31 results about "Metronizole" patented technology

The invention provides a preparation method of artificial bezoar-metronidazole capsules. The capsules contain 2 parts of artificial bezoar, 80 parts of metronidazole, and 30-40 parts of starch in parts by weight. The preparation method comprises the steps of preparing raw materials and auxiliary materials, premixing, wet processing, and filling. The prepared artificial bezoar-metronidazole capsules have small weight variation, high content uniformity, and stable quality after accelerated storage for 6 months.

The invention discloses metronidazole particles, a preparation containing the metronidazole particles and a preparation method of the metronidazole particles. The metronidazole particle comprises a drug core and a coating layer, wherein the coating layer is coated on the outer surface of the drug core; the medicine core comprises metronidazole; the coating layer comprises a film-forming material, and the film-forming material comprises gastric-soluble acrylic resin and ethyl cellulose. The metronidazole granule has low dissolution rate in water and a medium with high pH (such as pH 6.8), especially the dissolution rate in 15 minutes is less than or equal to 10%, the dissolution rate at low pH (such as pH 1.2-4.5) is consistent with the dissolution rate of commercially available tablets, and the metronidazole granule is rapidly dissolved out.

The invention discloses a continuous flow synthesis method of metronidazole, which comprises the following steps: by taking glyoxal and acetaldehyde as starting raw materials, continuously synthesizing a high-purity metronidazole product through a cyclization reaction, a nitration reaction and a hydroxyethylation reaction by utilizing a micro-mixer, a micro-reactor and a self-developed vaporization separation and recovery device. And effective recycling of glyoxal, acetaldehyde, nitric acid, formic acid and the like is realized, the removal efficiency is high, continuous synthesis is ensured, the production efficiency is greatly improved, and the stability of product quality is ensured.

The utility model discloses a packaging device for metronidazole tablet manufacturing, and relates to the technical field of packaging, the packaging device comprises a slow pushing mechanism and a base station, the top of the slow pushing mechanism is provided with a conveying and packaging mechanism, and the top of the base station is fixedly connected with a fixing block. A rotating block drives a moving rod to move through a third fixing shaft, a second limiting disc limits the position of the moving rod, the moving rod drives a rotating rod to move through a second fixing shaft while moving, a driving rod is driven to rotate through a motor, the rotating block can be matched with the rotating rod connected with a fixing block, and the rotating rod is driven to move through a second limiting disc. According to the metronidazole tablet packaging device, the metronidazole tablets can be pushed by the push plate through the connecting rod, and the effects that the metronidazole tablets are gradually and slowly pushed, the metronidazole tablets are fully collected in the packaging box, the packaging box is convenient to replace, and the packaged metronidazole tablets are convenient to package are achieved.

1. The name of the product of this design: Packaging box (metronidazole chlorhexidine lotion). 2. Purpose of this design product: used for product packaging. 3. The key design point of this product lies in the combination of pattern and color. 4. The picture or photo that best illustrates the key points of the design: Main view of Design 1. 5. The design for which protection is sought includes color. 6. Designate Design 1 as the base design.

The invention discloses a method for detecting nitrite in a metronidazole bulk drug. According to the method, an ultraviolet spectrophotometric method is adopted, diazotization with sulfanilamide is carried out, then color development with N-(1-naphthyl) ethylenediamine hydrochloride is carried out, and the content of nitrite is detected at the wavelength of 530-534 nm. According to the detection method, the content of nitrite in the metronidazole bulk drug can be rapidly and accurately detected, and the method is high in recovery rate and sensitivity and good in precision, repeatability and linearity.

The invention provides a preparation method of a high-stability metronidazole suppository, and relates to the technical field of metronidazole suppository preparation. The high-stability metronidazole suppository is prepared from metronidazole, ginseng stem and leaf saponin, vitamin E, a polyethylene glycol composition, polyoxyethylene stearate, distilled water and vitamin C palmitate, and the high-stability metronidazole suppository is prepared by the following steps: dissolving the vitamin E, the polyethylene glycol composition, the polyoxyethylene stearate and the distilled water as matrixes; the metronidazole suppository is obtained by mixing metronidazole and ginseng stem and leaf saponin with vitamin C palmitate, then mixing the mixture with part of the matrix, dropwise adding the remaining matrix in a nitrogen atmosphere, and then performing stirring treatment by adopting carbon dioxide to obtain the final metronidazole suppository. The metronidazole suppository overcomes the defects in the prior art, the disintegration time of the metronidazole suppository in a human body can be effectively shortened, meanwhile, the stability of the metronidazole suppository is improved, and the safety of medicine storage is guaranteed.

