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84 results about "Metronizole" patented technology
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Metronidazole preparation method
The invention relates to the field of medicine manufacturing techniques, in particular to a metronidazole API preparation method, and solves the problems that a current metronidazole preparation method is high in cost and low in yield. The method comprises the following steps: (1), acid mixing, adding 100 parts (by weight) of formic acid of concentration of 95-99 percent in a reaction kettle for stirring to a temperature of 20 DEG C, then adding 25-35 parts (by weight) of concentrated sulphuric acid, so as to prepare the mixed acid for further use; (2), synthesis reaction, adding 100-120 parts (by weight) of reaction raw materials 2-methyl-5-nitroimidazole into a reaction tank, and adding the mixed acid prepared in the step 1, stirring to a temperature of 75-80 DEG C, completely dissolving the 2-methyl-5-nitroimidazole, and maintaining 10-20 minutes. According to the invention, the design is reasonable; and the mixed acid is adopted to provide an acidic condition, an applicable reaction raw material ratio and an appropriate control reaction parameter, so as to allow the yield of the nitroimidazole to reach 65-70 percent.
Owner:SHANXI TONGJI PHARMA
Recovery method and device for formic acid solvent during metronidazole production
InactiveCN103408082AQuality improvementProcess Design ScienceNature of treatment waterWater/sewage treatment by heatingHigh concentrationIndustrial waste water
The invention discloses a recovery method and device for a formic acid solvent during metronidazole production, which solves the problems that in the prior art, the cost of waste water recovery is large, the environment is polluted due to the direct emission of the waste water, and the like, and is characterized in that the recovery device formed by an evaporator (1), a storage kettle (7), a water absorption tower (8), filling materials (9 and 19), a high position feeding tank(10), a condenser (12), a storage tank (16), a perforated pipe (17), a screw (18) and the like performs recovery treatment on industrial waste water; the particular technological processes are as follows: the hydroxylation solution is evaporated through adopting the evaporator so as to obtain dilute formic acid vapor with the mass concentration of 30-70%; the formic acid vapor firstly passes through the cold material filling layer at the upper part of the evaporator to remove entrainment substances, such as metronidazole, of the formic acid vapor; part of water in the formic acid vapor is removed through the water absorption tower of the material filling layer with sticky polyphosphoric acid and high concentration phosphoric acid both flowing downwards; water in the formic acid vapor is further removed through a pipeline with phosphorus pentoxide; the concentrated formic acid vapor is condensed into high concentration formic acid liquid. The method and the device can be widely applied to a production enterprise for recycling a great deal of produced dilute formic acid waste water in chemical engineering production enterprises.
Owner:HUANGGANG NORMAL UNIV
Fast detection method and detection reagent kit for metronidazole, and its use in detection of cosmetic and disinfector added with metronidazole
ActiveCN101504372AQuick strikeEliminate distractionsOrganic chemistryMaterial analysis by observing effect on chemical indicatorWater bathsOrganic solvent
The invention discloses a rapid detection method and a detection reagent kit for metronidazole and application thereof in detecting the adding of the metronidazole in cosmetics and disinfectants. The detection method comprises the following steps: firstly, performing acid dissolution and enrichment on a sample to be tested, and then further purifying and separating the sample by organic solvent; and finally developing color development by alkali, and judging whether the sample contains the metronidazole according to the change of the color. The detection method can rapidly detect that whether the metronidazole is added in the cosmetics and the disinfectants; and the detection method has simple and convenient operation, does not need large-scale instruments, and has low detection cost. The method adopts two-step purification of acid and the organic solvent, so that the metronidazole is concentrated and enriched to ensure the correction rate of alkali color development. An alkali color development reaction of the invention adopts sodium hydroxide solid, utilizes the heat released by dissolving sodium hydroxide to reach the temperature needed by the color development reaction, saves water bath equipment, and is more favorable for the fluidity detection of basic level field.
