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A kind of preparation method of acemetquine taste-masking nanometer prodrug

Acemequine and nanotechnology are applied in the field of preparation of taste-masking nanometer prodrugs of acemequine, which can solve problems such as fast metabolism, achieve the effects of simple preparation method, avoidance of feeding refusal of farmed animals, and cheap and easily available materials

Inactive Publication Date: 2020-11-03
JIANGXI AGRICULTURAL UNIVERSITY
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  • Abstract
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Problems solved by technology

[0004] In order to overcome the problems of bitter taste and fast metabolism of acemethaquine, the invention provides a method for preparing acemetaquine taste-masking nano-prodrug

Method used

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Embodiment 1

[0025] 1 Materials and methods

[0026] 1.1 Test time and place

[0027] The present invention was completed from October 2013 to April 2014 in the Veterinary Medicine Institute of Jiangxi Agricultural University Animal Science and Technology Institute.

[0028] 1.2 Test materials and instruments

[0029] 1.2.1 Experimental Reagents Cetyltrimethylammonium bromide (CTAB, chemically pure), 3-aminopropyltriethoxysilane (APTES, chemically pure), tetraethyl orthosilicate (TEOS) used in the experiment , chemically pure) were purchased from China Pharmaceutical Group Shanghai Chemical Reagent Company; acetylmequine, Huanggang Branch of Beijing Zhongnongfa Pharmaceutical Co., Ltd.; concentrated hydrochloric acid (analytical pure), sodium hydroxide (analytical pure), anhydrous ethanol (analytical pure ) and other conventional reagents were purchased from Tianjin Fuchen Chemical Reagent Factory, twice distilled water (self-made).

[0030] 1.2.2 Experimental equipment The field emissi...

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Abstract

The invention provides a method for preparing the taste-masking nano-prodrug of acemethaquine, which uses amino functionalized MCM-41 type mesoporous nano-material MSN-NH 2 As a carrier, acemethaquine was immobilized in the pores of mesoporous nanomaterials through acid-sensitive Schiff base covalent bonds to prepare acemetquine nano-prodrug MEQ@MSN‑NH 2 , to achieve the purpose of taste masking. Acetomequine was successfully loaded into the pores of mesoporous silica and formed dispersed spherical particles with an average diameter of about 100 nm. The results of in vitro release experiments showed that the release rate of the nanomedicine in simulated saliva was only 8.7% within 5 minutes, showing that its taste-masking performance was good; it was released rapidly in artificial gastric juice, and 67% of the total drug load could be released within 30 minutes. The release is basically completed within 24 hours, indicating its excellent drug delivery and sustained release properties.

Description

technical field [0001] The invention relates to a preparation method of acemetquine taste-masking nanometer prodrug. Background technique [0002] Mequindox, also known as Mequindox (MEQ), is an antibacterial and growth-promoting drug successfully developed in my country. It has a good effect on piglet yellow scour, pullorum, calf diarrhea, paratyphoid fever, chicken pullorum, poultry colibacillosis, etc. It has a wide antibacterial spectrum, is not easy to produce drug resistance, and is low in price, so it is the first choice for the treatment of intestinal infections in livestock and poultry. However, due to its poor water solubility, bitter taste and fast metabolism, the application of acemethaquine is limited. Therefore, it is an urgent need for veterinary clinics to develop acemetaquine taste-masking nano-prodrugs through simple and effective methods to overcome the problems of acemetaquine's bitter taste and fast metabolism. [0003] MCM-41 type mesoporous silica nan...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/52A61K31/498A61P31/04A61P3/00B82Y5/00
CPCA61K31/498B82Y5/00
Inventor 鲍光明袁厚群胡国良何后军刘宝生王小莺刘婵娟王立琦罗军荣陈书鹏
Owner JIANGXI AGRICULTURAL UNIVERSITY
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