The utility model discloses a tablet conveying device for metronidazole tablet manufacturing, and relates to the technical field of medicine production, the tablet conveying device comprises a support frame, the inner wall of the support frame is fixedly connected with a plurality of connecting rods, the outer wall of the top of the support frame is provided with a conveying seat, the inner wall of the conveying seat is rotatably connected with a rotating rod, and the rotating rod is fixedly connected with the support frame. By means of the screening plate, complete tablets can be naturally conveyed in a sliding mode along the inclination angle of the screening plate, incomplete tablets and disintegrating slag can directly pass through the interior of screening holes and naturally fall off, and therefore the tablets and the disintegrating slag can be completely conveyed. Then, the tablets naturally slide on the surface of a second screening plate and fall on the surface of a conveying belt through a discharging opening, and crushed materials fall into a crushed material collecting box, so that the tablets can be reasonably screened, and the complete tablets are conveyed to the subsequent working procedures; and incomplete tablets and disintegrating slag are screened out for subsequent dumping or recycling treatment.

This invention discloses a method for synthesizing a terbium complex fluorescent probe and its application in the detection of metronidazole, belonging to the field of food safety technology. This invention utilizes 2,6-difluorobenzoic acid and 1,10-phenanthroline as ligands to synthesize a luminescent rare earth complex [Tb2(2,6-dfba)6(phen)2] with Tb(NO3)3·6H2O. The crystal structure shows that it is a binuclear terbium complex, which exhibits strong Tb2 fluorescence at 489, 545, 584, and 621 nm. 3+ The complex exhibits characteristic emission peaks and good time stability of its fluorescence intensity. It specifically and sensitively recognizes metronidazole, demonstrating rapid response (<1 min), a low limit of detection (43.7 nM), and a wide linear detection range (0–100 μM). It can be used for the quantitative detection of metronidazole in animal feed.

1. Name of the product in this design: Packaging Box (Metronidazole Gel). 2. Purpose of this design: For use in pharmaceutical packaging. 3. The key design features of this product are the combination of shape and pattern. 4. The image or photograph that best illustrates the design's key points: a 3D model.

A metronidazole derivative of formula I, a preparation method, and a use in preparation of a drug. The metronidazole derivative can effectively ameliorate the symptoms of rosacea. Moreover, compared with metronidazole, the metronidazole derivative has less medication dosage and low medication frequency, but still can achieve a better improvement effect. Therefore, the metronidazole derivative has the prospect of being developed into a drug for ameliorating the symptoms of rosacea. The preparation method for the metronidazole derivative involves simple steps and mild conditions, and is easy for industrial production.

The invention relates to the technical field of pharmaceutical preparations, and particularly discloses a metronidazole tablet and a preparation method thereof. The preparation method comprises the following steps: micronizing metronidazole to obtain pretreated metronidazole; mixing the pretreated metronidazole, corn starch, cane sugar, carboxymethyl starch sodium and an adhesive, granulating, drying, and finishing to obtain a core material; and mixing the core material, carboxymethyl starch sodium and magnesium stearate, and tabletting to obtain the metronidazole tablet. The micronization treatment comprehensively improves the physical and chemical properties of metronidazole by regulating and controlling the particle size, form and crystal form. The carboxymethyl starch sodium has a relatively high expansion rate, and can cooperate with particle pores formed by the adhesive by adopting a specific internal and external addition mode, so that the dissolution rate is improved; the cane sugar assists in dissolving, so that the dissolution peak reaching time is shortened, and the medicine takes effect quickly; the corn starch and the adhesive enhance the compressibility of the particles, and the magnesium stearate controls the amount and prevents sticking, so that the formability is improved, and the loss is reduced.

Suspensions of metronidazole or baclofen and / or salts or ester derivative thereof, such as metronidazole benzoate, are disclosed. The suspension my include metronidazole or baclofen, and / or a salt or ester derivative thereof a hydrocolloid stabilizer, simethicone emulsion, a buffer, such as sodium citrate, (dihydrate), a preservative, a thickening agent, a sweetener, and water.