Owner:广东省药品检验所
Metronidazole effervescence patch and technique of preparing the same
ActiveCN101152176AImprove the bactericidal effectGood synergyOrganic active ingredientsAntimycoticsChlorhexidine AcetateTalc
The invention discloses a Metronidazole, Clotrimazole and Chlorhexidine Acetate Effervescent Tablet and the preparation method. Each tablet has the following proportion of contents: metronidazole 0.2 gram, clotrimazole 0.16 gram, acetic acid chlorhexidine acetate 0.008 gram, fumaric acid 0.108 to 0.162 gram, tartaric acid 0.012 to 0.018 gram, solium bicarbonate 0.12 to 0.18 gram, starch 0.02 to 0.04 gram, dextrin 0.003 to 0.007 gram, hydroxypropyl cellulose 0.007 to 0.013 gram, talc 0.01 to 0.017 gram, sodium dodecyl sulfate 0.01to 0.02 gram, and proper proportion of povidone K30 water solution. According to the preparation method, the components are mixed to produce granule (1) and granule (2); the talc, sodium dodecyl sulfate and the granule (1) and granule (2) are mixed uniformly; granule content is tested and according to the granule content, the tablet weight is identified for tabletting. The invention overcomes the shortages with prior art, enables the acetic acid chlorhexidine acetate to perform functions normally, performs synergistic effects of the three drugs, and greatly enhances the cure rate. Besides, the frothing volume is high, and within storage period, the quality is stable and the drug effects are not affected.
Owner:SHANDONG SBOND PHARMA
Metronidazole composition freeze-dried disintegrating tablets for vaginas and preparation method thereof
ActiveCN102784120ADisintegrates quicklyPromote dissolutionAntibacterial agentsOrganic active ingredientsEffervescent tabletFreeze-drying
The invention provides metronidazole composition freeze-dried disintegrating tablets for vaginas and a preparation method of the freeze-dried disintegrating tablets, relates to the field of a medicine and a medicine preparation method technology and mainly solves the technical problems that the metronidazole suppositories and effervescent tablets are inconvenient to transport and store, the application is limited; and the inflamed mucosas are frequently stimulated by the metronidazole suppositories and effervescent tablets when metronidazole suppositories and effervescent tablets are utilized, and the clinical application is influenced. The metronidazole composition freeze-dried disintegrating tablets are prepared from the following components by weight: 10-24% of metronidazole, 24-50% of mannitol, 2-4% of gelatin, 32-74% of hydroxypropyl-beta-cyclodextrin with medium substitution degree and 50% of purified water. The metronidazole composition freeze-dried disintegrating tablets for vaginas prepared by the above components are easy in preparation process, and simple in components, moreover, the metronidazole composition freeze-dried disintegrating tablets for vaginas have the advantages of being fast to disintegrate, convenient to take, and good in compliance, and the tablets take effect quickly and are fully absorbed; and the disintegrating tablets can be completely disintegrated in the vaginas while meeting water, so that foreign body sensation does not exist in the vaginas.
Owner:HAINAN WEI KANG PHARMA QIANSHAN
ssDNA aptamer for specifically identifying metronidazole and application thereof
ActiveCN110684773AHigh sensitivityEasy to manufactureBiological testingAgainst vector-borne diseasesAptamerNucleotide
A ssDNA aptamer for specifically identifying metronidazole and an application thereof belongs to the fields of biochemistry, molecular biology, analytical chemistry and combinatorial chemistry. In thepresent invention, a ssDNA initial library containing 35 random nucleotides is amplified by PCR through a magnetic beads-SELEX technology, and then immobilized on magnetic beads modified with streptavidin, added with metronidazole to separate ssDNAs with affinity by competition, and amplified for next screening. After ten rounds of screening and clone sequencing, 39 metronidazole aptamer sequences are obtained. After further affinity evaluation, four sequences with higher affinity including ap2, ap19, ap21, and ap32 are selected, wherein, the ap32 is selected as an optimal metronidazole aptamer due to the advantages of high affinity, high specificity and stable structure. The invention provides an identification element with excellent performance for metronidazole detection.
