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Orally disintegrating tablet with functions of oral cavity paralysis and taste masking and preparation method of orally disintegrating tablet

An orally disintegrating tablet and oral cavity technology, applied in the field of medicine, can solve the problems of short taste masking time, poor taste masking effect, high price and the like, and achieve the effect of good taste masking effect, good masking effect and swallowing convenience.

Active Publication Date: 2015-03-04
安徽万春日化有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The existing oral taste-masking preparations are generally realized by adding flavoring agents, sugar-coating or film-coating, but the taste-masking time of these technologies is relatively short, the taste-masking effect is poor, and the price is expensive, affecting other tastes, especially For the elderly and children who have difficulty swallowing, it is easy to feel bitter when the medicine is in the mouth for a long time.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] An orally disintegrating tablet for paralyzing the oral cavity and masking taste, comprising the following raw materials in percentage by weight: drug core 55%, taste-masking auxiliary material 30%, cross-linked polyvinyl pyrrolidone 7%, low-substituted hydroxypropyl fiber Vegetables 6%, Magnesium Stearate 1.5%, Sesame Oil Flavor 0.5%; Taste-masking agent is water decoction of pepper.

[0025] In this embodiment, a method for preparing an orally disintegrating tablet for paralyzing the oral cavity and masking taste comprises the following sequential steps:

[0026] (1) Making the drug core: by weight, 1 part of roxithromycin, 10 parts of acrylic resin, and 10 parts of cyclodextrin are mixed evenly, dissolved, clathrated, dried, and passed through a 60-mesh sieve to make powder drug core;

[0027] (2) Preparation of auxiliary materials with a taste-masking agent: in parts by weight, 1 part of cellulose absorbs 2 parts of a taste-masking agent that has the effect of para...

Embodiment 2

[0030] An orally disintegrating tablet for paralyzing the oral cavity and masking taste, comprising the following raw materials in percentage by weight: drug core 80%, taste-masking adjuvant 10%, effervescent disintegrant 2%, sodium carboxymethyl starch 5.5%, hard Magnesium fatty acid 2%, sesame oil essence 0.5%; taste masking agent is a water decoction of pepper and Chinese prickly ash.

[0031] In this embodiment, a method for preparing an orally disintegrating tablet for paralyzing the oral cavity and masking taste comprises the following sequential steps:

[0032] (1) Making the drug inner core: by weight, after mixing 1 part of norfloxacin and 0.5 part of alginate evenly, dissolving, inclusion, drying, and passing through a 60-mesh sieve to make a powdered drug inner core;

[0033] (2) Preparation of auxiliary materials with a taste-masking agent: by weight, 1 part of starch is dried;

[0034] (3) Tablet compression: by weight percentage, 80% of the inner core of the dru...

Embodiment 3

[0036] An orally disintegrating tablet for paralyzing the oral cavity and masking the taste, comprising the following raw materials in percentage by weight: 40% of the drug core, 40% of auxiliary materials with taste-masking agents, 10% of dry starch, and 10% of gellan gum; the taste-masking agents are capsicum, Water decoction of pepper combination.

[0037] In this embodiment, a method for preparing an orally disintegrating tablet that paralyzes the oral cavity and masks taste comprises the following sequential steps:

[0038] (1) Making the inner core of the medicine: in parts by weight, after mixing 1 part of amoxicillin, 10 parts of gelatin, and 10 parts of gum arabic, dissolve, clathrate, dry, and pass through a 60-mesh sieve to make a powdery medicine inner core ;

[0039] (2) Preparation of auxiliary materials with a taste-masking agent: in parts by weight, 0.5 part of xanthan gum and 0.5 part of galactomannan absorb 1.5 parts of a taste-masking agent with the effect ...

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Abstract

The invention relates to the technical field of medicine and discloses an orally disintegrating tablet with functions of oral cavity paralysis and taste masking and a preparation method of the orally disintegrating tablet. The orally disintegrating tablet with the functions of oral cavity paralysis and taste masking comprises the following raw materials in percentage by weight: 40-80 percent of a medicine core, 10-50 percent of an auxiliary material absorbed with a taste masking agent, 5-30 percent of a disintegrating agent, 0-2 percent of a lubricating agent and 0-0.5 percent of an essence, wherein the taste masking agent is a water decoction formed by one or a combination of more of chili, black pepper and Sichuan pepper. The orally disintegrating tablet tastes good, has a spicy fragrance, and has a good taste masking effect; the taste masking effect on roxithromycin, norfloxacin and amoxicillin is extremely good by virtue of verification at present; by adding sesame oil and the essence, the stink of the amoxicillin can be well masked.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an orally disintegrating tablet for paralyzing the oral cavity and masking taste and a preparation method thereof. Background technique [0002] With the continuous improvement of people's living standards, people's requirements for the quality of medicines are getting higher and higher. "Good medicine tastes bitter" is no longer a fashion. People hope to get products with good efficacy, good taste and convenient consumption to improve the quality of life. Meet physical and mental needs. Especially for pediatric medicine, the taste is easy for children to accept, which can greatly improve the compliance of medication. Therefore, effectively masking the bad taste of medicines and improving product quality have been paid more and more attention by people in the pharmaceutical industry. Taste masking technology is to cover up the original bad taste of the main drug, especially th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K47/46A61K31/7048A61K31/496A61K31/43
Inventor 张景亮张佳高婉妃王岩岩孙中华
Owner 安徽万春日化有限公司
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