1. The name of the design product: packaging box (metronidazole tablets). 2. The use of the design product: used for the outer packaging of products. 3. The design points of the design product: the combination of shape and pattern. 4. The picture or photo that best indicates the design points: unfolded state reference drawing.

The invention discloses a metronidazole derivative, a preparation method and application in medicine preparation. The invention provides a metronidazole derivative. The metronidazole derivative can effectively improve the symptoms of rosacea. Moreover, compared with metronidazole, the metronidazole derivative has the advantages that the dosage is reduced, the medication frequency is reduced, but a better improvement effect can be obtained, and the effect is unexpected. Therefore, the metronidazole derivative has the prospect of being developed into the medicine for improving the acne rosacea symptom. The invention also provides a preparation method of the metronidazole derivative, which has the advantages of simple steps, mild conditions and easiness in industrial production.

The application discloses a synthesis method of a stable isotope-labeled metronidazole, and belongs to the field of organic synthesis. The preparation steps are three hydrogen-deuterium exchanges: adding metronidazole and a deuterium source into a reaction container, adding a deuterium water solution of a catalyst under stirring, reducing to room temperature after reaction at 75 DEG C to 85 DEG C for 110 min to 130 min, and standing for 10 h to 15 h; adjusting pH to 6 to 7 by using a deuterated acid, and removing a solvent. Finally, recrystallization by using ethanol is performed to obtain the product. The application effectively improves the purity and abundance of the isotope-labeled metronidazole through multiple hydrogen-deuterium exchanges, ensures the quality and stability of the obtained product, and realizes high raw material utilization rate, and the obtained product has high purity and high abundance.

The invention relates to a production device and a production method, in particular to a production device and a production method of metronidazole vaginal effervescent tablets. The metronidazole vaginal effervescent tablet prepared by the production device and the production method can be rapidly disintegrated through matching of anhydrous citric acid, carboxymethyl starch sodium and sodium bicarbonate, on one hand, metronidazole can be rapidly released through rapid disintegration, the metronidazole vaginal effervescent tablet can rapidly act on a focus to digest inflammation, on the other hand, the metronidazole vaginal effervescent tablet can be rapidly dissolved into a solution through rapid disintegration, and the metronidazole vaginal effervescent tablet can be rapidly disintegrated. And foreign body sensation can be quickly eliminated. The tablets can be isolated from air through aluminum foil packaging, and the tablets are prevented from absorbing moisture. The problems that an existing effervescent tablet takes effect slowly and has foreign body sensation for a long time due to the fact that the existing effervescent tablet has a coating layer are solved.

The utility model discloses a metronidazole filtering device, which is characterized in that a buffer unit, a flushing unit and a filtering unit are arranged in a filtering tank, and the impact force of mixed liquid on a filter screen due to the flow velocity and gravity action is weakened by utilizing a buffer slope, so that the loss of the filter screen is reduced; the holes are formed in the buffer slope and the platform, so that part of the mixed liquid can flow onto the filter screen through the holes, and the dispersion uniformity of the mixed liquid on the filter screen is improved; the flushing unit is arranged in the open groove below the supporting beam, so that the equipment structure is simplified while high-pressure flushing of the filter screen is realized; the filter screen is fixed to the supporting rod, the motor drives the supporting rod to rotate, the filter screen can rotate to any angle for high-pressure washing, and the service life of the filter screen is prolonged; the partition plate is arranged in the middle of the filter screen, and the upper surface of the partition plate is a convex surface, so that the mixed liquid can be shunted to the filter screens on two sides of the partition plate, unfiltered mixed liquid is prevented from remaining in a support rod area, and waste and raw material cost are reduced.

1. Name of the product of this design: Pharmaceutical packaging box (metronidazole vaginal effervescent tablets). 2. Purpose of this design product: for packaging boxes. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

The application discloses a treatment method of metronidazole pharmaceutical wastewater. The treatment method comprises the following steps: S1, constructing a pulse electro-Fenton reactor: taking inert electrodes and iron electrodes as anodes, taking an air diffusion electrode as a cathode, and taking metronidazole pharmaceutical wastewater as an electrolyte; and S2, operation: alternately electrifying the inert electrodes and the iron electrodes, and continuously electrifying the cathode to form a pulse current. The treatment method adopts the pulse electro-Fenton technology to treat the metronidazole pharmaceutical wastewater, and through cooperation of various conditions, efficient removal of metronidazole in the metronidazole pharmaceutical wastewater can be realized. In addition, the steps S1 and S2 of the treatment method do not need to additionally add ferrous catalyst, and problems that the traditional Fenton oxidation method needs to additionally add ferrous catalyst and generates a large amount of iron sludge are avoided, and the efficiency of the electro-Fenton oxidation method is improved.