Owner:JIANGNAN UNIV
Anti-corrosion, anti-wax and anti-scale coating and preparation method thereof
PendingCN110317536AImprove anti-corrosion performanceHigh anti-fouling rateAntifouling/underwater paintsPaints with biocidesTemperature resistanceSolvent
The invention relates to an anti-corrosion, anti-wax and anti-scale coating and a preparation method thereof. The coating is prepared from, by weight, 10-12 parts of a metronidazole-modified grapheneoxide composite material, 4-7 parts of a polysulfide-epoxy block copolymer, 15-20 parts of polyimide resin, 2-6 parts of polytetrafluoroethylene resin, 1-2 parts of tetramethyl thiuram disulfide, 14-19 parts of a filler, 40-48 parts of a solvent, 3-5 parts of an anti-scale agent and 6-8 parts of a curing agent. The coating can effectively prevent the formation of barium and strontium sulfate scales and the like, the situation that pipelines and equipment are blocked by scaling is avoided, and the anti-scale rate is high; the anti-corrosion performance and the anti-wax effect are good, and thecoating has excellent wear resistance and high-temperature resistance and high impact strength; the curing time is short, and the engineering cycle can be shortened; the coating is convenient to prepare, low in cost, stable in performance and capable of being widely used for protecting oil casing pipes, drill rods, oil pipes and the like in oilfield exploitation.
Owner:QINGYANG ZHOUYANG MACHINERY MFG
Preparation method and application of compound ketoconazole ointment
ActiveCN107625765AWell mixedImprove stabilityAntimycoticsHydroxy compound active ingredientsSodium sulfiteDrug
The invention provides a preparation method and application of compound ketoconazole ointment. The preparation method utilizes medicinal effective components such as ketoconazole, metronidazole and menthol and aids such as anhydrous sodium sulfite, a surfactant and hydrochloric acid as raw materials. Through adjustment and optimization of the preparation method, the compound ketoconazole ointmenthas stable performances and good bactericidal performances, effectively treats pet skin diseases and can be further used in preparation of a drug containing ketoconazole or metronidazole.
Owner:FOSHAN NANHAI EASTERN ALONG PHARMA CO LTD
Metronidazole and chlorhexidine lotion with improved performance
The invention discloses a sprayable metronidazole gel composition. The composition comprises metronidazole, water, a water-miscible solvent, carboxymethylcellulose, gamma-type carrageen glycan and 2000-20000 parts of PEG1 (polyethylene glycol 1). The gel composition is high in physical stability, high in salt-resistant capacity and convenient to use.
Owner:JIANGSU SEMPOLL PHARMA
Method for detecting chloramphenicol, thiamphenicol, metronidazole residuals in prawns by using pressurized capillary electrochromatographic instrument
Owner:NINGBO ACAD OF SCI & TECH FOR INSPECTION & QUARANTINE
Coffee-flavored metronidazole chewing gum
InactiveCN103583781ALower tone valueReduce VSCs levelsOrganic active ingredientsAntisepticsMouth careAdditive ingredient
The invention relates to a chewing gum capable of removing bad breath. The chewing gum is characterized by comprising the following components in parts by weight: 18 parts of synthetic gum base, 25 parts of xylitol, 3 parts of cocoa powder, 0.5 part of metronidazole, 1.5 parts of maltodextrin, 1 part of glycerol, 0.1 part of soybean phospholipid, 0.5 part of spearmint essential oil, 0.2 part of titanium dioxide and 0.2 part of carnauba wax. The chewing gum is a coffee-flavored metronidazole chewing gum. The bad breath removing effect of the coffee-flavored metronidazole chewing gum lasts for 4 to 8 hours, but the bad breath removing effect of the common chewing gum does not exceed 1 hour. The coffee-flavored metronidazole chewing gum also can be applied to oral care of critical patients. The metronidazole is used for killing odor producing bacteria of an oral cavity, so that the bad breath value is reduced; the oral cavity is cleaned by chewing the chewing gum; the bad odor of the oral cavity is covered by the perfume ingredient of the chewing gum. The chewing gum is organic combination of mechanical therapy and chemical therapy, achieves a synergistic effect of removing bad breath and obviously improves the effect of removing bad breath. The screened formula of the chewing gum can obviously cover the bitter taste of the metronidazole, so people can easily accept the chewing gum.
