9 results about "Metronizole" patented technology

The invention discloses metronidazole particles, a preparation containing the metronidazole particles and a preparation method of the metronidazole particles. The metronidazole particle comprises a drug core and a coating layer, wherein the coating layer is coated on the outer surface of the drug core; the medicine core comprises metronidazole; the coating layer comprises a film-forming material, and the film-forming material comprises gastric-soluble acrylic resin and ethyl cellulose. The metronidazole granule has low dissolution rate in water and a medium with high pH (such as pH 6.8), especially the dissolution rate in 15 minutes is less than or equal to 10%, the dissolution rate at low pH (such as pH 1.2-4.5) is consistent with the dissolution rate of commercially available tablets, and the metronidazole granule is rapidly dissolved out.

The invention discloses a method for detecting nitrite in a metronidazole bulk drug. According to the method, an ultraviolet spectrophotometric method is adopted, diazotization with sulfanilamide is carried out, then color development with N-(1-naphthyl) ethylenediamine hydrochloride is carried out, and the content of nitrite is detected at the wavelength of 530-534 nm. According to the detection method, the content of nitrite in the metronidazole bulk drug can be rapidly and accurately detected, and the method is high in recovery rate and sensitivity and good in precision, repeatability and linearity.

1. Name of the product in this design: Packaging Box (Metronidazole Gel). 2. Purpose of this design: For use in pharmaceutical packaging. 3. The key design features of this product are the combination of shape and pattern. 4. The image or photograph that best illustrates the design's key points: a 3D model.

1. Name of the product in this design: Packaging Box (Artificial Bezoar Metronidazole Capsules). 2. Purpose of this design: A packaging box for packaging pharmaceuticals. 3. The key design feature of this product is its pattern. 4. The image or photograph that best illustrates the design's key points: a 3D model.

1. Name of the product in this design: Ointment Tube (Metronidazole Gel). 2. Intended use of this design: for pharmaceutical packaging. 3. The key design features of this product are the combination of shape and pattern. 4. The image or photograph that best illustrates the design's key points: 3D view 1. 5. As shown in 3D diagrams 1 and 2, the left and right views are omitted.

The invention discloses an ultraviolet spectrophotometric detection method for metronidazole cleaning verification. The ultraviolet spectrophotometric detection method comprises the following steps: sampling and preparing a solution; performing determination; and calculating. According to the method, ultraviolet spectrophotometry is adopted, ethyl alcohol serves as a solvent, detection is carried out under the detection wavelength of 320 nm, the industrial problems that residues are not completely dissolved and the detection result is seriously deviated due to poor water solubility of metronidazole are thoroughly solved, and the authenticity and reliability of a cleaning verification result are ensured; the analysis time is shortened to several minutes, the detection efficiency is greatly improved, and the detection cost is reduced; through system verification, the method has the excellent performance of high sensitivity, good precision, stable recovery rate and the like, trace metronidazole residues on the surface of equipment can be accurately and effectively measured, and a powerful technical guarantee is provided for safe production of drugs.

The invention discloses a metronidazole gel composition and a preparation method thereof. The metronidazole gel composition is prepared from the following components in percentage by mass: 0.6 to 0.8 percent of metronidazole, 0.5 to 0.7 percent of carbomer (benzene-free type), 1.0 to 5.0 percent of a humectant, 0.05 to 0.15 percent of a preservative, a pH (Potential of Hydrogen) regulator, and / or other pharmaceutically acceptable auxiliary materials, and the balance of water. Wherein the metronidazole gel composition does not contain benzene. The metronidazole gel composition is stable in quality and high in safety, particularly, the safety of the gel composition can be further improved by adopting a benzene-free auxiliary material carbomer homopolymer 980, metronidazole is prevented from making contact with benzene in the long-term external use process, and then the harmfulness of metronidazole is avoided; moreover, by further optimizing the dosage of carbomer 980, the pH value of the product and the like, the impurities of the product can be better controlled, and the stability of the product is further improved.

To provide a full continuous chemical synthesis apparatus and method for metronidazole, which have high production efficiency, excellent product quality and less emission of three wastes (waste water, waste gas and solid waste generated in industrial production).SOLUTION: Using a full continuous apparatus comprising multiple improved micromixers, microreactors, on-line solvent switching systems, reagent recovery equipment, low-boiling-point reagent supply equipment, and other equipment communicated in sequence, a high-purity metronidazole product is synthesized from a starting material 2-methylimidazole through a three-step chemical reaction and continuous operation, and recovery and reuse of a sulfuric acid and a formic acid are realized, and the problem of accurate and continuous feeding of ethylene oxide is solved. The crude metronidazole is subjected to decoloring, recrystallization, filtration and drying to obtain pure metronidazole with purity of greater than 99.9%. The sulfuric acid consumption can be reduced by 80% or more, thereby efficiently reducing the production of a waste acid and a waste salt and reducing the production cost.SELECTED DRAWING: Figure 1

The invention belongs to the technical field of metal salicylhydroxamic acid molecular cage complex materials, and particularly discloses a metal salicylhydroxamic acid molecular cage for detecting metronidazole and a preparation method and application of the metal salicylhydroxamic acid molecular cage. The structural general formula of the metal salicylhydroxamic acid molecular cage is {M2Ga8 (shi) 8 (X) 4}; wherein M is one of lanthanide series rare earth metal elements; shi represents a salicylhydroxamic acid ligand; x is a dicarboxylic acid ligand. Compared with the prior art, the prepared metal salicylhydroxamic acid molecular cage has a specific cavity and skeleton structure, adsorption and aggregation of small molecular compounds can be achieved, and due to the fact that rare earth elements emit light, the content of the small molecular compounds can be detected through fluorescence intensity changes. The molecular cage provided by the invention is used for fluorescence sensing detection of the content of metronidazole in wastewater, and has the advantages of high sensitivity, fast response and the like.