1. Name of the product in this design: Packaging Box (Artificial Bezoar Metronidazole Capsules). 2. Purpose of this design: A packaging box for packaging pharmaceuticals. 3. The key design feature of this product is its pattern. 4. The image or photograph that best illustrates the design's key points: a 3D model.

1. Name of the product in this design: Ointment Tube (Metronidazole Gel). 2. Intended use of this design: for pharmaceutical packaging. 3. The key design features of this product are the combination of shape and pattern. 4. The image or photograph that best illustrates the design's key points: 3D view 1. 5. As shown in 3D diagrams 1 and 2, the left and right views are omitted.

This invention discloses a light-free carbon nitride photocatalyst, its preparation method, and its application in the degradation of pollutants in water using activated persulfate. It belongs to the field of environmental pollution removal technology. This invention obtains a light-free carbon nitride photocatalyst by high-temperature calcination of 2,5-thiophene-dicarboxylic acid, nickel acetate tetrahydrate, and cobalt acetate tetrahydrate with urea. Its activated persulfate can efficiently degrade various high-concentration pollutants without light exposure. 15 mg of this catalyst can degrade 50 mg of persulfate. ‑1 The degradation rates of methyl orange, methylene blue, rhodamine B, tetracycline, ciprofloxacin, and metronidazole reached 100% (1 min), 100% (2 min), 99% (5 min), 97% (30 s), 97% (20 min), and 88% (30 min), respectively; after five consecutive cycles, 50 mg L of the product was degraded. ‑1 Tetracycline, degradation rate >96%; 10 mg of this catalyst degrades 50 mg L in different water sources. ‑1 Tetracycline degradation rate >95%. High degradation efficiency, high stability and versatility indicate that this catalyst has great potential for application in the field of water pollution control.

The invention discloses an ultraviolet spectrophotometric detection method for metronidazole cleaning verification. The ultraviolet spectrophotometric detection method comprises the following steps: sampling and preparing a solution; performing determination; and calculating. According to the method, ultraviolet spectrophotometry is adopted, ethyl alcohol serves as a solvent, detection is carried out under the detection wavelength of 320 nm, the industrial problems that residues are not completely dissolved and the detection result is seriously deviated due to poor water solubility of metronidazole are thoroughly solved, and the authenticity and reliability of a cleaning verification result are ensured; the analysis time is shortened to several minutes, the detection efficiency is greatly improved, and the detection cost is reduced; through system verification, the method has the excellent performance of high sensitivity, good precision, stable recovery rate and the like, trace metronidazole residues on the surface of equipment can be accurately and effectively measured, and a powerful technical guarantee is provided for safe production of drugs.

The utility model discloses a press filter for metronidazole production, which relates to the technical field of press filters and comprises a barrel body for the press filter, a discharge valve arranged at the bottom of the barrel body, a barrel cover arranged on the barrel body, an air inlet arranged on the barrel cover and a conveying device arranged on the barrel cover. The conveying device comprises a feeding pipe fixedly penetrating through the barrel cover, a connecting block is fixedly connected to the bottom of the feeding pipe, a filter plate for filtering a nidazole solution is fixedly connected to the bottom of the fixing block, a through hole for discharging the nidazole solution is formed in the position, above the fixing block, of the feeding pipe, and a supporting device is arranged on the inner wall of the barrel body below the filter plate. The filter plate can be directly taken out when the barrel cover is taken out, the situation that the filter plate needs to be taken out independently is avoided, the fixing plate and the support can effectively support the filter plate, the situation that a filter screen deforms during filter pressing is avoided, and the use effect of the filter screen is improved.

The present invention discloses a metronidazole tablet and a preparation method thereof. The metronidazole tablet is prepared from the following components in parts by weight: 55-60 parts of metronidazole, 35-40 parts of a filler, 5-10 parts of sorbitol, 1-5 parts of povidone K30, 5-15 parts of a binder, 0.2-0.5 parts of magnesium stearate, and 2-6 parts of a coating agent. The use of sorbitol and povidone K30 in the excipients of the present invention can improve the brittleness of the tablet, increase its hardness and stability, and make it less prone to breakage during production and storage. In addition, the synergistic effect of sorbitol and povidone K30 can improve the dissolution rate of the tablet, thereby increasing the bioavailability of the drug.