Owner:THE FIRST AFFILIATED HOSPITAL HENGYANG MEDICAL SCHOOL UNIV OF SOUTH CHINA
Metronidazole and sodium chloride injection as well as preparation method and application thereof
InactiveCN109431994AGood dispersionGood synergyAntibacterial agentsOrganic active ingredientsSodium Chloride InjectionMETRONIDAZOLE/SODIUM CHLORIDE
The invention relates to the field of metronidazole medicaments, and discloses a metronidazole and sodium chloride injection as well as a preparation method and application thereof. Based on the totalweight of the injection, the metronidazole and sodium chloride injection is prepared from the following components in percentage by weight: (1) 0.2 to 0.9 percent of metronidazole, (2) 0.1 to 0.9 percent of sodium chloride, (3) 0.01 to 0.1 percent of citric acid, (4) 0.05 to 0.3 percent of sodium dihydrogen phosphate, (5) 0.1 to 2 percent of disodium hydrogen phosphate, and (6) 96 to 99 percent of water for injection. The metronidazole and sodium chloride injection provided by the invention has good stability.
Owner:江西润泽药业有限公司
Colon positioning and adhering preparation and its preparing process
InactiveCN1593403APrecise positioningGrowth inhibitionOrganic active ingredientsDigestive systemBletilla striataPolymer science
Disclosed is a colon positioning and adhering preparation and its preparing process which comprises mixing Metronidazole, starch, dextrin and bletilla striata, charging starch grout and preparing particles, obtaining wet micro-pullet, drying, pressing into tablet, mixing dressing material, ethanol, castor-oil, dibutyl phthalate into dressing liquid, preparing dressed micro-pullet or dressed tablet, and loading the dressed micro-pullet into capsule or directly split charging into micro-pullet pills.
Owner:SHAANXI UNIV OF SCI & TECH
Method, device for formic acid solvent recycling in metronidazole production and application thereof
The invention provides a method, a device for formic acid solvent recycling in metronidazole production and an application thereof. In a metronidazole synthesis process, the recycling of formic acid is realized, and the production cost is saved. In a metronidazole production process, sulfur trioxide consumes water to generate sulfuric acid, the water in formic acid solution is gradually consumed,and the sulfuric acid needed for the metronidazole synthesis is generated. The reduction of the water is beneficial to a follow-up synthetic process of the metronidazole. The device is capable of introducing the sulfur trioxide into an injector by using the injector and mixing with solution, and improving the mixing efficiency. Because of the action of the injector, the sulfuric acid concentrationof liquid at the bottom of a negative pressure tank is greater than the sulfuric acid concentration of the liquid at the top, the liquid at the top is replaced in a storage tank for recycling by using a hose and a floating head, and pumped back by a power pump, thereby the sulfuric acid concentration of the liquid mixed with the sulfur trioxide is the lowest, and beneficial to the high-efficientmixing. Alkaline liquor in a liquid seal tank is used for absorbing an acid gas, and the pollution is prevented.
Owner:HUANGGANG NORMAL UNIV
Preparation method and application of electrochemical sensing element based on immunogold
InactiveCN104730234AIncrease surface areaResponsiveMaterial electrochemical variablesNitroimidazoleMetabolite
The invention discloses a preparation method of an electrochemical sensing element based on immunogold. A common nitroimidazole type structure hapten is prepared, and the nitroimidazole hapten is coupled with carrier proteins (BSA and OVA) by adopting an active ester method to prepare an immunogen and a coating antigen, wherein the mol ratio of coupling molecules is (11 to 1) and (10 to 1). A nitroimidazole antibody is simultaneously prepared and the valence is (1 to 100000), and immune nano gold is prepared; and a monomolecular film is formed on a gold electrode by using a monomolecular film self-assembling technology, and is connected with the immune nano gold through DCC and NHS to prepare the sensing element. The sensing element has the good responses on metronidazole, tinidazole and dimetridazole; the cross reaction rate is 90% or more; metronidazole, tinidazole and dimetridazole and metabolites of metronidazole, tinidazole and dimetridazole in a concentration range of 0.001-100mg / L can be determined; and the detection limit is about 0.0019mg / L and the recycling rate is about 90%.
