, and continuously electrifying the cathode to form a pulse current. The treatment method adopts the pulse electro-Fenton technology to treat the metronidazole pharmaceutical wastewater, and through cooperation of various conditions, efficient removal of metronidazole in the metronidazole pharmaceutical wastewater can be realized. In addition, the steps S1 and S2 of the treatment method do not need to additionally add ferrous catalyst, and problems that the traditional Fenton oxidation method needs to additionally add ferrous catalyst and generates a large amount of iron sludge are avoided, and the efficiency of the electro-Fenton oxidation method is improved.