The utility model discloses a dropping device in metronidazole production, which comprises a dropping unit, a driving unit, a reaction unit, a stirring unit and the like, a third space between a vertical rod of the stirring unit and a dropping pipe is filled with cooling water, and the whole dropping pipe is immersed in the cooling water to ensure that an acetaldehyde solution is continuously cooled in the dropping process; the first space is filled with cooling water, so that acetaldehyde which does not react in time and is volatilized drips again after being condensed in time, and the utilization rate of acetaldehyde is increased; an exchange area is arranged at the intersection of the vertical rod and the first space, so that the flowability of cooling water is realized, and the cooling effect is improved; the liquid outlet holes are formed in the cross rod, so that an acetaldehyde solution is dispersed in reaction liquid in time while being stirred, the contact area of the acetaldehyde solution and the reaction liquid is increased, rapid reaction is achieved, and acetaldehyde volatilization caused by local overheating due to the fact that the acetaldehyde solution is directly dripped into the reaction liquid is avoided; a common vertical rod is arranged, and simultaneous stirring of the dropwise adding unit and the reaction unit can be realized only by using one set of driving unit, so that the equipment cost is reduced.

The invention discloses a metronidazole gel composition and a preparation method thereof. The metronidazole gel composition is prepared from the following components in percentage by mass: 0.6 to 0.8 percent of metronidazole, 0.5 to 0.7 percent of carbomer (benzene-free type), 1.0 to 5.0 percent of a humectant, 0.05 to 0.15 percent of a preservative, a pH (Potential of Hydrogen) regulator, and / or other pharmaceutically acceptable auxiliary materials, and the balance of water. Wherein the metronidazole gel composition does not contain benzene. The metronidazole gel composition is stable in quality and high in safety, particularly, the safety of the gel composition can be further improved by adopting a benzene-free auxiliary material carbomer homopolymer 980, metronidazole is prevented from making contact with benzene in the long-term external use process, and then the harmfulness of metronidazole is avoided; moreover, by further optimizing the dosage of carbomer 980, the pH value of the product and the like, the impurities of the product can be better controlled, and the stability of the product is further improved.

To provide a full continuous chemical synthesis apparatus and method for metronidazole, which have high production efficiency, excellent product quality and less emission of three wastes (waste water, waste gas and solid waste generated in industrial production).SOLUTION: Using a full continuous apparatus comprising multiple improved micromixers, microreactors, on-line solvent switching systems, reagent recovery equipment, low-boiling-point reagent supply equipment, and other equipment communicated in sequence, a high-purity metronidazole product is synthesized from a starting material 2-methylimidazole through a three-step chemical reaction and continuous operation, and recovery and reuse of a sulfuric acid and a formic acid are realized, and the problem of accurate and continuous feeding of ethylene oxide is solved. The crude metronidazole is subjected to decoloring, recrystallization, filtration and drying to obtain pure metronidazole with purity of greater than 99.9%. The sulfuric acid consumption can be reduced by 80% or more, thereby efficiently reducing the production of a waste acid and a waste salt and reducing the production cost.SELECTED DRAWING: Figure 1

The invention relates to the field of sewage treatment, in particular to a method for degrading metronidazole in water by catalyzing persulfate by utilizing a medicinal residue astragalus-based biochar composite material. The method comprises the following steps: 1) preparing a catalyst, namely cleaning, drying and crushing radix astragali dregs, uniformly mixing the crushed radix astragali dregs with a nitrogen-containing compound and a transition metal salt solution, dipping and drying, performing high-temperature pyrolysis in an inert atmosphere, cooling, performing acid pickling and water washing to be neutral, drying again, and grinding to obtain the dreg radix astragali-based biochar composite material; and 2) degradation reaction: sequentially adding the decoction dreg astragalus-based charcoal composite material and persulfate into a to-be-treated water body containing metronidazole, and carrying out catalytic oxidation reaction under a stirring or aeration condition to realize degradation of metronidazole. According to the method, a nitrogen-doped porous biochar composite material prepared from radix astragali residues is used as a catalyst to activate persulfate to generate strong oxidizing free radicals, so that efficient degradation and mineralization of metronidazole are realized.