Owner:CHINA JILIANG UNIV
Method for recovering metronidazole finished product from industrial waste residue of metronidazole
ActiveCN101914062AGood choiceImprove solubilityOrganic chemistryProcess engineeringEnvironmental engineering
The invention discloses a method for recovering a metronidazole finished product from industrial waste residue of metronidazole, and the technical scheme is as follows: firstly adding solution of an amide solvent of saturated metronidazole at room temperature into the industrial waste residue of the metronidazole with residual heat, leading the metronidazole to be leached from the industrial waste residue of the metronidazole by hot melting, then re-crystallizing leachate at the room temperature, filtering and obtaining a metronidazole solid product. Filtrate after filtration is still the amide solution of the saturated metronidazole at the room temperature, and the solution can be continuously used for recovering the metronidazole from the industrial waste residue of the metronidazole, thereby realizing the recycling. The method has simple process flow and great benefits, can save energy consumption and is applicable to industrial production.
Owner:SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES +1
Metronidazole detection method
InactiveCN106483183AHigh sensitivitySimple and fast operationMaterial electrochemical variablesSquare wave voltammetryDifferential pulse voltammetry
The invention provides a metronidazole detection method and belongs to the technical field of metronidazole. The method includes: adopting a mode of dropwise smearing amino functionization MCM-41 on a glass carbon electrode to prepare an amino functionalization MCM-41 modified electrode; utilizing a three-electrode system, and adopting a square wave voltammetry to detect metronidazole. A result shows that amino functionalization MCM-41 modified electrode differential pulse voltammetry is adopted to detect metronidazole different in concentration, peak current is constantly increased along with increase of concentration of a metronidazole solution, the peak current of metronidazole presents good linear relation with the concentration of metronidazole, and correlation coefficient is 0.9974. Detection limit of the method is 1.7x10-7mol / L; comparison tests show that the peak current of metronidazole on the amino functionalization MCM-41 modified electrode is obviously higher than those on an MCM-41 modified electrode and a naked glass carbon electrode. The metronidazole detection method has the advantages of high sensitivity, simplicity and convenience in operation, quickness, low instrument cost and easiness in realizing automation.
Owner:GUANGXI NORMAL UNIV FOR NATITIES
Drug for shortening sow labor process and preparation method thereof
ActiveCN103385906ANormal physiological functionReduce laborAntibacterial agentsDigestive systemFiltrationPhosphoric acid
The invention discloses a drug for shortening a sow labor process and a preparation method thereof. The preparation method comprises the following steps of adding 88.8806-88.8810% of injection water into a concentration tank, carrying out stirring, slowly adding 0.1-0.3% of metronidazole into the concentration tank, carrying out heating boiling, adding 9-11% of weighed glucose, 0.008-0.012% of triphosadenine, 0.006-0.01% of dexamethasone and 0.8-1.0% of common salt into the boiling solution until complete dissolution, adding active carbon of which humidity is pre-adjusted into the mixed solution for decoloration, filtering the hot mixed solution by a concentration and filtration titanium rod, collecting the filtrate by a dilution tank, carrying out stirring by the dilution tank, diluting the filtrate by injection water until the diluent filtrate volume is 90% of the total dilution tank volume, adjusting a pH value to 6.0-7.0 by a sodium hydroxide solution having the content of 0.1mol / L, carrying out dilution until the diluent filtrate volume is equal to the total dilution tank volume, adding active carbon of which humidity is pre-adjusted into the diluent filtrate for decoloration, carrying out filtration by a filter membrane until the filtrate is clear and transparent, feeding the filtrate to a soft bag liquid-conveying production line by a delivery pump, and carrying out loading.
