Taste masking preparation

A preparation and water swelling technology, applied in the field of medicine, can solve the problems of short taste masking time and poor taste masking effect, and achieve the effects of easy industrialization, simple preparation method and delaying contact time.

Active Publication Date: 2012-01-04
HANGZHOU ZHONGMEI HUADONG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the shortcomings of short taste-masking time and poor taste-masking effect in the prior art, and provide an oral preparation with good taste-masking effect, long taste-masking time and good lubricity

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1 clarithromycin dry suspension

[0022] Clarithromycin 25.0g

[0023] Powdered sugar 35.0g

[0024] Starch 15.0g

[0025] Polyvinylpyrrolidone 2.3g

[0026] Acrylic resin E100 11.2g

[0027] Talc powder 5.6g

[0028] Carbomer 12.5g

[0029] Triethyl citrate 0.6g

[0030] Preparation process: powdered sugar and starch are used to make blank ball cores, polyvinylpyrrolidone ethanol / water solution is used as a binder, clarithromycin is wrapped on the blank ball cores in the form of the above drug, and then acrylic resin, triethyl citrate Coating with the suspension of talcum powder, while spraying the coating solution, add carbomer powder, so that the carbomer powder can adhere to the wet balls to form a coating layer containing carbomer, and pack Instantly.

Embodiment 2

[0031] Embodiment 2 clarithromycin tablet

[0032] Clarithromycin 25.0g

[0033] Microcrystalline Cellulose 4.7g

[0034] Lactose 3.0g

[0035] Starch 2.1g

[0036] Sodium carboxymethyl starch 2.4g

[0037] 10% starch slurry 20.0g

[0038] Magnesium stearate 0.3g

[0039] Opadry 1.2g

[0040] Carbomer 25.0g

[0041] Preparation process: first place clarithromycin in a wet granulator, add starch, microcrystalline cellulose, lactose, and sodium carboxymethyl starch, mix evenly, then wet granulate with 10% starch slurry, dry and arrange , add magnesium stearate and sodium carboxymethyl starch, mix evenly, and press into tablets; then coat with Opadry's ethanol / water solution, and wrap a layer of carbomer while coating, to obtain.

Embodiment 3

[0042] Embodiment 3 chloramphenicol particles

[0043] Chloramphenicol 25.0g

[0044] Lactose 100g

[0045] Microcrystalline Cellulose 200g

[0046] 10% starch slurry 100g

[0047] Carbomer 50.0g

[0048] Hypromellose 6.0g

[0049] Magnesium Stearate 1.0g

[0050] Preparation process: Mix chloramphenicol, lactose and microcrystalline cellulose evenly, granulate with 10% starch slurry as binder, dry and granulate, coat with hypromellose and carbomer, add hard Magnesium fatty acid is mixed evenly, and then packed.

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PUM

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Abstract

The invention relates to an oral taste masking preparation and a preparation method thereof. The invention is characterized in that an auxiliary material which expands with water is added in the preparation process, owning to the hydro-expansiveness of the auxiliary material, a film is formed in the outer layer of a medicine, thus enabling the medicine to form a shape similar to an frog egg, delaying the contact time between the medicine and body liquid and masking the taste; and an preparation formula and an preparation process of the original product do not need to be changed, and a production spot and a device do not need to be reformed. The preparation method is simple and convenient, and industrialization can be easily achieved.

Description

technical field [0001] The invention relates to the field of medical science and technology, in particular to an oral taste-masking preparation and a preparation method thereof. Background technique [0002] Oral dosage forms of drugs are convenient and low-cost, and are currently the most common way of drug delivery. However, many drugs have unbearable bad taste, which is greatly restricted in the development and clinical use of dosage forms. [0003] With the continuous improvement of people's living standards, people's requirements for the quality of medicines are getting higher and higher. "Good medicine tastes bitter" is no longer a fashion. People hope to get products with good efficacy, good taste and convenient consumption to improve the quality of life. Meet physical and mental needs. Especially for pediatric medicine, the taste is easy for children to accept, which can greatly improve the compliance of medication. Therefore, effectively masking the bad taste of m...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/00A61K47/32A61K47/38A61K9/28A61K31/7048A61P31/04
Inventor 姚忠立张洪记姚忠明
Owner HANGZHOU ZHONGMEI HUADONG PHARMA
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