Preparation method of mequindox taste-masking nanometer prodrug

An acemequine and nanotechnology is applied in the field of preparation of taste-masking nanometer prodrugs of acemequine, which can solve problems such as fast metabolism, and achieve the effects of simple preparation method, prolonging action time, and avoiding feeding refusal of farmed animals.

Inactive Publication Date: 2018-06-15
JIANGXI AGRICULTURAL UNIVERSITY
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  • Abstract
  • Description
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Problems solved by technology

[0004] In order to overcome the problems of bitter taste and fast metabolism of acemethaquine, the invention provides a method for preparing acemetaquine taste-masking nano-prodrug

Method used

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  • Preparation method of mequindox taste-masking nanometer prodrug

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Embodiment 1

[0025] 1 Materials and methods

[0026] 1.1 Test time and place

[0027] The present invention was completed from October 2013 to April 2014 in the Veterinary Medicine Institute of Jiangxi Agricultural University Animal Science and Technology Institute.

[0028] 1.2 Test materials and instruments

[0029] 1.2.1 Experimental Reagents Cetyltrimethylammonium bromide (CTAB, chemically pure), 3-aminopropyltriethoxysilane (APTES, chemically pure), tetraethyl orthosilicate (TEOS) used in the experiment , chemically pure) were purchased from China Pharmaceutical Group Shanghai Chemical Reagent Company; acetylmequine, Huanggang Branch of Beijing Zhongnongfa Pharmaceutical Co., Ltd.; concentrated hydrochloric acid (analytical pure), sodium hydroxide (analytical pure), anhydrous ethanol (analytical pure ) and other conventional reagents were purchased from Tianjin Fuchen Chemical Reagent Factory, twice distilled water (self-made).

[0030] 1.2.2 Experimental equipment The field emissi...

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Abstract

The invention provides a preparation method of a mequindox taste-masking nanometer prodrug, an amino functionalized MCM-41 type mesoporous nanomaterial MSN-NH2 is taken as a carrier, the mequindox isimmobilized in a porous channel of the mesoporous nanomaterial through an acid-sensitive Schiff base covalent bond to prepare the mequindox nanometer prodrug MEQ@MSN-NH2, and the purpose of masking the taste is fulfilled. The mequindox is successfully loaded in a pore of mesoporous silica, and forms a dispersion spherical particle, and the average diameter of the dispersion spherical particle is about 100 nm. The result of the external release experiment shows that the release rate of the nanometer prodrug in simulated saliva in five minutes is only 8.7%, and the taste masking performance is excellent; the nanometer prodrug is rapidly released in the artificial gastric juice, 67% of the total drug loading capacity of the nanometer prodrug is released within 30 minutes, the nanometer prodrug is basically completely released within 24 hours, and the result proves the excellent drug delivery and sustained-release properties.

Description

technical field [0001] The invention relates to a preparation method of acemetquine taste-masking nanometer prodrug. Background technique [0002] Mequindox, also known as Mequindox (MEQ), is an antibacterial and growth-promoting drug successfully developed in my country. It has a good effect on piglet yellow scour, pullorum, calf diarrhea, paratyphoid fever, chicken pullorum, poultry colibacillosis, etc. It has a wide antibacterial spectrum, is not easy to produce drug resistance, and is low in price, so it is the first choice for the treatment of intestinal infections in livestock and poultry. However, due to its poor water solubility, bitter taste and fast metabolism, the application of acemethaquine is limited. Therefore, it is an urgent need for veterinary clinics to develop acemetaquine taste-masking nano-prodrugs through simple and effective methods to overcome the problems of acemetaquine's bitter taste and fast metabolism. [0003] MCM-41 type mesoporous silica nan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/52A61K31/498A61P31/04A61P3/00B82Y5/00
CPCA61K31/498B82Y5/00
Inventor 鲍光明袁厚群胡国良何后军刘宝生王小莺刘婵娟王立琦罗军荣陈书鹏
Owner JIANGXI AGRICULTURAL UNIVERSITY
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