Owner:福建奥姆龙生物工程有限公司
Metronidazole tablet and preparation method thereof
ActiveCN110917161AGuarantee product qualityQuality improvementAntibacterial agentsOrganic active ingredientsTabletingPharmaceutical Substances
The invention belongs to the technical field of medicines, and particularly relates to a metronidazole tablet and a preparation method thereof. The preparation method comprises the following steps of:smashing metronidazole raw materials, and screening through a first-mesh sieve to obtain metronidazole, wherein the particle size of the metronidazole is not greater than 300 micrometers; according to preset parts by weight, weighing the metronidazole, a filler and disintegrant, evenly mixing the metronidazole, the filler and the disintegrant in a wet granulator, adding an adhesive for granulation, and screening the mixture by a second-mesh sieve to obtain wet particles, wherein the particle size of the filler is not greater than 150 micrometers; after the wet particles are dried, carrying out particle arrangement, adding a lubricating agent, and mixing in a mixer to obtain an intermediate particle; and carrying out tableting, coating and packaging on the intermediate particle to obtain the metronidazole tablet. The preparation method, which is provided by the embodiment of the invention, for the metronidazole tablet has a stable technology, the product quality of the metronidazole tablet which is finally obtained is guaranteed, the metronidazole table exhibits a better dissolution rate, the dissolution effect of the metronidazole tablet is effectively improved, and the quality and the curative effect of the metronidazole tablet are improved.
Owner:北京鑫开元医药科技有限公司 +1
Liquid fertilizer and preparation method thereof
ActiveCN110105147ASolve the bottle problemPrevent bottle inflationAlkali orthophosphate fertiliserAmmonium orthophosphate fertilisersBottleInorganic nutrient
The invention relates to a liquid fertilizer and a preparation method thereof. The liquid fertilizer is composed of an inorganic nutrient substance, an organic nutrient substance and water, and is characterized by containing metronidazole. The liquid fertilizer and the preparation method thereof have the advantages that the liquid fertilizer can be prevented from swelling out of a bottle, the fertilizer loss is reduced, the quality of the fertilizer is stable, and the utilization rate of the fertilizer in soil is also increased.
Owner:山东爱果者生物技术有限公司
Method for preparing metronidazole vaginal gel
InactiveCN108853004AImprove securityNo reduction in skin permeabilityAntibacterial agentsOrganic active ingredientsDisodium EdetateChemistry
The invention relates to a method for preparing metronidazole vaginal gel. The method comprises the following steps that (1) edetate disodium is mixed with water, then carbomer 974P is added, the mixture is subjected to sufficient swelling and vacuum homogenous emulsification, and a gel substrate is obtained; (2) the pH value of the gel substrate is conditioned to be 4.0-4.5, and blank gel is obtained; and (3) methyl parahydroxybenzoate and propyl p-hydroxybenzoate are mixed at the mass ratio of (2 to 6) to 1 and added into propylene glycol, and a propylene glycol solution is obtained; the propylene glycol solution is mixed with water, metronidazole is added to be sufficiently dissolved, the mixture is sufficiently mixed with the blank gel, and the metronidazole vaginal gel is obtained. The method provided by the invention optimizes the preparation technology of the metronidazole vaginal gel, the adding order and the mixing mode of the raw materials, particularly carbomer 974P is adopted to replace carbomer 934P commonly applied in the prior art, the condition that the drug efficacy performance is not declined after the ingredient is replaced is ensured, and the safety is higher.
Owner:ZHUZHOU QIANJIN PHARMA
Preparation method and applications of fluorescent carbon quantum dots
The invention relates to a preparation method and applications of fluorescent carbon quantum dots. The method comprises: carrying out a hydrothermal reaction on houttuynia cordata as a carbon source and redistilled water at 80-160 DEG C for 3-10 h to obtain a brown yellow liquid, centrifuging, taking the supernatant, and filtering to obtain a fluorescent carbon quantum dot solution. According to the invention, the maximum excitation wavelength of the fluorescent carbon quantum dots prepared by taking houttuynia cordata as the carbon source is 320 nm and is overlapped with the maximum absorption wavelength of metronidazole; a metronidazole determining method using carbon quantum dots as fluorophores, using metronidazole as an absorbent and using fluorescence internal filtration as a quenching mechanism is provided; the modification of carbon quantum dots is not required, and the covalent bond bonding between metronidazole and the carbon quantum dots is not needed; and the method is simple, rapid, low in cost and capable of saving time.
Owner:JIANGSU UNIV OF TECH
Synthesis method of sodium glycididazole
InactiveCN102190626AEasy to operatePromote environmental protectionOrganic chemistrySodium acetateAcetic anhydride
Relating to the field of medicinal chemistry, the invention discloses a synthesis method of sodium glycididazole. According to the method, iminodiacetic acid as a starting material reacts with acethlchloride / anhydrous sodium acetate in DMF (dimethyl formamide), and then reacts with metronidazole to generate imido bisazolyl ester which is further condensed with chloroacetic acid into acid glycididazole. And finally, an ethanol solution with 40 wt% of sodium hydroxide is added to generate sodium glycididazole salt trihydrate. According to the invention, the synthesis method of sodium glycididazole, without using pyridine and acetic anhydride, is environmentally friendly. With an overall yield of 34.5%, the method is suitable for industrial production.
Owner:NAN JING RHINE PHARM TECH
Metronidazole synthesizing device and metronidazole synthesizing method applying same
The invention provides a metronidazole synthesizing device and a metronidazole synthesizing method applying the same. The device comprises a rectifying tower, a reaction kettle, an alcohol storage tank, a condenser and an ester storage tank. The synthesizing method achieves circular application of ethylene glycol in the metronidazole synthesizing process. The device and method provided by the invention have the beneficial effects that circular application of ethylene glycol in the metronidazole synthesizing process is achieved, the resources are saved, and meanwhile, the continuity of the synthesizing process is ensured, the solvent is used circularly, and the equipment investment is little.
Owner:HUANGGANG NORMAL UNIV
Metronidazole tablet for pets and preparation method thereof
PendingCN112076164AGood taste masking effectUniform contentAntibacterial agentsOrganic active ingredientsBitter tastePharmaceutical Aids
The invention belongs to the field of pet medicines, and relates to a metronidazole tablet for pets and a preparation method of the metronidazole tablet. The metronidazole tablet is coated by adding adisintegrating agent, a diluent and an adhesive when metronidazole coated pellets are prepared, and auxiliary material particles added with a phagostimulant, the disintegrating agent, the diluent andthe adhesive are prepared. The metronidazole coated pellets and the auxiliary material particles are mixed to prepare the metronidazole tablet, so that the bitter taste of metronidazole is masked, the purpose of inducing pets to take the metronidazole tablet actively is achieved, the compliance of pets is improved, and the convenience of clinical medication is also improved.
Owner:河北远征药业有限公司 +1
Process and device for improving utilization rate of ethylene oxide of metronidazole production raw materials
ActiveCN103342681BIncrease profitImprove processing efficiencyOrganic chemistryChemical synthesisFluid phase
The invention discloses a process and a device for improving a utilization rate of ethylene oxide of metronidazole production raw materials. The process comprises: during chemical synthesis preparation of metronidazole, two identical reaction kettles are added and arranged above a hydroxylation reaction kettle, and the three kettles are arranged in series at the device height direction according to an upper, middle and lower order. In the manner of flowing from top to bottom and under the action of high-position differences, liquid phase materials flow from the pre-dissolving kettle to the pre-reaction kettle, and then flow to the synthesis reaction kettle through pipelines by self; in the manner of flowing from bottom to top and under the action of pressure differences between the three kettles, gas phase materials flow from the synthesis reaction kettle to the pre-reaction kettle, then flow to the pre-dissolving kettle through pipelines, and finally are dragged by a draw-off pump. Gas escaping from the hydroxylation reaction kettle is cooled to condense with cold water, tail gas discharged by the pre-dissolving kettle is cooled to condense with salt water, and the inletting time of ethylene oxide is shortened, so that the process and the device enable the utilization rate of ethylene oxide to be increased by more than one time, reduce the discharge of three wastes, reduce the production cost, greatly improve the process efficiency, and have quite good environmental, social and economic benefits.
Owner:黄冈银河阿迪药业有限公司
Composite nano material, preparation method and application thereof
ActiveCN113219045AIncreased peak intensityReduce background noiseMaterial analysis by electric/magnetic meansGold ColloidMetabolite
The invention discloses a composite nano-material, a preparation method and application thereof, and belongs to the technical field of mass spectrometric detection.The composite nano-material comprises a gold colloidal solution and ferronickel-layered double hydroxides, the volume ratio of the gold colloidal solution to the ferronickel-layered double hydroxides is (1-3):(1-3), and according to the preparation method, an improved Frens method is used for synthesizing a nano-gold material; and NiFe-LDHs and AuNPs are self-assembled to form the composite nano material, the composite nano material is used for detecting metronidazole and metabolite thereof, the detection result repeatability is good, the linear relation is good, and the composite nano material can be used for quantification.
Owner:SHANDONG AGRICULTURAL UNIVERSITY
Metronidazole/azelaic acid compositions for the treatment of rosacea
InactiveUS20070219263A1Unpleasant side effectWithout riskBiocideAnimal repellantsPharmacologyMetronidazole
Pharmaceutical compositions useful for the treatment of rosacea, in particular for the treatment of the inflammatory component thereof, contain synergistically effective amounts of each of (i) metronidazole or derivative or salt thereof and (ii) azelaic acid or derivative or salt thereof.
Owner:GALDERMA RES & DEV SNC
Method for applying formic acid glycol ester in metronidazole production, device for achieving method and method for applying device
PendingCN107857732AReduce the amount of formic acidReduce manufacturing costOrganic chemistryChemistryMetronidazole
The invention provides a method for applying formic acid glycol ester in metronidazole production, a device for achieving the method and a method for applying the device. According to the method for applying formic acid and glycol ester in metronidazole production, circulation application of formic acid glycol ester in the synthesis process of metronidazole is achieved, a part of formic acid is replaced by formic acid glycol ester, the application amount of formic acid can be reduced, and the production cost is saved. The device for achieving the method comprises a rectifying tower, a reactionkettle, a heavy component liquid collection bottle, a heavy component outlet pipe, a light component liquid collection bottle, a condenser and a light component outlet pipe. The device is simple in structure, convenient to use and high in practicability.
Owner:HUANGGANG NORMAL UNIV
Method for removing PPCPs in water by catalyzing H2O2 with MIL-100 (Fe/Mn) derivative
ActiveCN112225307AReduce manufacturing costImprove efficiencyWater contaminantsGrey water treatmentPtru catalystEngineering
The invention discloses a method for removing drugs and personal care products (PPCPs) in water by catalyzing H2O2 with an MIL100 (Fe / Mn) derivative. The method comprises the following steps of: (1) preparing MIL-100 (Fe / Mn) by using a hydrothermal method; (2) calcining the MIL-100 (Fe / Mn) prepared in the step (1) to prepare an MIL-100 (Fe / Mn) derivative; (3) separately preparing a metronidazole target solution of which the concentration is 0.5-5mg / L and a butylparaben target solution of which the concentration is 0.5-5mg / L, and adjusting the pH values to 3-9; and (4) respectively adding a certain amount of MIL-100 (Fe / Mn) derivative catalyst and H2O2 into the two PPCPs solutions, and performing reactions at the temperature of between 10 and 40 DEG C. It is found for the first time that the effect of the MIL-100 (Fe / Mn) derivative for catalyzing H2O2 to degrade PPCPs is superior to that of other catalysts, and the high removal rate can be maintained under the acidic to neutral condition. The method is easy to operate, simple in process and low in equipment requirement, can be widely used for removing emerging pollutants in a water environment, and has a wide market application prospect.
Owner:HUAQIAO UNIVERSITY +1
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